Artocarpus nigrifolius: Cytotoxic and Antibacterial Constituents

Tran Minh Hoi,김영호,Ha Van Anh,Nguyen Thi Thanh Huong,Nguyen Van Tuyen,Le Thi Tu Anh,Nguyen Thanh Tra,Ba Thi Cham,Nguyen Thi Thu Ha,Pham Thuy Linh,Doan Duy Tien,Phan Van Kiem,Ninh Khac Ban,Lidziya Kukha 한국응용생명화학회 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6

Six known compounds including α-amyrin 3-acetate (1), β-sitosterol (2), betulinic acid (3), friedelan-3-one (4),artochamin B (5), and 2-C-methyl-D-erythritol 4-O-α-D-glucopyranoside (6) were isolated from the stem barks and leaves of Artocarpus nigrifolius (Moraceae) for the first time. Their structures were identified by spectroscopic methods as well as comparison with literatures. Cytotoxicity and antibacterial activity of 1-6 were evaluated. Results showed that artochamin B (5)possessed the highest cytotoxicity towards MCF7, Lu, HepG2,and KB cell lines with IC50 values of 4.59, 20.00, 3.60, and 1.18μg/mL, respectively. It also inhibited the growth of Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), whereas inactive on the growth of both Gram-negative bacteria and yeast.

Artocarpus nigrifolius: Cytotoxic and Antibacterial Constituents

Hoi, Tran Minh,Anh, Ha Van,Huong, Nguyen Thi Thanh,Tuyen, Nguyen Van,Anh, Le Thi Tu,Tra, Nguyen Thanh,Cham, Ba Thi,Ha, Nguyen Thi Thu,Linh, Pham Thuy,Tien, Doan Duy,Kiem, Phan Van,Ban, Ninh Khac,Kukha The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6

Six known compounds including ${\alpha}$-amyrin 3-acetate (1), ${\beta}$-sitosterol (2), betulinic acid (3), friedelan-3-one (4), artochamin B (5), and 2-C-methyl-D-erythritol 4-O-${\alpha}$-D-glucopyranoside (6) were isolated from the stem barks and leaves of Artocarpus nigrifolius (Moraceae) for the first time. Their structures were identified by spectroscopic methods as well as comparison with literatures. Cytotoxicity and antibacterial activity of 1-6 were evaluated. Results showed that artochamin B (5) possessed the highest cytotoxicity towards MCF7, Lu, HepG2, and KB cell lines with $IC_{50}$ values of 4.59, 20.00, 3.60, and $1.18{\mu}g/mL$, respectively. It also inhibited the growth of Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), whereas inactive on the growth of both Gram-negative bacteria and yeast.

Facile synthesis of multifunctional Ag/Fe3O4-CS nanocomposites for antibacterial and hyperthermic applications

Ngoan Thi Nguyen,Dai Lam Tran,Duc Cuong Nguyen,Thai Loc Nguyen,Thi Cham Ba,Binh Hai Nguyen,Thi Duong Ba,Nam Hong Pham,Dzung Tuan Nguyen,Thai Hoa Tran,Gia Dien Pham 한국물리학회 2015 Current Applied Physics Vol.15 No.11

Nanocomposites containing two or more functional constituents are attractive candidates for advanced nanomaterials. In this study, multifunctional Ag/Fe3O4-CS nanocomposites were successfully prepared, using chitosan as a stabilizing and cross-linking agent. The as-synthesized nanocomposites were characterized by Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Energy-dispersive X-ray spectroscopy (EDS), UVevisible spectrophotometer (UVeVis) and vibrating sample magnetometer (VSM). The results demonstrated that Ag/Fe3O4-CS composite nanoparticles (NPs) were composed of parent components, Fe3O4 and Ag NPs, which were uniformly dispersed in the chitosan matrix. The hybrid NPs exhibited strong antibacterial property against Pseudomonas aeruginosa. With high magnetization value (67 emu/g), the synthesized Ag/Fe3O4-CS composite can be easily separated or recycled in potential biomedical applications. Furthermore, the results showed that the multicomponent hybrid nanostructures appeared to be the promising material for local hyperthermia, which can be used as thermoseeds for localized hyperthermia treatment of cancers.

