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Association between Hepatitis B Surface Antigen Seropositivity and Metabolic Syndrome
Tae-Heum Chung,Moon-Chan Kim,Chang-Sup Kim 대한가정의학회 2014 Korean Journal of Family Medicine Vol.35 No.2
Background: Infection with hepatitis B virus (HBV) may be a risk factor for cardiovascular disease. We investigated the relationship between HBV infection and metabolic syndrome.Methods: We performed a cross-sectional study of 9,474 Korean men and women who were at least 20 years old and who underwent a routine health check-up at Ulsan University Hospital in Ulsan, South Korea between March 2008 and February 2009. The associations of hepatitis B surface antigen (HBsAg) seropositivity with the presence of metabolic syndrome and its components were investigated by logistic regression analysis. Data were analyzed separately for males and females.Results: HBsAg seropositivity was significantly negatively associated with hypertriglyceridemia and metabolic syndrome in men (odds ratio [OR], 0.39; 95% confidence interval [CI], 0.29 to 0.50; P < 0.001 and OR, 0.75; 95% CI, 0.57 to 0.98, P = 0.033). In women, HBsAg seropositivity was also significantly negatively associated with hypertriglyceridemia, but not with metabolic syndrome (OR, 0.40; 95% CI, 0.17 to 0.91; P = 0.029 and OR, 0.80; 95% CI, 0.38 to 1.66, P = 0.545).Conclusion: HBV infection was significantly negatively associated with hypertriglyceridemia and metabolic syndrome in men and hypertriglyceridemia in women.
Laparoscopic and robotic pectopexy in pelvic organ prolapse: pilot study
( Tae Kyu Jang ),( Hye Won Chung ),( So Jin Shin ),( Chi Heum Cho ),( Sang Hoon Kwon ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Pelvic organ prolapse (POP) is one of the most prevalent gynecological conditions requiring surgical treatment. Pectopexy using minimal invasive surgery was developed to reduce the short-term morbidity and recurrence associated with the open abdominal approach, providing the same results. The aim of this study is to evaluate the feasibility and safety of laparoscopic and robotic pectopexy in POP. Methods: Data were retrospectively collected from database at Dongsan Medical Center, for POP patients who underwent laparoscopic or robotics pectopexy from January 2019 to December 2019. Laparoscopic pectopexy was performed through a standard multi-port (4 port) platform and robotic pectopexy was performed using the da Vinci Xi or X Surgical System (Intuitive Surgical, Sunnyvale, CA). Results: Total 6 POP patients who underwent laparoscopic and robotic pectopexy were identified. We performed 3 of laparoscopic pectopexy and 3 of robotic pectopexy each. All procedures were successfully performed, without complication and conversion to laparotomy. The mean operation time was 100 minutes in laparoscopic surgery and 150 minutes in robotic surgery. The patient returned to clinic at postoperative 10 days, and normal position of pelvic organ was confirmed by pelvic examination. The patient is currently follow-up state at postoperative 6 month without any recurrence or complication. Conclusion: Laparoscopic and robotic pectopexy is feasible and safe in patients with apical POP. Operative times were reasonable and surgical procedure was well tolerated by patients. Further evaluation should be performed in large-scale comparative studies with vaginal or abdominal approach to confirm the safety and benefits of laparoscopic and robotic pectopexy in apical POP.
( Tae-kyu Jang ),( Hyewon Chung ),( So-jin Shin ),( Sang-hoon Kwon ),( Soon-do Cha ),( Chi-heum Cho ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Human Papillomavirus (HPV) is known as prevalent sexually transmitted virus causing cytological abnormalities. More than 100 HPVs have been sequenced, among which approximately 15 types are classified as oncogenic types. Although Atypical Squamous Cells of Undetermined Significance (ASC-US) or Low-Grade Squamous Intraepithelial Lesion (LSIL) are the most frequent cytological alteration, association of HPV genotype and abnormal cervical cytology of either ASC-US or LSIL is uncertain. The aim of this study is to investigate nature of progression, persistence or regression according to HPV genotype in women with both HPV infection and cytological abnormality of either ASC-US or LSIL. 방법: A cohort study with ASC-US or LSIL cytology was accomplished between November 2011 and June 2014 at Dongsan medical center, Keimyung University. 198 HPV positive women with abnormal cervical cytology (ASC-US or LSIL) were included for our study. The follow-up lasted at least two years and enrolled patients received cervical cytology and HPV DNA testing every six months 결과: Among enrolled 198 patients, 168 patients were followed in 24 months study. Cervical cytology alterations showed progression in 22.9% of women, persistence in 9.3%, and regression in 67.8% of women at 24 months. According to the subdivision of HPV genotype, all of 10 patients in low risk HPV showed regression. On the other hand, high risk and mixed infection of HPV showed progression in 19.8% (high risk HPV) and 38.5% (mixed HPV) of women. The most prevalent HPV genotypes was 16 (15.8%), 53 (13.3%), 58 & 51 (10.9%) and 52 (10.2%). In the high oncogenic types (types 16 and 18), there was 52.9% (HPV 16) and 37.5% (HPV 18) progression in lesions. 결론: In our study, HPV 16 was the most frequent genotype found in women ASC-US or LSIL. The progression rate was positive correlated to infection to the high oncogenic type (types 16 and 18). The 50’s number of HPV genotype was frequent in women with ASC-US and LSIL.
