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Kim, Suji,Lee, Kyu-Sun,Choi, Seunghwan,Kim, Joohwan,Lee, Dong-Keon,Park, Minsik,Park, Wonjin,Kim, Tae-Hoon,Hwang, Jong Yun,Won, Moo-Ho,Lee, Hansoo,Ryoo, Sungwoo,Ha, Kwon-Soo,Kwon, Young-Guen,Kim, Youn American Society for Biochemistry and Molecular Bi 2018 The Journal of biological chemistry Vol.293 No.49
<P>Inflammatory cytokines, including tumor necrosis factor-α (TNFα), were elevated in patients with cardiovascular diseases and are also considered as crucial factors in the pathogenesis of preeclampsia; however, the underlying pathogenic mechanism has not been clearly elucidated. This study provides novel evidence that TNFα leads to endothelial dysfunction associated with hypertension and vascular remodeling in preeclampsia through down-regulation of endothelial nitric-oxide synthase (eNOS) by NF-κB–dependent biogenesis of microRNA (miR)-31-5p, which targets eNOS mRNA. In this study, we found that miR-31-5p was up-regulated in sera from patients with preeclampsia and in human endothelial cells treated with TNFα. TNFα-mediated induction of miR-31-5p was blocked by an NF-κB inhibitor and NF-κB p65 knockdown but not by mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase inhibitors, indicating that NF-κB is essential for biogenesis of miR-31-5p. The treatment of human endothelial cells with TNFα or miR-31-5p mimics decreased endothelial nitric-oxide synthase (eNOS) mRNA stability without affecting <I>eNOS</I> promoter activity, resulting in inhibition of eNOS expression and NO/cGMP production through blocking of the functional activity of the eNOS mRNA 3′-UTR. Moreover, TNFα and miR-31-5p mimic evoked endothelial dysfunction associated with defects in angiogenesis, trophoblastic invasion, and vasorelaxation in an <I>ex vivo</I> cultured model of human placental arterial vessels, which are typical features of preeclampsia. These results suggest that NF-κB–responsive miR-31-5p elicits endothelial dysfunction, hypertension, and vascular remodeling via post-transcriptional down-regulation of eNOS and is a molecular risk factor in the pathogenesis and development of preeclampsia.</P>
Son, Suji,Lee, Jang Mee,Kim, Se-Jun,Kim, Hyejin,Jin, Xiaoyan,Wang, Kang Kyun,Kim, Minho,Hwang, Jeong Wook,Choi, Wonyong,Kim, Yong-Rok,Kim, Hyungjun,Hwang, Seong-Ju Elsevier BV 2019 Applied Catalysis B Vol.257 No.-
<P><B>Abstract</B></P> <P>Hybridization with conductive 2D nanosheets (NSs) attracts plenty of research activities because of its effectiveness for improving the photocatalyst performance of diverse semiconductors. Here, versatile roles of conductive NSs in hybrid-type photocatalysts are systematically investigated with three representative conductive 2D NSs to synthesize highly efficient visible light-active photocatalysts. Among several conductive NS-based nanohybrids, the RuO<SUB>2</SUB> NS-based nanohybrid exhibits the highest photocatalytic activities. Based on systematic spectroscopic analyses, polar RuO<SUB>2</SUB> NS appears to be more effective as electron reservoir, photosensitizer, cocatalyst and charge carrier pathway in hybrid-type photocatalyst than MoS<SUB>2</SUB> and graphene NSs. The high efficiency of RuO<SUB>2</SUB> NS as hybridization matrix is attributable to the high surface hydrophilicity, high surface bond polarity, and enhanced interfacial electronic coupling of this hydrophilic NS with semiconductor. The present study underscores that hydrophilic conductive metal oxide NS can act as the most efficient hybridization matrix for exploring high-performance photocatalysts with strong interfacial electronic coupling.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2D conductive nanosheets play versatile roles in hybrid-type photocatalysts. </LI> <LI> Hybridization with conductive nanosheet remarkably enhances photocatalyst activity. </LI> <LI> Interfacial electronic coupling is the most crucial factor for hybrid-type photocatalyst. </LI> <LI> Hydrophilic metal oxide nanosheet is the most efficient hybridization matrix. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Choi, Suji,Park, Jinkyung,Hyun, Wonji,Kim, Jangwon,Kim, Jaemin,Lee, Young Bum,Song, Changyeong,Hwang, Hye Jin,Kim, Ji Hoon,Hyeon, Taeghwan,Kim, Dae-Hyeong American Chemical Society 2015 ACS NANO Vol.9 No.6
<P>Thermal therapy is one of the most popular physiotherapies and it is particularly useful for treating joint injuries. Conventional devices adapted for thermal therapy including heat packs and wraps have often caused discomfort to their wearers because of their rigidity and heavy weight. In our study, we developed a soft, thin, and stretchable heater by using a nanocomposite of silver nanowires and a thermoplastic elastomer. A ligand exchange reaction enabled the formation of a highly conductive and homogeneous nanocomposite. By patterning the nanocomposite with serpentine-mesh structures, conformal lamination of devices on curvilinear joints and effective heat transfer even during motion were achieved. The combination of homogeneous conductive elastomer, stretchable design, and a custom-designed electronic band created a novel wearable system for long-term, continuous articular thermotherapy.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-6/acsnano.5b02790/production/images/medium/nn-2015-02790x_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b02790'>ACS Electronic Supporting Info</A></P>
김수지(Suji Kim),박완주(Wanjoo Park),기두찬(Du-Chan Ki),김병남(Byung-nam Kim),이종환(Jonghwan Lee),김래현(Laehyun Kim) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.6
Stroke is one of most common fatal diseases. It has heavy influence over the quality of life of patients and their careers due to accompanied impairment. Thus rehabilitation after stroke is important and brain-computer-interface (BCI) based on EEG (electroencephalography) can be an effective solution as it can provide quantitative analysis and neuro-feedback training. However, there are only a few studies about the correlation between the degree of motor impairment and ERS (event-related synchronization) after motor execution. In this paper, we investigated the differences in ERS patterns between healthy controls and stroke patients and between two patient groups with severe and mild motor impairments to look at the possibility of ERS as the assessment of feature to the degree of motor impairment. Based on the results, we proposed that ERS has a possibility as a measurement feature in BCI rehabilitation system.