http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ha, Eun Jin,Gwak, Ho-Shin,Rhee, Chang Hun,Youn, Sang Min,Choi, Chang-Woon,Cheon, Gi Jeong The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.3
Objective : Intracavitary injection of beta-emitting radiation source for control of cystic tumors has been tried with a benefit of localized internal radiation. The authors treated cystic brain tumor patients with Holmium-166-chitosan complex (Ho-166-chico), composed of a beta-emitting radionuclide Holmium-166 and biodegradable chit polymer, and evaluated the safety and effective measurement for response. Methods : Twenty-two patients with recurrent cystic brain tumor and/or located in a deep or eloquent area were enrolled in this pilot study. The cyst volume and wall thickness were determined on CT or MRI to assess radiological response. The activity of Ho-166-chico injected via Ommaya reservoir was prescribed to be 10-25 Gy to the cyst wall in a depth of 4 mm. Results : There was neither complications related to systemic absorption nor leakage of Ho-166-chico in all 22 patients. But, two cases of oculomotor paresis were observed in patients with recurrent craniopharyngioma. Radiological response was seen in 14 of 20 available follow-up images (70%). Seven patients of 'evident' radiological response experienced more than 25% decrease of both cyst volume and wall thickness. Another 7 patients with 'suggestive' response showed decrease of cyst volume without definitive change of the wall thickness or vice versa. All patients with benign tumors or low grade gliomas experienced symptomatic improvement. Conclusion : Ho-166-chico intracavitary radiation therapy for cystic tumor is a safe method of palliation without serious complications. The determination of both minimal effective dosage and time interval of repeated injection through phase 1 trial could improve the results in the future.
Cheon, Seung-Hoon,Park, Joon-Suck,Chung, Byung-Ho,Choi, Bo-Gil,Cho, Won-Jae,Choi, Sang-Un,Lee, Chong-Ock The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2
A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidazo[2,$1-a$]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxyporpyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[$4^1$-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,$1-a$]isoquinoline (1).
General Pharmacological Study of GCSB-5, a Herbal Formulation
( Sang Won Park ),( Chan Ho Lee ),( Sung Hwa Kim ),( Young Jae Cho ),( Jeong Haing Heo ),( Jin Gu Park ),( Ho Jun Cheon ),( Sung Youl Lee ),( Jie Wan Kim ),( Sun Mee Lee ) 한국응용약물학회 2006 Biomolecules & Therapeutics(구 응용약물학회지) Vol.14 No.4
The general pharmacological properties of GCSB-5, a herbal formulation consisting of 6 Oriental herbs (Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma, Glycine Semen and Eucommiae Cortex), were investigated in mice, rats, guinea pigs and rabbits. The administration of GCSB-5 had no effect on general behavior, and did not influence the central nervous system. Mean blood pressure, heart and respiratory rate and contractile response of the isolated guinea pig atrium were unaffected by the treatment of GCSB-5. Addition of GCSB-5 did not cause spontaneous relaxation and contraction of the isolated guinea pig ileum and rat uterus. And also, GCSB-5 had no effect on the gastrointestinal system and the blood system of the animals examined in this study. GCSB-5, at higher doses (1,000 and 3,000 mg/kg), increased the urinary excretion of electrolytes, however, the urine volume and pH in rats were unaffected. Taken together, these results indicate that GCSB-5 does not induce any adverse effects in experimental animals and is expected to have no significant general pharmacological activities.
P133 An epidemiologic study of condyloma acuminatum and bowenoid papulosis in Korea
( Sung Soo Han ),( Dong Uk Cheon ),( Hyun Seok Choi ),( Hyung Kwon Park ),( Ho Song Kang ),( Joung Soo Kim ),( Hee Joon Yu ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Both condyloma acuminatum and bowenoid papulosis are human papillomavirus (HPV) associated tumor. Although condyloma acuminatum is quite common disease, there have been no epidemiologic study of condyloma acuminatum and bowenoid papulosis since 1978 in Korea. Objectives: This study was designed to evaluate epidemiology and HPV type of condyloma acuminatum and bowenoid papulosis in Korea. Methods: We conducted a retrospective analysis of patients clinically and histologically diagnosed with condyloma acuminatum and bowenoid papulosis in Hanyang university Guri hospital from January 2002 to August 2016. Results: 73 patients with condyloma acuminatum (53 male, 20 female) were enrolled. Mean age at diagnosis was 36.9 and duration of disease was 7.0 month. The most common site was penile shaft in male and labia majora in female. 26 patients relapsed with a mean duration of 1.6 month. HPV typing was performed in 19 patients. HPV type 6 (58%) was most frequently detected followed by type 11 (16%) and type 16 (11%). Meanwhile, 9 patients with bowenoid papulosis were enrolled. All of them were male and mean age at diagnosis was 37.1. Three patients relapsed with a mean duration of 6.9 month. As in condyloma acuminatum, penile shaft was the most common site. HPV type 6 was detected 2 of 3 patients and the other was type 16. Conclusion: We report a recent epidemiology and HPV type of condyloma acuminatum and bowenoid papulosis in Korea.
