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활성화된 마우스 대식세포가 Toxoplasma gondii의 증식에 미치는 영향
엄대자,민득영,안명희 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.1
The present study was aimed to elucidate the effect of antitoxoplasma activity and oxidative capacity of peritoneal macrophage of immunized and/or normal mouse. BALB/c mice were immunized with dozens of cyst (Beverly of Fukaya strain) intraperitoneally. Glass adherent cells were used as macrophage from immunized and normal mouse peritoneal cells. Macrophage(?? cells/ml) and Toxoplasma tachyzoite(RH strain) were incubated in 10% fetal calf serum-minimum essential medium, 37℃, 5% CO₂ incubator. The ratio of cell to Toxoplasma was 1:1 or 2:1. After 4 and 24hr incubation, cell rupture and infection rate of macrophage, number of tachyzoite in a cell were observed under microscope. Production of hydrogen peroxide from immunized or normal macrophage after 1hr incubation of Toxoplasma or Toxoplasma with phorbol myristate acetate(PMA) were measured. After 4hr incubation of macrophage and Toxoplasma tachyzoite, 10% of cell rupture were observed in normal and immunized macrophages. One to five organisms per cell were observed 32.8~38.7% of normal macrophage and 50.7~52.6% of immunized macrophages. After 24hr incubation, Toxoplasma multiply freely in normal mouse macrophage and 90% of cells were ruptured. Meanwhile immunized mouse macrophage display toxoplasmacidal effect and 50% of cells were survived. Toxoplasma invation into cell were 34.~48.7% of normal macrophage and 59.4% of immunized macrophage. Immunized macrophages released 2~7 times of H₂O₂than those of normal macrophages. With above results, it is assumed that peritoneal macrophage from immunized mouse has high producibility of H₂O₂and then might enhance the subsequential toxoplasmastatic and/or toxoplasmacidal effect.
Lee, Ji Hye,Bae, Yeon Su,Kim, Su Jin,Song, Dae Woong,Park, Young Hwan,Bae, Do Gyu,Choi, Jin Hyun,Um, In Chul ELSEVIER 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.106 No.-
<P><B>Abstract</B></P> <P>Electro-spun regenerated silk webs have been extensively studied for biomedical applications because of the simplicity of their fabrication methods However, the productivity of the electro-spinning process is low for web fabrication and the mechanical properties of the electro-spun silk web are not satisfactory, which restricts its commercialization. In this study, a new silk non-woven fabric was successfully fabricated by wetting and hot press treatments using the excellent binding characteristic of sericin. The effects of the press temperature and residual sericin content on the preparation, structure, and properties of the silk non-woven fabric were examined. A press temperature of 200°C was optimum for obtaining non-woven fabrics with best mechanical properties, without yellowing. The silk non-woven fabric could not be fabricated without sericin, and a minimum of 8% sericin was required to fabricate it. As the sericin content was increased, the strength and Young’s modulus of the silk non-woven fabric increased, while the tensile elongation remained constant. Regardless of the press temperature and sericin content, all the silk non-woven fabrics showed good cell viability, comparable to that of the tissue culture plate (TCP) used as a control until 4days, which however decreased compared to that of TCP after 7days.</P>
Molecular discrimination of Panax ginseng species
Um, Jae-Young,Chung, Hwan-Suck,Kim, Hyun-Ju,Kim, Dae-Ki,Shim, Kyung-Shik,Lee, Kang-Yong,Kim, Jeong-Sook,Choi, Tae-Jin,Kim, Nam-Song,An, Nyeon-Hyoung,Lee, Kang-Min,Lee, Young-Mi,Kim, Jeong-Joong Kyung Hee Oriental Medicine Research Center 2000 International journal of oriental medicine Vol.1 No.2
In order to develop convenient and reproducible methods for identification of ginseng drugs at a DNA level, RAPD (randomly amplified polymorphic DNA) and PCR-RFLP (PCR-Restriction fragment length polymorphism) analysis were applied within Panax species. To authenticate Panax ginseng betvyeen Chinese and Korean ginseng population, RAPD analysis were carried out using 20 mer-random primer. The similarity coefficients among the DNA of ginseng plants analyzed were low, ranging from 0.197 to 0.491. In addition, using PCR-RFLP analysis, very different fingerprints were obtained within Korean ginseng plants. These results suggest that these methods are able to authenticate the concerned Panax species. Broader application of this approach to authenticate other morphologically similar medicinal materials is rationalized.
