전산화단층상을 이용한 안면골의 3차원재구성상의 비교연구

송남규,고광준 大韓口腔顎顔面 放射線學會 1992 Imaging Science in Dentistry Vol.22 No.2

The purpose of this study was to evaluate the spatial relationship of facial bone more accurately. For this study, the three-dimensional images of dry skull were reconstructed using computer image analysis system and three-dimensional reconstructive program involved CT. The obtained results were as follows ; 1. Three-dimensional reconstructive CT results in images that have better resolution and more contrast. 2. It showed good marginal images of anatomical structure on both three-dimensional CT and computer image analysis system. but the roof of orbit, the lacrimal bone and the squamous portion of temporal bone were hardly detectable. 3. The partial loss of image date were observed during the regeneration of saved image data on three-dimensional CT. 4. It saved the more time for reconstruction of three-dimensional images using computer image analysis system. But, the capacity of hardware was limited for imputting of image data and three-dimensional reconstructive process. 5. We could observe the spatial relationship between the region of interest and the surrounding structures by three-dimensional reconstructive images without invasive method.

경계강조 보간법을 이용한 디지탈방사선사진상의 개선에 관한 연구

송남규,고광준 大韓口腔顎顔面 放射線學會 1998 Imaging Science in Dentistry Vol.28 No.1

The purpose of this study was to aid in the use of the digital images by edge-detect interpolation for direct digital periapical images using edge-detect interpolation . This study was performed by image processing of 20 digital periapical images; pixel replication, linear non-interpolation, linear interpolation, and edge-sensitive interpolation. The obtained results were as follows: 1. Pixel replication showed blocking artifact and serious image distortion. 2. Linear interpolation showed smoothing effect on the edge. 3. Edge-sensitive interpolation overcame the smoothing effect on the edge and showed better image.

악교정 수술 후 하악과두의 위치 및 골변화에 관한 단층방사선학적 연구

송남규,김민숙,고광준 全北大學校 齒醫學硏究所 1992 전북치대논문집 Vol.10 No.1

The purpose of this study was to aid in the evaluation of prognosis of temporomandibular joint following orthognathic surgery. For this study, 20 patients(40 TMJ) who had undergone orthognathic surgery were examined. Preoperative and postoperative tomograms of TMJ were taken. And the subjects were divided into 3 groups according to postoperative periods. The results were as follows ; 1. There were no significant differences between preoperative and postoperative changes in joint spaces in each group and between groups(P<0.05). 2. There were no significant differences between preoperative and postoperative ratio of joint space(P<0.05). 3. There were no significant differences between preoperative and postoperative changes in the range of motion of condylar head(P<0.05). 4. The bony changes of condylar head were observed in 14(35% ) condyles(6 erosion, 2 flattening, 5 double contour, 1 osteophyte).

전산화단층상을 이용한 안면골의 3차원재구성상의 비교 연구

송남규,김민숙,고광준 全北大學校 齒醫學硏究所 1992 전북치대논문집 Vol.10 No.1

The purpose of this study was to evaluate the spatial relationship of facial bone more accurately. For this study, the three-dimensional images of dry skull were reconstructed using computer image analysis system and three-dimensional reconstructive program involved CT. The obtained results were as follows : 1. Three-dimensional reconstructive CT results in images that have better resolution and more contrast. 2. It showed good marginal images of anatomical structure on both three-dimensional CT and computer image analysis system, but the roof of orbit, the lacrimal bone and the squamous portion of temporal bone were hardly detectable. 3. The partial loss of image data were observed during the regeneration of saved image data on three-dimensional CT. 4. It saved the more time for reconstruction of three-dimensional images using computer image analysis system. But, the capacity of hardware was limited for inputting of image data and three-dimensional reconstructive process. 5. We could observe the spatial relationship between the region of interest and the surrounding structures by three-dimensional reconstructive images without invasive method.

악교정 수술 후 하악과두의 위치 및 골변화에 관한 단층방사선학적 연구

송남규,고광준,김민숙 大韓口腔顎顔面 放射線學會 1992 Imaging Science in Dentistry Vol.22 No.2

The purpose of this study was to aid in the evaluation of prognosis of temporomandibular joint following orthognathic surgery. For this study, 20 patients(40 TMJ) who undergone orthognathic surgery were examined. Preoperative and postoperative tomograms of TMJ were taken. And the subjects were divided into 3 groups according to postoperative periods. The obtained results were as follows ; 1. There were no significant differences between preoperative and postoperative changes in joint spaces in each group and between groups(p<0.05). 2. There were no significant differences between preoperative and postoperative ratio of joint space(p<0.05). 3. There were no significant differences between preoperative and postoperative changes in the range of motion of condylar head(p<0.05). 4. The bony changes of condylar head were observed in 14(35%) condyles(6 erosion, 2 flattening, 5 double contour, 1 osteophyte).

