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일본 대학교 한국어 문화교육의 현황과 과제 -제2외국어교육으로서의 한국어교육을 중심으로-
타니자키미쯔코 ( Tanizaki Mitsuko ) 연세대학교 언어정보연구원(구 연세대학교 언어정보개발원) 2012 언어사실과 관점 Vol.30 No.-
Based on the understanding that cultural education is an inevitable part of language education, this paper discusses what kind of cultural education should be pursued in teaching Korean as a second foreign language in Japan. After subdividing cultural education into education on cultural knowledge, cultural application for communication and culture as a goal in itself, this paper examines which types of cultural education are appropriate from the perspective of the Japanese government`s education policy, the reality of Korean language education in universities, and the demands of learners. The results of the examination show that cultural education for teaching Korean as a second foreign language in Japan is most appropriate when consideration is given to the fact that the educational policy for second foreign language focuses on teaching communication, the university education environment has time limitations, learners study Korean because of their interest in the language itself, and the demands of learners include the possibility of immediate use of Korean as well as its future use.
문화에 기반을 둔 감정 표현 교육 시론- 한국어교육에서 한,일 "산" 이미지 차이를 통해 -
타니자키미쯔코 ( Tanizaki Mitsuko ) 한국어교육학회(구 한국국어교육연구학회) 2015 국어교육 Vol.0 No.148
The emotional education in Korean education has been performed only in a word and the expression in conjunction with the body. However, the language as is done in culture, emotion is also carried out in culture. Therefore, not only emotional expression of the past, there is a need for recognition and their education about emotional expression that put the foundation in culture. Also, that to learn the emotional expressions that put the foundation in culture, there is a significance also in cultural education in Korean. In this paper, for the sake of emotional education that put the foundation in culture, through the difference of image of Korea-Japan “mountain”, would like to clarify the difference between the Korea-Japan emotional expression. And the differences, the future, you’re going to make the education of Korean emotional expression of Japanese learners.
A Study on Market Efficiency with the Indexes of SSEC and SZSEC of China
Guo Xi DUAN(Guo Xi DUAN ),Hisashi TANIZAKI(Hisashi TANIZAKI ) 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.9
This paper studies market efficiency from a weak form aspect using opening and closing prices of the Shanghai stock exchange composite index (SSEC) and Shenzhen stock exchange composite index (SZSEC) under the expected return theory. Classical methods (autocorrelation and runs test) are used to examine the features of stock returns, and little evidence against mutual independence of returns is found. We predict daily returns of SSEC and SZSEC with AR(p) and VAR(p) models (in this paper, p = 5 is taken as a one-week lag) and perform a virtual experiment on two indexes based on the predicted value of daily returns from AR(p) or VAR(p) model. From the results of AR(p) and VAR(p) for two indexes, we attempt to find out how the market efficiency level changes when the information from the other market is under consideration as we check the market efficiency level in one market. We find that SSEC in 2014–2016 and SZSEC in 2015–2016 are inefficient from the result of autocorrelation, that SSEC in 2016 and SZSEC in 2013 are not efficient from the result of runs test, that the stock market is efficient except 2005, 2009, 2010 and 2017 in SSEC and 2005, 2016 and 2017 in SZSEC and that SSEC is more influenced by SZSEC but SSEC influences SZSEC less from the result of the virtual experiment.
