The Long Shadow

Xiaoguang Fan,Fei Yan 한국사회학회 2018 한국사회학회 심포지움 논문집 Vol.2018 No.5

Study of the relationship between variants near CCNL1/LEKR1 and in ADCY5 with low birth weight in a Chinese population

Xuejin Fan,Qi Peng,Yanhua Chen,Zeke Ma,Xiaoguang He,Biying Deng,Hui Huang,Juan Zeng,Chuyun Cheng,Shaoji Liu,Xiaomei Lu 한국유전학회 2015 Genes & Genomics Vol.37 No.12

The aim of this study was to test the impact of variants rs900400 (located near LEKR1 and CCNL1) and rs9883204 (located in ADCY5) on birth weight in a Chinese population. We conducted a case–control study including 156 low-birth- weight infants as the case group and 100 normal-birth-weight infants as the control group. The rs900400 and rs9883204 variants were analyzed by gene sequencing in all the participants. Our results revealed a significant difference in the genotype distribution (v2 = 10.449, p = 0.005) and allele distribution (v2 = 9.277, p = 0.002) of rs900400 between the case group and the control group. The C allele of rs900400 was associated with lower birth weight (OR 1.771 [95 % CI 1.237–2.535]) in the Chinese population. However, the rs9883204 polymorphism was not informative in the Chinese population. Our study shows that the ‘‘birth weightlowering’’ variant rs900400 located near LEKR1 and CCNL1, which is strongly associated with birth weight in European cohorts, appears to have a similar association in Chinese cohorts. However, the rs9883204 variant located in ADCY5 does not appear to be correlated with low birth weight in the same population. Moreover, we found that the variant rs900400 may also be associated with premature birth, thereby supporting the need for further research in this area.

Adaptive V1-MT model for motion perception

( Shuai Li ),( Xiaoguang Fan ),( Yuelei Xu ),( Jinke Huang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.1

Motion perception has been tremendously improved in neuroscience and computer vision. The baseline motion perception model is mediated by the dorsal visual pathway involving the cortex areas the primary visual cortex (V1) and the middle temporal (V5 or MT) visual area. However, few works have been done on the extension of neural models to improve the efficacy and robustness of motion perception of real sequences. To overcome shortcomings in situations, such as varying illumination and large displacement, an adaptive V1-MT motion perception (Ad-V1MTMP) algorithm enriched to deal with real sequences is proposed and analyzed. First, the total variation semi-norm model based on Gabor functions (TV-Gabor) for structure-texture decomposition is performed to manage the illumination and color changes. And then, we study the impact of image local context, which is processed in extra-striate visual areas II (V2), on spatial motion integration by MT neurons, and propose a V1-V2 method to extract the image contrast information at a given location. Furthermore, we take feedback inputs from V2 into account during the polling stage. To use the algorithm on natural scenes, finally, multi-scale approach has been used to handle the frequency range, and adaptive pyramidal decomposition and decomposed spatio-temporal filters have been used to diminish computational cost. Theoretical analysis and experimental results suggest the new Ad-V1MTMP algorithm which mimics human primary motion pathway has universal, effective and robust performance.

Bridge widening with composite steel-concrete girders: application and analysis of live load distribution

Yang, Yue,Zhang, Xiaoguang,Fan, Jiansheng,Bai, Yu Techno-Press 2015 Advances in concrete construction Vol.3 No.4

A bridge widening technology using steel-concrete composite system was developed and is presented in this paper. The widened superstructure system consists of a newly built composite steel-concrete girder with concrete deck and steel diaphragms attached to the existing concrete girders. This method has been applied in several bridge widening projects in China, and one of those projects is presented in detail. Due to the higher stiffness-to-weight ratio and the rapid erection of composite girders, this widening method reveals benefits in both mechanical performance and construction. As only a few methods for the design of bridges with different types of girders are recommended in current design codes, a more accurate analytical method of estimating live load distribution on girder bridges was developed. In the analytical model, the effects of span length, girder pacing, diaphragms, concrete decks were considered, as well as the torsional and flexural stiffness of both composite box girders and concrete T girders. The study shows that the AASHTO LRFD specification procedures and the analytical models proposed in this paper closely approximate the live load distribution factors determined by finite element analysis. A parametric study was also conducted using the finite element method to evaluate the potential load carrying capacities of the existing concrete girders after widening.

A New FE Modeling Method for Isothermal Local Loading Process of Large-scale Complex Titanium Alloy Components Based on DEFORM-3D

Dawei Zhang,He Yang,Zhichao Sun,Xiaoguang Fan 한국소성가공학회 2010 기타자료 Vol.2010 No.6

Isothermal local loading process provides a new way to form large-scale complex titanium alloy components. The forming process is characterized by an extreme size (large scale in global and compared small size in regional), multi-parameter effects, and complicated loading path. To establish a reasonable finite element model is one of the key problems urgently to be solved in the research and development of isothermal local loading forming process of largescale complex titanium alloy components. In this paper, a new finite element model of the isothermal local loading process is developed under the DEFORM-3D environment based on the solution of some key techniques. The modeling method has the following features: (1) different meshing techniques are used in different loading areas and the number of meshed elements is determined according to the deformation characteristic in different local loading steps in order to improve computational efficiency; (2) the accurate magnitude of the friction factor under titanium alloy hot forming (isothermal forming) condition is adopted instead of the typical value for lubricated hot forming processes; (3) different FEM solvers are chosen at different stages according to the loading characteristic and the contact state; (4) in contrast to the local component model, a full 3D component is modeled to simulate the process. The 3D-FE model is validated by experimental data of a large-scale bulkhead forming under isothermal local loading. The model can describe the quantitative relationships between the forming conditions and the forming results. The results of the present study may provide a basis for studying the local deformation mechanism, selecting the reasonable parameters, optimizing the die design and the process control in isothermal local loading process of large-scale complex titanium alloy components.

Influence of the Billet Volume Distribution on Macro Deformation and Microstructure Response in Transitional Region of Ti-Alloy Multi-rib Component Under Isothermal Local Loading

Ke Wei,Qing Ma,Haibing Tang,Xiaoguang Fan,Jian Zhang 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.12

The folding, die underfilling, rib shifting and average grain size of primary equiaxed were investigated using five different unequal thickness billets in transitional region of Ti-alloy multi-rib component under isothermal local loading and compared with integral loading. In terms of the macro deformation, the results show that the material transfers from the second-loading zone into the first-loading zone and the die underfilling decreases with the initial volume of the first-loading zone increasing, which reduces the risk of folding and rib shifting. However, that folding and rib shifting did not appear during the integral loading. Nevertheless, when the initial volume of the first-loading zone reaches a certain value, the die underfilling is aggravated both in local and integral loading. With respect to the microstructure, as the initial volume of the first-loading zone increases, the average grain size is decreased after the first-loading step, but increased after the second-loading step with consideration of one single loading step, which lead to the grain size being barely influenced by different billet volume distribution under both loading steps.