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Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia
Weiwei Shan,Chao Wang,Zhenbo Zhang,Chao Gu,Chengcheng Ning,Xuezhen Luo,Qiongjie Zhou,Xiaojun Chen 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.3
Objective: To compare the efficacy of metformin plus megestrol acetate (MA) with that of MA alone for treating endometrial atypical hyperplasia (EAH). Methods: This pilot study included 16 EAH patients who met at least one metabolic syndrome (MS) criterion and received either adjunctive metformin plus MA (MET group) or MA monotherapy (MA group). Each patient in the MA group received 160 mg of MA daily, whereas patients in the MET group received the same dose of MA plus 0.5 g of metformin thrice daily. Treatment response was assessed by histological examination of dilation and curettage specimens obtained after 12 weeks of therapy. Results: Each group had eight patients, and half of the patients in each group were diagnosed with MS. The complete response (CR) rate was 75% (6/8) in the MET group and 25% (2/8) in the MA group (p=0.105). Complications of MS did not affect the response rates in either group. In the MET group, 75% (3/4) of the patients had CR in the presence or absence of MS. In the MA group, 50% (2/4) of the patients with MS had CR, whereas no patient without MS had CR. No irreversible toxicities were observed. Conclusion: Metformin plus MA may be a potential alternative therapy for treating EAH, and the MS status of patients may have no effect on the efficacy of metformin plus MA therapy.
Yanbin Luo,Yunfei Wu,Jianxun Chen,Fangfang Dong,Weiwei Liu,Lijun Chen,Yao Li,Zhou Shi 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.1
Rock mass pressure has always been a research hotspot in the field of tunnel engineering, especially in the super large-span tunnel, which is characterized by flat section, large excavation span, and complex stress field. Based on the Letuan Tunnel (a bi-directional tunnel with eight traffic lanes) of Binlai expressway expansion project in Shandong Province, China, this paper focused on the calculation method of rock mass pressure and the evolution law of load release in the construction process of the super large-span tunnel excavated by upper-bench central diaphragm (CD) method. Based on field measured data of Letuan Tunnel, the deformation behavior of primary lining and the distribution state of rock mass pressure during the tunnel construction were analyzed. According to the bearing mode of supporting structure, the mechanical models of different construction stages were established. Then, the rock mass pressures in different construction stages were back-calculated using mechanical models and compared with the measured values, and the evolution law of load release during the tunnel construction was discussed. The study results show that the tunnel deformation and rock mass pressure were significantly affected by the construction process and support form, and the excavation span was the key factor affecting the stability of rock mass. For the shallow-buried super large-span tunnel constructed by upper-bench CD method, the primary support of upper bench was under eccentric pressure. The comparison between the back-calculated value and the field measured value indicated that they were similar, and the average relative error was 17.23%. According to the concept of load release coefficient proposed in this paper, the load release coefficient after the pilot tunnel ahead (Part I) excavation reached 63%, and the load release coefficient after the pilot tunnel behind excavation (Part II) was 37%, which means that the rock mass pressure of Part I is increased about 59% due to the excavation of Part II.
Failure Mechanisms and Modes of Tunnels in Monoclinic and Soft-Hard Interbedded Rocks: A Case Study
Jianxun Chen,Weiwei Liu,Lijun Chen,Yanbin Luo,Yao Li,Haijiang Gao,Daochuan Zhong 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.4
The issue of large deformation mechanism in soft rock tunnels has puzzled tunnel scholars for decades. Previous studies have not evolved a clear and common understanding. Therefore, detailed on-site measurement, full investigation and statistical analysis have been conducted on the instability and failure of Muzhailing Tunnel since its construction, whose length is beyond 15 km. The study aims at systematically analyzing the failure mechanisms and modes of Muzhailing Tunnel in monoclinic and soft-hard interbedded rock strata. Study results show that the angle between strata strike and tunnel axis greatly determines the magnitude of deformation, the dip direction significantly controls the bias direction and maximum deformation direction, and the dip angle deeply affects the deformation form. The failure modes of surrounding rock mainly include four types: spalling and overturning failure, bending failure, shear slip failure and buckling failure. Large deformation characteristics are summarized from six aspects: failure form, groundwater, sensitivity to influencing factors, deformation degree, deformation speed and deformation duration. The instability modes of primary lining include in-plane (transverse) instability and out-plane (longitudinal) instability. Finally, the causes of large deformation are analyzed from geological, structural, engineering and human factors.
