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Immobilization stress increased cytochrome P450 1A2 (CYP1A2) expression in the ovary of rat
Hwang, Jong-Chan,Kim, Hwan-Deuk,Park, Byung-Joon,Jeon, Ryoung-Hoon,Baek, Su-Min,Lee, Seoung-Woo,Jang, Min,Bae, Seul-Gi,Yun, Sung-Ho,Park, Jin-Kyu,Kwon, Young-Sam,Kim, Seung-Joon,Lee, Won-Jae The Korean Society of Animal Reproduction and Biot 2021 한국동물생명공학회지 Vol.36 No.1
Under the stressed condition, a complex feedback mechanism for stress is activated to maintain homeostasis of the body and secretes several stress hormones. But these stress hormones impair synthesis and secretion of the reproductive hormones, followed by suppression of ovarian function. Cytochrome P450 1A2 (CYP1A2) plays a major role in metabolizing exogenous substances and endogenous hormones, and its expression is recently identified at not only the liver but also several organs with respect to the pancreas, lung and ovary. Although the expression of CYP1A2 can be also affected by several factors, understanding for the changed pattern of the ovarian CYP1A2 expression upon stress induction is still limited. Therefore, CYP1A2 expression in the ovaries from immobilization stress-induced rats were assessed in the present study. The stress-induced rats in the present study exhibited the physiological changes in terms of increased stress hormone level and decreased body weight gains. Under immunohistological observation, the ovarian CYP1A2 expression in both control and the stressed ovary was localized in the antral to pre-ovulatory follicles. However, its expression level was significantly (p < 0.01) higher in the stress-induced group than control group. In addition, stress-induced group presented more abundant CYP1A2-positive follicles (%) than control group. Since expression of the ovarian CYP1A2 was highly related with follicle atresia, increased expression of CYP1A2 in the stressed ovary might be associated with changes of the ovarian follicular dynamics due to stress induction. We hope that these findings have important implications in the fields of the reproductive biology.
An Experimental Study on Sodium-Concrete Reactions
Bae, Jae-Heum,Shin, Min-Chul,Min, Byong-Hun,Kim, Su-Man,Kim, Byong-Ho,Kwon, Sang-Woon,Hwang, Seong-Tae Korean Nuclear Society 1998 Nuclear Engineering and Technology Vol.30 No.6
A sodium-concrete reaction facility with a test chamber of 0.226㎥($\Phi$0.6m$\times$H0.8m) was constructed to carry out experiments of sodium-concrete reaction which might take place in sodium metal fast-breeder reactor Utilizing this facility, several experiments were conducted to closely examine the characteristics of sodium-concrete reactions under different conditions : Sodium mass : 100, 250g ; Sodium temperature : 450, 550, $650^{\circ}C$ ; Concrete age = 30, 45, 50, 90days. Our experiments show that the amount of the H2 generated by sodium-concrete reaction has increased up to its flammable range as the amount of spilled sodium and its temperature have increased. The maximum hydrogen concentration was 31mo1% at the concrete age of 30days, sodium temperature : 55$0^{\circ}C$, and sodium mass : 250g. The major components of sodium-concrete reaction products were also determined as Na$_2$SiO$_3$ and NaAlO$_2$.
Bae Dae-Hwan,Kim Min,Lee Dae In,Lee Ju-Hee,Kim Sangmin,Lee Sang Yeub,Bae Jang-Whan,Hwang Kyung-Kuk,Kim Dong-Woon,Cho Myeong-Chan 대한의학회 2022 Journal of Korean medical science Vol.37 No.21
With the global spread of severe acute respiratory syndrome coronavirus 2, several vaccines were developed; messenger RNA (mRNA) vaccines have recently been widely used worldwide. However, the incidence of myocarditis following mRNA vaccination is increasing; although the cause of myocarditis has not yet been clearly identified, it is presumed to be caused by a problem in the innate immune system. Immune-mediated thrombocytopenia (ITP) after vaccination is rare but has been reported and is also assumed to occur by the same mechanism. We report the first case of simultaneous myocarditis and ITP after mRNA vaccination. A 38-year-old woman presented with chest pain, mild dyspnea, and sweating after vaccination with mRNA-1273 vaccine (Moderna) 4 days prior to admission. Upon admission to the emergency department, cardiac enzymes were elevated; blood test performed 5 months ago showed normal platelet count, but severe thrombocytopenia was observed upon admission. After administration of intravenous immunoglobulin, the platelet count improved; subsequently, myocarditis was observed on endomyocardial biopsy. Thus, myocarditis and ITP were judged to have occurred simultaneously due to the expression of the innate immune system markers after mRNA vaccination. The patient was discharged on day 6 of admission.
