A virtual-sample technology based artificial-neural-network for a complex data analysis in a glass-ceramic system

Wen Qi-Ye,Zhang Huai-Wu,Yang Qing-Hui,Zhang Pei-Xin 한양대학교 세라믹연구소 2008 Journal of Ceramic Processing Research Vol.9 No.4

Artificial neural network has becoming a mainstream technology in the domain of complex materials data analysis. Based on a slag glass-ceramic system we brought forward a virtual sample technology to increase the training samples by fluctuating the content of main compositions in a proper small amplitude. Simulation results proved that a good virtual sample set can not only improve the network’s prediction ability considerably, but can also suppress the “overtraining” phenomenon. Therefore a virtual sample improved neural network model can learn the relationship from a small size experimental data set and give an accurate and stable prediction for the test samples. This is more helpful to the material data analysis and can facilitate the design and development for new materials. Artificial neural network has becoming a mainstream technology in the domain of complex materials data analysis. Based on a slag glass-ceramic system we brought forward a virtual sample technology to increase the training samples by fluctuating the content of main compositions in a proper small amplitude. Simulation results proved that a good virtual sample set can not only improve the network’s prediction ability considerably, but can also suppress the “overtraining” phenomenon. Therefore a virtual sample improved neural network model can learn the relationship from a small size experimental data set and give an accurate and stable prediction for the test samples. This is more helpful to the material data analysis and can facilitate the design and development for new materials.

Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis

Deng, Qi-Wen,He, Bang-Shun,Pan, Yu-Qin,Sun, Hui-Ling,Xu, Ye-Qiong,Gao, Tian-Yi,Li, Rui,Song, Guo-Qi,Wang, Shu-Kui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.

Distinct mutations in MLH1 and MSH2 genes in Hereditary Non-polyposis Colorectal Cancer (HNPCC) families from China

( Wen Qian Wei ),( Fang Qi Liu ),( Lei Liu ),( Zuo Feng Li ),( Xiao Yan Zhang ),( Fan Jiang ),( Qu Shi ),( Xiao Yan Zhou ),( Wei Qi Sheng ),( San Jun Cai ),( Xuan Li ),( Ye Xu ),( Peng Nan ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.5

Hereditary non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant inheritance syndrome. HNPCC is the most common hereditary variant of colorectal cancer (CRC), which accounts for 2-5% CRCs, mainly due to hMLH1 and hMSH2 mutations that impair DNA repair functions. Our study aimed to identify the patterns of hMSH2 and hMLH1 mutations in Chinese HNPCC patients. Ninety-eight unrelated families from China meeting Amsterdam or Bethesda criteria were included in our study. Germline mutations in MLH1 and MSH2 genes, located in the exons and the splice-site junctions, were screened in the 98 probands by direct sequencing. Eleven mutations were found in ten patients (11%), with six in MLH1 (54.5%) and five in MSH2 (45.5%) genes. One patient had mutations in both MLH1 and MSH2 genes. Three novel mutations in MLH1 gene (c.157_160delGAGG, c.2157dupT and c.-64G>T) were found for the first time, and one suspected hotspot in MSH2 (c.1168C>T) was revealed. [BMB reports 2011; 44(5): 317-322]

An Experimental Study on the Fire Behavior Characteristics of Pinus koraiensis Litter by Slope Conditions

Ye-Eun Lee,Qi Wen Li,Sung Yong Kim,Song Eu,Sang Jun Im 위기관리 이론과 실천 2019 Crisisonomy Vol.15 No.6

이 연구에서는 잣나무 낙엽을 대상으로 실내 연소실험을 진행하여 경사조건에 따라 변화하는 화염 의 연소특성을 파악하고자 하였다. 이를 위해 경사조건을 0゜⋅10゜⋅15゜⋅20゜⋅25゜로 부여하여 연소 연료판의 최하단부와 최상단부에 불을 놓은 후 실험조건에 따라 잣나무 낙엽의 연소특성이 어떻게 변화하는지를 관찰하였다. 상향확산의 경우 경사도가 커질수록 확산속도가 증가하였으나, 하향확산 은 줄어들었다. 산불강도는 상향확산의 경우 21~37kW, 하향확산에서는 21~29kW로 상향확산이 다소 높았다. 경사도가 커질수록 최대화염길이는 증가하고, 화염각은 줄어들었는데 이는 화염이 미연 소 연료로 열전달이 빨라져 산불확산속도를 증가시킬 수 있다. 이 연구의 결과는 지형조건에 따라 다양하게 변화하는 산불행동을 예측하는 데 기초자료로 활용이 가능하다. In this study, a laboratory burning experiment was conducted to experimentally examine the combustion characteristics of Pinus koraiensis litter with different slopes. Using several slope conditions, we observed how forest fire behavior changed after igniting the upper and lower sections of fuel bed. The results showed that the rate of fire spread on uphill slopes increased with slope gradient, but that on downhill decreased. The measures of fire intensities on uphill ranged from 21 to 37kW and those on downhill are 21 to 29kW, indicating that fire intensities on uphill slopes were larger than on downhill. As the slope increased, the flame length increased but the flame tilt angle decreased. This meant that the flame can accelerate heat transfer to unburned fuels and increase fire spread rate. The results of this study can be used as basic data to accurately predict fire behavior under different slope conditions.

