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Clinical Results of Drug-Coated Balloon Treatment in a Large-Scale Multicenter Korean Registry Study
Sang Yeub Lee,Yun-Kyeong Cho,Sang-Wook Kim,Young-Joon Hong,Bon-Kwon Koo,Jang-Whan Bae,Seung-Hwan Lee,Tae Hyun Yang,Hun Sik Park,Si Wan Choi,Do-Sun Lim,Soo-Joong Kim,Young Hoon Jeong,Hyun-Jong Lee,Kwan 대한심장학회 2022 Korean Circulation Journal Vol.52 No.6
Background and Objectives: The aim of this study was to demonstrate the efficacy and safety of treatment with drug-coated balloon (DCB) in a large real-world population. Methods: Patients treated with DCBs were included in a multicenter observational registry that enrolled patients from 18 hospitals in Korea between January 2009 and December 2017. The primary outcome was target lesion failure (TLF) defined as a composite of cardiovascular death, target vessel myocardial infarction, and clinically indicated target lesion revascularization at 12 months. Results: The study included 2,509 patients with 2,666 DCB-treated coronary artery lesions (1,688 [63.3%] with in-stent restenosis [ISR] lesions vs. 978 [36.7%] with de novo lesions). The mean age with standard deviation was 65.7±11.3 years; 65.7% of the patients were men. At 12 months, the primary outcome, TLF, occurred in 179 (6.7%), 151 (8.9%), 28 (2.9%) patients among the total, ISR, and de novo lesion populations, respectively. A history of hypertension, diabetes, acute coronary syndrome, previous coronary artery bypass graft, reduced left ventricular ejection fraction, B2C lesion and ISR lesion were independent predictors of 12 months TLF in the overall study population. Conclusions: This large multicenter DCB registry study revealed the favorable clinical outcome of DCB treatment in real-world practice in patient with ISR lesion as well as small de novo coronary lesion.
Inducible Nitric Oxide Synthase Inhibitor form Mela azedarach var. Japonica
Kwon, Hak-Cheol,Lee, Byeong-Gon,Kim, Seung-Hee,Jung, Chil-Mann,Hong, Sung-Youl,Han, Jeung-Whan,Lee, Hyang-Woo,Zee, Ok-Pyo,Lee, Kang-Ro The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.4
In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two $\beta$-carboline (2) have been isolated form the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 to 2 showed marked inhibitory activity of iNOS on LPS-and interferon-${\gamma}$-stimulated RAW 264.7 cells.
Disorders of Small and Large Intestine : Colonic Pseudo-Obstruction
( Sung Yeun Yang ),( Su Kyoung Kwon ),( Jae Whan Kim ),( Tae Hee Kim ),( Sang Hoon Seol ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Alms: Pseudoobstruction occurs in the absence of mechanical obstruction, thus is thought to result from impaired bowel motility. The characteristic symptoms are nausea, vomiting, abdominal distension and constipation. Neuroparhic disorders more common and may be primary or secondary (eg, fetal alcohol syndrome, ischemic events, viral infections). Methods: A 45-year old women presented with a one-month history of nausea, vomiting and poor oral intake. The patient had history of epilepsy and had been took valproate daily since she was middle school age. Results: On examination, the patient had abdominal distension and tympanic sound on the abdomen at percussion. Laboratory test were unremarkable. A plain abdominal radiograph showed marked distended colonic bowel gas (Fig. 1). There was no visible peristalsis at ascending and transverse colon. A computed tomographic scan of the abdomen showed abnormal cystic dilatation of large bowel loop of the cecum, ascending and transverse colon. The most severely dilated portion of the colon is about. 11 cm in diameter (Fig. 2). There was no evidence of mass or stricture. There was air density in the rectum on the simple abdomen, we excluded the presence of the mechanical obstruction of the colon, and diagnosed as colonic pseudo-obstruction. She was slightly improved after administration of intravenous neostigmine. But symptom was aggravated two days later. The patient underwent operation with total colectomy. She has subsequently shown a steady improvement after operation, remains free of symptoms until present. Conclusions: Colonic decompression with nasogastric tubes, enemas, rectal tubes and colonoscopy may be helpful. Also administration of intravenous neostigmine may be beneficial. Inspite of these treatments, surgical colectomy should be considered as decompression treatment.
Kwon, Osung,Kang, Soo-Jin,Kang, Se Hun,Lee, Pil Hyung,Yun, Sung-Cheol,Ahn, Jung-Min,Park, Duk-Woo,Lee, Seung-Whan,Kim, Young-Hak,Lee, Cheol Whan,Han, Ki Hoon,Park, Seong-Wook,Park, Seung-Jung American Heart Association, Inc. 2017 Circulation. Cardiovascular imaging Vol.10 No.7
<P>Conclusions-With 12-month rosuvastatin therapy, a greater hsCRP reduction (not low-density lipoprotein-cholesterol) was associated with a greater decrease in % necrotic core volume and the absence of VH-TCFA, indicating a link between the anti-inflammatory action of statin and plaque stabilization by reducing NC and reinforcing fibrous cap.</P>
( Sung Noh Hong ),( Young Il Min ),( Jeong Whan Kim ),( Sun Young Lee ),( Won Hyeok Choe ),( In Kyung Sung ),( So Young Kwon ),( Hyung Seok Park ),( Choon Jo Jin ),( Chang Hong Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Emerging evidence revealed that the metabolic syndrome (MeS) is associated with the risk of colorectal adenoma. In addition, the individual component of MeS may attribute the development of colorectal adenoma respectively. However, there was no previous study to evaluate whether the clustering of multiple components of MeS has a greater impact on risk of colorectal adenoma. Thus, we evaluate that relationship the colorectal adenoma and ``metabolic score``, the sum of the five metabolic syndrome components in age, sex, lifestyle and dietary factor adjusted model. Methods: Cross-sectional data from 126 cases (adenoma group) and 762 adenoma-free controls (control group) who underwent colonoscopies and completed lifestyle and dietary questionnaires at the Health. Promotion Center, Konkuk University Hospital, from July 2006 to June 2007, were used in this analysis. According to the modified ATP III criteria, metabolic syndrome was diagnosed. Multivariable logistic regression was used to estimate the association between ``metabolic score`` and prevalence of colorectal adenoma. Results: The prevalence for metabolic syndrome was 38% in the adenoma group and 24% in the control group. On the multiple logistic regression analyses, metabolic syndrome was found to be associated with increased risk of colorectal adenoma (odds ratio, 1.93; 95% confidence interval, 1.30-2.82). Also, age, sex, lifestyle and dietary factor adjusted odds ratios of colorectal adenoma for accumulation of component of metabolic syndrome of 0, 1, 2, 3, and 4-5 were 1.0 (referent), 2.25, 3.18, 3.64 and 9.28, respectively (95% confidence interval; 2.04, 42.20; p-trend<0.001). Conclusions: The risk of colorectal adenoma was increased as the components of the MeS were accumulated. The clustering of multiple components of MeS appears to have an additive effect on risk of colorectal adenoma.