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Prediction of Wear Depth Distribution by Slurry on a Pump Impeller
Sugiyama, Kenichi,Nagasaka, Hiroshi,Enomoto, Takeshi,Hattori, Shuji Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.1
Slurry wear with sand particles in rivers is a serious problem for pump operation. Therefore, a technique to predict wear volume loss is required for selecting wear resistant materials and determining specifications for the maintenance period. This paper reports a method for predicting the wear depth distribution on the blade of an impeller. Slurry wear tests of an aluminum pump impeller were conducted. Prediction results of wear depth distribution approximately correspond with the results of slurry wear tests. This technique is useful for industrial application.
Influence of Isoflavone Intake and Equol-producing Intestinal Flora on Prostate Cancer Risk
Sugiyama, Yukiko,Masumori, Naoya,Fukuta, Fumimasa,Yoneta, Akihiro,Hida, Tokimasa,Yamashita, Toshiharu,Minatoya, Machiko,Nagata, Yoshie,Mori, Mitsuru,Tsuji, Hirokazu,Akaza, Hideyuki,Tsukamoto, Taiji Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: The age-adjusted incidence rate of prostate cancer (PCa) has been reported to be lower among Asians than Western populations. A traditional Japanese meal, high in soybean products or isoflavones, may be associated with a decreased risk of PCa. Equol, which is converted from daidzein by human intestinal flora, is biologically more active than any other isoflavone aglycone. Materials and Methods: We reviewed not only recent epidemiological studies on association of isoflavones with PCa risk, but also recent research on human intestinal bacteria responsible for converting daidzein into equol. Studies were systematically searched from the database published within the last 5 years of from 2008-2012. Results: Five out of 6 articles showed significant association of isoflavones with a decreased risk of PCa, and two of them consistently showed that equol-producers carry a significantly reduced risk of PCa. Furthermore, 5 human intestinal bacteria that can convert daidzein into equol were identified in the last 5 years. Conclusions: If equol can reduce risk of PCa, a possible strategy for reducing the risk of PCa may be to increase the proportion of equol-producers by changing the intestinal flora to carrying an equol-producing bacterium with dietary alteration or probiotic technology.
SUGIYAMA, KOICHIRO,YONEKURA, YOSHINORI,MOTOGI, KAZUHITO,SAITO, YU,FUJISAWA, KENTA,ISHII, SHOTA,MOMOSE, MUNETAKE,HONMA, MAREKI,TAZAKI, FUMIE,TANAKA, KEI E.I.,HOSOKAWA, TAKASHI,UCHIYAMA, MIZUHO,INAYOSHI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
We have initiated single-dish monitoring observations of ~400 methanol maser sources at 6.7 GHz using the Hitachi 32-m radio telescope from December 2012 to systematically research periodic flux variations, which are observed in some methanol maser sources associated with high-mass (proto-)stars. In our monitoring, we have made daily monitoring, so that each source has been observed every nine days with an integration time of 5 min (typical $3{\sigma}$ detection sensitivities of 0.9 Jy). The monitoring observations help us statistically understand periodic flux variations with a period longer than 50 days. As an initial result, we present a new detection of periodic flux variations in the 6.7 GHz methanol maser source G 036.70+00.09. The period of the flux variations is ~53 days (~0.019 cycles $day^{-1}$), and seems to be stable over 9 cycles, at least until the middle of August 2014.
Photocurrent attenuation by a single polar-to-nonpolar point mutation of channelrhodopsin-2
Sugiyama, Yuka,Wang, Hongxia,Hikima, Takuya,Sato, Minami,Kuroda, Jun,Takahashi, Tetsuo,Ishizuka, Toru,Yawo, Hiromu Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.3
Channelrhodopsin-2 (ChR2), one of the algal light-gated cation channel rhodopsins, contains five peculiar glutamic acid residues in the N-terminal region corresponding to the second to third transmembrane helices. Here we made systematic mutations of these polar amino acid residues of ChR2 into nonpolar alanine, and evaluated their photocurrent properties. Amongst them, the photocurrent generated by the E97A mutation, ChR2(E97A), was much smaller than expected from its expression. The ChR2(E97A) photocurrent was similar to wild-type ChR2 in the kinetic profiles, the reversal potential and the dependency to the light power density. Our results suggest that the residue E97 is one of the molecular determinants involved in the ion flux regulation.
