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Bioinformatics Analysis Reveals Connection of Squamous Cell Carcinoma and Adenocarcinoma of the Lung
Fan, Wei-Dong,Zhang, Xian-Quan,Guo, Hui-Lin,Zeng, Wei-Wei,Zhang, Ni,Wan, Qian-Qian,Xie, Wen-Yao,Cao, Jin,Xu, Chang-Hua Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small cell lung cancer. Because they differ on the basis of histopathological and clinical characteristics and their relationship with smoking, their etiologies may be different; for example, different tumor suppressor genes may be related to the genesis of each type. We used microarray data to construct three regulatory networks to identify potential genes related to lung adenocarcinoma and squamous cell carcinoma and investigated the similarity and specificity of them. In the network, some of the observed transcription factors and target genes had been previously proven to be related to lung adenocarcinoma and squamous cell carcinoma. We also found some new transcription factors and target genes related to SCC. The results demonstrated that regulatory network analysis is useful in connection analysis between lung adenocarcinoma and squamous cell carcinoma.
Jin-Hua Liang,Yun-Ping Zhang,Jun Xia,Chong-Yang Ding,Wei Wu,Li Wang,Lei Cao,Hua-Yuan Zhu,Lei Fan,Tian-Nv Li,Jian-Yong Li,Wei Xu 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose The purpose of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) in patients with follicular lymphoma (FL) at baseline and mid-treatment with 18F-fluorodeoxyglucose positron emission tomography computed tomography (PET-CT) scans. Materials and Methods The study analyzed data from 48 patients with FL who were treated in Jiangsu Province Hospital and reviewed their baseline PET-CT scans. TMTV and TLG were computed by using the absolute value of 2.0, 2.5, and 3.0 thresholding method, respectively. Results Median age was 53 years, 75.0% of patients had stage III to IV disease, 43.8% had a Follicular Lymphoma International Prognostic Index 1 (FLIPI1) score of 3 to 5 and 20.8% had a FLIPI2 score of 3 to 5. Receiver operating characteristic (ROC) curve analysis showed the optimal cut-off values for TMTV3.0 and TLG3.0 were 476.4 (sensitivity, 85.7%; specificity, 78.0%; area under the curve [AUC], 0.760; p=0.003) and 2,676.9 (sensitivity, 71.4%; specificity, 78.0%; AUC, 0.760; p=0.003). On multivariable analysis, TMTV3.0 and TLG3.0 were independent predictors of both progression-free survival (PFS) (hazard ratio [HR], 5.406; 95% confidence interval [CI], 1.326 to 22.040; p=0.019 and HR, 6.502; 95% CI, 1.079 to 39.182; p=0.042) and overall survival (OS) (HR, 4.111; 95% CI, 1.125 to 15.027; p=0.033 and HR, 5.885; 95% CI, 1.014 to 34.148; p=0.049). ROC curve analysis showed the optimal cut-off values for TMTV3.0 and TLG3.0 were 66.3% (sensitivity, 85.7%; specificity, 63.4%; AUC, 0.774; p < 0.001) and 64.5% (sensitivity, 85.7%; specificity, 65.9%; AUC, 0.777; p < 0.001). Conclusion Baseline TMTV and TLG are strong predictors of PFS and OS in FL. Furthermore, interim TMTV (TMTV > 66.3%) and TLG (TLG > 64.5%) reduction are valuable tools for early treatment response assessment in FL patients.
Hua Zhang,Bin Chen,Wei-dong Shi,Zhong-yong Pan,Wei-dong Cao 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.3
With the expansion of the engineering application of solid-liquid two-phase flow, the overload characteristics of low-specific-speedsewage pumps become an important obstacle to the development of the products. In this paper, the traditional diffusion-type impeller isutilized to carry out hydraulic design of a low-specific-speed sewage pump. And on this basis, the thickness of the blades is increased forgetting an impeller with contractive-type flow channel. It was found out that through external characteristics, the efficiency of contraction-type impeller is slightly lower than that of diffusion-type impeller, but it shows obvious non-overload performance. PIV experimentis arranged to find the inherent. The results show that although internal flow field distribution of contraction-type impeller is better thanthat of diffusion-type impeller, the severe uneven distribution of absolute velocity of the impeller outlet along the circumference is one ofmain reasons of inefficiency. In addition, another five impellers with different contraction ratio are designed to research relationship betweencontraction ratio and character of non-overload. The characteristics are predicted by CFD, and after comparing the results, it isfound out that, the smaller the contraction ratio is, the closer the condition of power extreme is to the design condition, which has importantimplications for the engineer.
Employing rotating vaneless diffuser to enhance the performance of plenum fan
Hua-Shu Dou,Lin Wu,Yikun Wei,Yongning Chen,Wenbin Cao,Cunlie Ying 한국유체기계학회 2017 International journal of fluid machinery and syste Vol.10 No.1
Numerical simulation is carried out for flow characteristics in a plenum fan and the influence of the diameter ratio of the rotating vaneless diffuser on the performance of plenum fan is analyzed. The diameter ratio of the rotating vaneless diffuser employed is from 1.03 to 1.3. The research results show that the rotating vaneless diffuser is able to enhance the performance of plenum fan. It is found that there is significant improvement in static pressure and efficiency at the diameter ratio of 1.05 at high flow coefficients, while the optimal diameter ratio is 1.2 at rated and low flow coefficient.
