Safety and Health Monitoring of Bridge Construction Based on Wireless Sensor Network

Xiaoling Li,Jimin Yuan 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.3

Phase II Trial of Epigallocatechin-3-Gallate in Acute Radiation-Induced Esophagitis for Esophagus Cancer

Xiaoling Li,Ligang Xing,Yujun Zhang,Peng Xie,Wanqi Zhu,Xiangjiao Meng,Yinxia Wang,Lingling Kong,Hanxi Zhao,Jinming Yu 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.1

Acute radiation-induced esophagitis (ARIE) is among the most serious form of toxicities associated with definitive radiotherapy or chemoradiotherapy used for treatment of patients with esophageal cancer. Our preliminary phase I and II trials of lung cancer patients who received radiotherapy indicated epigallocatechin-3-gallate (EGCG) as a promising therapeutic option against ARIE. Therefore, we conducted a prospective phase II study to validate the efficacy and safety of EGCG in the treatment of ARIE. The patients who received chemoradiotherapy or definitive radiotherapy for treatment of esophageal cancer in the Shandong Cancer Hospital and Institute in China were enrolled for the present study. EGCG (440 μM) was administered with first onset of ARIE and then at weeks after final radiotherapy. The patients were monitored every week for dysphagia, Radiation Therapy Oncology Group (RTOG) score, and esophagitis-related pain. Moreover, tumor response and the effect on survival following the treatment were also evaluated. Comparison of the RTOG score in the first, second, third, fourth, fifth, and even sixth week after EGCG prescription and the first and second week after radiotherapy with baseline indicates a significant reduction. The tumor response rate was 86.3%. The overall survival rate in 1, 2, and 3 years was found to be 74.5%, 58%, and 40.5%. Oral administration of EGCG solution seems to be feasible for treating ARIE in patients with esophageal cancer who receive radiation therapy. EGCG might be an ARIE-reliever without compromising the efficacy of radiation therapy. A randomized study with a control group is needed for further evaluation.

l2-l∞ Control for Sampled-data Systems with Packet Dropout: Switched System Method

Xiaoling Li,Linlin Hou 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.11

In this paper, the problem of l2 −l∞ control is investigated for the sampled-data systems including packet dropout. The sampled-data system is modeled as a discrete-time switched system based on the number of lost packets. Then the controller is designed to guarantee the discrete-time switched system is exponentially stable with a prescribed l2 −l∞ performance subject to mode dependent average dwell time approach. The sufficient conditions to solve the controller gain is derived via a set of linear matrix inequalities (LMIs). Finally, an example is presented to show the effectiveness of the obtained results.

Whole Exome Sequencing in the Accurate Diagnosis of Bilateral Breast Cancer: a Case Study

Xiaoling Li,Mei Yang,Qiangzu Zhang,Yanhui Fan,Teng Zhu,Fulong Chen,Kun Wang 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1

When faced with a case of bilateral breast cancer (BBC), understanding how to differentiate bilateral primary breast cancer from contralateral metastatic breast cancer is essential for treatment, but clear identification criteria have not been established to date. Diverse events play different roles in the therapy and prognosis of BBC; hence, it is of great significance to detect a more comprehensive and convincing technique to make an accurate differential diagnosis. We report a rare case of synchronous BBC in a 61-year-old Chinese woman. Based on her clinical and pathological features and the use of whole exome sequencing and cancer genome analysis, we concluded that the patient developed contralateral metastatic breast cancer which metastasized from left to right. Therefore, together with clinical, pathological and cancer genomics information, we could precisely define the origin and evolution of BBC.

Detection of the SRY Transcript and Protein in Bovine Ejaculated Spermatozoa

Li, Chunjin,Sun, Yongfeng,Yi, Kangle,Li, Chengjiao,Zhu, Xiaoling,Chen, Lu,Zhou, Xu Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.10

The sex-determining region on the Y (SRY) gene is important in mammalian sex determination and differentiation. We report a study of the abundance of SRY gene products in bovine ejaculate. RT-PCR experiments using RNA extracted from bovine spermatozoa with SRY-specific primers yielded a 456 bp product, but the amount of SRY mRNA in sperm was lower than that in the testes (p<0.01). A protein of approximately 27 KDa was detected by western blotting. The SRY transcript was detected in the midpiece of approximately half the spermatozoa by in situ hybridization, and the SRY protein was detected in the heads of half the spermatozoa by immunofluorescence, indicating that SRY mRNA and protein may only be present in Y-bearing spermatozoa. These results suggest that the SRY transcript and protein are present in bovine ejaculated Y-sperm. The roles of the SRY gene in spermatogenesis, sperm motility, and the sperm-oocyte interaction merit further investigation.

Bearing Habits of Acer truncatum and the Relationship Between Its Branch Characteristics and Fruiting Performance

Chao Li,Xiaoling Liu,Yi Feng,Tian Bao,Changqi Ye,Dailong Li,Shuchai Su 한국원예학회 2021 원예과학기술지 Vol.39 No.2

In recent years, seeds of the Shantung maple have attracted attention for their economic and medicinal value due to the high nervonic acid content in their seed oil, which has a curative effect on some demyelinating diseases. However, few studies have investigated its fruiting habits and branch characteristics; therefore, the purpose of this research was to investigate the fruit bearing habits of A. truncatum and analyze the relationship between its branch characteristics and fruiting performance to provide a basis for management. The branch structure, flower-bearing position, and continuous fruiting ability of 200 A. truncatum individuals were recorded from 2014–2017. The results showed that parent and bearing shoots of A. truncatum were usually short (less than 10 cm) with fruit developed by terminal mixed buds of the parent shoot. A. truncatum can form a Y-shaped branch group with continuous fruiting ability for many years via a lateral shoot of the bearing shoot. The position and slenderness of the parent shoot had a significant influence on the yield of the bearing shoot and seed weight, length, and thickness. The top and basal diameters of the parent shoot had a significant influence on the yield of the bearing shoot. Group comparison results showed that the most effective and convenient method for the selection of parent shoots with high fruiting performance was based on the position and top diameter of the parent shoots, among which the parent shoots with a top diameter thicker than 3.08 mm developed by a lateral bud in a vegetative branch had greater yield, number of fruit, and seed weight.

