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Sohee Cheon,Won Woo Lee,Won Il Park,Joo-Yun Jung,Jun-hyuk Choi,Dae-geun Choi,Sohee Jeon,Jun-ho Jeong,Jihye Lee 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.81 No.-
Vertically aligned ZnO nanorods have been widely investigated for use in piezoelectric generators,photovoltaic devices, nanotemplates, photoelectrochemical applications, etc. In addition to verticalalignment, intentional arrangement of ZnO nanorods according to a careful design can enhance thedevice performance. In this work, we used metal nanotransfer printing to fabricate arrangement-controlled and vertically grown ZnO nanorods on both hard andflexible substrates. Highly verticalgrowth and periodical arrangement of the ZnO nanorods were confirmed by microscope images. Theircrystallinity and photoluminescence characteristics were also investigated. Transmission spectra of thesubstrates show the enhancement of optical transmission after the nanorod growth. We believe that thisfabrication technique lends itself to simple fabrication of arrangement-controlled and vertically grownone-dimensional nanostructures on both hard andflexible substrates for application in solar cells, watersplitting, metamaterials, etc.
Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-κB and MAP Kinase
Jung Eun Lee,Soo-Muk Cho,Eunkyo Park,Seung Min Lee,Yuri Kim,Joong Hyuck Auh,Hyung-Kyoon Choi,Sohee Lim,Sung Chul Lee,Jung-Hyun Kim 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.5
BACKGROUND/OBJECTIVES: Rubus Coreanus Miquel (RCM), used as a traditional Korean medicine, reduces chronic inflammatory diseases such as cancer and rheumatoid arthritis. However, its mechanism has not been elucidated. In this study, we examine the anti-inflammatory effects of RCM and their possible mechanisms using RAW 264.7 cells. MATERIALS/METHODS: Unripe RCM ethanol extract (UE), unripe RCM water extract (UH), ripe RCM ethanol extract (RE), and ripe RCM water extract (RH) were prepared. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (iNOS, COX-2, TNF-α, IL-1β, and IL-6) and NO and PGE2 productions were assessed. To determine the anti-inflammatory mechanism of RCM, we measured NF-κB and MAPK activities. RESULTS: UE and UH treatment significantly reduced NF-κB activation and JNK and p38 phosphorylation and reduced transcriptional activities decreased iNOS, COX-2, and pro-inflammatory cytokines expressions, and NO and PGE2 productions. RE and RH treatments reduced IL-1β and IL-6 expressions through suppressions of JNK and p38 phosphorylation. CONCLUSIONS: In this study, we showed that RCM had anti-inflammatory effects by suppression of pro-inflammatory mediator expressions. Especially, unripe RCM showed strong anti-inflammatory effects through suppression of NF-κB and MAPK activation. These findings suggest that unripe RCM might be used as a potential functional material to reduce chronic inflammatory responses.
Transformative Two-Dimensional Layered Nanocrystals
Jeong, Sohee,Han, Jae Hyo,Jang, Jung-tak,Seo, Jung-wook,Kim, Jin-Gyu,Cheon, Jinwoo American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.37
<P>Regioselective chemical reactions and structural transformations of two-dimensional (2D) layered transition-metal chalcogenide (TMC) nanocrystals are described. Upon exposure of 2D TiS<SUB>2</SUB> nanodiscs to a chemical stimulus, such as Cu ion, selective chemical reaction begins to occur at the peripheral edges. This edge reaction is followed by ion diffusion, which is facilitated by interlayer nanochannels and leads to the formation of a heteroepitaxial TiS<SUB>2</SUB>–Cu<SUB>2</SUB>S intermediate. These processes eventually result in the generation of a single-crystalline, double-convex toroidal Cu<SUB>2</SUB>S nanostructure. Such 2D regioselective chemical reactions also take place when other ionic reactants are used. The observations made and chemical principles uncovered in this effort indicate that a general approach exists for building various toroidal nanocrystals of substances such as Ag<SUB>2</SUB>S, MnS, and CdS.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-37/ja2049594/production/images/medium/ja-2011-049594_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja2049594'>ACS Electronic Supporting Info</A></P>
Sohee Cha,Kwangheon Park,Jeongyeon Lee,Ranyeong Choi,Seol Kim,Hogyu Yi,Jong-Pil Jung,Jae Hak Cheong,Sangjoon Ahn,Won Pyo Jeong,Seungyeon Choi 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