Bae, Mi-Ok,Choi, Kyung-Ho,Lee, Hu-Jang,Kim, Hyun-Woo,Kim, Jun-Sung,Hwang, Soon-Kyung,Park, Jin-Hong,Cho, Hyun-Sun,Cho, Myung-Haing The Korean Society of Veterinary Science 2004 大韓獸醫學會誌 Vol.44 No.3
When an organism is exposed to various toxicants chronically, reactive oxygen species(ROS) are accumulated and eventually result in several biological effects from gene expression to cell death. In the present study we investigated the oxidative damage of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) and/or benzo(a)pyrene (B(a)P) in C100 cells. C100 cells treated with TCDD(30 nM) and B(a)P($3{\mu}M$) underwent diverse oxidative stress as determined through thiobarbituric acid-reactive substances(TBARS) formation, DNA fragmentation, DNA single strand break(SSB) assay, immunohistochemical staining of 8-hydroxy-2'-deoxyguanosine(8-OHdG), and mRNA expressions of antioxidant enzymatic genes such as Cu/Zn-SOD gene, GPx(glutathione peroxidase 5) gene, and catalase gene. Lipid peroxidation in C100 cells was determined through measuing the formation of TBARS. For theat, the cells were pretreated with TCDD(30 nM) and/or B(a)P($3{\mu}M$) for 0.5, 1, 2 and 4 days. TBARS formation was increased in TCDD(30 nM) and B(a)P($3{\mu}M$) and mixture($30nM\;TCDD+3{\mu}M\;B(a)P$) and positive control treatment groups comparing to the controls. Mixture treatment induced more DNA fragmentation than the single treatment group at day 6. Also, SSB in all treatment groups was clearly observed when compared with the negative control group. As with the expression of antioxidant enzyme, GPx 5mRNA, B(a)P alone and mixture($30nM\;TCDD+3{\mu}M\;B(a)P$) treatment were higher comparing to those of the negative control and TCDD treatment groups. Our results suggest that exposure of C100 cells to mixture of TCDD and B(a)P leads to significant oxidative damage comparing to the exposures to the individual chemicals. Mechanisms of action are discussed. Additional studies are needed to elucidate the detailed mechanism of mixture-induced toxicity.
The roots of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock
Bae, Gi-Sang,Seo, Sang-Wan,Kim, Min-Sun,Park, Kyoung-Chel,Koo, Bon Soon,Jung, Won-Seok,Cho, Gil-Hwan,Oh, Hyun Cheol,Yun, Seung-Won,Kim, Jong-Jin,Kim, Sung Gyu,Hwang, Sung-Yeon,Song, Ho-Joon,Park, Sung Springer-Verlag 2011 Journal of natural medicines Vol.65 No.1
Hwang, Woo-Sung,Bae, Ji-Hyun,Yeom, Su-Cheong Informa UK (TaylorFrancis) 2016 Bioscience, Biotechnology, and Biochemistry Vol.80 No.12
<P>Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10(-/-)) mice. To elucidate correlation between stress, IL-10, and mammary gland involution, corticosterone was injected into the lactating wild type and IL-10-deficient mice and assessed mammary gland phenotype. Repetitive corticosterone injection developed premature mammary gland involution only in B6.IL-10(-/-) mice; moreover, it induced alopecia in nursing pups. Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland. Overall incidence of pup alopecia and mammary gland involution was relatively high in corticosterone than control B6.IL-10(-/-) group (57% vs. 20%). Our finding demonstrates that IL-10 is important for stress modulation, and B6.Il-10(-/-) with corticosterone has several advantage such as simple to establish, well-defined onset of mammary gland involution, high incidence, and inducing pup alopecia.</P>
Web-based design and analysis tools for CRISPR base editing
Hwang, Gue-Ho,Park, Jeongbin,Lim, Kayeong,Kim, Sunghyun,Yu, Jihyeon,Yu, Eunchong,Kim, Sang-Tae,Eils, Roland,Kim, Jin-Soo,Bae, Sangsu BioMed Central 2018 BMC bioinformatics Vol.19 No.1
<P><B>Background</B></P><P>As a result of its simplicity and high efficiency, the CRISPR-Cas system has been widely used as a genome editing tool. Recently, CRISPR base editors, which consist of deactivated Cas9 (dCas9) or Cas9 nickase (nCas9) linked with a cytidine or a guanine deaminase, have been developed. Base editing tools will be very useful for gene correction because they can produce highly specific DNA substitutions without the introduction of any donor DNA, but dedicated web-based tools to facilitate the use of such tools have not yet been developed.</P><P><B>Results</B></P><P>We present two web tools for base editors, named BE-Designer and BE-Analyzer. BE-Designer provides all possible base editor target sequences in a given input DNA sequence with useful information including potential off-target sites. BE-Analyzer, a tool for assessing base editing outcomes from next generation sequencing (NGS) data, provides information about mutations in a table and interactive graphs. Furthermore, because the tool runs client-side, large amounts of targeted deep sequencing data (< 1 GB) do not need to be uploaded to a server, substantially reducing running time and increasing data security. BE-Designer and BE-Analyzer can be freely accessed at http://www.rgenome.net/be-designer/ and http://www.rgenome.net/be-analyzer/, respectively.</P><P><B>Conclusion</B></P><P>We develop two useful web tools to design target sequence (BE-Designer) and to analyze NGS data from experimental results (BE-Analyzer) for CRISPR base editors.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s12859-018-2585-4) contains supplementary material, which is available to authorized users.</P>