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Pulmonary Embolism during a Retrial of Low-dose Clozapine
Gregg Alan Robbins-Welty,Shannon Coats,Andrew N. Tuck,Bryan K. Lao,Zachary Lane 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Pulmonary emboli (PE) are increasingly recognized as an adverse effect of clozapine. However, little is known about the characteristics or mechanisms of clozapine-associated PE. We present a case of a 34-year-old with treatment-refractory schizophrenia who developed rhabdomyolysis during his first clozapine trial. During re-trial on a lower dose than his initial trial, the patient developed chest pain that he attributed to “pacemakers.” The pleuritic description and associated tachycardia prompted medical workup and the patient was ultimately diagnosed with a clozapine-associated PE. The patient’s only risk factors for PE were obesity and tobacco use, while his hypercoagulability workup was unrevealing. Clozapine use was continued at a lower dose following these adverse effects given inefficacy of other agents in managing the patient’s psychotic symptoms. The patient experienced significant relief of psychotic symptoms with continued clozapine therapy and a course of electroconvulsive therapy. The patient’s presentation was unusual in that it occurred during a retrial of clozapine, after the initial trial was stopped when he developed rhabdomyolysis. This case demonstrates the importance of maintaining vigilance for PE in patients on clozapine as well as not dismissing somatic complaints in patients experiencing psychosis. Additionally, given his history rhabdomyolysis, an uncommon adverse effect of clozapine, the development of a second uncommon adverse effect (PE) raises the question of whether these events may be associated.
Jules Woolf,Guangzhou Chen,Matt Haugen,Jon Welty Peachey 글로벌지식마케팅경영학회 2024 Journal of Global Sport Management Vol.9 No.1
The number of Chinese student-athletes (CSAs) at National Collegiate Athletic Association (NCAA) schools in the United States has increased dramatically in recent years. However, little is known about the distinct challenges CSAs face as they adopt the role of student and athlete, and the potential for role conflict to occur. This study explored the ways in which CSAs experienced role conflict and how they managed this conflict. Ten interviews were conducted with current or former CSAs at NCAA Division I schools. Findings revealed that CSAs experienced role conflict due to con-trasting expectations from different stakeholders, the lack of aca-demic preparedness, and unfamiliarity with the collegiate sport system. Meanwhile, CSAs managed their role conflict by realigning role expectations and shifting role identity. The findings demon-strate how role conflict can be applied to a cross-cultural context, while informing collegiate sport administrators of efforts to man-age CSAs transition into the NCAA system.
Park, Min Soo,Rieger-Fackeldey, Esther,Schanbacher, Brandon L,Cook, Angela C,Bauer, John A,Rogers, Lynette K,Hansen, Thomas N,Welty, Stephen E,Smith, Charles V Williams & Wilkins Co.[etc.] 2007 Pediatric research Vol.62 No.6
<P>In the present study, we tested the hypothesis that exposure of newborn mice to sublethal hyperoxia would alter lung development and expressions of fibroblast growth factor receptors (FGFRs)-3 and FGFR-4. Newborn FVB mice were exposed to 85% O2 or maintained in room air for up to 14 d. No animal mortality was observed, and body weight gains were not affected by hyperoxia. At postnatal d 7 and 14 (P7, P14), lungs of mice exposed to 85% O2 showed fewer alveolar secondary crests and larger alveoli or terminal air spaces than did mice in room air. In pups kept in room air, lung levels of FGFR-3 and FGFR-4 mRNA were greater at P3 than at P1, but similar increases were not observed in hyperoxic mice. Immunoreactivity of FGFR-3 and FGFR-4 was lower in lungs of hyperoxic mice than in controls at P14. In pups kept in room air, lung fibroblast growth factor (FGF)-7 mRNA levels were greater at P14 than at P1, but similar changes were not observed in hyperoxic mice. The temporally and spatially specific alterations in the expressions of FGFR-3, FGFR-4, and FGF-7 in the mice exposed to hyperoxia may contribute to aberrant lung development.</P>
Kim, Taehyong,Dreher, Kate,Nilo-Poyanco, Ricardo,Lee, Insuk,Fiehn, Oliver,Lange, Bernd Markus,Nikolau, Basil J.,Sumner, Lloyd,Welti, Ruth,Wurtele, Eve S.,Rhee, Seung Y. American Society of Plant Biologists 2015 Plant Physiology Vol.167 No.4
<P><I>Global patterns of metabolic responses upon single gene perturbations are specific to gene functions, but they are coordinated with characteristics of the perturbed genes.</I></P><P>Metabolomics enables quantitative evaluation of metabolic changes caused by genetic or environmental perturbations. However, little is known about how perturbing a single gene changes the metabolic system as a whole and which network and functional properties are involved in this response. To answer this question, we investigated the metabolite profiles from 136 mutants with single gene perturbations of functionally diverse Arabidopsis (<I>Arabidopsis thaliana</I>) genes. Fewer than 10 metabolites were changed significantly relative to the wild type in most of the mutants, indicating that the metabolic network was robust to perturbations of single metabolic genes. These changed metabolites were closer to each other in a genome-scale metabolic network than expected by chance, supporting the notion that the genetic perturbations changed the network more locally than globally. Surprisingly, the changed metabolites were close to the perturbed reactions in only 30% of the mutants of the well-characterized genes. To determine the factors that contributed to the distance between the observed metabolic changes and the perturbation site in the network, we examined nine network and functional properties of the perturbed genes. Only the isozyme number affected the distance between the perturbed reactions and changed metabolites. This study revealed patterns of metabolic changes from large-scale gene perturbations and relationships between characteristics of the perturbed genes and metabolic changes.</P>