( Yong Dae Kwon ),( Hoon Jai Chun ),( Soon Ho Um ),( Chang Duck Kim ),( Ho Sang Ryu ),( Yoon Tae Jeen ),( Jin Su Jang ),( Ju Young Kim ),( Chul Young Kim ),( Sang Hoon Park ),( Bora Keum ),( Yeon Seok 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Screening guideline for colorectal cancer in average-risk asymptomatic population recommends colonoscopy starting at age 50. One prior study has reported the prevalence and low cost-effectiveness of colorectal neoplasia with colonoseopic screening in asymptomatic population aged 40-49 (Imperale et al.). However, recently colonoscopic detection rate of colorectal cancer of young age (<50) is increasing. Therefore, we investigated the prevalence of advanced neoplasia with colonoscopy according to age and evaluated the optimal age of screening colonoscopy. Methods: We reviewed the medical records of average-risk asymptomatic 1.745 persons performed screening colonoscopy from January 2001 to December 2006 in Korea university medical center. High risk patients (family history of cancer, IBD, previous history of adenoma) were excluded. Advanced neoplasia was defined as tubular adenoma measuring 1 cm or larger, any villous histology, high grade dysplasia, or cancer. Results: Overall prevalence of colorectal adenoma was 38.9% (679 of 1,744) and prevalence of advanced adenoma was 2.06% (36 of 1.744). Of the 489 persons in the 40-49 age group, 127 (25.97%) had one or more adenomas, and 6 (1.23%) had an advanced neoplasia, 2 (0.41%) had cancer. Of the 633 persons in the 50-59 age group, 270 (42.65%) had one or more adenomas, and 9 (1.42%) had an advanced neoplasia, 3 (0.47%) had cancer. Conclusions: The prevalence of advanced neoplasia in 40-49 and 50-59 age groups was lower than previous study. However, our study shows similar prevalence of advanced neoplasia between 40-49 and 50-59 age groups. Therefore, we should consider screening colonoscopy for early colorectal cancer earlier than 50 in average-risk asymptomatic population.
<i>Saengmaeksan</i> inhibits inflammatory mediators by suppressing RIP-2/caspase-1 activation
Jeong, Mi-Young,Park, Dae-Hee,Kim, Min-Cheol,Park, Jinbong,Kim, Dae-Seung,Jeon, Yong-Deok,Kim, Su-Jin,Ahn, Kwang Seok,Kim, Sung-Hoon,Lee, Jong-Hyun,Jung, Hyun-Ju,Hong, Seung-Heon,Um, Jae-Young Informa Healthcare USA, Inc. 2013 Immunopharmacology and immunotoxicology Vol.35 No.2
<P><I>Background and objectives</I>: <I>Saengmaeksan</I> (SMS) is a Korean herbal prescription consisting of three different herbal drugs: Liriopis Tuber (tuber of <I>Liriope platyphylla</I>, Liliaceae), Ginseng Radix (root of <I>Panax ginseng</I>) and Schisandrae Fructus (fruit of <I>Schisandra chinensis</I>). SMS is commonly used in Korea to treat various diseases that involve the respiratory and cardiovascular systems. However, to date, the mechanism underlying the anti-inflammatory effects of SMS is not clearly understood. In this study, we attempt to determine the effects of SMS on lipopolysaccharide (LPS)-induced inflammatory responses in mouse peritoneal macrophages.</P><P><I>Methods</I>: Cell viability was measured by using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and nitric oxide (NO) levels were measured by using Griess reagent. The tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels secreted by the cells were measured using a modified enzyme-linked immunosorbent assay. Expression of cyclooxygenase (COX)-2 and nuclear factor-kappa B (NF-κB), respectively was investigated using a western blot analysis. A caspase colorimetric assay kit was used to assay enzymatic caspase-1 activity.</P><P><I>Results</I>: The findings of this study showed that SMS reduced TNF-α and IL-6 production induced by LPS. During the inflammatory process, COX-2 and NO levels were increased in mouse peritoneal macrophages, but SMS decreased the enhanced levels of COX-2 and the production of NO. In addition, SMS suppressed the activation of NF-κB and receptor interacting protein-2/caspase-1.</P><P><I>Discussion and conclusion</I>: Our results provide novel insights into the pharmacological actions of SMS, a molecule that can potentially be exploited in the treatment of inflammatory diseases.</P>
Controlled releasing properties of gelatin nanofabric device containing chlorhexidine
( Dae-ung Park ),( Heung-sik Um ),( Beom-seok Chang ),( Si-young Lee ),( Ki-yeon Yoo ),( Won-youl Choi ),( Jae-kwan Lee ) 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 2021 Oral Biology Research (Oral Biol Res) Vol.45 No.2