Erbium-Doped Silicon-Rich Oxide Waveguides Fabricated by Using an Electro-Chemical Method

Pham Van Hoi,Bui Huy,Tran Thi Cham,Ha Xuan Vinh,Do Khanh Van 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.3

In this article, we describe and electro-chemical method for fabricating erbium-doped silicon-rich oxide (SRO) waveguides. The porosity, the Er-ion concentration and the refractive index can be controlled by varying the current density (continuous or pulsed currents) during the production process. The refractive index difference between the core and the cladding layers and the profile of the SRO waveguides were tested by using an m-line spectrometer and Field-emission scanning electron microscope (FE-SEM). The photo-luminescent (PL) emission of Er-ions at 1550 nm in the SRO waveguides could be obtained even when the excitation wavelength was away from the resonance absorption band of the Er-ions. This result revealed that Er-ions are possibly excited from the ground state 4I15/2 to the first excited state 4I13/2 by energy transfer from excited Si nanocrystallites. The Er-doped SRO waveguides can be applied to optoelectronic devices compatible with Si-based integrated circuit technology.

Improvement of Tomato Seedling Quality under Low Temperature by Application of Silicate Fertilizer

Ngoc-Thang Vu(넉탕부),Anh-Tuan Tran(안추안트란),Thi-Tuyet-Cham Le(띠투엣참리),Jong-Kuk Na(라종국),Si-Hong Kim(김시홍),Jong-Man Park(박종만),Dong-Cheol Jang(장동철),Il-Seop Kim(김일섭) (사)한국생물환경조절학회 2017 시설원예‧식물공장 Vol.26 No.3

규산 시비가 토마토 플러그 묘소질에 미치는 영향과 묘의 저온저장시 규산의 저온장해 경감효과를 검토하였다. ‘Rapito’품종을 공시하여 30일간 32구 규격의 플러그 트레이에서 육묘한 뒤, 여섯 개의 규산 처리농도구 (8, 16, 32, 64, 128 및 256mM)를 설계하여 20일 동안 주 2회 관주 처리한 뒤, 묘소질을 대조구와 비교하였다. 처리 농도는 16mM과 32mM 처리가 초장, 엽면적, 생체중, T/R율 및 근권부 발육 등 대부분의 생육지표에서 타 처리구에 비해 양호했으며, 특히 16mM의 농도에서 가장 좋은 묘소질을 보였으나, 64mM 이상의 고농도에서는 대조구에 비해 전반적으로 생육이 억제되는 경향을 보였다. 토마토 묘의 생리적 반응에서 엽온에서는 처리구별 차이가 나타나지 않았으나, 증산율은 32mM이상의 농도 처리구에서 기공확산 저항이 증가하면서 증산율이 감소되는 경향을 보였다. 또한, 처리 횟수에 따른 효과를 검토하기 위해 16mM농도의 규산을 20일 동안 6, 10, 20회 관주처리 한 결과, 대부분의 생육지표에서 처리 횟수간에는 큰 차이가 없었으나, 무처리구에 비해 묘소질이 향상되었으며, 특히 뿌리표면적, 근장, root tip수등 근권부의 생육이 현저히 증가하였다. 아울러 규산처리가 저온저장시 토마토 묘의 저온장해를 감소시키는 효과가 있음을 확인하였다. The object of this study was to improve tomato seedling quality in low temperature(below 7, 10℃ during night time or daily mean air temperature was 18℃) by application of silicate fertilizer. Six different silicate fertilizer concentrations (8, 16, 32, 64, 128, and 256mM) or water as the control were applied to tomato seedlings twice a week for 20 days. Positive effects were observed in the growth parameters of the seedlings treated with 16 and 32mM silicate fertilizer; the most effective concentration of silicate at which seedlings showed the best performance was 16mM. However, a high concentration of silicate (256mM) caused negative effects on the growth. The transpiration rate decreased alongside with the increase of silicate concentration up to 32mM, possibly due to the increased stomatal diffusive resistance. Silicate stimulated the growth and development of tomato seedlings, resulting in increased growth parameters and root morphology. However, no significant differences were observed among treatment numbers of soil-drenching wuth the silicate (6, 10, or 20 times with 16mM) for 20 days, suggesting that silicate treatment with 6 times may be sufficient to induce the silicate effects. The application of 16mM of silicate fertilizer reduced relative ion leakage and chilling injury during low temperature storage. In addition, the seedlings treated with silicate fertilizer recovered faster than those without silicate treatment after low temperature storage.

