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Understanding of Pathomechanisms and Clinical Practice for Vitiligo
Atsushi Tanemura 대한피부과학회 2023 Annals of Dermatology Vol.35 No.5
Vitiligo is a disease caused by the acquired depletion of melanocytes and/or melanocyte precursor cells in response to genetic and environmental factors, resulting in depigmentation of the entire body. It is roughly divided into segmental and non-segmental vitiligo, and it has been found that abnormalities of melanocytes themselves and dysregulation of autoimmune responses to melanocytes are greatly involved in the pathology of non-segmental vitiligo. Segmental vitiligo pathology is largely unknown; however, it has been suggested that it may be caused by skin or melanocyte mosaicism. Treatments for vitiligo include topical therapy, ultraviolet therapy, and surgical transplantation, and it is extremely important to correctly understand the pathology to perform optimal treatment. In recent years, the development of vitiligo treatments using Janus kinase (JAK) inhibitors has progressed rapidly. We herein outline the latest pathology of vitiligo, from general vitiligo treatment to the progress of clinical trials using JAK inhibitors, along with what clinicians should consider in archiving precision medicine, including my own ideas thereon.
The Measurement Method and 3D Reconstruction Algorithm of X ray CT Inspection for Flat Objects
Mitsukuni Tanemura,Toshiyuki Tanaka,Kazuo Kikuchi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
X ray CT system is used for nondestructive inspection in industrial field. But there are some problems whenwe get the inner images of flat objects, namely rate of expansion and beam hardening. This study aims at solving theseproblems by developing scan system with the use of new sinogram restoration techniques. Although there is a lack of projection data, the proposed system enables to reconstruct a region of interest accurately with high rate of expansion. The supportive simulation results show that the proposed method can get inner images of plate shaped objects without suffering from beam hardening.
Wilfried Wunderlich,Torsten Oekermann,Lei Miao,Nguyen Thi Hue,Sakae Tanemura,Masaki Tanemura 한양대학교 세라믹연구소 2004 Journal of Ceramic Processing Research Vol.5 No.4
The electronic properties of anatase, rutile and ZnO thin films are of interest for many applications such as photocatalysis, or dye-sensitised solar cells. This paper describes the correlation between microstructure and electronic properties of photoactive TiO2 and ZnO thin films, which are based on experimental data and are interpreted by ab-initio simulations. This study considers the influence of three main factors on the optical and electrical properties: Strain of epitaxially grown thin films, nano-particle- and nano-pore- structures, and finally the interface to adsorbed dye molecules. The first part describes the search for a suitable substrate to grow titania layers with a smaller band-gap and ab-initio simulations showed excellent agreement to the experimental data. A narrow band gap is predicted for strained lattice constants in the a-direction and compressed in the c-direction. The second part describes the fabrication of nano-porous thin films by sol-gel processing using appropriate precursor solutions (titanium-tetra-iso-propanol(TTIP), di-ethanol-amine (DEA)) applied on suitable nanotemplates. Due to the surface curvatures the nano-porous TiO2 has a narrow band gap, while nano-particles of titania show a larger band-gap. In the third part Dvxα ab-initio simulations were applied to dye-sensitized solar cells (DSSC), based on ZnO and TiO2. The results are compared to experimental data obtained for different dyes on nanoporous electrodeposited ZnO films. The ranking in efficiency found experimentally for the different combinations could be explained by the calculation results. This finding is discussed in the view of further optimization of solar cells.
Tomohiko Kiriyama,Rumi Tanemura,Yoshihiro Nakamura,Chiaki Takemoto,Mariko Hashimoto,Hirohiko Utsumi 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.8
Objective Substantial research has revealed cognitive function impairments in patients with major depressive disorder (MDD). However, the relationship between MDD cognitive function impairment and brain activity is yet to be elucidated. This study aimed to reveal this relationship using near-infrared spectroscopy (NIRS) to extensively measure frontotemporal cortex function. Methods We recruited 18 inpatients with MDD and 22 healthy controls. Regional oxygenated hemoglobin changes (oxy-Hb) were measured during a verbal fluency task and its relationship to cognitive function was assessed. Cognitive function was assessed using the Japanese version of the Brief Assessment of Cognition in Schizophrenia. Results Compared to healthy controls, patients with MDD displayed poorer motor speed, attention and speed of information processing, and executive function. In the bilateral prefrontal and temporal surface regions, regional oxy-Hb changes were significantly lower in patients with MDD than in healthy individuals. Moreover, we observed a correlation between reduced activation in the left temporal region and poor motor speed in patients with MDD. Conclusion We suggest that reduced activation in the left temporal region in patients with MDD could be a biomarker of poor motor speed. Additionally, NIRS may be useful as a noninvasive, clinical measurement tool for assessing motor speed in these patients.
