PEC: A Privacy-Preserving Emergency Call Scheme for Mobile Healthcare Social Networks

Liang, Xiaohui,Lu, Rongxing,Chen, Le,Lin, Xiaodong,Shen, Xuemin (Sherman) The Korea Institute of Information and Commucation 2011 Journal of communications and networks Vol.13 No.2

In this paper, we propose a privacy-preserving emergency call scheme, called PEC, enabling patients in life-threatening emergencies to fast and accurately transmit emergency data to the nearby helpers via mobile healthcare social networks (MHSNs). Once an emergency happens, the personal digital assistant (PDA) of the patient runs the PEC to collect the emergency data including emergency location, patient health record, as well as patient physiological condition. The PEC then generates an emergency call with the emergency data inside and epidemically disseminates it to every user in the patient's neighborhood. If a physician happens to be nearby, the PEC ensures the time used to notify the physician of the emergency is the shortest. We show via theoretical analysis that the PEC is able to provide fine-grained access control on the emergency data, where the access policy is set by patients themselves. Moreover, the PEC can withstandmultiple types of attacks, such as identity theft attack, forgery attack, and collusion attack. We also devise an effective revocation mechanism to make the revocable PEC (rPEC) resistant to inside attacks. In addition, we demonstrate via simulation that the PEC can significantly reduce the response time of emergency care in MHSNs.

A Novel 3-D Imaging Configuration Exploiting Synthetic Aperture Ladar

Liang Guo,Yinli Huang,Xiaozhen Li,Xiaodong Zeng,Yu Tang,Mengdao Xing 한국광학회 2017 Current Optics and Photonics Vol.1 No.6

Traditional three-dimensional (3-D) laser imaging systems are based on real aperture imaging technology,whose resolution decreases as the range increases. In this paper, we develop a novel 3-D imaging techniquebased on the synthetic aperture technology in which the imaging resolution is significantly improved anddoes not degrade with the increase of the range. We consider an imaging laser radar (ladar) system usingthe floodlight transmitting mode and multi-beam receiving mode. High 3-D imaging resolutions areachieved by matched filtering the linear frequency modulated (LFM) signals respectively in range, syntheticaperture along-track, and the real aperture across-track. In this paper, a novel 3-D imaging signal modelis given first. Because of the motion during the transmission of a sweep, the Doppler shift induced bythe continuous motion is taken into account. And then, a proper algorithm for the 3-D imaging geometryis given. Finally, simulation results validate the effectiveness of the proposed technique.

PEC: A Privacy-Preserving Emergency Call Scheme for Mobile Healthcare Social Networks

Xiaohui Liang,Rongxing Lu,Le Chen,Xiaodong Lin,Xuemin (Sherman) Shen 한국통신학회 2011 Journal of communications and networks Vol.13 No.2

In this paper, we propose a privacy-preserving emergency call scheme, called PEC, enabling patients in life-threatening emergencies to fast and accurately transmit emergency data to the nearby helpers via mobile healthcare social networks (MHSNs). Once an emergency happens, the personal digital assistant (PDA)of the patient runs the PEC to collect the emergency data including emergency location, patient health record, as well as patient physiological condition. The PEC then generates an emergency call with the emergency data inside and epidemically disseminates it to every user in the patient’s neighborhood. If a physician happens to be nearby, the PEC ensures the time used to notify the physician of the emergency is the shortest. We show via theoretical analysis that the PEC is able to provide fine-grained access control on the emergency data, where the access policy is set by patients themselves. Moreover,the PEC can withstandmultiple types of attacks, such as identity theft attack, forgery attack, and collusion attack. We also devise an effective revocation mechanism to make the revocable PEC (rPEC) resistant to inside attacks. In addition, we demonstrate via simulation that the PEC can significantly reduce the response time of emergency care in MHSNs.

Research on Operation Risk and Perceived Physical Condition of Old People : an Empirical Analysis based on Online Follow-Up Survey

Long Xiaodong,Chen Liang,Wang Yuefeng,,Tao Ganchen,Chen Yuanping 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.9

With the development of Internet, the mass media of health management have brought great change to the previous health management model. Based on big data technology and intelligence, new technology allows doctors to make more detailed tracking investigation for the elderly. In this paper, we collected data from 561 senior citizens by using online follow-up survey, and find out the influencing factors related to perceived physical condition. The result shows that the score of the perceived physical condition is 72.91 as compared to gender (T=4.032,P=0.045), age group(T=35.561,P=0.000), educational level (T=15.116, P=0.000), monthly income (T=2.800,P=0.039), marital status (T=15.458,P=0.000), self-care ability (T=49.675,P=0.000), place of abode (T=21.127,P=0.000), previous profession (T=10.030, P=0.000), type of registered permanent residence(T=11.542,P=0.001), chronic disease (T=107.02,P=0.000).