Functional Roles of Long Non-coding RNA in Human Breast Cancer

Ye, Ni,Wang, Bin,Quan, Zi-Fang,Cao, San-Jie,Wen, Xin-Tian,Huang, Yong,Huang, Xiao-Bo,Wu, Rui,Ma, Xiao-Ping,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.

An Experimental Study on the Fire Behavior Characteristics of Pinus koraiensis Litter by Slope Conditions

Lee, Ye-Eun,Li, Qi Wen,Kim, Sung Yong,Eu, Song,Im, Sang Jun Crisis and Emergency Management:Theory and Praxis 2019 Crisisonomy Vol.15 No.6

In-Situ Dehydration Test of Shield Spoil in Mudstone and Pebble Soil Composite Stratum

Dongping Zhao,Sixun Wen,Qi He,Feng Wang,Baihao Zhang,Zhuyan Wang,Huachang Fang,Ye Qin 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1

When earth pressure balance (EPB) shield machine is driving in mudstone sand pebble composite stratum, it will produce a large amount of spoil with high water content. The high moisture content of spoil not only increases the difficulty and cost of transportation, but also easily leads to environmental pollution problems. In this paper, based on the shield tunnel project of Chengdu Metro Line 30, the hydraulic characteristic of shield spoil was tested, and on this basis, laboratory tests of shield spoil dehydration were carried out according to the designed precipitation scheme. The results show that: 1) The moisture content of the EPB shield spoil in the mudstone sand pebble composite stratum is as high as 55.2%, and its permeability coefficient is basically the same as that of silt, and the shield residue has the condition of in-situ dehydration. 2) The dehydration amount and residue moisture content of spoil in slope-type spoil pit showed a linear relationship with time, and the dehydration rate is slow and the total precipitation is less. In other schemes, the dehydration amount and water content of spoil increase rapidly in the first 24 hours and slowly in the later period. 3) Considering the total amount and speed of dehydration within 24 hours, the dehydration effect of spoil pit is ranked from high to low: 3D gravel cage wall spoil pit > 3D spoil pit with vacuum pumping > 3D permeable stone spoil pit > 3D spoil pit > Slope-type spoil pit. 4) 3D gravel cage wall spoil pit has high dewatering efficiency, and vacuum pumping can assist the discharge of water. It is recommended to use 3D gravel cage wall spoil pit and vacuum pumping scheme for on-site EPB tunnel spoil dewatering.

Biomechanical Evaluation of 2 Endoscopic Spine Surgery Methods for Treating Lumbar Disc Herniation: A Finite Element Study

Yang Zou,Shuo Ji,Hui Wen Yang,Tao Ma,Yue Kun Fang,Zhi Cheng Wang,Miao Miao Liu,Ping Hui Zhou,Zheng Qi Bao,Chang Chun Zhang,Yu Chen Ye 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: This study aimed to evaluate the effects of 2 endoscopic spine surgeries on the biomechanical properties of normal and osteoporotic spines. Methods: Based on computed tomography images of a healthy adult volunteer, 6 finite element models were created. After validating the normal intact model, a concentrated force of 400 N and a moment of 7.5 Nm were exerted on the upper surface of L3 to simulate 6 physiological activities of the spine. Five types of indices were used to assess the biomechanical properties of the 6 models, range of motion (ROM), maximum displacement value, intervertebral disc stress, maximum stress value, and articular protrusion stress, and by combining them with finite element stress cloud. Results: In normal and osteoporotic spines, there was no meaningful change in ROM or disc stress in the 2 surgical models for the 6 motion states. Model N1 (osteoporotic percutaneous transforaminal endoscopic discectomy model) showed a decrease in maximum displacement value of 20.28% in right lateral bending. Model M2 (unilateral biportal endoscopic model) increased maximum displacement values of 16.88% and 17.82% during left and right lateral bending, respectively. The maximum stress value of L4–5 increased by 11.72% for model M2 during left rotation. In addition, using the same surgical approach, ROM, maximum displacement values, disc stress, and maximum stress values were more significant in the osteoporotic model than in the normal model. Conclusion: In both normal and osteoporotic spines, both surgical approaches were less disruptive to the physiologic structure of the spine. Furthermore, using the same endoscopic spine surgery, normal spine biomechanical properties are superior to osteoporotic spines.

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy

Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.