High‑Temperature Deformation Behavior of MnS in 1215MS Steel

Fei‑Ya Huang,Yen‑Hao Frank Su,Jui‑Chao Kuo 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.6

The effect of manganese sulfide (MnS) inclusions on the machinability of free-cutting steel is based on their morphology,size and distribution. Furthermore, the plasticity of MnS is high during the hot working caused different characterizationof MnS. In this study, the deformation behavior of MnS in 1215MS steel after a thermomechanical process was investigatedat 1323 K. The microstructures of MnS inclusions were characterized by optical microscopy, scanning electronmicroscopy, energy-dispersive spectrometry, and electron backscattering diffraction (EBSD). As the thickness reductionof the inclusions increased from 10 to 70%, their average aspect ratio increased from 1.20 to 2.39. In addition, the deformabilityof MnS inclusions was lower than that of the matrix. The possible slip systems of A, B, C, and D plane traces werē10̄1̄101 , 10̄ 1 [101], (011) 01̄ 1 , and (110) 1̄10 . Furthermore, the EBSD measurements suggested that slip planes inMnS inclusions occur on {110} planes.

Relationships between Perceived Stresses, Coping Styles, and Depression in College Nursing Students

Su-Fei Huang,I-Ling Huang 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

Study on maximizing catalytic performance of cobalt(II) 5,10,15, 20-tetrakis(4-pyridyl)porphyrin for cyclohexane oxidation

Xian-Fei Huang,Guang-Ping Yuan,Guan Huang,Su-Juan Wei 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-

Aiming at the most enhancing the catalytic performance of simple and cheap cobalt(II) 5,10,15,20-tetrakis(4-pyridyl)porphyrin (Co TPyP), guided by the nowadays-advanced various technologies, Co TPyP wasanchored onto nanoporous bar with thiol-functionalized silica (npb-SiO2-SH). The resulting npb-SiO2-SCoTPyP catalyst was characterized using various techniques, determining its structure. The total surfacearea ratios (TSAR) of the immobilized cobalt porphyrin to the npb-SiO2-SH, and the catalytic cyclohexaneoxidation reaction conditions were at the same time optimized via Response Surface Methodology(RSM). Compared with those obtained from traditional optimizing method (TOM), on average, RSM couldenhance as high as more than 60% catalyst turnover frequency (TOF) and yields of cyclohexanone andcyclohexanol (KA oil). The anchored 0.05 mg Co TPyP could catalyze the oxidation of 200 mL ofcyclohexane, under not using any solvents and additives, offering 2.5106 1/h of TOF, and 19% of yields. The npb-SiO2-S (20%-0.0438)-Co TPyP catalyst showed better reusability, excellent catalytic

RNAi-Mediated Gene Silencing of Trcot1 Induces a Hyperbranching Phenotype in Trichoderma reesei

Fei Gao,Mengzhu Li,Weiquan Liu,Yingguo Bai,Tu Tao,Yuan Wang,Jie Zhang,Huiying Luo,Bin Yao,Huoqing Huang,Xiaoyun Su 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.2

Trichoderma reesei is the major filamentous fungus used to produce cellulase and there is huge interest in promoting its ability to produce higher titers of cellulase. Among the many factors affecting cellulase production in T. reesei, the mycelial phenotype is important but seldom studied. Herein, a close homolog of the Neurospora crassa COT1 kinase was discovered in T. reesei and designated TrCOT1, which is of 83.3% amino acid sequence identity. Functional disruption of Trcot1 in T. reesei by RNAi-mediated gene silencing resulted in retarded sporulation on potato dextrose agar and dwarfed colonies on minimal medium agar plates containing glucose, xylan, lactose, xylose, or glycerol as the sole carbon source. The representative mutant strain, SUS2/Trcot1i, also displayed reduced mycelia accumulation but hyperbranching in the MM glucose liquid medium, with hyphal growth unit length values decreased to 73.0 μm/tip compared to 239.8 μm/tip for the parent strain SUS2. The hyperbranching phenotype led to slightly but significantly increased cellulase secretion from 24 to 72 h in a batch culture. However, the cellulase production per unit of mycelial biomass was much more profoundly improved from 24 to 96 h.