We aimed to evaluate the degradation and antimicrobial activity of novel chlorhexidine-containing gelatin nanofabric devices and their cytotoxicity in animals. The electro-spun device with a size of 3.4.0.4 mm<sup>3</sup> was prepared by entrapping chlorhexidine gluconate (CHX) in a gelatin matrix. The devices were divided into three groups based on the CHX percentage (G1: 46%, G2: 50%, and G3: 54%), and the commercial product, PerioChip (CP), was used for the control group. We used an in vitro test for the degradation and antibacterial activity and investigated cytotoxicity using an in vivo test. Artificial saliva was used for the degradation test of chips and blood agar plates seeded with the oral bacteria Streptococcus sanguinis to address antibacterial activity. Furthermore, the devices were inserted between the skin and muscle of rat abdomens to evaluate infection and inflammatory reactions. We detected no obvious differences in the antibacterial or degradation test results between the test and control groups. In the histological analysis, the scaffold without CHX showed no signs of infection or inflammatory reaction. Both CHX-containing groups exhibited inflammation and necrosis in the muscle and skin, although the reaction in the test group was milder. In the degradation tests, antibacterial tests, and cytotoxic reactions in animal experiments, the electro-spun gelatin-based device showed similar results to those of the commercial device in the control group. Further studies on the quantitative analysis and clinical outcome evaluation of the electro-spun gelatin-based device in humans are necessary.
Case Reports : Caroli`s disease misdiagnosed as intraductal papillary neoplasm of the bile duct
( Dae Hoe Gu ),( Min Seon Park ),( Chang Ho Jung ),( Yang Jae Yoo ),( Jae Young Cho ),( Yun Ho Lee ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Soon Ho Um ),( Ho Sang Ryu ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Caroli’s disease is a rare autosomal-recessive disorder caused by malformation of the ductal plate during embryonic development. Although it is present at birth, Caroli’s disease is typically not diagnosed until between the second and fourth decades of life, as it was in the present patient. Here we report a rare case of Caroli’s disease limited to one liver segment, which was initially misdiagnosed as an intraductal papillary neoplasm of the bile duct. The asymptomatic patient was treated with liver segmentectomy. (Clin Mol Hepatol 2015;21:175-179)
( Dae Hoe Gu ),( Min Seon Park ),( Tae Jung Yun ),( Seok Bae Yoon ),( Sun Young Yim ),( Jin Yong Jung ),( Jin Dong Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Soon Ho Um ),( Ho Sang Ryu ),( Yun Ji Pa 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: The use of antiviral agent has changed the prognosis of patients with hepatitis B virus (HBV)-related end stage liver disease. In these patients, therefore, a more efficient prognostic model for determining early mortality is necessary to properly select those who require liver transplantation. In this study, we aimed to develop a new prognostic model. Methods: We retrospectively analyzed a total of consecutive 194 patients with decompensated HBV-related liver cirrhosis (≥CTP score 7, ascites, or jaundice) who had initially started antiviral treatment in Korea university Anam hospital. Univariate and multivariate cox-regression modeling was used to develop a model for predicting 6-month mortality Results: The study population was predominantly male (128/194) and median age was 51 years. Antiviral agents were administered for a median of 41 months (lamivudine in 157 patients, entecavir in 37). At baseline 147 and 12 patients had ascites and encephalopathy, respectively, with a mean CTP score of 9. Twenty-one (10.8%) patients died within the first 6 months of treatment. Univariate analysis revealed that baseline variables such as age, the presence of ascites or encephalopathy, serum bilirubin, prothrombin time, albumin, Na, BUN, alkaline phosphatase, and HBV DNA levels were associated with the deaths within 6-months (all P<0.05). Among them serum bilirubin, prothrombin time, HBV DNA levels and age were found to be independent risk factors in multivariate analysis. Using these four risk factors, we developed new scoring system to predict 6-months mortality. This new prediction model showed AUROC of 0.941, higher than those of CTP score and MELD score which were 0.893 and 0.862, respectively. Conclusions: This newly developed prediction model for early mortality will be useful in selecting the candidates of urgent liver transplantation in patients with decompensated HBV-related liver cirrhosis.