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Mesoporous organosilica hybrids with a tunable amphoteric framework for controlled drug delivery
Moorthy, Madhappan Santha,Park, Ji-Hye,Bae, Jae-Ho,Kim, Sun-Hee,Ha, Chang-Sik The Royal Society of Chemistry 2014 Journal of Materials Chemistry B Vol.2 No.38
<P>The chemical conversion of nitrile groups integrated in the pore wall frameworks of mesoporous organosilica hybrids (MSHs) into either carboxylic acid groups or amine groups by an acid or base hydrolysis method without altering the mesostructural order is suggested. By this approach, bifunctional derivatives could be produced in the silica pore walls. The nitrile groups integrated covalently into the pore walls of the mesoporous organosilica hybrids were converted to reactive functionalities, such as carboxylic acid (-COOH) or amine (-NH2) groups, by treatment with H2SO4or LiAlH4as the catalytic reagents. This facile approach allows the production of high amounts of either -COOH groups (3.26 mmol g<SUP>−1</SUP>) or amine (-NH2) groups (4.13 mmol g<SUP>−1</SUP>) into the pore walls of the mesoporous organosilica hybrids. The synthesised materials were characterised by X-ray diffraction, N2sorption isotherms, Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and solid state<SUP>13</SUP>C cross-polarization magic angle spinning nuclear magnetic resonance spectroscopy (CP MAS NMR). Owing to the presence of hydrophilic basic diurea functional groups and -COOH or -NH2derivatives in the pore walls, the obtained samples could behave like bifunctional materials. The mesoporous organosilica hybrids with chemically derivatised carboxylic acid groups or amine functionalities in the pore wall frameworks were found to be suitable drug carriers for the controlled delivery of both hydrophilic (for example, 5-FU) and hydrophobic (<I>e.g.</I>IBU) drugs under an intracellular environment. The biocompatibility of the synthesised materials was also evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cellular uptake was monitored by confocal laser scanning microscopy (CLSM). These results show that the synthesised materials have potential use as efficient carriers for drug delivery applications.</P>
Moorthy, M.S.,Kim, H.B.,Sung, A.R.,Bae, J.H.,Kim, S.H.,Ha, C.S. Elsevier 2014 Microporous and mesoporous materials Vol.194 No.-
A new fluorescent mesoporous organosilicas bearing ethidium bromide in the framework was conveniently synthesized using 3-aminopropyltriethoxysilane as bridging organosilane functionality. Powder X-ray diffraction, N<SUB>2</SUB> sorption, transmission electron microscopy and scanning electron microscopy, and UV-visible absorption and fluorescence spectroscopy have been employed to characterize the materials. This material showed a selective monitoring of Hg<SUP>2+</SUP> and Fe<SUP>3+</SUP> ions with fluorescence quenching and visible color transition over a wide range of tested metal ions, which is due to the selective interactions of Hg<SUP>2+</SUP> and Fe<SUP>3+</SUP> ions with integrated functional groups at its pore wall framework. The experimental measurements reveal that the mesoporous organosilica material shows Hg<SUP>2+</SUP> and Fe<SUP>3+</SUP> ion selectivity upon addition of various concentrations of other competitive metal ions. Thus, the synthesized mesoporous organosilicas could monitor Hg<SUP>2+</SUP> and Fe<SUP>3+</SUP> ions in water and biological cells even in the trace amount.
Moorthy, S.M.,Krishnan, N.,Bhattacharya, Tanmay,Chaudhuri, A. Korean Society of Sericultural Science 2007 International Journal of Industrial Entomology Vol.15 No.2
A differential specific pattern of variation in the metabolism of protein and cholesterol was noticed in non -diapause and diapause eggs due to the significant differences in embryonic development. The rate of metabolism was different due to specific demands of such metabolites during active embryogenesis and maintenance of diapause respectively. In general, the metabolic rate was found to be accelerated in non- diapause eggs just after egg deposition, while it was very slow in diapause eggs. When the diapause eggs were treated with hydrochloric acid within 16-20 hrs, the rate of turnover was found to very similar to non- diapause eggs, though the base level of protein and cholesterol was recorded to be different.
Moorthy, S.M.,Das, S.K.,Mukhopadhyay, S.K.,Mandal, K.,Urs, S. Raje Korean Society of Sericultural Science 2007 International Journal of Industrial Entomology Vol.15 No.1
An indigenous multivoltine silkworm, Nistari was evaluated for their thermo tolerance by exposing the larvae to various temperature regimes for eight hours. Among different temperature exposed, this strain has significant tolerance at $32^{\circ}C$. Analysis of heat shock protein revealed the expression of 70 kDa and 64 kDa polypeptides in fat body and midgut tissues. Interestingly esterase isozyme pattern in midgut showed characteristic expression of Est-1 and Est-3 at different temperatures signifying role in heat and cold shock.
Moorthy S.M.,Das S.K.,Rao, P.R.T.,Urs S. Rao,,Sarkar A. Korean Society of Sericultural Science 2007 International Journal of Industrial Entomology Vol.14 No.1
In order to find out the appropriate parents for the breeding programme, twelve bivoltine and three multivoltine silkworm breeds were evaluated on the basis of multivariate selection index and isozyme analysis. Of which, four [CSR2, D6 (P), SK3, SK4] bivoltine and two multivoltine (Nistari, Cambodge) breeds were selected and breeding initiated to develop higher survival bivoltine silkworm breed suitable for tropical conditions. Among two isozyme (Esterase and acid phosphatase) analyzed, only esterase exhibited polymorphism among the bivoltine breeds. No polymorphism was observed among multivoltine in respect of esterase as well as acid phosphatase.
Ion-imprinted mesoporous silica hybrids for selective recognition of target metal ions
Moorthy, M.S.,Tapaswi, P.K.,Park, S.S.,Mathew, A.,Cho, H.J.,Ha, C.S. Elsevier 2013 Microporous and mesoporous materials Vol.180 No.-
A novel ion-imprinted functional ligand derivative bearing periodic mesoporous organosilica (IIPMO) was obtained using a sol-gel process from a chemically synthesized organopolysilane precursor with a metal template (Co<SUP>2+</SUP> ion) imprinted ligand centre with tetraethylorthosilicate (TEOS) and cetyltrimethylammoniumbromide (CTAB) as a structural directing surfactant under basic conditions. The imprinted metal template was easily leached out from the hybrid materials during an acid treatment, which resulted in a template-free ion-imprinted network in the PMO pore wall framework with an unaltered particle size and morphology. The ion-imprinted hybrid PMO materials were characterized by X-ray diffraction, Fourier transform-infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, solid-state <SUP>29</SUP>Si and <SUP>13</SUP>C cross polarization magic angle spinning nuclear magnetic resonance spectroscopy, N<SUB>2</SUB> adsorption-desorption analysis and elemental analysis. Furthermore, the removal of the imprinted metal template was confirmed by inductively coupled plasma-atomic emission spectroscopy. The selective rebinding ability of the template ions on the ion-imprinted PMO hybrid adsorbents was examined using a cobalt nitrate solution. The rebinding results showed that the selective efficiency of Co<SUP>2+</SUP> ions on the IIPMOs were 10.1, 7.4 and 9.3 for Cu<SUP>2+</SUP>, Cd<SUP>2+</SUP> and Zn<SUP>2+</SUP>, respectively.