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      • KCI등재

        How image-processing parameters can influence the assessment of dental materials using micro-CT

        Torres Fernanda Ferrari Esteves,Reinhilde Jacobs,Mostafa EzEldeen,Karla de Faria-Vasconcelos,Guerreiro-Tanomaru Juliane Maria,Bernardo Camargo dos Santos,Mário Tanomaru-Filho 대한영상치의학회 2020 Imaging Science in Dentistry Vol.50 No.2

        Purpose: The aim of this study was to evaluate the influence of voxel size and different post-processing algorithms on the analysis of dental materials using micro-computed tomography (micro-CT). Materials and Methods: Root-end cavities were prepared in extracted maxillary premolars, filled with mineral trioxide aggregate (MTA), Biodentine, and Intermediate Restorative Material (IRM), and scanned using micro- CT. The volume and porosity of materials were evaluated and compared using voxel sizes of 5, 10, and 20 μm, as well as different software tools (post-processing algorithms). The CTAn or MeVisLab/Materialise 3-matic software package was used to perform volume and morphological analyses, and the CTAn or MeVisLab/Amira software was used to evaluate porosity. Data were analyzed using 1-way ANOVA and the Tukey test (P<0.05). Results: Using MeVisLab/Materialise 3-matic, a consistent tendency was observed for volume to increase at larger voxel sizes. CTAn showed higher volumes for MTA and IRM at 20 μm. Using CTAn, porosity values decreased as voxel size increased, with statistically significant differences for all materials. MeVisLab/Amira showed a difference for MTA and IRM at 5 μm, and for Biodentine at 20 μm. Significant differences in volume and porosity were observed in all software packages for Biodentine across all voxel sizes. Conclusion: Some differences in volume and porosity were found according to voxel size, image-processing software, and the radiopacity of the material. Consistent protocols are needed for research evaluating dental materials.

      • KCI등재

        Harnessing Technology in the Evolving Tourism Servicescape during the Post-Covid-19 Era

        Torres, Arnelyn Manaluz 차세대컨버전스정보서비스학회 2022 차세대컨버전스정보서비스기술논문지 Vol.11 No.4

        The tourism industry is reopening after two years of disruption due to the COVID-19 pandemic. With its re-emergence, new ways of welcoming, receiving, and serving tourists and visitors will be necessary to restore their travel confidence. Governments and destinations should address tourists' health concerns and reassure them to feel at ease, secure, and safe while traveling. This paper argues that technology is an essential strategic partner for redesigning the tourism servicescape. A tourism servicescape combines products, places, services, and activities that contribute to tourists' overall experience. It also includes the interactions between tourists and several organizations at different touchpoints. This study attempts to redesign the tourism servicescape in the Post-Covid-19 by leveraging technology and aligning it with service delivery and interaction. Five technology pillars would facilitate a new service landscape in the travel and tourism industry. For each of these pillars, the author explores how to harness technology and how it can benefit organizations, businesses, and tourists. Technology will likely play an essential role in realigning tourism services and business models in the post-COVID-19 era.

      • SCIESCOPUSKCI등재

        LMI-Based Robust Controllers for DC-DC Cascade Boost Converters

        Torres-Pinzon, Carlos Andres,Giral, Roberto,Leyva, Ramon The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.4

        This paper presents two different robust controllers for boost converters with two stages in a cascade. The first robust controller is monovariable; that is, the duty-cycle is the same for the two switches. The monovariable controller ensures that some prescribed constraints on pole placement and control effort are met, and optimizes the load disturbance rejection, while takes into account the uncertainty in certain parameters. The first controller is then compared with a multivariable robust controller; that is, with independent duty cycles in each switch. The multivariable controller takes into account the same uncertainty, constraints and optimization function. The comparison shows that the multivariable controller performs better at the expense of a slightly more complex implementation; that is, the multivariable controller provides a better rejection of the load disturbance. The paper also describes simulations and experimental results that are in perfect agreement with theoretical derivations.

      • Functional Interaction between Monoamine Plasma Membrane Transporters and the Synaptic PDZ Domain-Containing Protein PICK1

        Torres, Gonzalo E.,Yao, Wei-Dong,Mohn, Amy R.,Quan, Hui,Kim, Kyeong-Man,Levey, Allan I.,Staudinger, Jeff,Caron, Marc G. 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

        PDZ domain-containing proteins play an important role in the targeting and localization of synaptic membrane proteins. Here, we report an interaction between the PDZ domain-containing protein PICK1 and monoamine neurotransmitter transporters in vitro and in vivo. In dopaminergic neurons, PICK1 colocalizes with the dopamine transporter (DAT) and forms a stable protein complex. Coexpression of PICK1 with DAT in mammalian cells and neurons in culture results in colocalization of the two proteins in a cluster pattern and an enhancement of DAT uptake activity through an increase in the number of plasma membrane DAT. Deletion of the PDZ binding site at the carboxyl terminus of DAT abolishes its association with PICK1 and impairs the localization of the transporter in neurons. These findings indicate a role for PDZ-mediated protein interactions in the localization, expression, and function of monoamine transporters.

