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Impurities-contributed abnormal thermoelectric effect in a parallel double quantum dot structure
Wei-Jiang Gong,Hui-Min Wang,Yu Han,Si-Jing Zhang 한국물리학회 2014 Current Applied Physics Vol.14 No.1
We discuss the influence of local impurities on the thermoelectric effect in a parallel double quantum dot (QD) structure. It is first found that in this structure, the Fano effect contributes significantly to the enhancement of thermoelectric efficiency, especially in the case of f ¼ p. Next, impurities are introduced to couple to the QDs, respectively. We readily find that regardless of which QD is coupled to a local impurity, the thermoelectric efficiency can be enhanced by the strengthening of impurityeQD coupling. This means that the destruction of the Fano interference is not the necessary condition to suppress the thermoelectric effect. Accordingly, we hope that the numerical results can help to understand the role of impurities in adjusting the thermoelectric properties of the QD structure.
Influence of Majorana doublet on transport through a quantum dot system with ferromagnetic leads
Wei-Jiang Gong,Zhen Gao,Xiao-Qi Wang 한국물리학회 2015 Current Applied Physics Vol.15 No.10
We investigate the electron transport through a quantum dot connected with two ferromagnetic leads, by coupling one Majorana doublet laterally to the quantum dot. It is found that Majorana doublet keeps the value of zero-bias conductance to be independent of the shift of structural parameters, including dot level, relative lead-magnetization direction, and magnetic field on the dot. Even in the cases of asymmetric dot-lead couplings, the zero-bias conductance is weakly dependent on the relative leadmagnetization direction. On the other hand, when Majorana doublet is replaced by Majorana singlet, the zero-bias conductance value becomes sensitive to the structural parameters. Via analyzing the respective particle motion processes, the different influences of Majorana doublet and singlet are explained. We believe that this work can be helpful for understanding the peculiar properties of Majorana doublet.
Andreev reflections in a Y-shaped junction with Majorana zero mode
Wei-Jiang Gong,Xiao-Qi Wang,Guang-Yu Yi,Yu Han 한국물리학회 2016 Current Applied Physics Vol.16 No.7
We investigate the Andreev transports through a double-dot Y-shaped junction with Majorana zero mode. It is observed that the additional direct coupling between the dots plays a nontrivial role in manipulating the Andreev transports. Due to its existence, finite magnetic flux can be introduced through this structure to adjust the local and crossed Andreev reflections in different ways. As a result, changing the interdot coupling is able to enhance the crossed Andreev reflection and weaken the local one at the same time in both the linear and nonlinear transport regions. Such a work can be helpful for controlling the Andreev transport behaviors related to Majorana bound state.
Universal transport properties of a quantum dot system with a laterally-coupled Majorana zero mode
Wei-Jiang Gong,Ying Zhao,Zhen Gao,Shu-Feng Zhang 한국물리학회 2015 Current Applied Physics Vol.15 No.4
We present a comprehensive analysis about the transport properties of a quantum dot (QD) system with a side-coupled Majorana zero mode. Our calculation result shows that when the coupling manners between the two leads and QDs are identical, the local Andreev reflection and the interlead normal tunneling have the same magnitude at the zero-bias limit. Accordingly, the zero-bias conductance value is always equal to e2/2h, which is exactly one half of the resonant-tunneling conductance. This result is independent of the level number and the level distribution in the single-QD case, and in the coupled-QD case it is irrelevant to the geometry of the QD molecule. The universal transport property is a powerful evidence for the feasibility to detect the MBSs based on a QD circuit. This result also means that the QD condition is not a key factor to achieve the detection. On the other hand, if the decoupling phenomenon appears, the Majorana zero mode may play a trivial role in contributing to the conductance property.
Gong, Lei,Jiang, Chunying,Zhang, Bing,Hu, Haiyan,Wang, Wei,Liu, Xianxi Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.6
To evaluated the effect of recombinant adenovirus Ad-ODC-AdoMetDCas which can simultaneously express both antisense ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) on cell cycle distribution in colorectal cancer cell and investigated underlying regulatory responses, human colorectal cancer cells HT-29 were cultured in RPMI 1640 medium and infected with Ad-ODC-AdoMetDCas. Cell cycle progression was detected by flow cytometry analysis. The expression levels of cell cycle regulated proteins were measured by Western blot analysis. The mRNA level of cyclin D1 was measured by RT-PCR. And a luciferase reporter plasmid of cyclin D1 promoter was constructed to observe the effect of Ad-ODC-AdoMetDCas on cyclin D1 promoter activity. The results showed that recombinant adenovirus Ad-ODC-AdoMetDCas significantly induced $G_1$ arrest, decreased levels of cyclin D1 protein and mRNA and suppressed the promoter activity. Ad-ODC-AdoMetDCas also inhibited nuclear translocation of $\beta$-catenin. In conclusion, downregulation of ODC and AdoMetDC mediated by Ad-ODC-AdoMetDCas transfection induces $G_1$ arrest in HT-29 cells and the arrest was associated with suppression of cyclin D1 expression and inhibition of $\beta$-catenin nuclear translocation. As a new anticancer reagent, the recombinant adenovirus Ad-ODC-AdoMetDCas holds promising hope for the therapy of colorectal cancers.
Single-index composite quantile regression
Jiang, Rong,Zhou, Zhan-Gong,Qian, Wei-Min,Shao, Wen-Qiong 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.3
In this paper, we extend the composite quantile regression (CQR) method to a single-index model. The unknown link function is estimated by local composite quantile regression and the parametric index is estimated through the linear composite quantile. It is shown that the proposed estimators are consistent and asymptotically normal. The simulation studies and real data applications are conducted to illustrate the finite sample performance of the proposed methods.
Single-index composite quantile regression
Rong Jiang,Zhan-Gong Zhou,Wei-Min Qian,Wen-Qiong Shao 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.3
In this paper, we extend the composite quantile regression (CQR) method to a single-index model. The unknown link function is estimated by local composite quantile regression and the parametric index is estimated through the linear composite quantile. It is shown that the proposed estimators are consistent and asymptotically normal. The simulation studies and real data applications are conducted to illustrate the finite sample performance of the proposed methods.
Oxaliplatin Sensitizes OS Cells to TRAIL-induced Apoptosis Via Down-regulation of Mcl1
Huang, Tao,Gong, Wei-Hua,Li, Xiu-Cheng,Zou, Chun-Ping,Jiang, Guang-Jian,Li, Xu-Hui,Qian, Hao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Purpose: To investigate the killing effect on OS cells of a combination of oxaliplatin and TRAIL and related molecular mechanisms. Methods: TRAIL and oxaliplatin were applied to OS732 cells singly or jointly and survival inhibition rates were measured by MTT assay, changes of cellular shape being assessed with inverted phase contrast and fluorescence microscopy. Apoptotic rates were analyzed by flow cytometry (FCM) and immunocytochemistry was used to examine Mcl1 expression of OS732 cells. Results: The survival inhibition rate of combined application of $100{\mu}g/ml$ TRAIL and $1{\mu}g/ml$ oxaliplatin on OS-732 cells was significantly higher than that of either agent singly (p<0.01). Changes of cellular shape and apoptotic rates also indicated apoptosis-inducing effects of combined application to be much stronger than those of individual application. Oxaliplatin had the effect of down-regulating Mcl1 expression and sensitizing OS cells to TRAIL-induced apoptosis. Conclusion: A combination of TRAIL and oxaliplatin exerts strong killing effects on OS-732 cells which might be related to down-regulation of Mcl1 expression.