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Prognostic Factors of Patients With Thymoma
( Won Sup Lee ),( Dae Seog Heo ),( Yung Jue Bang ),( Keun Seok Lee ),( Jin Seok Ahn ),( Chul Won Jung ),( Sung Koo Han ),( Sook Whan Sung ),( Joo Hyun Kim ),( Young Soo Shim ),( Chan Il Park ),( Noe K 대한내과학회 1996 The Korean Journal of Internal Medicine Vol.11 No.1
Active sealing for soft polymer microchips: method and practical applications
Bang, Hyunwoo,Lee, Won Gu,Park, Junha,Yun, Hoyoung,Lee, Joonmo,Chung, Seok,Cho, Keunchang,Chung, Chanil,Han, Dong-Chul,Chang, Jun Keun IOP 2006 JOURNAL OF MICROMECHANICS AND MICROENGINEERING - Vol.16 No.4
<P>This paper presents a new sealing method for soft polymer (elastomer) microchips. A robust and reversible sealing method, which allows various materials to be bonded and sealed tightly with each other even in aqueous solutions, is developed. A poly (dimethylsiloxane) microchip system, which can actively generate bonding and sealing forces by itself, is invented. By inducing negative pressure into additional closed areas, an instant sucking disc is made. This disc is used to tighten up the conformal contact of soft polymers. Other functionalities of active sealing such as making reusable microchips, patterning cells and performing cellular assays in a single dish have also been examined and will be discussed hereunder. This technique gives a robust and universal solution for microchip sealing issues by sealing soft polymers with diverse materials under various conditions. Active sealing will simplify numerous assays in lab-on-a-chip industry and will open a new era for cellular microchip assays.</P>
Bang, Kyong-Won,Seo, Soo-Young,Lee, Jae-Wook,Jang, Pil-Sang,Jung, Min-Ho,Chung, Nack-Gyun,Cho, Bin,Jeong, Dae-Chul,Suh, Byung-Kyu,Kim, Hack-Ki The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.4
Purpose: Improved survival of patients with childhood acute lymphoblastic leukemia (ALL) has drawn attention to the potential for late consequences of previous treatments among survivors, including metabolic syndrome. In this study, we evaluated changes in 3 parameters, namely, random blood glucose, body mass index (BMI), and Z score for BMI (Z-BMI), in children with ALL during chemotherapy and after completion of treatment. Methods: Patients newly diagnosed with ALL from January, 2005 to December, 2008 at Saint Mary's Hospital, The Catholic University of Korea, who completed treatment with chemotherapy only were included (n=107). Random glucose, BMI, and Z-BMI were recorded at 5 intervals: at diagnosis, before maintenance treatment, at completion of maintenance treatment, and 6 and 12 months after completion of maintenance treatment. Similar analyses were conducted on 2 subcohorts based on ALL risk groups. Results: For random glucose, a paired comparison showed significantly lower levels at 12 months post-treatment compared to those at initial diagnosis ($P$ <0.001) and before maintenance ($P$ <0.001). The Z-BMI score was significantly higher before maintenance than at diagnosis ($P$ <0.001), but decreased significantly at the end of treatment ($P$ <0.001) and remained low at 6 months ($P$ <0.001) and 12 months ($P$ <0.001) post-treatment. Similar results were obtained upon analysis of risk group-based subcohorts. Conclusion: For a cohort of ALL patients treated without allogeneic transplantation or cranial irradiation, decrease in random glucose and Z-BMI after completion of chemotherapy does not indicate future glucose intolerance or obesity.