      • KCI등재

        Clavulanic Acid Is a Leading Culprit Beta-Lactam in Immediate Allergic Reactions to Penicillins

        Torres-Rojas Isabel,Pérez-Alzate Diana,Somoza Maria Luisa,Pfeifer Ana Prieto-Moreno,Diaz Elisa Haroun,Jimenez-Rodriguez Teodorikez W,Sánchez Javier Fernández,Ruano Francisco J,Blanca Miguel,Blanca-Lóp 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2

        Purpose: Clavulanate, a beta-lactam associated with amoxicillin, is frequently prescribed in patients at all ages. Recent data implicate amoxicillin-clavulanate in up to 80% of beta-lactam allergy cases. We assessed clavulanate’s role in inducing allergic reactions to this combination treatment, with a focus on selective immediate reactions. Methods: Adults (≥ 16 years) reporting a history of immediate reactions to amoxicillin-clavulanate were evaluated through a beta-lactam allergological workup, using modified European Academy of Allergy and Clinical Immunology guidelines. Patients first underwent skin testing, and if negative, drug provocation tests. Expected outcomes were: Group A, subjects with immediate reaction to classical penicillin group determinants (penicilloyl polylysine, minor determinants mixture, and/or penicillin G); Group B, subjects with selective immediate reaction to amoxicillin; Group C, subjects with selective immediate reaction to clavulanate and Group D, those immediate reactions with co-sensitization to clavulanate plus penicillin group determinants or amoxicillin. Results: Of 1,170 included patients, 104 had immediate reactions: 36.5% to penicillin group determinants (Group A), 26.9% to amoxicillin (Group B), 32.7% to clavulanate (Group C), and 3.8% to clavulanate plus penicillin determinants or amoxicillin (Group D). Diagnosis was made by skin testing in 79%, 75% and 47% of the patients, respectively, in the first 3 groups (P < 0.001). Drug provocation tests were necessary to establish most other diagnoses. Anaphylaxis predominated over urticaria/angioedema in all groups. Conclusions: Selective immediate reactions to clavulanate accounted for over a third of cases with confirmed reactions after amoxicillin-clavulanate intake, with more than half experiencing anaphylaxis. Within this group, skin test sensitivity was below 50%. People taking amoxicillin-clavulanate may also be co-sensitized to both drugs.

      • KCI등재
      • KCI등재

        First-principles calculation of volatile organic compound adsorption on carbon nanotubes: Furan as case of study

        Torres Ana M.,Correa J. D. 한국탄소학회 2021 Carbon Letters Vol.31 No.5

        Sensing of volatile organic compounds (VOCs) is a growing research topic because of the concern about their hazard for the environment and health. Furan is a VOC produced during food processing, and it has been classifed as a risk molecule for human health and a possible biomarker of prostate cancer. The use of carbon nanotubes for VOCs sensing systems design could be a good alternative. In this work, a theoretical evaluation of the interactions between furan and zigzag single-wall carbon nanotubes takes into account diferent positions and orientations of the furan molecule, within a density-functional theory frst-principles approach. The van der Waals interactions are considered using diferent exchange-correlation functionals (BH,C09, DRSLL and KBM). The results indicate that vdW-functionals do not signifcantly afect geometry; however, the binding energy and the distance between furan and nanotube are strongly dependent on the selected exchange-correlation functional. On the other hand, the efects of single and double vacancies on carbon nanotube are considered. It was found that the redistribution of charge around the single-vacancy afects the bandgap, magnetic moment, and binding energy of the complex, while furan interaction with a double-vacancy does not considerably change the electronic structure of the system. Our results suggest that to induce changes in the electronic properties of carbon nanotubes by furan, it is necessary to change the nanotube surface, for example, by means of structural defects.

      • Mass transfer analysis for CO<sub>2</sub> bubble absorption in methanol/Al<sub>2</sub>O<sub>3</sub> nanoabsorbents

        Torres Pineda, Israel,Kim, Dongmin,Kang, Yong Tae Elsevier 2017 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.114 No.-