우리 나라 都市와 農村地方의 母乳授乳 實態에 關한 調査硏究 : 全南地方을 中心으로

文松洙,具光鍊,金成宜,韓圭炯,羅昌洙 朝鮮大學校 附設 醫學硏究所 1983 The Medical Journal of Chosun University Vol.8 No.1

Human milk is the best source of nutrients for the human infant, and its nutritional and immunologic benefits are now established, In spite of these advantages, the incidence and duration of breast feeding- is decreasing in many part of the world. The purpose of the study is to collect the data on breast feeding practice in rural and urban area of Chullanamdo, Korea and to follow the trend toward breast feeding in fuutre. Between July 1981 and January 1982, 674 mothers with the children under 2 years of age have been interviewed at Out-Patient Department. The breast feeding situation at the time of interviewed was recorded. The percentage of wholly breast-fed in the age group of 0~1, 1-2, 2~3 ,3~4, 4~5, 5~6, 6-12 and 12~24 months were 61.8%, 50.0%, 51.6%, 65.2%, 50.0%, 45.7%, 23.0% and 17.3% respectively. And the percentage of partially breast-fed in the age group of 0~1, 1~2, 2~3, 3~4, 4~5, 5~6, 6~12, and 12~24 months were 29.4%, 33.3%, 25.8%, 17.4%, 34.2%, 39.1%, 8.6% and 80.0% respectively, In the incidence of wholly breast feeding, there was no correlation between deliveries in hospital and deliveries at home attended by midwives or traditional midwives. The most frequent reasons for partially breast-fed in the age group of 0~1, 1~2, 2~3, and 3~4 months were not enough breast milk.

하악골에 발생된 법랑모치아종

고광준,송남규,하쌍용 大韓口腔顎顔面放射線學會 1996 Imaging Science in Dentistry Vol.26 No.2

Ameloblastic ldontoma is a mixed odontogenic tumor, which is characterized as being extremely rate, displaying aggressive clinical behavior, resembling a mixed radiopaque and radiolucent radiographic appearance and containing both ameloblastoma and a composite odontoma. Seven-year-old boy complaining of delayed eruption of the left lower permanent 1st molar came to the department of Oral & Maxillofacial Radiology at Chonbuk National University Hospital. The list of our radiographic differential diagnosis included the dental follicle, compound odontoma, complex odontoma and cystic odontoma. The microscopic analysis showed the lesion with the characteristics of and ameloblastic odontoma. The obtained results were as follows; 1. The area was asymptomatic, but the delayed eruption of the left lower permanent lst molar was observed. 2. Radiographically, well-defined widened pericoronal radiolucency containing several tooth-like radiopacities involving the impacted left lower permanent lst molar and well-defined round radiolucency containing irregular radiopaque mass were observed. 3. Histopathologically, several tooth-like structures, odontoma components with the area of typical enamel, dentin and pulp, and ameloblastic components with typical follicular ameloblastoma were observed.

In vitro 방법에 의한 천연물의 지용성분 중 면역활성제 개발 연구

李廣鎬,宋泯東,朴台奎,李承珏 建國大學校 自然科學硏究所 1994 建國自然科學硏究誌 Vol.5 No.1

To develope activating agents of immune system from natural products, we focused on the activation of T and macrophage cells. We chose 35 kinds of candidates to do this. We used in vitro method such as Fetal Thymic Organ Culture(FTOC) system and bacterial phagocytic method to do test the inducing ability for T cell activation and phagocytosis of peritoneal macrophages. The results obtained from above way are as follows: Atractylis Rhizoma, Japanese touchwood and Astragali Radix showed T cell activating effect, particullary Astragali Radix is affecting most strongly between these 3 samples. Wherease Polyporus and corni Fructus which is known to be T cell activator are affecting on the decrease of fetal thymic T cells. Malvae Semer used as negative control showed predicted results. From the flow cytometric analysis, the results from Atractylis Rhizoma, Japanese Touchwood. Astragali Radix, Polyporus and Corni Fructus showed large population of CD4 positive helper T cells. Malvae Semer affect on the increasing of CD8 positive T cells, as opposed to the samples known to be T cell activating agents. From the analysis of phagocytic activityof peritoneal macrophage cells, Angelicae Gigantis Radix, Polyporus and Codonopsi Radix showed the increasing effect on phagocytic activity. Codonopsi Radix is particullary affecting most powerfully. Phellodendri Cortex which is known to be the activating agent on macrophage showed negative effect.

