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조아름,김탁수,서정관,윤효정,김필제,최경희,Jo, Areum,Kim, Taksoo,Seo, JungKwan,Yoon, Hyojung,Kim, Pilje,Choi, Kyunghee 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.6
Objectives: Risk assessment is a tool for predicting and reducing uncertainty related to the effects of future activities. Probability approaches are the main elements in risk assessment, but confusion about the interpretation and use of assessment factors often undermines the message of the analyses. The aim of this study is to provide a guideline for systematic reduction plans regarding uncertainty in risk assessment. Methods: Articles and reports were collected online using the key words "uncertainty analysis" on risk assessment. Uncertainty analysis was conducted based on reports focusing on procedures for analysis methods by the World Health Organization (WHO) and U.S. Environmental Protection Agency (USEPA). In addition, case studies were performed in order to verify suggested methods qualitatively and quantitatively with exposure data, including measured data on toluene and styrene in residential spaces and multi-use facilities. Results: Based on an analysis of the data on uncertainty, three major factors including scenario, model, and parameters were identified as the main sources of uncertainty, and tiered approaches were determined. In the case study, the risk of toluene and styrene was evaluated and the most influential factors were also determined. Five reduction plans were presented: providing standard guidelines, using reliable exposure factors, possessing quality controls for analysis and scientific expertise, and introducing a peer review system. Conclusion: In this study, we established a method for reducing uncertainty by taking into account the major factors. Also, we showed a method for uncertainty analysis with tiered approaches. However, uncertainties are difficult to define because they are generated by many factors. Therefore, further studies are needed for the development of technical guidelines based on the representative scenario, model, and parameters developed in this study.
다매체 노출을 고려한 Perchloroethylene의 인체위해성평가연구
서정관,김탁수,조아름,김필제,최경희,Seo, Jungkwan,Kim, Taksoo,Jo, Areum,Kim, Pilje,Choi, Kyunghee 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.5
Objectives: Perchloroethylene (PCE) is a volatile chemical widely used as a solvent in the dry-cleaning and textile processing industries. It was evaluated as Group 2 "probably carcinogenic to humans" by the Integrated Risk Information System (IRIS) of the United State Environmental Protection Agency (U.S. EPA) in 2012. In order to provide a scientific basis for establishing risk management measures for chemicals on the national priority substances list, aggregate risk assessment was conducted for PCE, included in the top-10 substances. Methods: We conducted the investigation and monitoring of PCE exposure (e.g., exposure scenario, detection levels, and exposure factors, etc.) and assessed its multi-media (e.g., outdoor air, indoor air, and ground water) exposure risk with a deterministic and probabilistic approach. Results: In human risk assessment (HRA), the level of human exposure was higher in the younger age group. The exposure level through inhalation at home was the highest among the exposure routes. Outdoor air or uptake of drinking water represented less than 1% of total contributions to PCE exposure. These findings suggested that the level of risk was negligible since the Hazard Index (HI) induced by HRA was below one among all age groups, with a maximum HI value of 0.17 when reasonable maximum exposure was applied. Conclusion: In conclusion, it was suggested that despite low exposure risk, further studies are needed considering main sources, including occupational exposure.
OECD QSAR Application Toolbox를 이용한 화학물질의 건강유해성 및 생태독성 예측
김정곤,서정관,김탁수,김현경,박상희,김필제,Kim, Jungkon,Seo, Jung-Kwan,Kim, Taksoo,Kim, Hyun-Kyung,Park, Sanghee,Kim, Pil-Je 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.2
Objectives: The OECD QSAR Application Toolbox was developed by the Organisation for Economic Cooperation and Development (OECD) to facilitate the practical use of QSAR approaches in regulatory contexts as well as to reduce the need for additional animal testing. In this study, human health and the ecotoxicity of chemicals were predicted by applying the OECD QSAR Application Toolbox and the results were compared with experimental data in order to evaluate the applicability of this program. Methods: Read-across, trend analysis, and QSAR of OECD QSAR Application Toolbox were used for the prediction of toxicity. Results: The toxicity prediction was conducted on 6,354 chemicals for which toxicity data have been produced on the six endpoints of skin sensitization, skin irritation, eye irritation, mutagenicity, and acute toxicities of fish and Daphnia. From the total of 6,354, we obtained prediction results for 1,621 chemicals (25.5%). Conclusions: The predicted properties of mutagenicity, skin sensitization, and acute aquatic toxicities were reasonably good when compared with experimental data, but other endpoints were not due to the limitation of applicable chemical groups.
