http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Building Resilience: Women Are Change Makers
Smriti Gurung 이화여자대학교 아시아여성학센터 2017 이화여자대학교 아시아여성학센터 학술대회자료집 Vol.2017 No.7
Disasters and natural calamities do not discriminate during their occurrence. Nonetheless, the impact of disaster on men, women and other groups is diverse, since different people have different capacities and needs. This is evident in any kind of disaster and so it was in the devastating earthquake that occurred in Nepal on 25 April 2015, where the number of female casualties outnumbered male casualties. Lack of recognition of women`s capacities, discriminatory social norms, and deep-rooted structural inequalities limited women`s mobility and access to both regular development and humanitarian crisis services in Nepal. Despite the fact that women were one of the most vulnerable groups impacted by the disaster, their significant roles in relief, response and recovery efforts as well as resilience building enabled them to serve as active agents of change. Therefore, through this paper, I want to authenticate the understanding that women are not always submissive in crises but can serve as role models for transformation, as evident in their vigorous contributions to the relief, recovery and reconstruction efforts of Nepal.
Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy
Vadevoo, Sri Murugan Poongkavithai,Gurung, Smriti,Khan, Fatima,Haque, Md. Enamul,Gunassekaran, Gowri Rangaswamy,Chi, Lianhua,Permpoon, Uttapol,Lee, Byungheon Springer-Verlag 2019 Archives of Pharmacal Research Vol.42 No.2
Peptides as multifunctional players in cancer therapy
Vadevoo Sri Murugan Poongkavithai,Gurung Smriti,Lee Hyun-Su,Gunassekaran Gowri Rangaswamy,Lee Seok-Min,Yoon Jae-Won,Lee Yun-Ki,Lee Byungheon 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue penetration and cell internalization than antibodies. Regardless of the pros and cons of peptides, they have been used as tumor-homing ligands for delivering carriers (such as nanoparticles, extracellular vesicles, and cells) and cargoes (such as cytotoxic peptides and radioisotopes) to tumors. Additionally, tumor-homing peptides have been conjugated with cargoes such as small-molecule or chemotherapeutic drugs via linkers to synthesize peptide–drug conjugates. In addition, peptides selectively bind to cell surface receptors and proteins, such as immune checkpoints, receptor kinases, and hormone receptors, subsequently blocking their biological activity or serving as hormone analogs. Furthermore, peptides internalized into cells bind to intracellular proteins and interfere with protein–protein interactions. Thus, peptides demonstrate great application potential as multifunctional players in cancer therapy.
HaqueMohammadEnamul,Fatima Khan,Lianhua Chi,Smriti Gurung,Sri Murugan Poongkavithai Vadevoo,박랑운,김동규,김상균,이병헌 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3
Purpose This study was carried out to identify a peptide that selectively binds to kidney injury molecule- 1 (KIM-1) by screening a phage-displayed peptide library and to use the peptide for the detection of KIM-1–overexpressing tumors in vivo. Materials and Methods Biopanning of a phage-displayed peptide library was performed on KIM-1–coated plates. The binding of phage clones, peptides, and a peptide multimer to the KIM-1 protein and KIM-1–overexpressing and KIM-1–low expressing cells was examined by enzyme-linked immunosorbent assay, fluorometry, and flow cytometry. A biotin-peptide multimer was generated using NeutrAvidin. In vivo homing of the peptide to KIM-1–overexpressing and KIM- 1–low expressing tumors in mice was examined by whole-body fluorescence imaging. Results A phage clone displaying the CNWMINKEC peptide showed higher binding affinity to KIM-1 and KIM-1–overexpressing 769-P renal tumor cells compared to other phage clones selected after biopanning. The CNWMINKEC peptide and a NeutrAvidin/biotin-CNWMINKEC multimer selectively bound to KIM-1 over albumin and to KIM-1–overexpressing 769-P cells and A549 lung tumor cells compared to KIM-1–low expressing HEK293 normal cells. Colocalization and competition assays using an anti–KIM-1 antibody demonstrated that the binding of the CNWMINKEC peptide to 769-P cells was specifically mediated by KIM-1. The CNWMINKEC peptide was not cytotoxic to cells and was stable for up to 24 hours in the presence of serum. Whole-body fluorescence imaging demonstrated selective homing of the CNWM-INKEC peptide to KIM-1–overexpressing A498 renal tumor compared to KIM- 1–low expressing HepG2 liver tumor in mice. Conclusion The CNWMINKEC peptide is a promising probe for in vivo imaging and detection of KIM-1– overexpressing tumors.