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( Sang Cheol Bae ),( Jinseok Kim ),( Jung Yoon Choe ),( Won Park ),( So Ra Lee ),( Yong Ho Ahn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Etanercept is a recombinant fusion protein that blocks TNF. HD203 is a biosimilar of etanercept with demonstrated comparability across pharmacokinetics, safety and tolerability. The objectives of this study were to evaluate equivalence in effi cacy and compare safety of HD203 with reference etanercept, in combination with MTX in patients with RA. (ClinicalTrials. gov NCT01270997). Methods: Korean patients (male or female aged =20 years) with active RA were randomized (1:1) to 25 mg HD203 or reference etanercept, administered subcutaneously twice weekly with MTX for 48 weeks. The primary endpoint was the proportion of patients achieving ACR20 at week 24. Secondary endpoints included ACRn, DAS28, andEULAR response at week 24 and 48, safety and immunogenicity. Results: In total, 294 patients were randomized: HD203, n=147; reference etanercept, n=147. The proportion of patients achieving ACR20 at week 24 was not signifi cantly different between HD203 and reference etanercept. Equivalent effi cacy was demonstrated within predefined margins. There were no significant differences between proportions achieving ACR20 at week 12 and 48. ACR50 and ACR70 displayed similar trends. There were no signifi cant differences between groups for ACRn, DAS28, and EULAR response. Safety set analysis (HD203, n=147; reference etanercept, n=146) revealed no signifi cant difference for treatment-emergent (all-causality) adverse events (AEs): HD203 76. 87% vs. reference etanercept 78. 08% (p=0. 8040). No significant differences between HD203 and reference etanercept were observed for adverse drug reactions, serious AEs, or discontinuations due to AEs. Few patients tested positive for anti-drug antibodies. Conclusions: The study met the primary endpoint of demonstrating equivalent effi cacy of HD203 compared to reference etanercept. HD203 was well tolerated, with a safety profi le comparable to reference etanercept in this population of patients with RA.
Bae, Sang-Cheol,Kim, Jinseok,Choe, Jung-Yoon,Park, Won,Lee, Sang-Heon,Park, Yong-Beom,Shim, Seung-Cheol,Lee, Shin-Seok,Sung, Yoon-Kyoung,Choi, Chan-Bum,Lee, So-Ra,Park, HanYu,Ahn, Yongho H. K. Lewis 2017 Annals of the rheumatic diseases Vol.76 No.1
<P>Conclusion The study met the primary objective of demonstrating equivalent efficacy of HD203 and ETN. HD203 was well tolerated, with safety comparable with ETN in this population of patients with RA.</P>
Suboptimal Robust Generalized H2 Filtering using Linear Matrix Inequalities
Ra, Won-Sang,Jin, Seung-Hee,Yoon, Tae-Sung,Park, Jin-Bae Institute of Control 1999 Transaction on control, automation and systems eng Vol.1 No.2
The robust generalized H2 filtering problem for a class of discrete time uncertain linear systems satisfying the sum quadratic constraints(SQCs) is considered. The objective of this paper is to develop robust stability condition using SQCs and design a robust generalized Ha filter to take place of the existing robust Kalman filter. The robust generalized H2 filter is designed based on newly derived robust stability condition. The robust generalized Ha filter bounds the energy to peak gain from the energy bounded exogenous disturbances to the estimation errors under the given positive scalar ${\gamma}$. Unlike the robust Lalman filter, it does not require any spectral assumptions about the exogenous disturbances . Therefore the robust generalized H2 filter can be considered as a deterministic formulation of the robust Kalman filter. Moreover, the variance of the estimation error obtained by the proposed filter is lower than that by the existing robust Kalman filter. The robustness of the robust generalized H2 filter against the uncertainty and the exogenous signal is illustrated by a simple numerical example.
Sang-Ho Park,Seung-Jin Lee,Jae Yun Kim,Min Jeong Kim,Ji Yeon Lee,A-Ra Cho,Hyeok-Gyu Lee,Se-Whan Lee,Won-Yong Shin,Dong-Kyu Jin 순천향대학교 순천향의학연구소 2011 Journal of Soonchunhyang Medical Science Vol.17 No.2
Objective: The importance of central blood pressure evaluation for cardiovascular risk stratification has been emphasized. The aim of this study is to evaluate whether brachial blood pressure obtained by the oscillometric method accurately reflects central blood pressure. Methods: The subjects consisted of 84 consecutive patients with suspected coronary artery disease who underwent cardiac catheterization. Central blood pressure was invasively measured in the origin of the left subclavian artery by using the fluid-filled system, and at the same time, brachial blood pressure in the left upper arm was measured by the oscillometric method. Results: No significant difference was found between central systolic pressure and brachial systolic pressure (144.49±18.84 mmHg vs. 142.44±14.96 mmHg, P=0.063). Bland-Altman analysis accounted for only a small bias of +2.25 mmHg, and the limits of agreement were 24.15 mmHg and -19.65 mmHg. Central diastolic pressure was significantly lower than brachial diastolic pressure (75.80± 8.74 mmHg vs. 86.70±10.48 mmHg, P<0.001). Bland-Altman analysis showed a significant bias of -5.45 mmHg, and the limits of agreement were 2.83 mmHg and -13.73 mmHg. Conclusion: These results indicate that central systolic pressure can be directly estimated from brachial systolic pressure using the noninvasive oscillometric method and observed biases seem to remain within the practical range. However, use of the brachial diastolic pressure and pulse pressure measured by the noninvasive oscillometric method is doubtful in clinical practice because of their large biases.
