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Sujin Choi,Sang-Hoon Kim,Mi Seon Han,Yoonsun Yoon,Yun-Kyung Kim,Hye-Kyung Cho,Ki Wook Yun,Seung Ha Song,Bin Ahn,Ye Kyung Kim,Sung Hwan Choi,Young June Choe,Heeji Lim,Eun Bee Choi,Kwangwook Kim,Seokhwa 대한면역학회 2023 Immune Network Vol.23 No.4
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccineinduced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARSCoV- 2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4+ T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4+ T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.
Investigation of Post Annealing Effect on the PZT Thin Films
Sujin Choi, Juyun Park, Sung-Wi Koh, Yong-Cheol Kang 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.4
The PZT thin films were deposited on Si(100) substrate using RF magnetron sputtering method. And the PZT thin films were post annealed at various temperatures to form perovskite phase. To analyze PZT thin films, surface profiler, XRD, XPS, CA, and SFE were used. The thickness increased from 536.5 to 833.2 nm as post annealing temperature increased. The perovskite PZT was observed from PZT-823 and pyrochlore PZT, ZrO2, TiO2, and perovskite PbZrO3 were observed. From the XPS, the atomic percentages of Pb, Zr, Ti, and O were calculated and the portion of Pb increased to PZT-823 and decreased to PZT-923 and then increased to PZT-1023. Also, the CA and SFE was effected on post annealing temperature and as a function of atomic percentage of Pb, the CA and SFE was transformed.
Deposition and XPS Study of Pb, Zr, and Ti Films
Choi, Sujin,Park, Juyun,Jeong, Eunkang,Kim, Beob Jun,Son, Seo Yoon,Lee, Jeong Min,Lee, Jin Seong,Jo, Hee Jin,Park, Jihun,Kang, Yong-Cheol The Basic Science Institute Chosun University 2014 조선자연과학논문집 Vol.7 No.3
Lead zirconate titanate (PZT) is significant material in electrical and optical devices for their ferroelectric, piezoelectric and dielectric properties. In this research, PZT films were fabricated by reactive RF co-sputtering method using Pb, Zr, and Ti targets. From XPS study, lead, zirconium, and titanium are successfully deposited on Si(100) substrate. Thickness of PZT films was measured with a surface profiler and the thickness was decreased as the oxygen gas ratio increased in the sputter gas.
Investigation of Post Annealing Effect on the PZT Thin Films
Choi, Sujin,Park, Juyun,Koh, Sung-Wi,Kang, Yong-Cheol The Basic Science Institute Chosun University 2015 조선자연과학논문집 Vol.8 No.4
The PZT thin films were deposited on Si(100) substrate using RF magnetron sputtering method. And the PZT thin films were post annealed at various temperatures to form perovskite phase. To analyze PZT thin films, surface profiler, XRD, XPS, CA, and SFE were used. The thickness increased from 536.5 to 833.2 nm as post annealing temperature increased. The perovskite PZT was observed from PZT-823 and pyrochlore PZT, $ZrO_2$, $TiO_2$, and perovskite $PbZrO_3$ were observed. From the XPS, the atomic percentages of Pb, Zr, Ti, and O were calculated and the portion of Pb increased to PZT-823 and decreased to PZT-923 and then increased to PZT-1023. Also, the CA and SFE was effected on post annealing temperature and as a function of atomic percentage of Pb, the CA and SFE was transformed.
