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      • Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant

        Seon-Kyung Park,Hwi-Soo Seol,Hee-Jin Park,Yoon-Seob Kim,Seung-Hun Ryu,Jaehoon Kim,Suejin Kim,Jong-Hyeon Lee,Jung-Hwan Kwon 환경독성보건학회 2020 환경독성보건학회지 Vol.35 No.2

        A mixture of 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT) had been used as an active ingredient in humidifier disinfectants (HDs). Owing to its high reactivity, the atmospheric concentration of CMIT/MIT, following its use in HD, would be lower than expected assuming that it is removed by ventilation only. In order to evaluate the exposure concentration of CMIT/MIT used as an HD, room-scale chamber studies were conducted under plausible use of three different HD doses at air change rates (ACR) of 0.3, 0.5, and 1.0 h<SUP>-1</SUP> . Atmospheric CMIT/MIT was sampled using two serial impingers containing deionized water after the attainment of steady state. Water samples in which CMIT/MIT was dissolved were concentrated using a cosolvent evaporation method with efficiencies of 35.5 and 77.9% for CMIT and MIT, respectively. The estimated air concentration, assuming that all the CMIT/MIT is absorbed in deionized water, increased linearly with increasing emission rate, but was independent of the ACR. This indicates that the removal rate of CMIT/MIT via chemical reactions is more than the removal rate by ventilation. Further investigations on homogeneous and heterogeneous chemical reactions of CMIT/MIT under ambient conditions are necessary to understand the actual exposure concentration of the mixture in HD.

      • SCISCIESCOPUS

        Neurodevelopment for the first three years following prenatal mobile phone use, radio frequency radiation and lead exposure

        Choi, Kyung-Hwa,Ha, Mina,Ha, Eun-Hee,Park, Hyesook,Kim, Yangho,Hong, Yun-Chul,Lee, Ae-Kyoung,Hwa Kwon, Jong,Choi, Hyung-Do,Kim, Nam,Kim, Suejin,Park, Choonghee Elsevier 2017 Environmental research Vol.156 No.-

        <P><B>Abstract</B></P> <P><B>Background</B></P> <P>Studies examining prenatal exposure to mobile phone use and its effect on child neurodevelopment show different results, according to child's developmental stages.</P> <P><B>Objectives</B></P> <P>To examine neurodevelopment in children up to 36 months of age, following prenatal mobile phone use and radiofrequency radiation (RFR) exposure, in relation to prenatal lead exposure.</P> <P><B>Methods</B></P> <P>We analyzed 1198 mother-child pairs from a prospective cohort study (the Mothers and Children's Environmental Health Study). Questionnaires were provided to pregnant women at ≤20 weeks of gestation to assess mobile phone call frequency and duration. A personal exposure meter (PEM) was used to measure RFR exposure for 24h in 210 pregnant women. Maternal blood lead level (BLL) was measured during pregnancy. Child neurodevelopment was assessed using the Korean version of the Bayley Scales of Infant Development-Revised at 6, 12, 24, and 36 months of age. Logistic regression analysis applied to groups classified by trajectory analysis showing neurodevelopmental patterns over time.</P> <P><B>Results</B></P> <P>The psychomotor development index (PDI) and the mental development index (MDI) at 6, 12, 24, and 36 months of age were not significantly associated with maternal mobile phone use during pregnancy. However, among children exposed to high maternal BLL <I>in utero</I>, there was a significantly increased risk of having a low PDI up to 36 months of age, in relation to an increasing average calling time (p-trend=0.008). There was also a risk of having decreasing MDI up to 36 months of age, in relation to an increasing average calling time or frequency during pregnancy (p-trend=0.05 and 0.007 for time and frequency, respectively). There was no significant association between child neurodevelopment and prenatal RFR exposure measured by PEM in all subjects or in groups stratified by maternal BLL during pregnancy.</P> <P><B>Conclusions</B></P> <P>We found no association between prenatal exposure to RFR and child neurodevelopment during the first three years of life; however, a potential combined effect of prenatal exposure to lead and mobile phone use was suggested.</P> <P><B>Highlights</B></P> <P> <UL> <LI> RFR exposure was measured by mobile phone use questionnaire and 24-h personal exposure meter among pregnant women. </LI> <LI> Child neurodevelopment was assessed by trained examiners at 6, 12, 24, and 36 months of age. </LI> <LI> Associations were not observed between prenatal exposure to RFR and child neurodevelopment during the first three years. </LI> <LI> A potential combined effect of prenatal exposure to lead and mobile phone use was suggested. </LI> </UL> </P>