Proactive Consultation by a Clinical Pathologist Prevents Diagnostic Delay in Hematological Malignancies

Chang, Chih-Chun,Su, Ming-Jang,Ho, Jung-Li,Sun, Jen-Tang,Tsai, Huang-Wen,Tang, Hui-Fei,Chu, Fang-Yeh Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3

Background: Diagnostic difficulties in hematological malignancies may lead to unacceptably prolonged help-seeking to diagnostic interval as well as increased complications and poor outcomes. Proactive consultation by a clinical pathologist (PCCP) may help clinical diagnosis and therapeutic strategy. Hence, the aim of this investigation was to evaluate the effect of PCCP on the help-seeking to diagnostic interval in hematological cancer cases. Materials and Methods: From January to November, 2015, abnormal results of hematological laboratory testing with added laboratory comment were selectively screened out, and patients with such abnormalities in hematological laboratory testing and accompanied laboratory comment with PCCP were enrolled. Results: A total of 125 aberrant results of hematological laboratory testing were given with accompanied laboratory comments with PCCP and 40.8% (n=51) of these patient-oriented comments had an effect on clinical diagnosis and therapeutic strategy. Twelve of the subjects belonged to newly diagnosed hematological malignancies with the assistance of PCCP, and the help-seeking to diagnostic interval was also shortened from 42 days to 26 days in chronic lymphoid leukemia (CLL), from 83 days to 11 days in multiple myeloma (MM), and from 128 days to 15 days in myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN). During the monitoring interval, neither complication events nor deaths were reported in the study group. Conclusions: It was seemingly that PCCP prevented diagnostic delay in hematological malignancies via shortening the help-seeking to diagnostic interval, particularly in CLL, MM and MDS/MPN cases. PCCP can be considered to play an essential role in prompt establishment of diagnosis in hematological malignancies for those who newly present.

Upregulation and Clinicopathological Significance of Long Non-coding NEAT1 RNA in NSCLC Tissues

Pan, Lin-Jiang,Zhong, Teng-Fei,Tang, Rui-Xue,Li, Ping,Dang, Yi-Wu,Huang, Su-Ning,Chen, Gang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: Recent reports have shown that nuclear enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), contributes to the precise control of gene expression and is related to several human malignancies. However, limited data are available on the expression and function of NEAT1 in lung cancer. The major objective of the current study was to profile the expression and clinicopathological significance of NEAT1 in non-small cell lung cancers (NSCLCs). Materials and Methods: NEAT1 expression in 125 NSCLC cases and paired adjacent non-cancer tissues was assessed by real-time quantitative reverse transcription-PCR (qRT-PCR). Relationships between NEAT1 and clinicopathological factors were also investigated. Results: The relative level of NEAT1 was $6.98{\pm}3.74$ in NSCLC tissues, significantly elevated as compared to that of the adjacent non-cancer lung tissues ($4.83{\pm}2.98$, p<0.001). The area under curve (AUC) of high expression of NEAT1 to diagnose NSCLC was 0.684 (95% CI: 0.619~0.750, p<0.001). NEAT1 expression was positively correlated with patient age (r=-2.007, p=0.047), lymphatic metastasis (r=-2.731, p=0.007), vascular invasion (r=-3.617, p=0.001) and clinical TNM stage (r=-4.134, p<0.001). Conclusions: This study indicates that NEAT1 might be associated with oncogenesis and progression in NSCLC, and suggests application in molecular targeted therapy.

Meta-Analysis of the Diagnostic Efficacy of the Luminex xTAG Respiratory Viral Panel FAST v2 Assay for Respiratory Viral Infections

Xu-Guang Guo,Li-Min Xie,Xin Yin,Tian-Ao Xie,Jian-Wen Su,Qin Huang,Jing-Hao Zhang,Yin-Fei Huang 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.1

Purpose: Acute respiratory viral infections pose significant morbidity and mortality, making it essential to diagnose respiratory viral infections rapidly. In this study, the diagnostic efficacy of the Luminex xTAG Respiratory Virus Panel (RVP) FAST v2 test was evaluated on respiratory viral infections. Materials and Methods: Information was retrieved from electronic databases, including Embase, Web of Science, PubMed, and Cochrane Library, for systematic review. Studies that fulfilled predefined inclusion criteria were included. After the extraction of information, statistical software was utilized for quality evaluation, data analysis, and assessment of publication bias. Results: Eighty groups in fourfold tables from nine articles were included to perform statistical analyses. Therein, the mean specificity and mean sensitivity of Luminex xTAG RVP FAST v2 test for the detection of respiratory viral infections were 0.99 (0.98–0.99) and 0.88 (0.87–0.90), respectively. Additionally, the negative and positive likelihood ratios were 0.14 (0.11–0.19) and 87.42 (61.88–123.50), respectively. Moreover, the diagnostic odds ratio and area under the curve of summary receiver operating characteristic were 714.80 and 0.9886, respectively. Conclusion: The Luminex xTAG RVP FAST v2 test could be a reliable and rapid diagnostic method for multiple respiratory viral infections.