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- 저자 : Wang Haidong (검색결과 14 건)
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Wang, Haidong,Li, Deyuan,Hu, Zhongze,Zhao, Siming,Zheng, Zhejun,Li, Wei Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.6
To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1-${\beta}$ (IL-1-${\beta}$) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.
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ZIF-67 modified MXene/sepiolite composite membrane for oil–water separation and heavy metal removal
Qiuxiang Wang,Zongxue Yu,Ximei Zhu,Qingcan Xiang,Haidong Chen,Yao Pang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
In this study, polyvinylpyrrolidone (PVP) was used as a cross-linking agent leading to ZIF-67 in-situ growon the surface of sepiolite (Sep) to increase the specific surface area and space volume of Sep. Subsequently, a hydrothermal synthesis method was used to form a stable super-hydrophilic compositemembrane from the composite MXene by polydopamine. Compared to the MXene/PDA/Sep (MPS) compositemembrane, the composite membrane with ZIF-67 exhibited improved hydrophilicity and heavymetal separation. In addition, the introduction of negatively charged Sep@ZIF-67–24 (SZ-24) increasedthe number of adsorption active sites and negative potential for the surface of the membrane, and thiswas conducive to the demulsification and adsorption of oil–water emulsions. The MXene/PDA/Sep@ZIF-67–1 (MSZ-1) composite membrane had excellent separation effects on surfactant-stabilizedemulsions (SSEs) and surfactant-free emulsions (SFEs) oil–water emulsions which were above 99.4 %. Furthermore, the separation effect on oil–water, under extreme water conditions, was greater than99 %. The MSZ-1 composite membrane can achieve excellent separation of heavy metal ions, especiallyCu2+ that the rejection was 79.9 %, under high flux and extreme conditions. Therefore, the MSZ-1 compositemembrane has broad application prospects in oil–water treatment and heavy metal separation.
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A Sample-Reducing Approach for Training Support Vector Machines (SVMs)
Shipin Lv,Haidong Zhao,Xiukun Wang 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-
The paper presents a novel approach to cut down the number of samples before training SVMs. It proves, among those samples that are collinear in the reproduced kernel feature space, only the two end points are useful for solving the SVM QP classification problem. By using 'kernel trick', those useless data points could be found out in the original space and removed from training samples. It brings twofold benefits: decrease in the number of samples and increase in the sparseness.
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Wei Li,Haidong Wang,Deyuan Li,Zhongze Hu,Siming Zhao,Zhejun Zheng 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.6
To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor- (TNF-), interleukin-1- (IL-1-) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb in-duced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.
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Li Feifei,Wang Haidong,Shaheen Tayyab,Pei Pei,Li Menglou,Tang Guanghui 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3
Chemical pesticides often applied to effectively control the long-horned beetles to protect the forests are reported to affect the non-target organisms adversely. Dastarcus helophoroides is an active natural enemy of long-horned beetles. Studying the molecular mechanism of P450 genes will help to elucidate the metabolic mechanism of pesticides in D. helophoroides to better coordinate the use of chemical and biological controls. In this study, two novel genes, CYP6BQ21, and CYP6BQ22 were successfully cloned from D. helophoroides using the rapid ampli fication of cDNA ends technique. The sequence and homology analyses indicated that CYP6BQ21 was highly similar to CYP6BQ1 from Tribolium castaneum, while CYP6BQ22 was closely related to CYP6BQ13 from T. castaneum. Gene expression patterns showed that CYP6BQ21 and CYP6BQ22 were specifically expressed in the adult stage of D. helophoroides. In addition, CYP6BQ21 and CYP6BQ22 were significantly expressed under the treatment of a high concentration of cypermethrin. Based on these findings, we proposed that CYP6BQ21 and CYP6BQ22 played possible roles in the development and pesticide stress of D. helophoroides. Our findings are an important first step in identifying and characterizing CYP6BQ21 and CYP6BQ22 from D. helophoroides, and lay the groundwork for future research into the role of these novel CYP6s in the regulation of pesticide resistance in D. helophoroides.
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Yanping Yao,Chunling Liu,Haidong Qi,Xi Chang,Chunwu Wang,Guangde Wang 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Temperature dependence of dark conductivity and photoconductivity has been studied in amorphous InSb thin films in the temperature range of 120―300 K. The experimental data suggest that conduction in the high temperature range occurs in the extended states; conduction in the intermediate temperature range is due to thermally assisted tunneling of charge carriers in localized states near the band edge; while conduction in low temperature range takes place through variable range hopping of charge carriers in the localized states near the Fermi level. The temperature dependence of photoconductivity shows that the temperature region is divided into two regions.Moreover the result of intensity dependence of steady state photoconductivity indicates that bimolecular recombination at high temperatures and monomolecular at low temperatures in amorphous InSb thin films.
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