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Kee-Hwan Kim,Sang Chul Lee,Sang Kuon Lee,Byung-Jo Choi,Wonjun Jeong,Say-June Kim 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.2
Purpose: As several years have passed since the implementation of the Korean diagnosis-related group (DRG) payment system for appendicitis, its early outcomes should be assessed to determine if further improvements are warranted. Methods: We retrospectively analyzed clinical data from Korean patients who underwent appendectomy, dividing the sample into 2 groups of those who received services before and after implementation of the DRG system. Based on the DRG code classification, patient data were collected including the amount of DRG reimbursement and the total in-patient costs. We subsequently performed univariate and multivariate analyses to identify independent factors contributing to higher total in-patient cost. Results: Although implementation of the DRG system for appendicitis significantly reduced postoperative length of stay (2.8 ± 1.0 days vs. 3.4 ± 1.9 days, P < 0.001), it did not reduce total in-hospital cost. The independent factors related to total in-hospital cost included patient age of 70 years or more (odds ratio [OR], 3.214; 95% confidence interval [CI], 1.769–5.840; P < 0.001) and operation time longer than 100 minutes (OR, 3.690; 95% CI, 2.007–6.599, P < 0.001). In addition, older patients (≥70 years) showed a nearly 10 times greater relative risk for having a comorbid condition (95% CI, 5.141–20.214; P < 0.001) and a 3.255 times greater relative risk for having higher total in-hospital cost (95% CI, 1.731–6.119, P < 0.001). Conclusion: It appears that older patients (>70 years) have greater comorbidities, which contribute to higher inpatient costs. Thus, our study suggests that patient age be considered as a DRG classification variable.
Microbiological survey of Korean animal facilities from 2014 to 2019
Sang woon Kim,Hi jo SHIN,Se hee PARK,Teak chang LEE,Hae jin LEE,Ok sung MOON,Ki hoan NAM,Won kee YOON,Hyoung chin KIM,Hyo jung KWON,Young Suk WON 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
To survey the mouse microbiological contamination rate in Korean animal facilities, we tested for common contaminants in these facilities using serological, culture, and parasitological methods. A total of 21,292 experimentally housed mice from 206 animal facilities, including hospitals, universities, companies and research institutes, were tested over a 6-year period from 2014 to 2019. The most commonly found contaminants were various species of non-pathogenic protozoa (47.2%). The most common pathogenic bacteria were Staphylococcus aureus (21.2%), Pasteurella pneumotropica (12.5%) and Pseudomonas aeruginosa (5.8%). Mouse hepatitis virus (6.1%) was detected, but no other viral or bacterial pathogens were found. These results establish that the main pathogens that currently contaminate animal facilities in Korea are opportunistic pathogens, whereas important such as those in categories B or C, were decreased.
( Kee-young Kim ),( Angelina F. Osabutey ),( Phuong Nguyen ),( Soo Bae Kim ),( You-young Jo ),( Haeyong Kweon ),( Hyun-tai Lee ),( Sang-deok Ji ),( Young Ho Koh ) 한국잠사학회 2019 International Journal of Industrial Entomology Vol.39 No.1
Steamed and freeze-dried mature silkworm powder (SMSP) is a natural food containing a large amount of various functional materials and has various health promoting effects. SMSP is known to increase the life expectancy and healthspan, simultaneously. The accomplishment of extension of healthspan should be possible to achieve by activating various signaling pathways delaying aging in various tissues, not by regulating only a few signaling pathways. Consistent with this notion, SMSP increased the resistant to Parkinson disease by enhancing olfaction and mitochondrial activity in neurons of animal models. In addition, SMSP could enhance the gastrointestinal functions. The animals consumed SMSP showed enhanced alcohol metabolisms, reduced cholesterols in bloods, increased resistance to carcinogens causing liver cancers, and protective effects in alcohol induced stomach ulcers. Furthermore, SMSP was also effective in appearance. The SMSP consumed animals showed reduced skin pigmentations and more hair growth compared with control animals. Taken together, the functional enhancement effects of SMSPs in various tissues and organs, which have been discovered to date, are combined to extend healthspan. Therefore, SMSP can be regarded as calorie restriction mimetics. Further studies in the health promoting effects of SMSP will contribute to identifying new applicable diseases, resulted in increased sales of SMSP and incomes of sericulture farmers. © 2019 The Korean Society of Sericultural Sciences Int. J. Indust. Entomol. 39(1), 1-8 (2019)