      • SCIESCOPUSKCI등재

        Optimum Application Amount, Timing, and Frequency of Slurry Composted and Biofiltered Liquid Fertilizer for Zoysia japonica ‘Millock’

        Suejin Park,Seung Youn Lee,Ju Hyun Ryu,Hyun Hwan Jung,Ki Sun Kim 한국원예학회 2012 원예과학기술지 Vol.30 No.6

        In Korea, slurry composted and biofiltered (SCB) liquid fertilizer is produced through the composting and biofiltering of animal waste. An appropriate guidelines involving proper treatment of SCB liquid fertilizer on turfgrass should be considered. An experiment was conducted to determine the optimum application amount, timing, and frequency of SCB liquid fertilizer for Zoysia japonica ‘Millock’. The SCB liquid fertilizer was applied in low, medium, and high amount (N at 15, 25, and 40 g·8m<SUP>-2</SUP> per year in 2010, and 10, 20, and 40 g·m<SUP>-2</SUP> per year in 2011, respectively) and treated during the growing season or dormancy period. During the growing season, SCB liquid fertilizer was applied twice or four times. The greatest improvement in turf quality for both years was in SCB plots applied four times with N at 40 g·m<SUP>-2</SUP> per year during the growing season (SH4). This treatment exhibited turf color retention in the fall, and enhanced clipping yield during the growing and fall seasons. SCB plots with four times during the growing season (SL4, SM4, and SH4) exhibited higher shoot density relative to the same amount of other SCB treatments. Plots treated during the dormancy period also showed a high turf color index during the next growing season in 2011. The results indicate that SCB with high amount up to N at 40 g·m<SUP>-2</SUP> per year applied four times during the growing season and dormant application produced high turf quality and growth, and could be recommended as an optimum application guide.

      • SCIESCOPUSKCI등재

        Optimum Application Amount, Timing, and Frequency of Slurry Composted and Biofiltered Liquid Fertilizer for Zoysia japonica 'Millock'

        Park, Suejin,Lee, Seung Youn,Ryu, Ju Hyun,Jung, Hyun Hwan,Kim, Ki Sun Korean Society of Horticultural Science 2012 원예과학기술지 Vol.30 No.6

        In Korea, slurry composted and biofiltered (SCB) liquid fertilizer is produced through the composting and biofiltering of animal waste. An appropriate guidelines involving proper treatment of SCB liquid fertilizer on turfgrass should be considered. An experiment was conducted to determine the optimum application amount, timing, and frequency of SCB liquid fertilizer for Zoysia japonica 'Millock'. The SCB liquid fertilizer was applied in low, medium, and high amount (N at 15, 25, and 40 $g{\cdot}m^{-2}$ per year in 2010, and 10, 20, and 40 $g{\cdot}m^{-2}$ per year in 2011, respectively) and treated during the growing season or dormancy period. During the growing season, SCB liquid fertilizer was applied twice or four times. The greatest improvement in turf quality for both years was in SCB plots applied four times with N at 40 $g{\cdot}m^{-2}$ per year during the growing season (SH4). This treatment exhibited turf color retention in the fall, and enhanced clipping yield during the growing and fall seasons. SCB plots with four times during the growing season (SL4, SM4, and SH4) exhibited higher shoot density relative to the same amount of other SCB treatments. Plots treated during the dormancy period also showed a high turf color index during the next growing season in 2011. The results indicate that SCB with high amount up to N at 40 $g{\cdot}m^{-2}$ per year applied four times during the growing season and dormant application produced high turf quality and growth, and could be recommended as an optimum application guide.

      • Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012–2014)

        Choi, Wookhee,Kim, Suejin,Baek, Yong-Wook,Choi, Kyungho,Lee, Keejae,Kim, Sungkyoon,Yu, Seung Do,Choi, Kyunghee Elsevier 2017 International journal of hygiene and environmental Vol.220 No.2

        <P><B>Abstract</B></P> <P>National biomonitoring program can offer solid scientific evidence on exposure profiles of environmental chemicals at a national level, and provide a snapshot of changing exposure level over time. Therefore, several countries have maintained such programs for developing environmental health policies. The Korean National Environmental Health Survey (KoNEHS) was designed to understand the level of human exposure to environmental chemicals by time and location, and to identify possible sources of such exposure. The 2nd stage of KoNEHS, which was conducted between 2012 and 2014, examined a total of 6478 adult subjects over 19 years of age, and measured 21 environmental chemicals of major policy concern. Compared to the findings from the first stage monitoring (2009–2011), slightly higher levels of blood lead were observed, while those of mercury remained similar. Blood metal concentrations, however, were higher than those reported from national biomonitoring programs of United States, Germany and Canada. The urinary concentrations of phthalates metabolites were lower, but those of t,t-muconic acid and BPA were higher than those reported in the first stage survey. The urinary cotinine level decreased perhaps reflecting general declining patterns of first- and second-hand smoking. The results of the second stage survey were made available for public use since April 2016.</P> <P>Some policy efforts appear to be at least in part effective on mitigating chemical exposure among people, e.g., urinary phthalate metabolites and cotinine, while further confirmations are warranted. In-depth assessments will be conducted to identify vulnerable groups and important exposure pathways.</P>

      • SCISCIESCOPUS

        Associations between urinary phthalate metabolites and bisphenol A levels, and serum thyroid hormones among the Korean adult population - Korean National Environmental Health Survey (KoNEHS) 2012–2014

        Park, Choonghee,Choi, Wookhee,Hwang, Moonyoung,Lee, Youngmee,Kim, Suejin,Yu, Seungdo,Lee, Inae,Paek, Domyung,Choi, Kyungho Elsevier BV 2017 Science of the Total Environment Vol.584 No.-

        <P><B>Abstract</B></P> <P><B>Background</B></P> <P>Phthalates and bisphenol A (BPA) have been used extensively in many consumer products, resulting in widespread exposure in the general population. Studies have suggested associations between exposure to phthalates and BPA, and serum thyroid hormone levels, but confirmation on larger human populations is warranted.</P> <P><B>Methods</B></P> <P>Data obtained from nationally representative Korean adults (n=6003) recruited for the second round of the Korean National Environmental Health Survey (KoNEHS), 2012–2014, were employed. Three di-(2-ethylhexyl) phthalate (DEHP) metabolites, along with benzyl-butyl phthalate (BBzP) and di-butyl phthalate (DBP) metabolites, and BPA were measured in subjects' urine. Thyroxine (T4), total triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were measured in serum. The associations between urinary phthalates or BPA and thyroid hormone levels were determined.</P> <P><B>Results</B></P> <P>Urinary phthalate metabolites were generally associated with lowered total T4 or T3, or increased TSH levels in serum. Interquartile range (IQR) increases of mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were associated with a 3.7% increase of TSH, and a 1.7% decrease of total T4 levels, respectively. When grouped by sex, urinary MEHHP levels were inversely associated with T4 only among males. Among females, mono-benzyl phthalate (MBzP) and mono-<I>n</I>-butyl phthalate (MnBP) levels were inversely associated with TSH and T3, respectively. In addition, negative association between BPA and TSH was observed.</P> <P><B>Conclusions</B></P> <P>Several phthalates and BPA exposures were associated with altered circulatory thyroid hormone levels among general Korean adult population. Considering the importance of thyroid hormones, public health implications of such alteration warrant further studies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phthalates and bisphenol A were associated with thyroid hormones in Korean adults. </LI> <LI> DEHP metabolites were positively associated with TSH but negatively with total T4. </LI> <LI> Negative associations were found between BPA and TSH, and MnBP and total T3. </LI> <LI> Consequences of thyroid disruption warrant further investigations. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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