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RISS 인기검색어
- 검색키워드
- 저자 : ( Dongmei Fu ) (검색결과 3 건)
- 무료
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Development of signal analysis method for the motional Stark effect diagnostic on EAST
FU, Jia,LYU, Bo,LIU, Haiqing,LI, Yingying,LIU, Dongmei,WEI, Yongqing,FAN, Chao,SHI, Yuejiang,WU, Zhenwei,WAN, Baonian IOP Publishing 2017 Plasma science & technology Vol.19 No.10
<P>A pilot single-channel Motional Stark Effect (MSE) diagnostic has been developed on EAST since 2015. The dual photo-elastic modulators (PEM) were employed to encode the polarization angle into a time-varying signal. The pitch angle was related to the ratio of modulation amplitude at the second harmonic frequency. A digital harmonic analyzer (DHA) technique was developed for extracting the second harmonic amplitude. The results were validated with a hardware phase lock-in amplifier, and is also consistent with the software dual phase-locking algorithm.</P>
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A New Multi-objective Evolutionary Algorithm for Inter-Cloud Service Composition
( Li Liu ),( Shuxian Gu ),( Dongmei Fu ),( Miao Zhang ),( Rajkumar Buyya ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.1
Service composition in the Inter-Cloud raises new challenges that are caused by the different Quality of Service (QoS) requirements of the users, which are served by different geo-distributed Cloud providers. This paper aims to explore how to select and compose such services while considering how to reach high efficiency on cost and response time, low network latency, and high reliability across multiple Cloud providers. A new hybrid multi-objective evolutionary algorithm to perform the above task called LS-NSGA-II-DE is proposed, in which the differential evolution (DE) algorithm uses the adaptive mutation operator and crossover operator to replace the those of the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) to get the better convergence and diversity. At the same time, a Local Search (LS) method is performed for the Non-dominated solution set F{1} in each generation to improve the distribution of the F{1}. The simulation results show that our proposed algorithm performs well in terms of the solution distribution and convergence, and in addition, the optimality ability and scalability are better compared with those of the other algorithms.
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Mingde Ding,Xiuling Liang,Xianfang Xin,Dongmei Qi,Chengyan Fu 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.2
Purpose: This study aimed to investigate the effects of PIK3CA on the sensitivity of acute B lymphocytic leukemia cells (Nalm-6cells) to chemotherapy drugs. Materials and Methods: Children’s normal B lymphocytes and Nalm-6 cells were cultured. Nalm-6 cells were transfected withPIK3CA siRNA (siPIK3CA group) or its negative control (PIK3CA-Control group). Normal Nalm-6 cells were named Mock group. Nalm-6 cells transfected by PIK3CA siRNA were treated with Akt inhibitor (siPIK3CA+Akti-1/2 group). mRNA and protein expressionwas detected by qRT-PCR and Western blot. Proliferation and sensitivity to chemotherapeutic drugs was detected by MTTassay. Cell cycle and apoptosis was explored by low cytometry. Transwell assay was performed to test invasion. Results: PIK3CA mRNA (p=0.008) and protein (p=0.006) expression was higher in Nalm-6 cells than that in normal B lymphocytes. Compared with the Mock group and PIK3CA-Control group, Nalm-6 cells of the siPIK3CA group had lower OD495 values (allp<0.05) and invasion cell numbers (p=0.03 and p=0.025), as well as a higher proportion of G0/G1 phase cells (p=0.020 and p=0.022), percentage of apoptosis (p=0.016 and p=0.022), and inhibition rate (all p<0.05). pAkt expression in the siPIK3CA group (p=0.026 and p=0.031) and siPIK3CA+Akti-1/2 group (p=0.019 and p=0.023) was lower than that in the Mock group. Conclusion: PIK3CA silencing inhibited Nalm-6 cell proliferation and invasion, and promoted their apoptosis and sensitivity tochemotherapeutic drugs, potentially through regulation of the PI3K/AKT signaling pathway.
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