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- 저자 : Xiaomei Qin (검색결과 4 건)
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Xiaomei Qin,Sheng Huang,Yanqing Liu,Mingdi Bian,Wuliang Shi,Zecheng Zuo,Zhenming Yang 한국식물학회 2017 Journal of Plant Biology Vol.60 No.1
Aluminium (Al) toxicity is a primary limitation of crop production in acid soils, which take over 40% of arable soil worldwide. In previous studies, a series of genes have been identified to regulate the plant Al resistance or tolerance. However, none of E3 ubiquitin ligase, the key factor of ubiquitination that plays an important role in plant growth and development, has been characterized for Al response in Arabidopsis. In this study, an E3 ubiquition ligase gene AtATRF1 (Al Tolerance RING Finger 1), a homolog of RAD18 interacting RAD6 to repair the damaged DNA in human and yeast, is isolated from Arabidopsis. It encodes a predicted protein of 296 amino acids with a C3HC4 type RING finger domain. The expression of AtATRF1 is induced by Al, and the transgenic plant overexpressing AtATRF1 enhances the Al tolerance. Similar as RAD18, the AtATRF1 locates in nucleus and regulates the expression of AtATR, which involves in DNA repair and Al response in Arabidopsis. Our results indicate that nuclearlocated AtATRF1 may interact and ubiquitinate the transcriptional regulator of AtATR to mediate the Al tolerance of Arabidopsis.
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Xiaomei Zhan,Jifeng Cheng,Li Xiang,Huiju Shao,Shuhao Qin 한국섬유공학회 2021 Fibers and polymers Vol.22 No.5
To obtain the excellent permeate flux, rejection performance and mechanical properties, the chlorinated polyvinylchloride (CPVC) porous membrane was fabricated on the polyethylene terephthalate (PET) non-woven fabric by non-solventinduced phase separation (NIPS), using Tween80 (polyoxyethylene sorbitan monooleate) as a hydrophilic surfactant to regulate themicrostructure of the membrane. Porous skin layer and sub-layer were achieved when 3 wt.% Tween80 was added with asmall amount of deionized water as additive, and internal layer consisted of various finger-like holes. The forming mechanism ofmicrostructures was investigated according to the effects of Tween80 molecular chain structure on the viscosity and surface tensionof casting solution. Significantly, the modified membranes obviously exhibited higher pure water flux, which was increasedby 257 % compared with the pristine membrane. The rejection to ink suspension was over 99 %. Furthermore, the antifoulingperformance of modified membrane was also greatly improved on account of the above microstructure and more hydrophilicsurface. This study provides a new idea for the construction of membrane microstructure and the hydrophilic modification.
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Liting Qin,Xiaole Qi,Honglei Gao,Yulong Gao,Zhigao Bu,Xiaomei Wang 한국미생물학회 2009 The journal of microbiology Vol.47 No.3
Infectious bursal disease virus (IBDV), belonging to Avibirnavirus genus in the Birnaviridae family, consists of two segments of double-strand RNA. There are two distinct serotypes of IBDV, the pathogenic serotype I and the non-pathogenic serotype II. Comparison of the deduced amino acid sequences of a panel of VP5 genes retrieved from GenBank revealed a high identity among strains within the serotype I or serotype II group but a low identity between strains across two serotypes. In this study, we rescued two mosaic viruses, rGtGxVP5 and rGt2382VP5 by exchanging the VP5 gene of a cell culture-adapted serotype I Gt strain with its counterpart of the very virulent IBDV Gx strain, or a non-pathogenic 23/82 strain of the serotype II. In comparison to the parental strain rGt virus, the rGtGxVP5 showed the similar viral replication, cytotoxicity and the ability of inducing apoptosis; however, the other mosaic virus rGt2382VP5 had a lower titer and a reduced cytotoxicity. Although exchange of VP5 within serotype I group did not alter the viral replication and cytotoxicity of Gt strain, exchange of VP5 in the serotype I with that of a serotype II reduced the viral replication and cytotoxicity on chicken embryo fibroblast (CEF) cells. Therefore, the VP5 of serotype II may be one of the factors responsible for the distinct pathogenic features of two serotypes.
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Misi He,Mingfang Guo,Qi Zhou,Ying Tang,Lin Zhong,Qing Liu,Xiaomei Fan,Xiwa Zhao,Xiang Zhang,Gang Chen,Yuanming Shen,Qin Xu,Xiao-jun Chen,Yuancheng Li,Dongling Zou 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3
Background: Cervical cancer is still present a major public health problem, especially in developing countries. In International Federation of Gynaecology and Obstetrics 2018, allowing assessment of retroperitoneal lymph nodes by imaging and/or pathological findings and, if deemed metastatic, the case is designated as stage IIIC (with r and p notations). Patients with lymph node metastases have lower overall survival (OS), progression free survival (PFS), and survival after recurrence, especially those who have unresectable macroscopical positive lymph nodes. Retrospective analysis suggests that there may be a benefit to debulking macroscopic nodes that would be otherwise difficult to sterilize with standard doses of radiation therapy. However, there are no prospective study reporting that resecting macroscopic nodes before concurrent chemoradiation therapy (CCRT) would improve PFS or OS of cervical cancer and no guidelines for surgical resection of bulky lymph nodes. The CQGOG0103 study is a prospective, multicenter and randomized controlled trial (RCT) evaluating lymph node dissection on stage IIICr of cervical cancer. Methods: Eligible patients are histologically confirmed cervical squamous cell carcinoma, adenocarcinoma, adeno-squamous cell carcinoma. Stage IIICr (confirmed by computed tomography [CT]/magnetic resonance imaging/positron emission tomography/CT) and the short diameter of image-positive lymph node ≥15 mm. 452 patients will be equally randomized to receive either CCRT (pelvic external-beam radiotherapy [EBRT]/extended-field EBRT + cisplatin [40 mg/m2] or carboplatin [the area under curve=2] every week for 5 cycles + brachytherapy) or open/minimally invasive pelvic and para-aortic lymph node dissection followed by CCRT. Randomization is stratified by status of para-aortic lymph node. The primary endpoint is PFS. Secondary endpoints are OS and surgical complications. A total of 452 patients will be enrolled from multiple hospitals in China within 4 years and followed up for 5 years.
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