KEDDY: a knowledge-based statistical gene set test method to detect differential functional protein-protein interactions

Jung, Sungwon,Berger, Bonnie Oxford University Press 2019 Bioinformatics Vol.35 No.4

Organosilicate compound filler to increase the mechanical strength of superhydrophilic layer-by-layer assembled film

Jung, Sungwon,Park, Sohyeon,Choi, Woojin,Heo, Jiwoong,Kwon, Jaesung,Choi, Sunghwan,Hong, Jinkee Elsevier 2020 Journal of industrial and engineering chemistry Vol.84 No.-

<P><B>Abstract</B></P> <P>Technologies that can overcome the poor mechanical properties of the coatings with bacterial anti-adhesion effect based on super-wetting properties are still challenging. In this study, we developed a durable superhydrophilic nanocomposite coatings composed of polysaccharide matrix and organosilicate (OS) compound filler. In brief, carboxymethylcellulose (CMC) and chitosan (CS)-based multilayer films were fabricated via Layer-by-layer (LbL) assembly then crosslinking for the films was performed to improve inner stability and induce superhydrophilicity. As second step, we synthesized a biocompatible and robust organosilicate compound via sol-gel reaction and incorporate it as reinforcing filler into the superhydrophilic films. Consequently, durable hybrid superhydrophilic nanocomposites were coated on the substrate, and various chemical analysis and performance evaluations of the coatings were performed. The mechanical properties of the composite coatings were significantly improved due to the OS acting as a reinforcing filler in the multilayer films. Furthermore, the coatings exhibited excellent biocompatibility and transparency and exerted antibacterial effect based on superhydrophilic property. This study presents a practical strategy to solve the poor durability, the limitation of super-wetting coatings widely applied in various fields.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Is video demonstration effective in practical classes?

Sungwon Jung 한국성인간호학회 2021 성인간호학회 학술대회 Vol.2021 No.8

Aim(s): Face-to-face classes are not possible due to COVID-19. Many nursing colleges have replaced practice classes with video demonstrations. This study identify the effectiveness of core basic nursing skills with video demonstrations of reported self confidence. Method(s): In the study, 67 students who gave voluntary consent taking practical classes participated. The four-step flipped learning model(preparation team-activity evaluation, reflection) was applied to students from August 31 to October 30, 2021. In the preparation step, the students studied the video demonstration for more than 1 hour per nursing skill. Students replied their self-confidence in nursing performance at the beginning and at the end of course. Confidence measured on a 5-point scale for 10 nursing skills was analyzed with a paired t-test. Result(s): Students studied with a total of 10 videos for nursing skill demonstration, 1 on the high level, 7 on the middle level, and 2 on the low level. The average video learning time per student was more than 15 hours, As a result of the self-report on performance confidence checked before video learning, only oral medication (4.134±0.790) scored 4 points or more out of 10 skills. Reports of the performance confidence evaluation after course, all 10 skills were 4 or higher. The nursing skill with the lowest performance confidence was simple catheterization(4.419±0.851). As for the correlation between the pre- and post-class reports to students’ performance confidence, the difference in the mean values of performance confidence in oral medication (p=.010), intramuscular injection (p=.005), and intravenous injection (p=.004) were statistically significant. Conclusion(s): In this study, it was confirmed that the video demonstration was effective in the practical class. In situations where face-to-face demonstrations are difficult, video demonstrations can be substituted, but confidence in performing nursing skills with high levels of nursing skills is low. Therefore, it is proposed to determine whether face-to-face and video learning are performed concurrently according to the difficulty.

(Papers) [Artificial Intelligence and Cognitive Science] Enabling Large-Scale Bayesian Network Learning by Preserving Intercluster Directionality

JUNG, Sungwon,Hyung LEE, Kwang,LEE, Doheon Institute of Electronics, Information and Communic 2007 IEICE transactions on information and systems Vol.90 No.7

<P>We propose a recursive clustering and order restriction (R-CORE) method for learning large-scale Bayesian networks. The proposed method considers a reduced search space for directed acyclic graph (DAG) structures in scoring-based Bayesian network learning. The candidate DAG structures are restricted by clustering variables and determining the intercluster directionality. The proposed method considers cycles on only <TEX>$c_{max}$</TEX>(<< n) variables rather than on all n variables for DAG structures. The R-CORE method could be a useful tool in very large problems where only a very small amount of training data is available.</P>

Transcendental Characteristic of Paul Tillich’s God and Its Fallacies

Sungwon Jung Presbyterian General Assembly Theological Seminary 2016 CHONGSHIN THEOLOGICAL JOURNAL Vol.21 No.-

Tillich, who is an existentialist philosopher and theologian, defines God not as a being who exists besides other beings, rather as Being - Itself or the Ground of being. He believes that the only way to know or experience God, who is not a being, is through mediation or correlation explaining the contents of the Christian faith through existential questions and theological answers in mutual interdependence. The correlation has a transcendental implication since God as the Ground of being or Being - Itself is a condition for the being. It is argued that God as Being - Itself or Ground of being can’t be known except a transcendental way. But the transcendence of Tillich’s God is far from that of the God of the Scriptures in the sense that the former is confined within the ontological scheme of being, while the latter is the creative source of both all beings and being - itself. The former is not separate from immanent beings, thus, in turn, not transcendental enough. The dialectical correlation between the transcendence and the immanence might be expressed only in a formal way. Thus Tillich’s God can’t explain how and when all existents came into being. His ontological scheme about beings and the Being - Itself is merely a phenomenological explanation. Tillich’s Ultimate Concern, i.e., his God, is nothing but his autonomous postulate. Only ultimate and transcendental ground for everything existent, physical, mental, symbolical, and spiritual is the self - existent, self - sufficient and personal Triune God and his revelation.