Sugiyama, Yukiko,Nagata, Yoshie,Fukuta, Fumimasa,Takayanagi, Akio,Masumori, Naoya,Tsukamoto, Taiji,Akasaka, Hiroshi,Ohnishi, Hirofumi,Saito, Shigeyuki,Miura, Tetsuji,Moriyama, Kaoru,Tsuji, Hirokazu,Ak Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: Isoflavones, which are included in soybeans, have been suggested to protect against prostate cancer. Equol, one of isoflavones, is an intestinally derived bacterial metabolite of daidzein. A newly identified equol-producing bacterium, Slackia sp. strain NATTS, with a high equol-producing activity was isolated from human feces in Japanese adults. Counts of Slackia sp. strain NATTS in intestinal flora have not been assessed with regard to prostate cancer risk. In this study, we investigated the association of serum isoflavones and counts of Slackia sp. strain NATTS with prostate cancer risk in a case-control study. Materials and Methods: Concentrations of isoflavones and counts of Slackia sp. strain NATTS in feces were measured from 44 patients with prostate cancer and 28 hospital controls. The risk of prostate cancer was evaluated in terms of odds ratios (ORs) and 95% confidence intervals (CIs) by the logistic regression analysis. Results: The detection proportions of Slackia sp. strain NATTS in cases and controls were 34.1% and 25.0%, respectively. Counts of Slackia sp. strain NATTS were significantly correlated with serum concentrations of equol both in cases and controls (Spearman correlation coefficients, $r_s$=0.639 and $r_s$=0.572, p<0.01, respectively). Serum concentrations of genistein, daidzein, glycitein, and equol were not significantly associated with risk of prostate cancer. Conclusions: This study found that counts of Slackia sp. strain NATTS correlated with serum concentrations of equol both in prostate cancer cases and controls, but serum isoflavone concentrations were not associated with risk of prostate cancer in our patients.
THE VLBI MONITORING PROJECT FOR 6.7 GHz METHANOL MASERS USING THE JVN/EAVN
SUGIYAMA, KOICHIRO,FUJISAWA, KENTA,HACHISUKA, KAZUYA,YONEKURA, YOSHINORI,MOTOGI, KAZUHITO,SAWADA-SATOH, SATOKO,MATSUMOTO, NAOKO,SAITO, YU,HIRANO, DAIKI,HAYASHI, KYONOSUKE,SHEN, ZHIQIANG,HONMA, MAREKI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
We have initiated a Very Long Baseline Interferometer (VLBI) monitoring project of 36 methanol maser sources at 6.7 GHz using the Japanese VLBI Network (JVN) and East-Asian VLBI Network (EAVN), starting in August 2010. The purpose of this project is to systematically reveal 3-dimensional (3-D) kine-matics of rotating disks around forming high-mass protostars. As an initial result, we present proper mo- tion detections for two methanol maser sources showing an elliptical spatial morphology, G 002.53+00.19 and G 006.79-00.25, which could be the best candidates associated with the disk. The detected proper motions indicate a simple rotation in G 002.53+00.19 and rotation with expansion in G 006.79-00.25, respectively, on the basis of disk model fits with rotating and expanding components. The expanding motions might be caused by the magnetic-centrifugal wind on the disk.
Sugiyama, Minetaka,Baek, Seong Yeol,Takashima, Shohei,Miyashita, Natsumi,Ishida, Kei,Mun, Jiyoung,Yeo, Soo-Hwan Elsevier 2018 Journal of bioscience and bioengineering Vol.126 No.6
<P>The yeast <I>Pichia kudriavzevii</I> N77-4 was isolated from the Korean traditional fermentation starter <I>nuruk</I>. In this study, fermentation performance and stress resistance ability of N77-4 was analyzed. N77-4 displayed superior thermotolerance (up to 44°C) in addition to enhanced acetic acid resistance compared to <I>Saccharomyces cerevisiae</I>. Moreover, N77-4 produced 7.4 g/L of ethanol with an overall production yield of 0.37 g/g glucose in 20 g/L glucose medium. However, in 250 g/L glucose medium the growth of N77-4 slowed down when the concentration of ethanol reached 14 g/L or more and ethanol production yield also decreased to 0.30 g/g glucose. An ethanol sensitivity test indicated that N77-4 was sensitive to the presence of 1% ethanol, which was not the case for <I>S. cerevisiae</I>. Furthermore, N77-4 displayed a severe growth defect in the presence of 6% ethanol. Because inositol biosynthesis is critical for ethanol resistance, expression levels of the <I>PkINO1</I> encoding a key enzyme for inositol biosynthesis was analyzed under ethanol stress conditions. We found that ethanol stress clearly repressed <I>PkINO1</I> expression in a dose-dependent manner and overexpression of <I>PkINO1</I> improved the growth of N77-4 by 19% in the presence of 6% ethanol. Furthermore, inositol supplementation also enhanced the growth by 13% under 6% ethanol condition. These findings indicate that preventing downregulation in <I>PkINO1</I> expression caused by ethanol stress improves ethanol resistance and enhances the utility of <I>P. kudriavzevii</I> N77-4 in brewing and fermentation biotechnology.</P>
Slenderness ratio of telescopic cylinder-columns
Sugiyama, Yoshihiko,Ohtomo, Takamitsu Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.12 No.3
The present paper deals with the effective slenderness ratio of telescopic cylinders as a long column having different cross sections. Firstly, the slenderness ratio defined in the current standard for the telescopic cylinders is discussed to point out some difficulties which arise when the ratio is applied to the column having different cross sections. Secondly, a new effective slenderness ratio is proposed for columns having different cross sections by introducing a partial effective slenderness ratio. Finally, the proposed slenderness ratio is applied, for extending and development of discussion, to a two-staged column having piece-wise constant cross sections and a cylindrical column having linearly varying diameters.