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RISS 인기검색어
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- 저자 : Xianzhe Wang (검색결과 6 건)
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Jiawei Wang,Ju Wang,Zhichao Zhou,Peng Wu,Haoran Sun,Jiale Dou,Nan Li,Xianzhe Duan 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.4
This study conducts a three-dimensional numerical simulation of the creep behavior of deep granite tunnels at 560 meters underground during the coupled thermal-stress process, with an aim to elucidate the effect of the temperature and stress fields on the creep behavior of these deep hard rock tunnels. A 100-h creep period was set, and the mechanical structure of the experimental chamber was accurately replicated at a 1:1 scale, considering the actual mechanical structure of the granite tunnels in the Beishan underground laboratory. The simulation results can demonstrate that: 1) The maximum stress at 90°C and 50°C are 2.86 and 1.91 times than that at 23°C, respectively, demonstrating significant strain accumulation in the deep granite tunnels at the surface. This phenomenon can primarily be attributed to the thermal stress resulted from the coupling between temperature and stress. 2) The maximum creep at 90°C and 50°C is 16 and 3.5 times than that at 23°C. Under the influence of thermal coupling, the creep increases significantly with increasing temperature, indicating that temperature is an important factor influencing creep in granite. 3) Compared with variations in the stress field, the temperature field emerges as the most critical factor influencing granite creep.
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Xianzhe Shi,Xiuxia Wang,Biao Chen,Junko Umeda,Katsuyoshi Kondoh,Jianghua Shen 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.8
In this work, a bimodal grain structure was developed for commercial purity Ti(CP-Ti) via powder metallurgy processing,followed by free hot forging and then heat treatment. The bi-modal grains were characterized with electron backscatterdiffraction. The mechanical tests showed that in comparison to the uniform and equiaxed grain structure, the bimodalgrains improved the yield strength of CP-Ti significantly, while it maintains a merely changed ultimate tensile strength andelongation to failure. In addition, an interesting yield plateau was observed in the bimodal CP-Ti. To explore underlyingmechanisms behind the phenomenon, the microstructures of the samples before and after testing were carefully examined. The results revealed that geometrically necessary dislocations accumulating at the interface between coarse and fine grainsinduced back stress hardening, which together with the statistically stored dislocations also accounted for the yield plateauin the bimodal CP-Ti.
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Elucidating the mechanism of cellular uptake of fullerene nanoparticles
Yeonjeong Ha,Xianzhe Wang,Howard M. Liljestrand,Jennifer A. Maynard,Lynn E. Katz 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.2
Understanding the molecular interactions between biological cells and engineered nanoparticles is a key to evaluating potential toxicities to humans and the environment. This study developed a method to determine the mechanisms by which fullerene aggregates are distributed into a representative cell line, human intestinal Caco-2 cells. First, we determined that the presence of fetal bovine serum (FBS) in the cell culture media changes the particle characteristics and inhibits particle adsorptions onto cell surfaces. Second, significantly lower amounts of fullerene were internalized at 4°C, a temperature at which active transport mechanisms are effectively impeded, than at 37°C. Third, metabolic inhibitors of active transport and a microtubule transport inhibitor decreased fullerene uptake at 37°C. Fourth, cellular uptake of fullerene increased with increasing fullerene concentration, suggesting that passive diffusion into lipid membranes contributed to uptake over the broad concentration range used in this study. Together, these results indicate fullerene transport into cells occurs via two mechanisms: passive diffusion across the lipid bilayer and active transport including microtubule involved endocytosis. The results also suggest that simple physical-chemical partitioning models do not fully describe fullerene uptake, and instead, active transport models are also required to estimate the cellular uptake and toxicity of fullerene.
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Cao Yang,Xinghuo Wu,Zhiwei Liao,Kun Wang,Wenbin Hua,Xianzhe Liu,Yu Song,Yukun Zhang,Shuhua Yang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Intervertebral disc degeneration (IDD) is characterized by excessive apoptosis of nucleus pulposus (NP) cells and hyperactive extracellular matrix (ECM) catabolism. Our previous studies revealed the relationship between human islet amyloid polypeptide (hIAPP) and NP cell apoptosis. However, the role of hIAPP aggregates in IDD has not yet been investigated. This study aimed to determine whether the accumulation of hIAPP aggregates promotes IDD progression. The aggregation of hIAPP increased in human NP tissues during IDD. The deposition of hIAPP aggravated the compression-induced IDD that promoted NP cell apoptosis and ECM degradation via IL-1β/IL-1Ra signaling in an ex vivo rat disc model. Moreover, neutralizing IL-1β augmented the protective effects of hIAPP overexpression by decreasing hIAPP aggregation in human NP cells. These results suggest that the aggregation of hIAPP promotes NP cell apoptosis and ECM degradation ex vivo and in vitro by disrupting the balance of IL-1β/IL-1Ra signaling.
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Low-Cost Flexible Strain Sensor Based on Thick CVD Graphene
Bailiang Chen,Ying Liu,Guishan Wang,Xianzhe Cheng,Guanjun Liu,Jing Qiu,Kehong Lv 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.11
Flexible strain sensors, as the core member of the family of smart electronic devices, along with reasonable sensing range and sensitivity plus low cost, have rose a huge consumer market and also immense interests in fundamental studies and technological applications, especially in the field of biomimetic robots movement detection and human health condition monitoring. In this paper, we propose a new flexible strain sensor based on thick CVD graphene film and its low-cost fabrication strategy by using the commercial adhesive tape as flexible substrate. The tensile tests in a strain range of ~30% were implemented, and a gage factor of 30 was achieved under high strain condition. The optical microscopic observation with different strains showed the evolution of cracks in graphene film. Together with commonly used platelet overlap theory and percolation network theory for sensor resistance modeling, we established an overlap destructive resistance model to analyze the sensing mechanism of our devices, which fitted the experimental data very well. The finding of difference of fitting parameters in small and large strain ranges revealed the multiple stage feature of graphene crack evolution. The resistance fallback phenomenon due to the viscoelasticity of flexible substrate was analyzed. Our flexible strain sensor with low cost and simple fabrication process exhibits great potential for commercial applications.
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