Repair of UV-induced Cyclobutane Pyrimidine Dimers in Human Mitochonrial DNA-less Cells
Ikushima, Takaji,Gu, Ning,Tanizaki, Yuichi Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
UV-induced DNA damage causes cell killing and mutations leading to carcinogenesis. In normal human cells, UV damage such as cyclobutane pyrimidine dimers (CPDs) and primidine-prymidone (6-4) photoproducts are mainly repaired by nucleotide excision repair mechanism. The molecular processes have been well characterized recently. To know the influence of mitochondrial genome on the nucleotide excision repair mechanism against CPDs, we comparatively examined the production of CPDs by UVC irradiation and their repair kinetics in human cells completely lacking mitochondrial DNA (mtDNA) and the parental HeLa S cells. Whole DNA extracted from the cells exposed to UVC was treated with T4-endonuclease V to break the phosphodiester bond adjacent to CPDs. The DNA was electrophoresed in a denaturing agarose gel, which was visualized by ethidium bromide staining. The relative amount of CPDs was determined by image analysis using NIH Image software. MtDNA- less (rho-O) cells were apparently more sensitive to UVC than HeLa S cells, while the level of induction of CPDs in rho-O and HeLa cells was comparable. The repair of CPDs was less efficient in rho-O cells compared with HeLa cells. The residual amount of CPDs after 24-h repair was larger in rho-O cells than in HeLa cells where more than 90 % of CPDs were repaired by then. The non-repaired CPDs would lead to apoptosis in rho-O cells. These results suggest that mitochondrial genome may contribute to some ATP-dependent steps in nucletide excision repair by supplying sufficient ATP which is generated through a respiratory chain in mitochondria.
Tan, Li,Wang, Jun,Tanizaki, Junko,Huang, Zhifeng,Aref, Amir R.,Rusan, Maria,Zhu, Su-Jie,Zhang, Yiyun,Ercan, Dalia,Liao, Rachel G.,Capelletti, Marzia,Zhou, Wenjun,Hur, Wooyoung,Kim, NamDoo,Sim, Taebo,G National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.45
<P><B>Significance</B></P><P>Inhibitors of the FGF receptors (FGFRs) are currently under clinical investigation for the treatment of various cancers. All currently approved kinase inhibitors eventually are rendered useless by the emergence of drug-resistant tumors. We used structure-based drug design to develop the first, to our knowledge, selective, next-generation covalent FGFR inhibitors that can overcome the most common form of kinase inhibitor resistance, the mutation of the so-called “gatekeeper” residue located in the ATP-binding pocket. We also describe a novel kinase inhibitor design strategy that uses a single electrophile to target covalently cysteines that are located in different positions within the ATP-binding pocket. These results have important implications for the design of covalent FGFR inhibitors that can overcome clinical resistance.</P><P>The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation. Resistance usually results from selection for mutant kinases that are impervious to the action of the drug or from up-regulation of compensatory signaling pathways. Preclinical studies have demonstrated that resistance to FGFR inhibitors can be acquired through mutations in the FGFR gatekeeper residue, as clinically observed for FGFR4 in embryonal rhabdomyosarcoma and neuroendocrine breast carcinomas. Here we report on the use of a structure-based drug design to develop two selective, next-generation covalent FGFR inhibitors, the FGFR irreversible inhibitors 2 (FIIN-2) and 3 (FIIN-3). To our knowledge, FIIN-2 and FIIN-3 are the first inhibitors that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. Because of the conformational flexibility of the reactive acrylamide substituent, FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. We report the cocrystal structure of FGFR4 with FIIN-2, which unexpectedly exhibits a “DFG-out” covalent binding mode. The structural basis for dual FGFR and EGFR targeting by FIIN3 also is illustrated by crystal structures of FIIN-3 bound with FGFR4 V550L and EGFR L858R. These results have important implications for the design of covalent FGFR inhibitors that can overcome clinical resistance and provide the first example, to our knowledge, of a kinase inhibitor that covalently targets cysteines located in different positions within the ATP-binding pocket.</P>
H. Uchida,K. Tanizaki,A. B. Khanikaev,A. A. Fedyanin,P. B. Lim,M. Inoue 한국자기학회 2006 Journal of Magnetics Vol.11 No.3
We fabricated new one-dimensional magnetophotonic crystal (1D-MPC) utilizing the second and third photonic band gaps where localized modes existed. Structure of the 1D-MPC was (Ta₂O?/SiO₂)?/Bi:YIG/(SiO₂/Ta₂O?)? with optical thicknesses of 3 λ/4 for Ta₂O? and SiO₂ dielectric layers and λ/2 for Bi:YIG defect layer, where λ is a wavelength of a localized mode in the second photonic band gap. Faraday rotation at the localized mode in the second photonic band gap was enhanced, which was confirmed by calculation using 4×4 matrix method.