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Hwang, So-Ryeon,Kim, Chang-Yul,Shin, Kyung-Min,Jo, Ji-Hoon,Kim, Hyoung-Ah,Heo, Yong TAYLOR & FRANCIS 2015 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH PAR Vol.78 No.8
<P>Autism is a brain developmental disorder with characteristics of social interaction defects, language and communication dysfunction, and repetitive behavior. Occurrence of autism is continuously increasing, but the cause of autism is not clearly defined. Genetic linkage or environmental factors were proposed as sources for pathogenesis of autism. BTBR T+tf/J (BTBR) mice were reported as an appropriate animal model for autism investigation because of their similarities in behavioral abnormalities with human autistic subjects. The aim of this study was to evaluate expression levels of proteins involved with brain development at fetal stage of BTBR mice. FVB/NJ mice were used as a control strain because of their social behaviors. Level of fetal brain immunoglobulin (Ig) G deposit was also evaluated. Fetal brains were obtained at d 18 of gestational period. Thirty-one and 27 fetuses were obtained from 3 pregnant BTBR and FVB dams, respectively. The level of glial fibrillary acidic protein expression was significantly lower in fetal brains of BTBR than FVB/NJ mice. Expression of brain-derived neurotrophic factor and myelin basic protein was significantly more upregulated in BTBR than in FVB/NJ mice. No significant difference was obtained for nerve growth factor between the two strains. Levels of IgG isotypes deposited in fetal brain of BTBR mice were significantly higher than in FVB mice except for IgG1. Overall, these results suggest that prenatal alterations in expression of various fetal brain proteins may be implicated in aberrant behavioral characteristics of BTBR mice.</P>
김소남 ( So Nam Kim ),여경욱 ( Kyeong Uk Yeo ),황소련 ( So Ryeon Hwang ),조지훈 ( Ji Hoon Jo ),손수정 ( Soo Jung Sohn ),염영나 ( Young Na Yum ),이용경 ( Yong Kyung Lee ),허용 ( Yong Heo ) 한국동물실험대체법학회 2011 동물실험대체법학회지 Vol.5 No.1
Alternative methods using various human or animal cell lines are under development to classify chemical ingredients to skin sensitizing or irritant chemicals. Keratinocyte cell line could be a good target cell, in that the cells are the first contact point for chemical absorption through skin, and immune reactions including inflammation are occurred through interactions among keratinocyte, Langerhans` cell, and T cells. This study introduced current research activities on development of alternative methods using keratinocyte cell lines for identifying skin sensitizers. In addition, a good laboratory practice was introduced to perform serial passage culture of HaCaT human keratinocyte cell line. Furthermore, optimal cell density and culture duration were demonstrated to determine both intracellular and extracellular levels of IL-1α, IL-6, IL-8, and IL-18 from HaCaT cells.
연구논문 : 정각질세포주의 피부감작물질 검색 관련 효용성 분석
김소남 ( So Nam Kim ),여경욱 ( Kyeong Uk Yeo ),황소련 ( So Ryeon Hwang ),조지훈 ( Ji Hoon Jo ),손수정 ( Soo Jung Sohn ),염영나 ( Young Na Yum ),이용경 ( Yong Kyung Lee ),허용 ( Yong Heo ) 한국동물실험대체법학회 2011 동물실험대체법학회지 Vol.5 No.1
Alternative methods using various human or animal cell lines are under development to classify chemical ingredients to skin sensitizing or irritant chemicals. Keratinocyte cell line could be a good target cell, in that the cells are the first contact point for chemical absorption through skin, and immune reactions including inflammation are occurred through interactions among keratinocyte, Langerhans` cell, and T cells. This study introduced current research activities on development of alternative methods using keratinocyte cell lines for identifying skin sensitizers. In addition, a good laboratory practice was introduced to perform serial passage culture of HaCaT human keratinocyte cell line. Furthermore, optimal cell density and culture duration were demonstrated to determine both intracellular and extracellular levels of IL-1α, IL-6, IL-8, and IL-18 from HaCaT cells.