        <P><B>Abstract</B></P> <P>In this paper computational fluid dynamics (CFD) analysis is carried out to investigate CO<SUB>2</SUB> bubble absorption characteristics in methanol/Al₂O<SUB>3</SUB> nanoabsorbents. Bubble size, rising velocity and mass transfer rate are compared to the previous experimental results for validation. It is found that the distance traveled for each CO<SUB>2</SUB> bubble increases as the concentration of Al<SUB>2</SUB>O<SUB>3</SUB> increases, which, in consequence, increases the residence time between liquid and gas phases resulting in higher interfacial mass transfer rates. For the case of a bubble rising in the gap between walls, the wall shear stress has a major effect on the bubble diameter and rising velocity which in consequence affects the mass transfer coefficient. It is concluded that the mass transfer coefficient enhances by about 40% by adding Al₂O<SUB>3</SUB> nanoparticles (0.01vol%) compared with pure methanol absorbent from the experimental and simulation results. It is also concluded that the use of nanoparticles has a higher impact on mass transfer rate than it does on mass transfer amount, which depends on the residence time and travel distance of CO<SUB>2</SUB> bubbles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mass transfer analysis is carried out for CO<SUB>2</SUB> bubble absorption in nanoabsorbents. </LI> <LI> CO<SUB>2</SUB> absorption enhancement by nanoabsorbents is evaluated. </LI> <LI> Mass transfer coefficient enhances by about 40% by adding Al₂O<SUB>3</SUB> nanoparticles (0.01vol%). </LI> <LI> The use of nanoparticles has a higher impact on mass transfer rate than it does on mass transfer amount. </LI> </UL> </P>

      • KCI등재

        Genetic evaluation of sheep for resistance to gastrointestinal nematodes and body size including genomic information

        Torres Tatiana Saraiva,Sena Luciano Silva,Santos Gleyson Vieira dos,Figueiredo Filho Luiz Antonio Silva,Barbosa Bruna Lima,Júnior Antônio de Sousa,Britto Fábio Barros,Sarmento José Lindenberg Rocha 아세아·태평양축산학회 2021 Animal Bioscience Vol.34 No.4

        Objective: The genetic evaluation of Santa Inês sheep was performed for resistance to gastrointestinal nematode infection (RGNI) and body size using different relationship matrices to assess the efficiency of including genomic information in the analyses. Methods: There were 1,637 animals in the pedigree and 500, 980, and 980 records of RGNI, thoracic depth (TD), and rump height (RH), respectively. The genomic data consisted of 42,748 SNPs and 388 samples genotyped with the OvineSNP50 BeadChip. The (co)variance components were estimated in single- and multi-trait analyses using the numerator relationship matrix (A) and the hybrid matrix H, which blends A with the genomic relationship matrix (G). The BLUP and single-step genomic BLUP methods were used. The accuracies of estimated breeding values and Spearman rank correlation were also used to assess the feasibility of incorporating genomic information in the analyses. Results: The heritability estimates ranged from 0.11±0.07, for TD (in single-trait analysis using the A matrix), to 0.38±0.08, for RH (using the H matrix in multi-trait analysis). The estimates of genetic correlation ranged from –0.65±0.31 to 0.59±0.19, using A, and from –0.42±0.30 to 0.57±0.16 using H. The gains in accuracy of estimated breeding values ranged from 2.22% to 75.00% with the inclusion of genomic information in the analyses. Conclusion: The inclusion of genomic information will benefit the direct selection for the traits in this study, especially RGNI and TD. More information is necessary to improve the understanding on the genetic relationship between resistance to nematode infection and body size in Santa Inês sheep. The genetic evaluation for the evaluated traits was more efficient when genomic information was included in the analyses. Objective: The genetic evaluation of Santa Inês sheep was performed for resistance to gastrointestinal nematode infection (RGNI) and body size using different relationship matrices to assess the efficiency of including genomic information in the analyses.Methods: There were 1,637 animals in the pedigree and 500, 980, and 980 records of RGNI, thoracic depth (TD), and rump height (RH), respectively. The genomic data consisted of 42,748 SNPs and 388 samples genotyped with the OvineSNP50 BeadChip. The (co)variance components were estimated in single- and multi-trait analyses using the numerator relationship matrix (A) and the hybrid matrix H, which blends A with the genomic relationship matrix (G). The BLUP and single-step genomic BLUP methods were used. The accuracies of estimated breeding values and Spearman rank correlation were also used to assess the feasibility of incorporating genomic information in the analyses.Results: The heritability estimates ranged from 0.11±0.07, for TD (in single-trait analysis using the A matrix), to 0.38±0.08, for RH (using the H matrix in multi-trait analysis). The estimates of genetic correlation ranged from –0.65±0.31 to 0.59±0.19, using A, and from –0.42±0.30 to 0.57±0.16 using H. The gains in accuracy of estimated breeding values ranged from 2.22% to 75.00% with the inclusion of genomic information in the analyses.Conclusion: The inclusion of genomic information will benefit the direct selection for the traits in this study, especially RGNI and TD. More information is necessary to improve the understanding on the genetic relationship between resistance to nematode infection and body size in Santa Inês sheep. The genetic evaluation for the evaluated traits was more efficient when genomic information was included in the analyses.

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