Xuenong Zhang,Weiwei Luo,Wenwen Zhao,Jinjian Lu,Xiuping Chen 한국유방암학회 2015 Journal of breast cancer Vol.18 No.2
Purpose: Isocryptotanshinone (ICTS) is a natural bioactive product that is isolated from the roots of the widely used medical herb Salvia miltiorrhiza. However, few reports exist on the mechanisms underlying the therapeutic effects of ICTS. Here, we report that ICTS has anticancer activity and describe the mechanism underlying this effect. Methods: The antiproliferative effect of ICTS was determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5- diphenyl-2-H-tetrazolium bromide (MTT) and clonogenic assays. The effect of ICTS on the cell cycle was measured using flow cytometry. Apoptosis was determined by Hoechst 33342 staining, DNA fragmentation assays, and Western blotting for apoptotic proteins. Finally, the effect of ICTS on mitogen-activated protein kinases (MAPKs) was determined by Western blotting. Results: ICTS significantly inhibited proliferation of MCF-7 and MDA-MB-231 human breast cancer cells, HepG2 human liver cancer cells, and A549 human lung cancer cells in vitro. Among the tested cell lines, MCF-7 cells showed the highest sensitivity to ICTS. ICTS significantly inhibited colony formation by MCF-7 cells. Furthermore, exposure of MCF-7 cells to ICTS induced cell cycle arrest at the G1 phase and decreased mitochondrial membrane potential. Hoechst 33342 staining and Western blot analysis for apoptotic proteins suggested that ICTS induced apoptosis in MCF-7 cells. In addition, ICTS activated MAPK signaling in MCF-7 cells by inducing time- and concentration-dependent phosphorylation of JNK, ERK, and p38 MAPK. Conclusion: Our results suggest that ICTS inhibited MCF-7 cell proliferation by inducing apoptosis and activating MAPK signaling pathways.
Two New Bibenzyl Glucosides from Dendrobium chrysotoxum
Fa-Wu Dong,Huai-Rong Luo,Qin-Li Wan,Feng-Qing Xu,Weiwei Fan,Kai-Jin Wang,Ning Li,Jiang-Miao Hu 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.7
Two new bibenzyl glucosides, 3,3',4',5-tetramethoxybibenzyl-4-O-β-D-glucopyranoside (1) and 3,4,4',5- tetramethoxybibenzyl-3'-O-β-D-glucopyranoside (2), together with five known ones, chrysotobibenzyl (3), erianin (4), chrysotoxine (5), gigantol (6) and tristin (7) were isolated from the stems of Dendrobium chrysotoxum. The structures of those compounds were elucidated by extensive spectroscopic analysis. Moreover, compounds 1-7 were assessed for inhibitory activity of two enzymes-AChE (acetylcholine esterase) and BChE (butyrylcholine esterase).
Li-xin Zhang,Jianxun Chen,Lijun Chen,Yanbin Luo,Weiwei Liu,Fangfang Dong,Hao Chen,Hao-yang Zhu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.10
A high-performance grouting material is proposed to enhance the support effect of anchoring pipes in soft rock mass tunnels in this paper. Through mix proportion and strength tests, the initial setting time, compressive strength, and flowability of the grouting material were determined. Furthermore, based on grouting and pulling tests, the recommended parameters of the anchoringpipe were proposed. The results show that pure cement paste is an ideal grouting material for on-site application, demonstrating excellent anchoring, fluidity, high strength, and rapid hardening. Under optimal conditions of water-cement ratio at 0.46 and retarder proportion at 0.4‰, the initial settling time and the compressive strength of the grouting material are approximately 45 minutes and 28.5 MPa within 4 hours, respectively. The anchoring force of an anchoring pipe with a length of 6 m and a diameter of 76 mm can reach 448.9 kN within the same period. A field test involving anchoring pipes and pure cement paste was conducted during tunnel construction, resulting in a substantial reduction of maximum settlement and convergence of the tunnel by 57.53% and 40.48%, respectively. These results demonstrate the effectiveness
New Structure Design of Magnet for 1 MJ HTS SMES
Wei Wei,Yinghong Luo,Liying Han 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.9
In recent years, the superconducting technology is popular in our production and life. An increasing number of researchers and institutions participate in study of the super-conducting magnetic energy storage (SMES) system. SMES is widely used in power sup-ply system, new energy system and pulsed power supply system. However, the leakage magnetic field of traditional SMES is more serious, which limited the application in engi-neering. This paper proposes an improved scheme for the 1 MJ single-solenoid structure magnet by using the actively shielding theory. Moreover, by using particle swarm optimi-zation, the structural parameters of the superconducting magnets are optimized respec-tively. Finally, the ANSYS modeling simulation is built by these structural parameters, all simulation data are analyzed and compared.