응집과 응결에 대한 이론적 고찰

박광하,김한수,정강연,송인규,권영두 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

일반적으로 수중에 존재하는 콜로이드 입자와 용존성 오염물질은 수중에서 안정한 분산상태를 유지하여 침전이나 여과와 같은 물리적 처리로는 제거할 수 없다. 이와 같은 크기의 입자를 효율적으로 제거하기 위한 고·액분리 공정으로 응집은 수처리에서 널리 사용되는 단위공정이다. 특히 응집은 산업폐수처리에서 입자성과 용존성 물질을 제거하여 유용한 금속성분을 회수하기도 하기에 중요한 공정이라고 할 수 있다. 콜로이드 입자의 응집은 두 입자 사이의 전기적 반발력과 van der Waals힘에 의한 인력사이의 에너지 장벽을 극복할 수 있는 충분한 운동에너지를 가해 주거나, 입자표면의 반대전하를 가진 응집제를 가하여 표면전하를 중화시키거나, 전해질을 첨가하여 입자간의 반발력을 감소시켜 에너지 장벽을 낮춤으로서 이루어진다. 수처리에서 응집공정을 효과적으로 운영하기 위해 적절한 응집제를 선택하고 최적 응집제 주입량을 적용하여 요구되는 수질기준을 향상시켜야 한다. 또한 응집공정은 수처리 시스템의 전체 공정을 경제적으로 설계하는데 중요한 역할을 하리라 생각된다.

Fluoroquinolone계 항균제의 penicillin 내성 폐렴구균(Streptococcus pneumoniae)에 대한 항균력 비교

이광준,배송미,황규잠,이영희,김기상 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.3

목적 : 최근들어 penicillin 내성 폐렴구균의 급속한 증가와 전세계로의 확산은 심각한 문제를 야기하고 있다. 1990년대 들어 그람음성 세균뿐 아니라 그람 양성 세균에 대한 항균력이 향상된 많은 fluoroquinolones계 항균제의 개발에 힘입어 폐렴구균성 감염질환 치료시 사용이 증대되고 있으며 한편, 이와 더불어 이미 fluoroquinolone계 항균제에 대한 내성을 보이는 폐렴구균에 대한 보고가 증가하고 있는 실정이다. 이에 본 실험에서는 국내 임상 분리 폐렴구균 중 penicillin에 고도내성을 보이는 균주를 대상으로 하여 fluoroquinolones계 항균제에 대한 감수성 여부를 확인하고자 하였다. 방법 : 항균제 감수성 검사는 3% 말혈액이 첨가된 Mueller-Hinton broth를 사용한 액체배지 미량희석법을 이용하여 NCCLS에서 제시한 방법에 준하여 실시하였다. 결과 : MIC_90를 기준으로 하였을 때 본 실험에서 사용한 5가지의 fluoroquinolones계 한균제 중 gatifloxacin과 moxifloxacin(MIC_90, 0.5㎍/㎖)이 ciprofloxacin (MIC_90, 4㎍/㎖), levofloxacin (mic_90, 2㎍/㎖) sparfloxacin (MIC_90, 1㎍/㎖)에 비해 penicillin 내성 폐렴구균에 대한 항균력이 높게 나타났다. 결론 : 5가지의 fluoroquinolones계 항생제 중 최근들어 새로이 개발된 항생제인 moxifloxacin과 gatifloxacin이 ciprofloxacin, levofloxacin, sparfloxacin보다 폐렴구균에 대한 더 우수한 항균력을 가지고 있음을 확인하였다. 한편, 국내 페니실링 고도 내성 폐렴구균에서 fluoroquinolones에 대한 고도 내성을 보이는 균주의 출현은 fluoroquinolones 내성 균주의 급속한 증가와 확산에 대한 지속적인 감시와 대책 마련이 요구된다. Background : Recently the rapid increase and global spread of penicillin-resistant S. pneumoniae has become a serious problem. In the 1990s, a varisty of novel fluoroquinolones with enhanced activity against gram-positive bacteria have been developed and used for the treatment of pneumococcal infections. In such situations, the fluoroquinolone-resistance in S. pneumonaie has been reported from many countries. In this study, we compared the activity of ciprofloxacin, levofloxacin, sparfloxacin, gatifloxacin and moxifloxacin against 93 isolates of S. pneumoniae which were highly- resistant to penicillin (MIC 2~8㎍/㎖). methods : Antimicrobial susceptibilities were determined by the broth microdilution method in cation-adjusted Muller-Hinton broth supplemented with 3% lysed horse blood according to the guidelines of the National Committee for Laboratory Standards (NCCLS). Results : Based on MIC_90s, sparfloxacin and moxifloxacin were the most potent fluoroquinolone tested against penicillin-resistant S. pneumoniae and retained excellent activity comparable with ciprofloxacin and levofloxacin. The rank order of bactericidal activity was ciprofloxacin (least active)《 levofloxacin 〈 sparfloxacin 〈 gatifloxacin and moxifloxacin (most active). Conclusion : In this study, the newer fluoroquinolones (moxifloxacin, sparfloxacin)showed improved activity over that observed with ciprofloxacin, levofloxacin, and sparfloxacin. The emergence of highly resistance to fluoroquinolones among penicillin-resistant pneumococci in Korea call for continuous attention and strategies to prevent rapid increase and spread of these strains.