Jo, Yun Kee,Choi, Bong-Hyuk,Zhou, Cong,Ahn, Jin-Soo,Jun, Sang Ho,Cha, Hyung Joon The Royal Society of Chemistry 2015 Journal of Materials Chemistry B Vol.3 No.41
<P>Successful titanium implantation strongly depends on early fixation through an osseointegration between the titanium fixture and adjacent bone tissue. From a clinical perspective, rapid recruitment of functional biomolecules from the blood and osteogenic cell binding is critical for osseointegration immediately after implant insertion. Thus, surface modifications aiming to improve the interactions between the blood and implant and to enhance the binding of osteogenic cells onto the implant surface can contribute to successful osseointegration. Mussel adhesive proteins (MAPs) derived from marine mussels have been considered as promising bioadhesives that have strong adhesion and coating abilities onto organic and inorganic surfaces, even in wet environments. Here, we investigated the<I>in vitro</I>and<I>in vivo</I>osteostimulating ability of the bioengineered mussel glue MAP-RGD, which is a recombinant MAP fused with an Arg-Gly-Asp (RGD) peptide, an effective cell recognition motif for activating intracellular signaling pathways, using a titanium mesh (Ti-mesh) as a model titanium implant. We found that the<I>in vitro</I>cell behaviors of pre-osteoblast cells, such as attachment, proliferation, spreading, and osteogenic differentiation, increased significantly on the MAP-RGD-coated Ti-mesh surface.<I>In vitro</I>blood responses including blood wetting, blood clotting, and platelet adhesion were also highly enhanced on the MAP-RGD-coated surface. Importantly, implantation of the MAP-RGD-coated Ti-mesh resulted in a remarkable acceleration of<I>in vivo</I>bone regeneration and maturation of a new bone in a rat calvarial defect. Consequently, the bioengineered mussel glue can be successfully utilized as an osteostimulating bone bioadhesive for titanium implant applications with further expansion to general bone tissue engineering.</P>
( Kee Wook Jung ),( Min Woo Jo ),( Seon Ha Kim ),( Woo Seung Son ),( Hyo Jeong Lee ),( Dong Hoon Yang ),( In Ja Yoon ),( So Young Seo ),( Hyun Sook Koo ),( Ji Beon Kim ),( Sang Hyoung Park ),( Kyung J 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Previous studies using Short Form-36 (SF-36) and Patient Assessment of Constipation Quality of Life (PAC-QOL) have shown a reduced quality of life (QOL) in patients with chronic constipation. However, these questionnaires were composed of more than 26 items, and these surveys taken at outpatient clinics were time-consuming. European Quality of Life-5 Dimensions (EQ-5D) is composed of 5 dimensions with 3 levels measuring people`s utility. However, the psychometric properties of EQ- 5D in chronic constipation have not been evaluated. We aimed to investigate the validity and reliability of EQ-5D and compare them with those of PAC-QOL and SF-36 in women with chronic constipation. Methods: Constipated 150 women (54 ± 16 years) who visited a constipation clinic were prospectively enrolled. They were asked to fi ll in bowel- and QOL-related questionnaires. Construct validity was examined by determining the difference betweenthe EQ-5D indexes among the questionnaires. In addition, differences in the EQ-5D index on the PAC-QOL score were analyzed. Results: The mean duration of constipation and the use of laxatives were 15.1 ± 13.6 years and 6.7 ±8.3 years, respectively. The EQ-5D index showed signifi cant differences in age, education, and comorbidities (all P< 3 times of bowel movement/week) than those with a higher frequency of defecation (= 3 times of bowel movement/week) (P Conclusions: The EQ-5D appears to be effective in measuring QOL in patients with chronic constipation. EQ-5D can be complementary to the previously used PAC-QOL and SF-36 in outpatient clinic settings.