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A New Cytotoxic Phenazine Derivative from a Deep Sea Bacterium Bacillus sp
Zhu, Weiming,Li, Dehai,Wang, Fengping,Xiao, Xiang,Zeng, Xiang,Gu, Qian-Qun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.
Liu Xiao,Xue Zhigang,Yu Jianchun,Ma Zhiqiang,Kang Weiming,Ye Xin,Li Zijian 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.5
BACKGROUND/OBJECTIVES Previous studies have reported that protein supplementation contributes to the attenuation of inflammation. Serious trauma such as burn injury usually results in the excessive release of inflammatory factors and organs dysfunction. However, a few reports continued to focus on the function of protein ingestion in regulating burn-induced inflammation and organ dysfunction. MATERIALS/METHODS This study established the rat model of 30% total body surface area burn injury, and evaluated the function of blended protein (mixture of whey and soybean proteins). Blood routine examination, inflammatory factors, blood biochemistry, and immunohistochemical assays were employed to analyze the samples from different treatment groups. RESULTS Our results indicated a decrease in the numbers of white blood cells, monocytes, and neutrophils in the burn injury group administered with the blended protein nutritional support (Burn+BP), as compared to the burn injury group administered normal saline supplementation (Burn+S). Expressions of the pro-inflammatory factors (tumor necrosis factor-α and interleukin-6 [IL-6]) and chemokines (macrophage chemoattractant protein-1, regulated upon activation normal T cell expressed and secreted factor, and C-C motif chemokine 11) were dramatically decreased, whereas anti-inflammatory factors (IL-4, IL-10, and IL-13) were significantly increased in the Burn+BP group. Kidney function related markers blood urea nitrogen and serum creatinine, and the liver function related markers alanine transaminase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase were remarkably reduced, whereas albumin levels were elevated in the Burn+BP group as compared to levels obtained in the Burn+S group. Furthermore, inflammatory cells infiltration of the kidney and liver was also attenuated after burn injury administered with blended protein supplementation. CONCLUSIONS In summary, nutritional support with blended proteins dramatically attenuates the burn-induced inflammatory reaction and protects organ functions. We believe this is a new insight into a potential therapeutic strategy for nutritional support of burn patients.
Liu, Jilong,Xiao, Fei,Ma, Weiming,Fan, Xuexin,Chen, Wei The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2
This paper proposes a pulse width modulation (PWM)-based sliding mode controller (SMC) for a full-bridge DC-DC converter that can eliminate static output voltage error. Hysteretic SMC in DC-DC converter does not have a fixed switching frequency, and applying hysteretic SMC to full-bridge converters is difficult. Fixed-frequency SMC, which is also called PWM-based SMC, based on equivalent control overcomes these shortcomings. However, the controller order reduction in equivalent control in PWM-based SMC causes static output voltage error. To resolve this issue, an integral item is added to the PWM-based SMC. Sliding mode coefficients are designed by applying a standard second-order system to the sliding mode surface. The effect of adding an integral item on the controller is analyzed, and an integral coefficient design method is proposed. Experiment results on a three-level full-bridge DC-DC converter verify the control scheme and design method proposed in this paper.
Zaharaddeen N. Garba,Wei Xiao,Weiming Zhou,Ibrahim Lawan,Yifan Jiang,Mingxi Zhang,Zhanhui Yuan 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.11
Due to increasing interest in the application of perovskites as promising adsorbents, the present study looks at how central composite design (CCD), a subset of response surface methodology (RSM), can statistically play a role in producing optimum lanthanum oxide-cobalt perovskite type nanoparticles (LaCoO3) by using a modified proteic synthesis method. The optimum LaCoO3 produced was tested for its capability in removing methyl orange (MO) and rhodamine B (RhB) dyes from aqueous solution. Calcination temperature and calcination time were optimized with the responses being percentage yield, MO and RhB removal. The best temperature and calcination time obtained were 775 oC and 62mins, respectively, giving good and appreciable values for the three responses. The resulting optimal LaCoO3 was characterized by Fourier transform infra-red (FTIR), ultraviolet-visible spectrophotometry (UV/vis), scanning electron microscopy (SEM), pH of zero point charge (pHpzc) as well as BET analysis, yielding a mesoporous adsorbent with surface area of 61.130m2 g−1 as well as 223.55 and 239.45mg g−1 as the monolayer adsorption capacity values for MO and RhB, respectively. Freundlich model was the best in describing the equilibrium adsorption data with respect to both MO and RhB with the kinetic data for the two dyes both obeying pseudo-second-order kinetics model.