어린이용품 함유 유해인자의 위해성평가를 위한 노출계수 조사
김정곤,서정관,김탁수,박건호,Kim, Jungkon,Seo, Jung-Kwan,Kim, Taksoo,Park, Gun-Ho 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.1
Background: Despite children's unique characteristics that distinguish them from adults, relatively few attempts have been made to measure exposure factors for characterization of children's exposure to hazardous chemicals in child-specific products (CSP). This study was conducted to establish the child-specific exposure factors for exposure and risk assessment of hazardous substances in CSP. Methods: We investigated the exposure factors (e.g., time use of child-products, time and frequency of object-to-body contact, time and frequency of object-to-mouth contact) influencing children's exposure to CSP (e.g., toys, playmats, oil pastels, etc.) in 650 children through a parent-completed questionnaire using a web-based survey. Participants were recruited in five age groups, <1, 1-2, 2-3, 3-6, and 6-12 years of age. Results: The child-specific exposure factors were presented as the mean, median, $95^{th}$ percentile, minimum, and maximum values. Time activity for play mats was the longest among CSP and infants spent more time on them than did elder age groups (189.3-224.7 min/day for <1-2 years vs. 91.2 min/day for 6-12 years). It is apparent that time and frequency of toy block- and plastic toy-to-mouth contact significantly decreased as a function of age. When the variation of CSP use patterns was compared by gender, the only variable that was statistically different between genders was time activity in child-products exposure space. Conclusion: We believe the five child-specific exposure factors suggested in the present study will be valuable for reducing uncertainty in the estimation of chemical exposure during risk assessment of CSP and furthermore, in the appropriate regulations to protect children's health.
어린이용품에 함유된 휘발성유기화합물의 비발암 위해성평가
김정곤,서정관,김탁수,박건호,Kim, Jungkon,Seo, Jung-Kwan,Kim, Taksoo,Park, Gun-Ho 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.3
Background: This study was conducted to assess health risks in regard to exposure by children to volatile organic compounds (VOCs) in children's products. Methods: Ten VOCs were measured by head-space gas chromatography in children's products, including toys, oil pastels, sign pens, furniture, ball pools, and playmats. We estimated the average daily dose (ADD) via inhalation during the use of these children's products and calculated hazard quotient (HQ) by dividing ADD by reference dose of VOCs. Results: Among the measured VOCs, five compounds were identified in children's products: benzene, ethylbenzene, styrene, toluene, and xylene. The detection rates of VOCs in toys, ball pools, furniture, playmats, sign pens, and oil pastels were 85%, 100%, 100%, 30%, 100%, and 60%, respectively. The maximum levels of VOCs were 0.18 mg benzene/kg in toys, 5.92 mg toluene/kg in playmats, 10.37 mg ethylbenzene/kg in ball pools, 24.85 mg xylene/kg in toys, and 118.29 mg styrene/kg in ball pools. From exposure levels of VOCs in the children's products HQs were calculated within a range of $5.71{\times}10^{-10}$ to $4.77{\times}10^{-4}$. The HQ of xylene was the highest for children aged 0-6 playing on the playmats. However, the HQ via inhalation exposure to VOCs in individual products did not exceed 1.00. Conclusion: Based on the results, it was concluded that the use of these children's products do not pose health risks to children.