http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Coating Chitosan Thin Shells: A Facile Technique to Improve Dispersion Stability of Magnetoliposomes
Phan, Thi Tuong Vy,Moorthy, Madhappan Santha,Kang, Hyun Wook,Nam, Seung Yun,Lee, Yong Wook,Oh, Junghwan American Scientific Publishers 2018 Journal of Nanoscience and Nanotechnology Vol.18 No.1
<P>Magnetoliposomes (ML) have been emerging as a novel multifunctional nanoparticle with a wide range of biomedical and therapeutic applications over the past decade. Although the ML system has shown excellent performances, the stability and lipid peroxidation of liposomal components are still remaining as key issues and need to be solved for intensive applications. Changing zeta potential of nanoparticles' surface can be seen as a potential way to achieve the stable dispersion. In this work, we have employed the positive charged, abundant and cheap chitosan to coat ML in order to change the zeta potential of the ML system and examined the stability of chitosan@magnetoliposomes (CML) in long-term storage. The combining of pH-sensitive chitosan with temperature-sensitive phospholipid formed a novel pH- and temperature-sensitive nanoparticles which can be promisingly used as controllable drug release applications. These novel CML with chitosan thin shells showed excellent stability in long-term storage; meanwhile, the bare ML sample showed aggregations and forming micrometer-size particles. The CML system can achieve a drug encapsulation efficiency of nearly 50% and an enhanced drug release behavior under pH 5 at 45 degrees C.</P>
Phan, Thi Tuong Vy,Bui, Nhat Quang,Moorthy, Madhappan Santha,Lee, Kang Dae,Oh, Junghwan Springer US 2017 Nanoscale research letters Vol.12 No.1
<P>Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron–platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as novel agents for combined photothermal therapy (PTT) and PAI. The obtained PPy-coated FePt NPs (FePt@PPy NPs) showed excellent biocompatibility, photothermal stability, and high near-infrared (NIR) absorbance for the combination of PTT and PAI. In vitro investigation experimentally demonstrated the effectiveness of FePt@PPy NPs in killing cancer cells with NIR laser irradiation. Moreover, the phantom test of PAI used in conjunction with FePt@PPy NPs showed a strong photoacoustic signal. Thus, the novel FePt@PPy NPs could be considered as promising multifunctional nanoparticles for further applications of photo-based diagnosis and treatment.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s11671-017-2337-9) contains supplementary material, which is available to authorized users.</P>
Mondal, Sudip,Hoang, Giang,Manivasagan, Panchanathan,Moorthy, Madhappan Santha,Nguyen, Thanh Phuoc,Vy Phan, Thi Tuong,Kim, Hye Hyun,Kim, Myoung Hwan,Nam, Seung Yun,Oh, Junghwan Elsevier 2018 CERAMICS INTERNATIONAL Vol.44 No.13
<P><B>Abstract</B></P> <P>Composite biomaterials can improve the mechanical and biological properties of ceramic scaffolds for bone tissue engineering application. In this study hydroxyapatite (HAp), and bioactive glass ceramics were synthesized by co-precipitation and ultrasound assisted sol-gel method. The synthesized HAp (80 wt.-%) and bioglass (15 wt.-%) bioceramics were further used with aluminum oxide (3 wt.-%) and starch (2 wt%) to prepare a composite biomaterial. The composite biomaterial was finally used to fabricate scaffold materials by employing nontoxic binder mediated gel-casting approach. The synthesized composite material and developed scaffolds were characterized through different physical, chemical, and morphological analyses, mechanical study, and in vitro biological assays. The synthesized scaffold exhibited 20–25% porosity, with a high compressive strength of ~ 157 ± 2 MPa, and Tensile strength of ~ 83 ± 2 MPa after sintering at 1200 °C for 2 h. The in vitro biological study confirmed the nontoxic behavior of the composite biomaterial and developed scaffolds with MG-63 osteoblast-like cell line. The developed composite scaffold facilitated new cell attachment, growth, and proliferation on its surface, all of which correlates with good osteoconductive properties. The developed scaffolds effectively simulated the morphology, porosity, mechanical property, and bioactivity of the bone structure for load-bearing tissue engineering application.</P>
Thanh-Truong Nguyen,Jeong-Tae Kim,Quoc-Bao Ta,Duc-Duy Ho,Thi Tuong Vy Phan,Thanh-Canh Huynh 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.1
The piezoelectric-based smart interface technique has shown promising prospects for electro-mechanical impedance (EMI)-based damage detection with various successful applications. During the process of EMI monitoring and damage identification, the operational functionality of the smart interface device is a major concern. In this study, common functional degradations that occurred in the smart interface are diagnosed using a deep learning-based method. Firstly, the effect of functional degradations on the EMI responses is analytically discussed. Secondly, a critical structural joint is selected as the test structure from which EM measurement using the smart interface is conducted. Thirdly, a numerical model corresponding to the experimental model is established and updated to reproduce the measured EMI responses. By using the updated numerical model, the EMI responses of the smart interface under the common functional degradations, such as the shear lag effect, the adhesive debonding, the sensor breakage, and the interface detaching, are simulated; then, the functional degradation-induced EMI changes are characterized. Finally, a convolutional neural network (CNN)-based functional assessment method is newly proposed for the smart interface. The CNN can automatically extract and directly learn optimal features from the raw EMI signals without preprocessing. The CNN is trained and tested using the datasets obtained from the updated numerical model. The obtained results show that the proposed method was successful to classify four types of common defects in the smart interface, even under the effect of noises.