Curcumin Alleviates the Side Effects of Cisplatin on Gastric Emptying of Mice by Inhibiting the Signal Changes of Acetylcholine and Interstitial Cells of Cajal

Hui Li,Wenhua Xu,Xuying Liu,Junli Ye,Peijie Li,Fangfang Shang,Xiaoling Yu 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9

Cisplatin is a widely used anticancer drug that has adverse effects on gastrointestinal function. Curcumin is a natural polyphenol extracted from the rhizome of turmeric that has a wide range of biological activities. The present study investigated the effects of cisplatin on gastric emptying in mice and examined whether these can be inhibited by curcumin. We found that pretreatment with curcumin (200 mg/kg/day) for 10–30 days partly inhibited the decreases in gastric emptying rate and body weight induced by cisplatin. Furthermore, cisplatin reduced acetylcholine (ACh) concentration and the messenger RNA (mRNA) level of ACh receptor (AChR) as well as acetylcholinesterase activity in the stomach of mice; caused ultrastructural damage to interstitial cells of Cajal (ICC); and altered the expression of c-kit/stem cell factor and the gap junction protein connexin 43 in ICC. Curcumin pretreatment inhibited the effects of cisplatin on ACh indicators and ICC. These results demonstrate that curcumin can protect against cisplatin-induced gastric emptying disorder and thus has therapeutic potential for alleviating this condition in cancer patients receiving cisplatin chemotherapy.

The characteristic of the synonymous codon usage and phylogenetic analysis of hepatitis B virus

Xiaoming Qi,Chaojun Wei,Yonghong Li,Yu Wu,Hui Xu,Rui Guo,Yanjuan Jia,Zhenhao Li,Zhenhong Wei,Wanxia Wang,Jing Jia,Yuanting Li,Anqi Wang,Xiaoling Gao 한국유전학회 2020 Genes & Genomics Vol.42 No.7

Background Hepatitis B virus (HBV) infection is a crucial medical issue worldwide. The dependence of HBV replication on host cell machineries and their co-evolutionary interactions prompt the codon usage pattern of viral genes to translation selection and mutation pressure. Objective The evolutionary characteristics of HBV and the natural selection effects of the human genome on the codon usage characteristics were analyzed to provide a basis for medication development for HBV infection. Methods The codon usage pattern of sequences from different HBV genotypes of our isolates and reference HBV genome sequences downloaded from the National Center for Biotechnology Information (NCBI) database were analyzed by computing the relative synonymous codon usage (RSCU), nucleotide content, codon adaptation index (CAI) and the effective number of codons (ENC). Results The highest ENC values were observed in the C genotypes, followed by the B genotypes. The ENC values indicated a weak codon usage bias (CUB) in HBV genome. The number of codons differentially used between the three genotypes was markedly higher than that of similarly used codons. High CAI values indicated a good adaptability of HBV to its host. The ENC plot indicated the occurrence of mutational pressure in the three genotypes. The mean Ka/Ks ratios in the three genotypes were lower than 1, which indicated a negative selection pressure. The CAI and GC3% plot indicated the existence of CUB in the HBV genome. Conclusions Nucleotide composition, mutation bias, negative selection and mutational pressure are key factors influencing the CUB and phylogenetic diversity in HBV genotypes. The data provided here could be useful for developing drugs for HBV infection.

Complete Mitochondrial Genome of the Chagas Disease Vector, Triatoma rubrofasciata

Li Dong,Xiaoling Ma,Mengfei Wang,Dan Zhu,Yuebiao Feng,Yi Zhang,Jingwen Wang 대한기생충학열대의학회 2018 The Korean Journal of Parasitology Vol.56 No.5

Triatoma rubrofasciata is a wide-spread vector of Chagas disease in Americas. In this study, we completed the mitochondrial genome sequencing of T. rubrofasciata. The total length of T. rubrofasciata mitochondrial genome was 17,150 bp with the base composition of 40.4% A, 11.6% G, 29.4% T and 18.6% C. It included 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and one control region. We constructed a phylogenetic tree on the 13 protein-coding genes of T. rubrofasciata and other 13 closely related species to show their phylogenic relationship. The determination of T. rubrofasciata mitogenome would play an important role in understanding the genetic diversity and evolution of triatomine bugs.

Blade aerodynamic asymmetry fault analysis and diagnosis of wind turbines with doubly fed induction generator

Xiaoling Sheng,Shuting Wan,Lifeng Cheng,Yonggang Li 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.10

The blade aerodynamic asymmetry fault must be detected early due to its important effect on wind turbines. This paper develops a fault diagnosis approach based on the current and power characteristics of a Doubly fed induction generator (DFIG). First, the blade aerodynamic characteristics and the influence on the nacelle and tower vibration under an aerodynamic asymmetry fault are analysed and an improved Blade element moment (BEM) method considering the blade, nacelle and tower vibration is proposed to calculate the aerodynamic torque. Then, the electrical characteristics of the DFIG are analysed. The output power is shown to decrease with oscillation when aerodynamic asymmetry occurs. In addition, the same modulation harmonic frequency as the blade rotating frequency exists in the stator and the rotor current. Finally, simulations under constant and stochastic wind conditions via MATLAB/Simulink show the effectiveness of the proposed method in this paper.