Sparstolonin B suppresses lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells

Qiaoli Liang,Fang Yu,Xiaodong Cui,Jin-ao Duan,Qinan Wu,Prakash Nagarkatti,Daping Fan 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7

Sparstolonin B (SsnB) is an isocoumarin compoundisolated from the tubers of both Sparganium stoloniferumand Scirpus yagara. We previously demonstratedthat SsnB blocked the Toll-like receptor (TLR) 2- andTLR4-triggered inflammatory signaling in macrophages byinhibiting the recruitment of MyD88 to the TIR domains ofTLR2 and TLR4. The present study was designed toexamine the effects of SsnB on vascular inflammatoryresponses in human umbilical vein endothelial cells (HUVECs)challenged by lipopolysaccharide (LPS, a TLR4ligand). We found that SsnB dose-dependently attenuatedthe LPS-induced expression of interleukin (IL)-1b andmonocyte chemoattractant protein 1 both at the transcriptionand translation levels in HUVEC. LPS-inducedendothelial cell adhesion molecules, intercellular adhesionmolecular-1 and vascular cell adhesion molecule-1expressions were also reduced by treatment with SsnB. Inaddition, co-incubation with SsnB attenuated THP-1monocyte adhesion to LPS-activated HUVECs. Furthermore,SsnB efficiently suppressed LPS-induced phosphorylationof extracellular -signal-regulated kinase (Erk1/2)and Akt in HUVECs. These findings show that SsnB cansuppress endothelial cell inflammation, suggesting thatSsnB might be suitable for development as a therapeuticagent for inflammatory cardiovascular disease.

MiR-26a promotes apoptosis of porcine granulosa cells by targeting the 3β-hydroxysteroid-Δ24-reductase gene

Zhang, Xiaodong,Tao, Qiangqiang,Shang, Jinnan,Xu, Yiliang,Zhang, Liang,Ma, Yingchun,Zhu, Weihua,Yang, Min,Ding, Yueyun,Yin, Zongjun Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.4

Objective: Apoptosis of ovarian granulosa cells (GCs) affects mammalian follicular development and fecundity. This study aimed to explore the regulatory relationship between microRNA-26a (miR-26a) and the 3β-hydroxysteroid-Δ24-reductase gene (DHCR24) gene in porcine follicular granular cells (pGCs), and to provide empirical data for the development of methods to improve the reproductive capacity of pigs. Methods: The pGCs were transfected with miR-26a mimic, miR-26a inhibitor and DHCR24-siRNA in vitro. The cell apoptosis rate of pGCs was detected by the flow cytometry. The secretion levels of estradiol (E2) and progesterone (P) in pGCs were detected by enzyme-linked immunosorbent assay. Double luciferase validation system was used to detect the binding sites between miR-26a and DHCR24 3'-UTR region. Qualitative real-time polymerase chain reaction and Western blotting were used to verify the DHCR24 mRNA and protein expression in pGCs, respectively, after transfecting with miR-26a mimic and miR-26a inhibitor. Results: Results showed that enhancement of miR-26a promoted apoptosis, and inhibited E2 and P secretion in pGCs. Meanwhile, inhibition of DHCR24 also upregulated the Caspase-3 expression, reduced the BCL-2 expression, promoted pGCs apoptosis, and inhibited E2 and P secretion in pGCs. There were the binding sites of miR-26a located within DHCR24 3'-UTR. Up-regulation of miR-26a inhibited DHCR24 mRNA and protein expression in pGCs. Conclusion: This study demonstrates that miR-26a can promote cell apoptosis and inhibit E2 and P secretion by inhibiting the expression of DHCR24 in pGCs.

Locally Resonant Periodic Wave Barriers for Vibration Isolation in Subway Engineering

Lijian Lei,Linchang Miao,Chao Li,Xiaodong Liang,Junjie Wang 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.4

Subway transportation is being promoted worldwide to effectively solve urban congestion. However, the vibration induced by subway traffic has caused a major adverse impact on building safety, precision instrument operation and human health. Wave barriers have been proven effective in mitigating ground vibration, whereas they have some limitations in achieving ideal attenuation zone and high efficiency to cover the low-frequency vibration in underground railway system. Based on locally resonant phononic crystals theory, this paper designs three-component locally resonant periodic wave barriers (LRPWBs), and investigates the effects of geometrical and material parameters on the bandgap features in detail. The band structures are calculated using improved plane wave expansion (IPWE), the transmission spectra and vibration modes are obtained by finite element method (FEM). The results indicate LRPWBs are able to give lower and wider bandgap to cover the main frequency of subway environment, which is proved by time and frequency domain analysis. For the bandgap mechanism, the local resonance features of LRPWBs result in the energy conversion between kinetic energy and elastic strain energy, thus the elastic wave energy is localized in resonance unit and then the locally resonant bandgap is created. In addition, the bandgap can be adjusted by carefully selecting proper geometrical and material parameters to actualize low-frequency broadband attenuation. Further studies about multi-oscillator system indicate that the appropriate combination of multiple LRPWBs are conductive to diverse and broad bandgaps. The investigations can provide inspiration for periodic wave barriers design in multi-frequency vibration attenuation field.

Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p

Pan Jiancheng,Liu Zihao,Yang Zhizhao,Liang Enli,Fang Cheng,Zhang Dingrong,Zhou Xiaodong,Niu Yuanjie,Xin Zhongcheng,Chen Yegang,Cai Qiliang 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.1

Purpose: As the mechanism of interaction between circular RNAs (circRNAs) and microRNAs (miRNAs) in regulating the development of prostate cancer (PCa) is not clear, this study focuses on investigating these effects. Materials and Methods: Sample tissues were collected from the PCa of patients, and microarray analysis of human circRNAs was conducted. The expression of circ_0001686, hsa_miR-411-5p (miR-411-5p) were also detected by qRT-PCR. Circ_0001686 and miR-411-5p mimics were transfected into the PCa cell lines (CWR22RV1and LNCaP) and MTT, colony formation, Transwell, and scratch wound assays were used to analyze the biological behaviors of PCa cells. Si-circ_0001686 and ASO-miR-411-5p were used as negative controls, and dual-luciferase reporter assays were performed to verify the interactions among circ_0001686, miR-411-5p, and SMAD3/TGFBR2. The levels of SMAD3 and TGFBR2 in different treated PCa cells were measured by western blot, and in vivo experiments in a nude mouse model were carried out to strengthen the in vitro findings of miR-411-5p. Results: The expression of circ_0001686 was up-regulated, while the expression of miR-411-5p was down-regulated in PCa cells. Moreover, circ_0001686 promoted cell proliferation, migration, and invasion. Molecular mechanism exploration revealed that circ_0001686 could reduce miR-411-5p, affecting the downstream target genes of SMAD3 and TGFBR2. In vitro and in vivo studies verified that miR-411-5p inhibits PCa progression. Conclusions: Circ_0001686 can reduce miR-411-5p to increase the expression of SMAD3/TGFBR2, which consequently promotes the proliferation, invasion, and migration of PCa cells.

Robust Key Agreement From Received Signal Strength in Stationary Wireless Networks

( Aiqing Zhang ),( Xinrong Ye ),( Jianxin Chen ),( Liang Zhou ),( Xiaodong Lin ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.5

Key agreement is paramount in secure wireless communications. A promising approach to address key agreement schemes is to extract secure keys from channel characteristics. However, because channels lack randomness, it is difficult for wireless networks with stationary communicating terminals to generate robust keys. In this paper, we propose a Robust Secure Key Agreement (RSKA) scheme from Received Signal Strength (RSS) in stationary wireless networks. In order to mitigate the asymmetry in RSS measurements for communicating parties, the sender and receiver normalize RSS measurements and quantize them into q-bit sequences. They then reshape bit sequences into new l-bit sequences. These bit sequences work as key sources. Rather than extracting the key from the key sources directly, the sender randomly generates a bit sequence as a key and hides it in a promise. This is created from a polynomial constructed on the sender`s key source and key. The receiver recovers the key by reconstructing a polynomial from its key source and the promise. Our analysis shows that the shared key generated by our proposed RSKA scheme has features of high randomness and a high bit rate compared to traditional RSS-based key agreement schemes.

Experimental Investigation on the Bond Behavior of Deformed Bars in a Class of Structural Expanded Polystyrene (EPS) Concrete

Chao Li,Linchang Miao,Quan You,Lijian Lei,Xiaodong Liang,Junjie Wang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.12

The structural expanded polystyrene (EPS) concrete (above 35 MPa) has the potential to be used as metro track bed to reduce and isolate vibration, but its bond behavior is still unclear. This inhibits its application because it is often used in combination with reinforcing bar. In this paper, a class of structural EPS concrete (above 35 MPa) was developed. Based on this, a series of pull-out tests were conducted and the bond behavior of deformed bars in these structural EPS concretes was investigated. In addition, effects of rebar bond length and rebar diameter were analyzed in detail. Experimental results indicate that the structural EPS concrete suffers splitting failure more easily than the conventional concrete (CC). Increase of EPS replacement, rebar bond length or rebar diameter tends to cause the splitting failure of structural EPS concrete. Moreover, with increase of EPS replacement, the failure process is less explosive and more gradual. The stress-slip relationships of the most specimens show three stages, namely linear ascending, non-linear progression, and descending stages. The bond strength of structural EPS concrete is found depended linearly on the power function of its compressive strength, relative cover thickness (c/d) and relative rebar bond length (L/d), respectively. Accordingly, a bond strength prediction model was formulated, and it can precisely predict the bond strength of deformed bars in structural EPS concrete, specimens failing in splitting or splitting-pull out modes, and no fiber added. The results can provide reference for the design of structural EPS concrete.