Choi, Sujin,Park, Han Woo SAGE Publications 2014 NEW MEDIA & SOCIETY - Vol.16 No.1
<P>This study provides an empirical account of how an online community has employed social media to mobilize people for a political goal. The case explored is a Twitter-based community in South Korea that calls for the elimination of a conservative national daily newspaper and whose activism is contextualized in the political history of Korea. Based on the mixed-method approach, the research results suggest that the role of the group organizer as an information provider and coordinator contributed to the sustainability of the group, and that group members formed a collective identity through the framing process of discourse. In addition, massive “retweeting” and “culture jamming” tactics were found to be strategically employed to enhance group solidarity, to broaden the base of support, and to crystallize involvement into political acts with other offline actions. Rather than decaying to an echo chamber or “slacktivism”, the online community seemed to demonstrate a new form of collective activism through the mediation of technology in everyday life.</P>
Choi Sujin,Kim Bo Kyung,Ahn Hong Yul,Hong Kyung Taek,Choi Jung Yoon,Shin Hee Young,Kang Hyoung Jin 대한혈액학회 2020 Blood Research Vol.55 No.4
Background Acute myeloid leukemia (AML) with internal tandem duplication in FMS-like tyrosine kinase 3 (FLT3-ITD) is associated with poor outcomes. This study aimed to analyze the outcomes of pediatric AML patients with FLT3-ITD mutations in the pre-FLT3 inhibitor era. Methods We retrospectively reviewed and identified 18 patients diagnosed with non-M3 AML with FLT3-ITD mutations at Seoul National University Children’s Hospital between May 2008 and August 2019. Results The median age was 13 years (range, 6‒19 yr). The median follow-up time was 43 months (range, 6‒157 mo). Fourteen patients received BH-AC-based (N4-Behenoy1-1--D-arabinofuranosy1cytosine) and 4 received cytarabine-based induction chemotherapy. Complete remission (CR) was achieved in 72.2% of the patients after the first induction chemotherapy and 80% of the patients achieved CR after salvage therapy. The overall CR rate was 94% (17/18 patients). These 17 patients underwent hematopoietic stem cell transplantation (9 matched unrelated donors, 5 matched related donors, and 3 haploidentical donors). Relapse occurred in 22% of the patients. Event free survival and overall survival rates were 53.8±12.1% and 53.6±12.1%, respectively, and they were not significantly different according to the type of induction chemotherapy (P =0.690) or the type of donor (P =0.102). Conclusion This study outlines the outcomes of pediatric AML patients with FLT3-ITD-mutations in one institution over a decade. Outcomes were significantly improved in this study compared to our previous report in 2004, where RFS and EFS were 0%. This study can provide baseline data for pediatric patients in the pre-FLT3 inhibitor era.
Choi, Sujin,Baek, Seungin,Im, Dajeong,Kahng, Hyun Kook,Kim, Hwi Optical Society of America 2014 Optics express Vol.22 No.15
<P>Fourier modal method based quantitative analysis method of optical power flow and energy loss in general multi-block photonic structures with an internal dipole emitter is described. The analytic expressions of modal power flow and loss are derived for accurate and efficient quantitative analysis. It is revealed that a few dominating excited photonic modes substantially govern the internal energy flow and energy loss. The optical characteristics of the dominant modes are investigated.</P>
Choi, Sujin,Song, Hyekyung,Jeong, Jaehwan,Jeon, Inho,Yoon, Hosung,Chung, Kiwha,Won, Yongjin,Choi, Jeyong,Kim, Unkyung Korean Society for Molecular Biology 2008 Molecules and cells Vol.25 No.2
Microsatellites, short tandem repeats, are useful markers for genetic analysis because of their high frequency of occurrence over the genome, high information content due to variable repeat lengths, and ease of typing. To establish a panel of microsatellite markers useful for genetic studies of the Korean population, the allele frequencies and heterozygosities of 207 microsatellite markers in 119 unrelated Korean, Indian and Pakistani individuals were compared. The average heterozygosity of the Korean population was 0.71, similar to that of the Indian and Pakistani populations. More than 80% of the markers showed heterozygosity of over 0.6 and were valuable as genetic markers for genome-wide screening for disease susceptibility loci in these populations. To identify the allelic distributions of the multilocus genetic data from these microsatellite markers, the population structures were assessed by clustering. These markers supported, with the most probability, three clustering groups corresponding to the three geographical populations. When we assumed only two hypothetical clusters (K), the Korean population was separate from the others, suggesting a relatively deep divergence of the Korean population. The present 207 microsatellite markers appear to reflect the historical and geographical origins of the different populations as well as displaying a similar degree of variation to that seen in previously published genetic data. Thus, these markers will be useful as a reference for human genetic studies on Asians.
The impact of conglomerate farming on the poor: Empirical evidence from the Brazil soy sector
Sujin Choi,Hanho Kim 한국외국어대학교 국제지역연구센터 2016 International Area Studies Review Vol.19 No.2
This paper provides the first econometric results which show that during the period 1976–2013, the conglomerate farming of soybeans aggravated poverty in Brazil. It was found that the impact of soy on poverty in the north of the country, where land consolidation is active, is precisely opposite that in the south, where family farming dominates. The result directly contradicts mainstream views that smallholder farmers’ losses would be offset by gains from the trickle-down effect. Based on the findings of this study, a necessity is raised that family farming be supported to help alleviate poverty