Molecular characterization of dysplasia-initiated colorectal cancer with assessing matched tumor and dysplasia samples

Jung Sungwon,이종률,김태원,Lee Jongmin,윤용식,Lee Kil Yeon,Song Ki-hwan,유창식,조용범 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.1

Purpose: Ulcerative colitis (UC) is known to have an association with the increased risk of colorectal cancer (CRC), and UC-associated CRC does not follow the typical progress pattern of adenoma-carcinoma. The aim of this study is to investigate molecular characteristics of UC-associated CRC and further our understanding of the association between UC and CRC. Methods: From 5 patients with UC-associated CRC, matched normal, dysplasia, and tumor specimens were obtained from formalin-fixed paraffin-embedded (FFPE) samples for analysis. Genomic DNA was extracted and whole exome sequencing was conducted to identify somatic variations in dysplasia and tumor samples. Statistical analysis was performed to identify somatic variations with significantly higher frequencies in dysplasia-initiated tumors, and their relevant functions were investigated. Results: Total of 104 tumor mutation genes were identified with higher mutation frequencies in dysplasia-initiated tumors. Four of the 5 dysplasia-initiated tumors (80.0%) have TP53 mutations with frequent stop-gain mutations that were originated from matched dysplasia. APC and KRAS are known to be frequently mutated in general CRC, while none of the 5 patients have APC or KRAS mutation in their dysplasia and tumor samples. Glycoproteins including mucins were also frequently mutated in dysplasia-initiated tumors. Conclusion: UC-associated CRC tumors have distinct mutational characteristics compared to typical adenoma-carcinoma tumors and may have different cancer-driving molecular mechanisms that are initiated from earlier dysplasia status.

Atmospheric Corrosion Monitoring with Time-of-Wetness (TOW) Sensor and Thin Film Electric Resistance (TFER) Sensor

Jung, Sungwon,Kim, Young-Geun,Song, Hong-Seok,Lee, Seung-Min,Kho, Young-Tai 한국부식방식학회 2002 Corrosion Science and Technology Vol.31 No.5

In this study, TOW sensor was fabricated with the same P. J. Serada's in NRC and was evaluated according to pollutant amount and wetldry cycle. Laboratorily fabricated thin film electric resistance (TFER) probes were applied in same environment for the measurement of corrosion rate for feasibility. TOW sensor could not differentiate the wet and dry time especially at polluted environment like 3.5% NaCl solution. This implies that wet/dry time monitoring by means of TOW sensor need careful application on various environment. TFER sensor could produce instant atmospheric corrosion rate regardless of environment condition. And corrosion rate obtained by TFER sensor could be differentiated according to wetldry cycle, wet/dry cycle time variation and solution chemistry. Corrosion behaviors of TFER sensor showed that corrosion could proceed even after wet cycle because of remained electrolyte at the surface.

Comparison of Land Surface Temperature Algorithm Using Landsat-8 Data for South Korea

( Sungwon Choi ),( Kyeong-sang Lee ),( Minji Seo ),( Noh-hun Seong ),( Donghyun Jin ),( Daeseong Jung ),( Suyoung Sim ),( Im Gook Jung ),( Kyung-soo Han ) 대한원격탐사학회 2021 大韓遠隔探査學會誌 Vol.37 No.1

Land Surface Temperature (LST) is the radiological surface temperature which observed by satellite. It is very important factor to estimate condition of the Earth such as Global warming and Heat island. For these reasons, many countries operate their own satellite to observe the Earth condition. South Korea has many landcovers such as forest, crop land, urban. Therefore, if we want to retrieve accurate LST, we would use high-resolution satellite data. In this study, we made LSTs with 4 LST retrieval algorithms which are used widely with Landsat-8 data which has 30 m spatial resolution. We retrieved LST using equations of Price, Becker et al. Prata, Coll et al. and they showed very similar spatial distribution. We validated 4 LSTs with Moderate resolution Imaging Spectroradiometer (MODIS) LST data to find the most suitable algorithm. As a result, every LST shows 2.160 ~ 3.387 K of RMSE. And LST by Prata algorithm show the lowest RMSE than others. With this validation result, we choose LST by Prata algorithm as the most suitable LST to South Korea.

Does the type of practice affect performance confidence in core basic nursing skills?

Sungwon Jung 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aim(s): In the subject of acquiring core basic nursing skills, practical practice is important. Due to the COVIRD-19, classroom practice has been replaced by online training. This study compared the difference between students" performance confidence in core skills after classroom practice before Corona situation and the performance confidence in core skills after online class in Corona. Method(s): The subjects of this study were 134, all of whom were senior nursing students. 67 students(gruop A) practiced 10 core basic nursing skills in the practice room in 2020 and the rest(group B) online in 2021, and self-reported their performance confidence measured on a 5-point scale after class. The two groups" confidence in performing 10 core basic nursing skills were analyzed by t-test with SPSS 21.0ver. Result(s): Students studied with a total of 10 nursing skills, 1 on the high level, 7 on the middle level, and 2 on the low level. Group A had high confidence in oral medication and administration management(5.000±0.000). Group B had the highest confidence in oral medication(4.627±0.569), CPR(4.537±0.698), and administration management (4.507±0.677) in that order. In group A, the lowest self-confidence was wearing protective equipment(4.299±0.489), and in group B, simple catheterization(4.149±0.851). Conclusion(s): Although the students showed confidence in performing core basic nursing skills even with online practice, there was a huge difference in confidence in simple catheterization, which had a high degree of difficulty. It is suggested that the type of practice be selected in consideration of the difficulty of the core basic nursing skills.

Data-driven target discovery in metabolic disease

Sungwon Jung 한국실험동물학회 2023 한국실험동물학회 학술발표대회 논문집 Vol.2023 No.2