Sorption kinetics of sulphate ions on quaternary ammonium-modified rice straw
Wei Cao,Zhi Dang,Bao-Ling Yuan,Chun-Hua Shen,Jin Kan,Xiu-Ling Xue 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
Batch sorption experiments with variable concentration of sulphate and temperature were conducted to investigate sorption kinetics of sulphate ions on quaternary ammonium-modified rice straw (QMRS). Kinetic data were discussed with pseudo first- and second-order rate equations and diffusion models. The results showed the sorption equilibrium time is about 20 min and the activated energy Ea is 19.3 kJ/mol. Increase of temperature and initial sulphate concentration favored sorption process. The sorption kinetics followed pseudo second-order rate equation, and the overall rate was determined by film diffusion. Additionally, characterization by 13C NMR and EDS confirmed the presence of quaternary ammonium groups in QMRS.
Wei Han,Cong Zhang,Xiao-jiao Gao,Hua-bing Wang,Fang Chen,Fang Cao,Yong-wei Hu,Jun Ma,Xing Gu,Hou-zhong Ding 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1
Purpose: Five members of the zinc finger of the cerebellum (ZIC) family—ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5—have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled. ZIC proteins in 241 pairs of breast tumors and corresponding normal tissues were investigated using immunohistochemistry and the clinicopathologic roles of proteins were analyzed using Pearson’s chi-square test. Kaplan-Meier curves and Cox regression analysis were also used to analyze the prognostic value of the ZIC proteins. In addition, 12 pairs of fresh-frozen breast tumors and matched normal tissues were used in the western blotting analysis and RT-qPCR. Results: Only ZIC1 expression in normal tissues was obviously higher than that in tumors (p<0.001). On multivariate analysis, ZIC1 expression (in overall survival analysis: hazard ratio [HR], 0.405, 95% confidence interval [CI], 0.233–0.702, p=0.001; in disease-free survival analysis: HR, 0.395, 95% CI, 0.234–0.669, p=0.001) was identified as a prognostic indicator of invasive breast cancer. Conclusion: ZIC1, but not the other proteins, was obviously decreased in breast tumors and associated with clinicopathologic factors. Thus, ZIC1 might be a novel indicator to predict the overall and disease-free survival of invasive breast cancer patients.
A Primary Permanent-Magnet Linear Motor for Urban Rail Transit
Cao, Ruiwu,Cheng, Ming,Mi, Chris,Hua, Wei,Zhao, Wenxiang Journal of International Conference on Electrical 2012 Journal of international Conference on Electrical Vol.1 No.1
In this paper, a new permanent-magnet (PM) linear motor is proposed, in which both the magnets and armature windings are placed in the short mover, while the long stator consists of iron core only. Hence, this new PM linear motor can be called a primary permanent-magnet linear motor. It exhibits the advantages of robustness, low cost, high efficiency, high power factor, and high thrust force density. It is especially suitable for long stator applications such as urban rail transit. In this paper, the topology and operation principle of this motor are discussed in detail. The steady-state characteristics including field distributions, flux-linkage, back-EMF, phase inductance and thrust force are investigated. In addition, the technique of skewing stator teeth is adopted to improve the electromagnetic performance. Results from finite element method (FEM) verified the theoretical analysis results.
Cao, Wei,Wu, Xianjian,Jia, Gang,Zhao, Hua,Chen, Xiaoling,Wu, Caimei,Cai, Jingyi,Wang, Jing,Liu, Guangmang Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.8
Objective: This study investigated whether spermine supplementation could regulate cell cycle, apoptosis, and amino acid transporter-related genes expression in the thymus and spleen of early weaned piglets. Methods: Eighty female piglets were randomly distributed to receive adequate nutrients supplemented with spermine (0.4 mmol/kg body weight/24 h) or to be provided with restricted nourishment supplemented with normal saline for 7 h or 3, 6, or 9 d in pairs. Results: Regardless of administration time, spermine supplementation significantly up-regulated cyclin A2 gene expression but down-regulated p21 and cyclin D3 mRNA levels in the thymus and spleen and reduced cyclin E2 gene expression in the thymus of piglets (p<0.05). Irrespective of the treatment period, the reduced Bax and caspase-3 gene expressions and improved Bcl-2 mRNA level were observed in the thymus and spleen of spermine-administrated piglets (p<0.05). Regardless of supplementation time, spermine intake significantly enhanced the expressions of amino acid transporter-related genes (SLC1A1, SLC1A5, SLC7A1, SLC7A7, and SLC15A1) in both thymus and spleen, as well as SLC7A9 in the spleen of piglets (p<0.05). In addition, extended spermine administration also markedly promoted cell proliferation, depressed apoptosis and modulated amino acid transport (p<0.05), and such effects were the greatest during prolonged spermine supplementation (6 d) compared to the other time periods (p<0.05). Conclusion: Spermine supplementation may regulate cell cycle during the G1/S phase, suppress apoptosis and modulate amino acid transport. A period of 6 d of spermine supplementation is required to produce the optimal effects on nutritional implications.
Employing rotating vaneless diffuser to enhance the performance of plenum fan
Dou, Hua-Shu,Wu, Lin,Wei, Yikun,Chen, Yongning,Cao, Wenbin,Ying, Cunlie Korean Society for Fluid machinery 2017 International journal of fluid machinery and syste Vol.10 No.1
Numerical simulation is carried out for flow characteristics in a plenum fan and the influence of the diameter ratio of the rotating vaneless diffuser on the performance of plenum fan is analyzed. The diameter ratio of the rotating vaneless diffuser employed is from 1.03 to 1.3. The research results show that the rotating vaneless diffuser is able to enhance the performance of plenum fan. It is found that there is significant improvement in static pressure and efficiency at the diameter ratio of 1.05 at high flow coefficients, while the optimal diameter ratio is 1.2 at rated and low flow coefficient.