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Ying Tang,Lei Liu,Jinju Han,Zhaolun Zhang,Shuyan Yang,Shuxian Li,Shuxian Li,Zhanhua Fan,Hua Zhao 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2
Herbal extracts have recently received considerable interest in acne therapy owing to their enhanced skincompatibility compared with antibiotics and synthetic agents. In this study, electrospun poly (vinyl alcohol)/chitosan (PVA/CS) fibrous patch incorporating a combination of herbal extracts with complementary mechanisms of action was developedas an alternative acne therapy for patients with resistance to the conventional treatments. The herbal extracts-loadedelectrospun fibers displayed uniform and smooth-surfaced nanofibers (dia. 100-300 nm), high drug loading efficiency (89.5-97.7 %) and good water absorbing properties. Results of the in vitro release and antibacterial studies suggest the patches arecapable of sustained release of polyphenol-rich extracts, which may, together with the chitosan present in the fiber, endow thepatch with potent bacterial inhibition of Propionibacterium acnes. The herbal extracts-loaded patches exhibited pronouncedclinical therapeutic efficacy in treating mild-to-moderate facial acne by rapidly reducing inflamed lesions and restoringepidermal barrier. Also, the herbal patches demonstrated improved biocompatibility or tolerability in comparison with thesynthetic drug benzoyl peroxide. Overall, the present study has provided a facile approach to develop biocompatiblepolymers based electrospun fibrous patch for the efficient delivery of herbal extracts for topical skin therapy, opening newperspectives for a new generation of cosmetotextiles.
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A New Multi-objective Evolutionary Algorithm for Inter-Cloud Service Composition
( Li Liu ),( Shuxian Gu ),( Dongmei Fu ),( Miao Zhang ),( Rajkumar Buyya ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.1
Service composition in the Inter-Cloud raises new challenges that are caused by the different Quality of Service (QoS) requirements of the users, which are served by different geo-distributed Cloud providers. This paper aims to explore how to select and compose such services while considering how to reach high efficiency on cost and response time, low network latency, and high reliability across multiple Cloud providers. A new hybrid multi-objective evolutionary algorithm to perform the above task called LS-NSGA-II-DE is proposed, in which the differential evolution (DE) algorithm uses the adaptive mutation operator and crossover operator to replace the those of the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) to get the better convergence and diversity. At the same time, a Local Search (LS) method is performed for the Non-dominated solution set F{1} in each generation to improve the distribution of the F{1}. The simulation results show that our proposed algorithm performs well in terms of the solution distribution and convergence, and in addition, the optimality ability and scalability are better compared with those of the other algorithms.
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3D Unsteady Simulation of the Transport Characteristics in the LEC Melt of In-Doped GaAs
Shuxian Chen,Shilin Li,Xiaoming Tan 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.5
A three-dimensional and time-dependent turbulent mathematical model is established for the mass, heat, momentum and dopant transport in the LEC melt of In-doped GaAs. The Solution scheme for the dopant segregation effect at the melt/crystal interface is put forward. Grid testing calculations have been performed for the choice of the grid. The turbulent mathematical model and numerical methodology are used to simulate the melt convections and dopant transports in the previously published experiments, and the numerical accuracy is validated by comparing the results with the experimental data in different model setups. Some transport characteristics in the LEC melt of In-doped GaAs have been concluded. Owing to the interacting forces associated with different length scales in the LEC melt, the fluid flow is non-axisymmetric. Because of the competition between buoyancy, Marangoni force, centrifugal force and the Coriolis force, the temperature fluctuates in the melt. Due to the segregation, the InAs concentration increase in the axial direction.
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Xiaoqing Lu,Yang Shao,Ke Li,Zigang Zhao,Shuxian Wei,Wenyue Guo 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.5
The intrinsic optoelectronic properties of heteroleptic bipyridyl Cu(I)complexes bearing functionalized acceptor subunits have beeninvestigated by density functional theory and time-dependent DFT. TheCu(I) complexes exhibit distorted trigonal-pyramidal geometries andtypical metal-to-ligand electron transfer characteristics at the longwavelength region. Replacing carboxylic acid with cyanoacrylic acid inacceptor subunits stabilizes the LUMO levels, thus lowering the HOMOLUMOenergy gaps and facilitating favorable donor-to-acceptorintramolecular electron transfer and charge separation. Introduction ofheteroaromatic groups and cyanoacrylic acid significantly improves thelight-harvesting capability of the complexes. Our results highlight theeffect of functionalized acceptors on the optoelectronic properties ofbipyridyl Cu(I) complexes and provide a fresh perspective on screeningof efficient sensitizers for dye-sensitized solar cells.