( Saori Itoi ),( Atsushi Tanemura ),( Mamori Tani ),( Shun Kitaba ),( Mika Terao ),( Hiroyuki Murota ),( Naoki Oiso ),( Ichiro Katayama ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.2
Background: Peculiar erythema known as annular erythema associated with Sjogren`s syndrome (AESS) can be differentiated from autoimmune annular erythema and subacute cutaneous lupus erythematosus, both clinically and histologically. However, there are no detailed investigations on immune competent cells infiltration. Objective: Preferential infiltration of interleukin-17-producing T helper (Th17) cells and regulatory T (Treg) cells into the labial salivary gland is reported to play a role in maintaining mucoepithelitis in patients with Sjogren`s syndrome. In this study, we evaluated Th17 and Treg cell infiltration into the lesional skin of AESS. Methods: We analyzed the numbers and infiltration patterns of Th17 and FoxP3 (+) Treg cells in seven cases of AESS using immunohistochemistry. Seven patients with systemic lupus erythematosus (SLE), atopic dermatitis (AD) and psoriasis vulgaris (PV), which are representatives of Th17 cell-involved skin disorders, were enrolled as disease controls. Results: Periappendageal and epidermal changes, such as follicular plugging and liquefaction, were evident in the annular erythema of SLE, not AESS, tissue samples. In AESS tissue samples, dense perivascular and periappendageal in-filtration of lymph cells was observed in the middle-to-deep dermis, as previously described, in contrast to the superficial infiltration pattern observed in both AD and PV samples. While the total number of infiltrated lymphocytes was similar between AESS and SLE tissue samples, Th17 cells were found to be preferentially infiltrated in the middle- to-deep dermis in AESS samples. Conclusion: These results suggest that an increased number and distribution of infiltration of Th17 cells is a preferential feature of AESS, rather than a characteristic feature of annular erythema of SLE.
Carbon nanofibers and multiwalled carbon nanotubes from camphor and their field electron emission
Savita P. Somani,Prakash R. Somani,M. Tanemura,S.P. Lau,M. Umeno 한국물리학회 2009 Current Applied Physics Vol.9 No.1
Vertically aligned carbon nanofibers (CNF) and multiwalled carbon nanotubes (MWCN) have been synthesized from camphor by catalytic thermal CVD method on Co and Co/Fe thin films (for CNF) and on silicon substrates using a mixture of camphor and ferrocene (for MWCN). CNF and MWCN are studied by field emission scanning electron microscopy, high-resolution transmission electron microscopy, visible Raman spectroscopy, X-ray diffraction in order to get insight into the microstructure and morphology of these materials. Field electron emission study indicates turn-on field of about 2.56, 3.0 and 6.5 V/㎛ for MWCN, Co/CNF and Co/Fe/CNF films, respectively. The best performance of MWCN in field electron emission among the materials studied can be due to the highest aspect ratio, good graphitization and good density. Vertically aligned carbon nanofibers (CNF) and multiwalled carbon nanotubes (MWCN) have been synthesized from camphor by catalytic thermal CVD method on Co and Co/Fe thin films (for CNF) and on silicon substrates using a mixture of camphor and ferrocene (for MWCN). CNF and MWCN are studied by field emission scanning electron microscopy, high-resolution transmission electron microscopy, visible Raman spectroscopy, X-ray diffraction in order to get insight into the microstructure and morphology of these materials. Field electron emission study indicates turn-on field of about 2.56, 3.0 and 6.5 V/㎛ for MWCN, Co/CNF and Co/Fe/CNF films, respectively. The best performance of MWCN in field electron emission among the materials studied can be due to the highest aspect ratio, good graphitization and good density.
Localization and quantitative analysis of Cx43 in porcine oocytes during in vitro maturation
Lee, Seunghoon,Hiradate, Yuuki,Hoshino, Yumi,Ko, Yeoung-gyu,Tanemura, Kentaro,Sato, Eimei Cambridge University Press 2016 Zygote Vol.24 No.3
<B>Summary</B><P>Many studies of the main gap junction protein, Cx43, have been conducted in porcine oocyte research, but they have been limited to investigations of cumulus-oocyte complexes (COCs). In this study, we verified Cx43 not in COCs, but in porcine oocytes during maturation, and conducted a quantitative time course analysis. The location and dynamics of Cx43 were examined by immunocytochemistry and western blotting, respectively. COCs were cultured in NCSU23 medium and processed for immunocytochemistry and western blotting at 0, 14, 28, and 42 h after denuding. A Cx43 signal was detected on oolemmas, transzonal projections and the surface of zona pellucidae. Western blotting showed that Cx43 band density increased from 0 to 14 h, and gradually decreased thereafter. Our results clarified that Cx43 is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.</P>