To address the pressing societal concern in Korea, characterized by the imminent saturation of spent nuclear fuel storage, this study was undertaken to validate the fundamental reprocessing process capable of substantially mitigating the accumulation of spent nuclear fuel. Reprocessing is divided into dry processing (pyro-processing) and wet reprocessing (PUREX). Within this context, the primary focus of this research is to elucidate the foundational principles of PUREX (Plutonium Uranium Redox Extraction). Specifically, the central objective is to elucidate the interaction between uranium (U) and plutonium (Pu) utilizing an organic phase consisting of tributyl phosphate (TBP) and dodecane. The objective was to comprehensively understand the role of HNO3 in the PUREX (Plutonium Uranium Redox Extraction) process by subjecting organic phases mixed with TBPdodecane to various HNO3 concentrations (0.1 M, 1.0 M, 5.0 M). Subsequently, the introduction of Strontium (Sr-85) and Europium (Eu-152) stock solutions was carried out to simulate the presence of fission products typically contented in the spent nuclear fuel. When the operation proceeds, the complex structure takes the following form. ??? ??(??) + 2??? ?(??) + 2???(???) ↔ ???(???)? ? 2???(???) Subsequently, separate samples were gathered from both the organic and aqueous phases for the quantification of gamma-rays and alpha particles. Alpha particle measurements were conducted utilizing the Liquid Scintillation Counter (LSC) system, while gamma-ray measurements were carried out using the High-Purity Germanium Detector (HPGe). The distribution ratio for U, Eu (Eu-152), and Sr (Sr-84) was ascertained by quantifying their activity through LSC and HPGe. Through the experiments conducted within this program, we have gained a comprehensive understanding of the selective solvent extraction of actinides. Specifically, uranium has been effectively separated from the aqueous phase into the organic phase using a combination of tributyl phosphate (TBP) and dodecane. Subsequently, samples containing U(VI), Eu(III), and Sr(II) underwent thorough analysis utilizing LSC and HPGe detectors. Our radiation measurements have firmly established that the concentration of nitric acid enhances the selective separation of uranium within the process.
Jung, Sung A.,Choi, Miseon,Kim, Sohee,Yu, Rina,Park, Taesun Hindawi Publishing Corporation 2012 PPAR research Vol.2012 No.-
<P>Cinchonine (C<SUB>19</SUB>H<SUB>22</SUB>N<SUB>2</SUB>O) is a natural compound of Cinchona bark. Although cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of cinchonine has never been studied. The main objective of this study was to investigate whether cinchonine reduces high-fat-diet- (HFD-) induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in these reductions. HFD-fed mice treated with 0.05% dietary cinchonine for 10 weeks had reduced body weight gain (−38%), visceral fat-pad weights (−26%), and plasma levels of triglyceride, free fatty acids, total cholesterol, and glucose compared with mice fed with the HFD. Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice. Cinchonine also attenuated the HFD-induced upregulation of proinflammatory cytokines by inhibiting toll-like-receptor-2- (TLR2-) and TLR4-mediated signaling cascades in the adipose tissue of mice. Our findings suggest that dietary cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity.</P>
Sohee Park,Sang Min Lee,도경현,June-Goo Lee,Woong Bae,Hyunho Park,Kyu-Hwan Jung,Joon Beom Seo 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.10
Objective: To retrospectively assess the effect of CT slice thickness on the reproducibility of radiomic features (RFs) of lung cancer, and to investigate whether convolutional neural network (CNN)-based super-resolution (SR) algorithms can improve the reproducibility of RFs obtained from images with different slice thicknesses. Materials and Methods: CT images with 1-, 3-, and 5-mm slice thicknesses obtained from 100 pathologically proven lung cancers between July 2017 and December 2017 were evaluated. CNN-based SR algorithms using residual learning were developed to convert thick-slice images into 1-mm slices. Lung cancers were semi-automatically segmented and a total of 702 RFs (tumor intensity, texture, and wavelet features) were extracted from 1-, 3-, and 5-mm slices, as well as the 1-mm slices generated from the 3- and 5-mm images. The stabilities of the RFs were evaluated using concordance correlation coefficients (CCCs). Results: The mean CCCs for the comparisons of original 1 mm vs. 3 mm, 1 mm vs. 5 mm, and 3 mm vs. 5 mm images were 0.41, 0.27, and 0.65, respectively (p < 0.001 for all comparisons). Tumor intensity features showed the best reproducibility while wavelets showed the lowest reproducibility. The majority of RFs failed to achieve reproducibility (CCC ≥ 0.85; 3.6%, 1.0%, and 21.5%, respectively). After applying the CNN-based SR algorithms, the reproducibility significantly improved in all three pairings (mean CCCs: 0.58, 0.45, and 0.72; p < 0.001 for all comparisons). The reproducible RFs also increased (36.3%, 17.4%, and 36.9%, respectively). Conclusion: The reproducibility of RFs in lung cancer is significantly influenced by CT slice thickness, which can be improved by the CNN-based SR algorithms.