Bharathiraja, Subramaniyan,Manivasagan, Panchanathan,Santha Moorthy, Madhappan,Bui, Nhat Quang,Jang, Bian,Phan, Thi Tuong Vy,Jung, Won-Kyo,Kim, Young-Mok,Lee, Kang Dae,Oh, Junghwan Elsevier 2018 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEU Vol.123 No.-
<P><B>Abstract</B></P> <P>Photodynamic therapy (PDT) and photothermal therapy (PTT) using nanoparticles have gained significant attention for its therapeutic effect for cancer treatment. In the present study, we fabricated polypyrrole nanoparticles by employing bovine serum albumin-phycocyanin complex and the formulated particles were stable in various physiological solutions like water, phosphate buffered saline and culture media. The formulated nanoparticles did not cause any noticeable toxicity to MDA-MB-231 and HEK-293 cells. The obtained nanoparticles effectively killed MDA-MB-231 cells in a dual way upon laser illumination, one is through phycocyanin propagated reactive oxygen species (PDT) upon laser illumination and in another way it eradicated the treated cells by converting optical energy into heat energy (PTT). Additionally, the nanoparticles generated good amplitude of ultrasound signals under photoacoustic imaging (PAT) system that facilitates imaging of treated cells. In conclusion, the fabricated particles could be used as a multimodal therapeutic agent for treatment of cancer in the biomedical field.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phycocyanin-BSA stabilized polypyrrole nanoparticles (Ppy@BSA-Pc) formulated. </LI> <LI> Ppy@BSA-Pc can be applied to PDT and PTT treatment. </LI> <LI> Ppy@BSA-Pc facilitates imaging of treated cells under PAI system. </LI> <LI> Ppy@BSA-Pc can act as a theranostic agent in biomedical field. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Mondal, Sudip,Hoang, Giang,Manivasagan, Panchanathan,Moorthy, Madhappan Santha,Kim, Hye Hyun,Vy Phan, Thi Tuong,Oh, Junghwan Elsevier 2019 Materials chemistry and physics Vol.228 No.-
<P><B>Abstract</B></P> <P>This present study illustrates the processing and comprehensive characterization of biogenic hydroxyapatite (FB-HAp) biomaterial from fish bone (Tuna fish) in a facile single step thermal decomposition procedure. Fish bones were calcined at 1000 °C in an air atmosphere for 1 h. The obtained FB-HAp flakes were ball milled for 30 h at a unidirectional milling speed of 300 rpm. A well-established wet chemical process was obtained to synthesize HAp nanoparticles (C-HAp). The synthesized non-stoichiometric (Ca/P = 1.87) FB-HAp phases were identified by X-ray diffraction study and compared with C-HAp. The thermal properties were studied by thermogravimetric and differential thermal analysis. Raman spectroscopy and Fourier transform infrared spectroscopy confirmed the structural and functional groups of FB-HAp and C-HAp. The morphological and elemental analysis was performed by transmission electron microscopy, energy dispersive X-ray spectroscopy and Inductive coupled plasma (ICP) spectroscopy. The synthesized FB-HAp and C-HAp were mixed with 2% starch porogen and compacted with ∼200 MPa unidirectional pressure to obtained small pellet scaffolds. The obtained scaffolds were sintered at 1000 °C in an air atmosphere for 2 h and further used for cell attachment and proliferation study. The FB-HAp biomaterials showed non-toxic behavior with MG-63 osteoblast cell lines similar to C-HAp. Additionally, FB-HAp scaffold showed enhanced cellular attachment and proliferation on its surface. The in-depth chemical, structural, and morphological analysis suggest that fish bone could be a promising sustainable biogenic source of HAp for biomedical applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Facile synthesis of biogenic hydroxyapatite from waste tuna bones. </LI> <LI> Comparative characterization of fish bone and chemically synthesized hydroxyapatite. </LI> <LI> Possible mechanism for enhanced bioactivity of biogenic hydroxyapatite. </LI> <LI> Scaffold fabrication and promising application for tissue engineering. </LI> </UL> </P>