Constrained Robust Kalman Filtering for Passive Source Localization
Won-Sang Ra,Ick-Ho Whang,Tae-Sung Yoon 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
In this paper, a constrained robust Kalman filter(CRKF) approach to passive target localization based on a geometrically constrained sensor network is newly proposed. Our approach is strongly motivated by the in he rent problem of the previous stochastic robust Kalman filters(RKFs) which are very sensitive to the in a ccurate aprioristatistical information on the stochastic parametric uncertainties. To solve this sensitivity problem, an additional state-equality constraint comes from the given sensor geometry is a ugmented with the conventional stochastic RKF costusing Lagrange multipliers. A minimizing solution to this constrained optimization problem givesus a new CRKF recursion. From the resultant filter structure, it is shown that the use of additional state-equality constraint corrects the imperfect statistical knowledge on the stochastic uncertainties and plays an important roleinensuring both the otimality and the reliability of the proposed filter. Computer simulations for the passive target tracking based on geometrically constrained sensor network demonstrate the reliable estimation perfomance of the proposed method compared to the existing ones.
The Interpretation of DST Data for Donghae - 1 Gas Field , block VI - 1 , Korea
Sung, Won Mo,Ryou, Sang Soo,Ra, Seung Hun,Kwon, Sun II 한국화학공학회 2001 Korean Journal of Chemical Engineering Vol.18 No.1
Donghae-1 gas field is located in Ulleung basin at offshore Ulsan, Korea, and its recoverable reserve is expected to be 170 to 200 BCF (Billion cubic feet). The held was confirmed to have potential gas and condensate reserves from an exploration well in 1998 and two appraisal wells in 1999. This field consists of five zones, with an average reservoir depth of about 7,000 to 8,000 ft. In this study, we have performed an analysis of Gorae V DST (Drillstem test) #2 for testing B4 zone which has the biggest reserves and Gorae V-1 DST #2 for testing B3 and B4 zones simultaneously among DST data achieved in a total of 11 zones at three wells. The pressure and flow rate recorded from two tested zones were used to obtain the reservoir characteristics and the well productivity. For pressure transient test data, we carried out the analysis of reservoir permeability, skin factor, wellbore storage effect and barrier effect by using the Horner plot and type curve matching methods. Also, with the deliverability test data, we estimated the absolute open flow which is the maximum flow rate of the gas well, and extracted the correlations representing production rate with reservoir pressure. According to the analysis, Gorae V DST #2 of B4 zone has a permeability and skin factor of 37 and (Millidarcy), 4.54, and Gorae V-1 DST #2 of B3 and B4 zones has 23 and and 21.0, respectively. It was also found that the wellbore storage effect was not significant for the two wells tested. From the deliverability test analysis, the AOF (Absolute open flow) of the Gorae V DST #2 is 152.8 MMSCFD (Million standard cubic feet per day), and that of the Gorae V-1 DST #2 is calculated to be 68.2 MMSCFD.
Won Seok Ju,Ilchan Song,Se-Ra Park,Sang Young Seo,Jin Hyoung Cho,Sung-Hun Min,Dae-Heon Kim,Ji-Su Kim,Sun-Uk Kim,Soon Ju Park,Kisung Ko,Young-Kug Choo 한국식물생명공학회 2019 JOURNAL OF PLANT BIOTECHNOLOGY Vol.46 No.3
Production of therapeutic monoclonal antibodies (mAbs) using a plant platform has been considered an alternative to the mammalian cell-based production system. A plant-derived mAb CO17-1AK (mAbP COK) can specifically bind to various types of cancer cell lines. The target protein of mAbP COK is the epithelial cell adhesion molecule (EpCAM) highly expressed in human epithelial cancer cells, including breast and colorectal cancer cells. It has been hypothesized that its overexpression supports tumor growth and metastasis. A ganglioside is extended well beyond the surfaces of the various cell membranes and has roles in cell growth, inflammation, differentiation, and carcinogenesis. However, the regulation of EpCAM gene expression in breast cancers and the role of gangliosides in oncogenesis are unclear. Here, the purpose of this study was to determine the effects of mAbP COK on human breast cancer cell proliferation, apoptosis, and ganglioside expression patterns. Our results show that treatment with mAbP COK suppressed the growth of breast cancer cells and induced apoptotic cell death. It also upregulated the expression of metastasis-related gangliosides in breast cancer cells. Thus, treatment with mAbP COK may have chemo-preventive therapeutic effects against human breast cancer.