Lin, Zhen-Jian,Lu, Xiao-Ming,Zhu, Tian-Jiao,Fang, Yu-Chun,Gu, Qian-Qun,Zhu, Weiming 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.
Jilong Liu,Fei Xiao,Weiming Ma,Xuexin Fan,Wei Chen 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2
This paper proposes a pulse width modulation (PWM)-based sliding mode controller (SMC) for a full-bridge DC-DC converter that can eliminate static output voltage error. Hysteretic SMC in DC-DC converter does not have a fixed switching frequency, and applying hysteretic SMC to full-bridge converters is difficult. Fixed-frequency SMC, which is also called PWM-based SMC, based on equivalent control overcomes these shortcomings. However, the controller order reduction in equivalent control in PWM-based SMC causes static output voltage error. To resolve this issue, an integral item is added to the PWM-based SMC. Sliding mode coefficients are designed by applying a standard second-order system to the sliding mode surface. The effect of adding an integral item on the controller is analyzed, and an integral coefficient design method is proposed. Experiment results on a three-level full-bridge DC-DC converter verify the control scheme and design method proposed in this paper.
Zhen-Jian Lin,Xiao-Ming Lu,Tian-Jiao Zhu,Yu-Chun Fang,Qian-Qun Gu,Weiming Zhu 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma..Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.
A New Cytotoxic Phenazine Derivative from a Deep Sea Bacterium Bacillus sp.
Dehai Li,Fengping Wang,Xiang Xiao,Xiang Zeng,Qian-Qun Gu,Weiming Zhu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.
Li Wan,Mingwei Yuan,Guowen Xiong,Shunli Shi,Weiming Xiao,Chao Chen,Fanrong Ai 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-
MOF-polymer mixed matrix catalytic membrane has excellent potential for applications in continuousflow separation and catalysis. However, scalable fabrication methods to produce ultra-high flux mixedmatrix catalytic membranes are urgently needed yet to be largely met. Inspired by the honeycomb structure,composite MOF with polymer materials possessing rapidly prepare large area MOF-polymer mixedmatrix catalytic membrane with penetrated honeycomb structure. The bulk loading of MOFs linked thewalls of the honeycomb, endowing the MOF-polymer mixed matrix membrane with large surface areasand abundant pore channels. The porous MOF material links the pore walls of the honeycomb structure,which not only enables the rapid passage of reactants, but also greatly enhances the mutual contact betweenthe membrane and the reactants, achieving rapid passage and efficient catalysis. The 0.6-ZIF-8/Pd-TPU porosity reaches 69% and the specific surface area can reach 828.35 m2/g. The water flux reached3290 L m2 h1 and the treatment efficiency of different dyes and 4-NP under vacuum pump filtrationreached 99%. This preparation method was extended to other porous materials, and membranes weresuccessfully prepared with good catalytic effects. This strategy paves the way for the development of highflux and efficient catalytic membranes.
Tong Zhijun,Xiu Zhihui,Ming Yao,Fang Dunhuang,Chen Xuejun,Hu Yafei,Zhou Juhong,He Weiming,Jiao Fangchan,Zhang Chi,Zhao Shancen,Jin Han,Jian Jianbo,Xiao Bingguang 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.6
Tobacco ( Nicotiana tabacum L.) is an economic crop and a model organism for studies of plant biology and genetics. As an allotetraploid plant generated from interspecific hybridization, tobacco has a massive genome (4.5 Gb). Recently, a genetic map with 45,081 single nucleotide polymorphism (SNP) markers was constructed using whole-genome sequencing data for a tobacco population including 274 individuals. This provides a basis for quantitative trait locus (QTL) mapping and genomic selection, which have been widely applied to other crops but have not been feasible in tobacco. Based on this high-density genetic map, we identified QTLs associated with important agronomic traits, chemical compounds in dry leaves, and hazardous substances in processed cigarettes. The LOD values for major QTLs were highest for agronomic traits, followed by chemical compounds and hazardous substances. In addition to the identification of molecular markers, we evaluated genomic selection models and found that BayesB had the highest prediction accuracy for the recombinant inbred line population. Our results offer new insights into the genetic mechanism underlying important traits, such as agronomic traits and quality-related chemical compounds in tobacco, and will be able to support the application of molecular breeding to tobacco.