Painful eccrine spiradenoma containing nerve fibers in the forearm: a case report
Tae Hyun Kim,Seong Heum Jeong,Hyun Jeong Ha,Chung Hun Kim 대한수부외과학회 2024 대한수부외과학회지 Vol.29 No.1
Eccrine spiradenomas are rare benign adnexal tumors that originate from the eccrine glands. They mainly arise in the head, neck, and upper trunk of young adults and are sometimes accompanied by pain and tenderness. Although spontaneous pain is a typical symptom of eccrine spiradenoma, the underlying mechanism remains unclear. We report the case of a patient who had a spiradenoma in the subcutaneous tissue of the left forearm that was accompanied by agonizing pain triggered by pressure. A 42-year-old man who had undergone surgical excision of a left forearm mass 5 years ago presented for relapsed pain and a palpable mass at the previous excision site. The agonizing pain had been triggered a few days ago, in response to even a slight touch. The mass measured approximately 0.8×0.8 mm, and ther e were no changes visible around the scar. Irregularly shaped masses, each measuring approximately 5 mm, were removed with a 2-mm safety margin from the subcutaneous fat. A histopathologic examination revealed the resected nodules were surrounded by delicate fibrous capsules, some parts of which contained blood vessels and prominent thickened nerve fibers. By the time of the 6-month follow-up, the masses had not recurred, and the biopsy site was well maintained without pain. We describe the surgical and histopathologic findings of an isolated eccrine spiradenoma accompanied by recurrent agonizing pain. The peculiar microscopic arrangement of the thickened nerve fibers encasing the nodule of eccrine spiradenoma may correlate with its pain mechanism.
( Tae-kyu Jang ),( So-jin Shin ),( Hyewon Chung ),( Sang-hoon Kwon ),( Soon-do Cha ),( Eunbi Lee ),( Changmin Shin ),( Chi-heum Cho ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.6
Objective The aim of our study is to compare the overall survival (OS), progression-free survival (PFS), and treatment-related morbidities between primary concurrent chemoradiation therapy (CCRT) vs. radical hysterectomy (RH) with or without tailored adjuvant therapy in patients with stages IB2 and IIA cervical cancer. Methods This was a retrospective study of 113 patients with IB2 or IIA cervical cancer treated with either primary CCRT (n=49) or RH (n=64) with or without tailored adjuvant therapy between 2002 and 2011 at Keimyung University Dongsan Medical Center. Patients in RH group was divided into those undergoing surgery alone (n=26) and those undergoing surgery with adjuvant therapy (n=38). Results The median follow up period was 66 months. The 5-year OS by treatment modality was 88.7% for the 64 patients in the RH group and 72.8% for 49 patients in the CCRT group (P=0.044). The 5-year PFS was 82.3% and 65.6% after RH group and CCRT group (P=0.048), respectively. Grade 3-4 complication was less frequent after RH alone (7.7%) than RH with adjuvant therapy (34.2%) or CCRT group (28.6%) (P=0.047). Conclusion The RH group seems to be superior to the CCRT group in oncologic outcomes. However, considering the selection bias including tumor size, lymph node meta, and parametrial invasion in pretreatment magnetic resonance imaging, both treatment modalities are reasonable and feasible in cervical cancer IB2 and IIA. It is important to choose the appropriate treatment modality considering the age and general condition of the patient. Randomized controlled study is needed to confirm the result of our study and determine the optimal treatment.
Gallbladder Pseudodiverticulosis Mimicking a Multiseptate Gallbladder with Stones
( Tae Hoon Lee ),( Sang Heum Park ),( Ji Young Park ),( Chang Kyun Lee ),( Il Kwun Chung ),( Hong Soo Kim ),( Sun Joo Kim ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.2
Gallbladder diverticula have the appearance of hernia- like protrusions of the gallbladder wall. This disorder may not be diagnosed until surgically resected because it has no clinical significance unless there are associated diseases. Gallbladder pseudodiverticula have an acquired cause, multiple fundal lesions, an association with gallstones, internal saccular lesions without external hernia-like protrusions, and little to no smooth muscle in the gallbladder wall. We report a unique anomaly of multiple pseudodiverticula presenting with calculous cholecystitis, which was pathologically different from true diverticula and had a unique shape similar to a bunch of grapes and a septation infilling pattern on endoscopic retrograde cholangiography. (Gut and Liver 2009;3:134-136)
( Tae Hoon Lee ),( Sang Heum Park ),( Sang Pil Kim ),( Sae Hwan Lee ),( Chang Kyun Lee ),( Il Kwun Chung ),( Hong Soo Kim ),( Sun Joo Kim ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.4
Biliary stent-related enteric perforations are very rare complications that are caused by the sharp end of a metallic stent, stent migration, or tumor invasion. Moreover, the choledochoduodenal fistula resulting from metallic biliary stent-induced perforation is extremely rare. Here, we report a case in which a spontaneous choledochoduodenal fistula occurred after biliary metallic stent placement in a patient with an Ampulla of Vater carcinoma but was successfully managed by supportive treatments, including nasobiliary drainage. This case might have occurred as the result of a rupture of the bile duct following pressure necrosis and inflammation caused by impacted calculi and food materials over the tumor ingrowth in the uncovered biliary stent. (Gut and Liver 2009;3:360-363)