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Moisture-Induced Reversible Softening of Polyacrylates-Stiffened Cotton Fabrics
Yifang Mi,Die Wu,Yongxiang Li,Xiaoxia Cheng,Xiaobo Yang,Shuxian Lan,Zhihai Cao 한국섬유공학회 2022 Fibers and polymers Vol.23 No.5
The stiffening finishing of cotton fabrics has been widely used in textile industry. However, the notorious softeningof stiffened fabrics attenuated the stiffening style during storage. To reveal crucial factors responsible for the softeningphenomenon and elucidate the mechanism, cotton twill woven fabrics finished with polyacrylates (PAcr) stiffening agentswere systematically analyzed. The sensitive index to stiffening effect, i.e. stiffness value, was found which can fully assessthe handle changes of stiffened fabrics. The stiffness value of stiffened cotton fabrics decreased rapidly in the initial stage ofstorage, and the declining extent was related to the hygroscopic behavior of stiffened fabrics. Based on the hygroscopickinetic data, hygroscopic-drying cyclic experiments, and morphology characterization, it was found that interfaces betweencotton fibers and stiffening agent film were maintained during the whole hygroscopic process, and the reason for handlechanges of stiffened cotton fabrics was ascribed to the reversible moisture-induced plasticization effect on PAcr stiffeningagent film and cotton fibers. Furthermore, the underlying softening mechanism was further proposed in this work. Collectively, the present results are crucial for anti-softening in stiffening finishing of hydrophilic fabrics and an importantpart for the research on the mechanism of softening of stiffened fabrics.
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A QEE-Oriented Fair Power Allocation for Two-tier Heterogeneous Networks
( Shiyu Ji ),( Liangrui Tang ),( Yanhua He ),( Shuxian Li ),( Shimo Du ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.5
In future wireless network, user experience and energy efficiency will play more and more important roles in the communication systems compared to their roles at present. Quality of experience (QoE) and Energy Efficiency (EE) become the widely used metrics. In this paper, we study a combinatorial problem of QoE and EE and investigate a fair power allocation in heterogeneous networks. We first design a new metric, QoE-aware EE (QEE) to reflect the relationship of QoE and energy. Then, the concept of Utopia QEE is introduced, which is defined as the achievable maximum QEE in ideal conditions, for each user. Finally, we transform the power allocation process to an optimization of ratio of QEE and Utopia QEE and use invasive weed optimization (IWO) algorithm to solve the optimization problem. Numerical simulation results indicate that the proposed algorithm can get converged and efficiently improve the system energy efficiency and the QoE for each user.
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Yifan Wang,Hao Wei,Zhen Song,Liqun Jiang,Mi Zhang,Xiao Lu,Wei Li,Yuqing Zhao,Lei Wu,Shuxian Li,Huijuan Shen,Qiang Shu,Yicheng Xie 고려인삼학회 2024 Journal of Ginseng Research Vol.48 No.1
Background: Lung inflammation occurs in many lung diseases, but has limited effective therapeutics. Ginseng andits derivatives have anti-inflammatory effects, but their unstable physicochemical and metabolic propertieshinder their application in the treatment. Panaxadiol (PD) is a stable saponin among ginsenosides. Inhalationadministration may solve these issues, and the specific mechanism of action needs to be studied. Methods: A mouse model of lung inflammation induced by lipopolysaccharide (LPS), an in vitro macrophageinflammation model, and a coculture model of epithelial cells and macrophages were used to study the effectsand mechanisms of inhalation delivery of PD. Pathology and molecular assessments were used to evaluate efficacy. Transcriptome sequencing was used to screen the mechanism and target. Finally, the efficacy andmechanism were verified in a human BALF cell model. Results: Inhaled PD reduced LPS-induced lung inflammation in mice in a dose-dependent manner, includinginflammatory cell infiltration, lung tissue pathology, and inflammatory factor expression. Meanwhile, the dose ofinhalation was much lower than that of intragastric administration under the same therapeutic effect, which maybe related to its higher bioavailability and superior pharmacokinetic parameters. Using transcriptome analysisand verification by a coculture model of macrophage and epithelial cells, we found that PD may act by inhibitingTNFA/TNFAR and IL7/IL7R signaling to reduce macrophage inflammatory factor-induced epithelial apoptosisand promote proliferation. Conclusion: PD inhalation alleviates lung inflammation and pathology by inhibiting TNFA/TNFAR and IL7/IL7Rsignaling between macrophages and epithelial cells. PD may be a novel drug for the clinical treatment of lunginflammation.
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