Santha Moorthy, Madhappan,Hoang, Giang,Subramanian, Bharathiraja,Bui, Nhat Quang,Panchanathan, Manivasagan,Mondal, Sudip,Thi Tuong, Vy Phan,Kim, Hyehyun,Oh, Junghwan The Royal Society of Chemistry 2018 Journal of materials chemistry. B, Materials for b Vol.6 No.32
<P>The fabrication of nanotherapeutic systems capable of stimuli-responsive drug delivery and photoacoustic imaging (PAI)-guided photothermal therapy (PTT) is considered significant for chemo-photothermal therapy applications in cancer therapy. In the present study, the Prussian blue nanoflake (PBNF) decorated mesoporous silica hybrid nanoparticle (PB@MSH-EDA NPs) is reported for PAI-guided chemo-photothermal therapy applications. The amine group enriched mesoporous silica channels can be used to encapsulate an anticancer drug for chemotherapy, and the surface decorated PBNFs can convert a near-infrared (NIR) laser (808 nm) into heat for photothermal therapy and can also be used for PAI applications. The PB@MSH-EDA NPs show pH-responsive drug release efficiency under acidic pH (pH 5.0 and 4.0) conditions. Furthermore, the PB@MSH-EDA NPs system shows strong NIR laser absorption and photothermal conversion efficiency under 808 nm laser irradiation. The <I>in vitro</I> experimental result shows that the PB@MSH-EDA NPs are biocompatible and could be efficiently taken up by MDA-MB-231 cells. In addition, the <I>in vivo</I> results demonstrate that the tumor-bearing mice fully recovered after injecting the drug (Dox)-loaded PB@MSH-EDA/Dox NPs and being further irradiated with the 808 nm laser. We believe that the PB@MSH-EDA NPs system could be utilized as an efficient PAI-guided chemo-photothermal therapy agent for the detection and treatment of tumors in an emerging cancer therapy application.</P>
Manivasagan, Panchanathan,Jun, Seung Won,Nguyen, Van Tu,Truong, Nguyen Thanh Phong,Hoang, Giang,Mondal, Sudip,Santha Moorthy, Madhappan,Kim, Hyehyun,Vy Phan, Thi Tuong,Doan, Vu Hoang Minh,Kim, Chang-S The Royal Society of Chemistry 2019 Journal of materials chemistry. B, Materials for b Vol.7 No.24
<P>The development of a new generation of multifunctional nanomaterials as a drug delivery system for chemo-photothermal therapy is of great necessity. In this study, we first prepared folic acid-conjugated and doxorubicin-loaded chitosan oligosaccharide encapsulated gold nanorods (FA-COS-TGA-GNRs-DOX) as a new photothermal agent for the delivery of drugs and heat to tumor areas. FA-COS-TGA-GNRs-DOX nanomaterials combine the advantages of COS, GNRs, FA, TGA, and DOX and have excellent biocompatibility, strong absorbance in the near-infrared (NIR) region, photostability, photothermal conversion efficiency, high targeting efficiency, fast drug release under laser irradiation, and tumor cell killing efficiency. FA-COS-TGA-GNRs-DOX exhibited significantly greater cell killing after laser irradiation. The intracellular uptake behavior of the targeted FA-COS-TGA-GNRs-DOX was confirmed by flow cytometry, two-photon fluorescence microscopy (TPFM), and confocal laser scanning microscopy (CLSM). More interestingly, the tumors in the presence of FA-COS-TGA-GNRs-DOX under laser irradiation were efficiently ablated and did not recur, showing an outstanding combined therapy of tumors. The combination of photothermal therapy (PTT) and photoacoustic imaging (PAI) could accurately locate and fully destroy tumor tissues after the intravenous injection of FA-COS-TGA-GNRs-DOX. Hence, this work offers a new avenue to develop a novel class of multifunctional nanomaterials as a drug delivery system for cancer therapy.</P>