The Prevalence and Characteristics of Positional Obstructive Sleep Apnea
( Cheon-sik Kim ),( Yong-seok Lee ),( Cheon-ung Cho ),( Sang-ho Pae ),( Sang-ahm Lee ) 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.2
Patients with obstructive sleep apnea (OSA) often have more aggravated symptoms in the supine position. We tried to investigate the clinical characteristics and the predictive factors for positional OSA. Polysomnographic data were reviewed for OSA patients (apnea hypopnea index, AHI≥5) from April, 2008 to April, 2011 at the Asan Medical Center. Clinical data, comorbid medical condition data and questionnaires (SF-36, MFI-20, ESS, BDI, STAI) were assessed. All patients were classified into two groups: positional patients (PP) group and non-positional patients (NPP) group. PP was defined as a patient who had the AHI in the supine position was at least twice as high as that in the lateral position. The body position of patients was confirmed by sleep position sensor and video monitor. All patients had at least 30 minutes of positional and 30 minutes of non-positional sleep. We compared clinical, medical, polysomnographic data, and questionnaire results between two (PP and NPP) groups and investigated predictive factors for the PP group using binary logistic regression analysis. In total, 371 patients were investigated. 265 (71.4%) was categorized as PP group and 106 (28.5%) as NPP group. The mean age (mean±SD) was higher in the PP group (52.4±9.8) than in the NPP group (49.5±11.9) (p<0.05). Comparison of sleep parameters between the PP and the NPP group showed that the PP group had significantly lower BMI (PP: 26.1±3.2 kg/m2; NPP: 27.8±4.3kg/m2, p<0.001), neck circumference (PP: 39.7±2.8 cm; NPP: 41.5±3.7 cm, p<0.001) and hypertension rate (PP: n=89/265 (33.5%); NPP: n=48/106 (45.2%), p=0.0240). In the PP group, the percentage of deep sleep (PP: 8.7±8.1%; NPP: 5.6±7.0%, P=0.001) and rapid eye movement (REM) (PP: 17.5±6.1%; NPP: 14.0±6.9%, p<0.001) were significantly higher whereas the percentage of light sleep (stage N1) was significantly lower than the NPP group (PP: 30.4±12.3; NPP: 44.5±20.8%, p<0.001). During the sleep, the AHI in the supine position (PP: 48.6±19.5; NPP: 60.5±22.6, p<0.001) and in the non-supine position (PP: 9.4±8.9; NPP: 48.4±24.8, p=<0.001) were significantly lower and the minimal arterial oxygen saturation in non-REM sleep was significantly higher in the PP group (PP: 80.3±7.6; NPP: 75.1±9.9, p=<0.001). There were no significant differences in all questionnaires including quality of life. The results of the binary logistic regression analysis showed that age, the amount of REM sleep(%) and AHI were significant predictive factors for positional OSA. The significant predictive factors for positional OSA were older age, higher percentage of REM and lower AHI. The questionnaire results were not significantly different between the two groups.
( Sang Hyok Lim ),( Hong Woo Cheon ),( Ho Sung Lee ),( Jae Sung Choi ),( Ki Hyun Seo ),( Yong Hoon Kim ),( Ju Ock Na ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Metastatic squamous cell carcinoma of intrathoracic lymph node with cancer of unknown primary (CUP) is very rare. We report a case of metastatic squamous cell carcinoma of hilar lymph node with CUP and review of the associated literatures. Abnormal mass in the right hilar was incidentally detected. The patient was performed a right pneumonectomy and mediastinal lymph node dissection. Microscopically, metastatic squamous cell carcinoma at hilar lymph nodes without primary lung or other lesion was diagnosed. He has currently been received adjuvant chemotherapy under diagnosis of T0N1M0 Lung cancer.