Improvement of Tomato Seedling Quality under Low Temperature by Application of Silicate Fertilizer

넉탕부,안추안트란,띠투엣참리,라종국,김시홍,박종만,장동철,김일섭,Vu, Ngoc-Thang,Tran, Anh-Tuan,Le, Thi-Tuyet-Cham,Na, Jong-Kuk,Kim, Si-Hong,Park, Jong-Man,Jang, Dong-Cheol,Kim, Il-Seop The Korean Society for Bio-Environment Control 2017 시설원예‧식물공장 Vol.26 No.3

규산 시비가 토마토 플러그 묘소질에 미치는 영향과 묘의 저온저장시 규산의 저온장해 경감효과를 검토하였다. 'Rapito' 품종을 공시하여 30일간 32구 규격의 플러그 트레이에서 육묘한 뒤, 여섯 개의 규산 처리농도구 (8, 16, 32, 64, 128 및 256mM)를 설계하여 20일 동안 주 2회 관주 처리한 뒤, 묘소질을 대조구와 비교하였다. 처리 농도는 16mM과 32mM 처리가 초장, 엽면적, 생체중, T/R율 및 근권부 발육 등 대부분의 생육지표에서 타 처리구에 비해 양호했으며, 특히 16mM의 농도에서 가장 좋은 묘소질을 보였으나, 64mM 이상의 고농도에서는 대조구에 비해 전반적으로 생육이 억제되는 경향을 보였다. 토마토 묘의 생리적 반응에서 엽온에서는 처리구별 차이가 나타나지 않았으나, 증산율은 32mM이상의 농도 처리구에서 기공확산 저항이 증가하면서 증산율이 감소되는 경향을 보였다. 또한, 처리 횟수에 따른 효과를 검토하기 위해 16mM농도의 규산을 20일 동안 6, 10, 20회 관주처리 한 결과, 대부분의 생육지표에서 처리 횟수간에는 큰 차이가 없었으나, 무처리구에 비해 묘소질이 향상되었으며, 특히 뿌리표면적, 근장, root tip수등 근권부의 생육이 현저히 증가하였다. 아울러 규산처리가 저온저장시 토마토 묘의 저온장해를 감소시키는 효과가 있음을 확인하였다. The object of this study was to improve tomato seedling quality in low temperature(below 7, $10^{\circ}C$ during night time or daily mean air temperature was $18^{\circ}C$) by application of silicate fertilizer. Six different silicate fertilizer concentrations (8, 16, 32, 64, 128, and 256mM) or water as the control were applied to tomato seedlings twice a week for 20 days. Positive effects were observed in the growth parameters of the seedlings treated with 16 and 32mM silicate fertilizer; the most effective concentration of silicate at which seedlings showed the best performance was 16mM. However, a high concentration of silicate (256mM) caused negative effects on the growth. The transpiration rate decreased alongside with the increase of silicate concentration up to 32mM, possibly due to the increased stomatal diffusive resistance. Silicate stimulated the growth and development of tomato seedlings, resulting in increased growth parameters and root morphology. However, no significant differences were observed among treatment numbers of soil-drenching wuth the silicate (6, 10, or 20 times with 16mM) for 20 days, suggesting that silicate treatment with 6 times may be sufficient to induce the silicate effects. The application of 16mM of silicate fertilizer reduced relative ion leakage and chilling injury during low temperature storage. In addition, the seedlings treated with silicate fertilizer recovered faster than those without silicate treatment after low temperature storage.