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- 저자 : Shuaishuai Hu (검색결과 5 건)
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Piezo channels in the urinary system: Correspondence
Hu Shuaishuai,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
We read an informative review article by Li et al.1, titled “Piezo channels in the urinary system”. They report that mRNA expression of Piezo2 increased significantly in both human bladder cancer tissues and mouse bladder cancer tissues. They further found that Piezo2 only correlates with tumor stage. However, this conclusion was based on the results of only one experiment. I read the original study that the author cited in the review. The study found that Piezo2 mRNA was significantly increased in the pT2 tumor stage compared to the pT0 tumor stage, but with no significant difference between the pT2 tumor stage and pT1 tumor stage. Therefore, it is not accurate to state that Piezo2 correlates with tumor stage based on this single experiment. This review provides very little information about the role of Piezo2 in bladder cancer. Here, we would like to provide more comprehensive information regarding the role of Piezo2 in bladder cancer based on current studies and tumor datasets.
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CDK1 promotes the proliferation of melanocytes in Rex rabbits
Dai Yingying,Hu Shuaishuai,Bai Shaocheng,Li Jiali,Yang Naisu,Zhai Pin,Zhao Bohao,Chen Yang,Wu Xinsheng 한국유전학회 2022 Genes & Genomics Vol.44 No.10
Background: The fur color constitutes one of the most important economic characteristics of fur animals and is determined by the content of melanin. A previous study has shown that the cyclin-dependent kinase 1 (CDK1) is a member of the protein kinase family, involved in forming the color of the fur in Rex rabbits. However, its effect on the melanocytes remains unclear. Objective: This study aimed to provide evidence for the role of CDK1 in melanogenesis. Methods: This study measured the expression of CDK1 in Rex rabbit skins of six coat colors using qRT-PCR. The CDK1-mediated regulation of the pigmentation-related genes and cyclin-dependent kinases were analyzed. The melanin content, proliferation, and apoptosis of the melanocytes were analyzed using the NaOH, CCK8, and Annexin V-FITC methods. Results: The CDK1 expression in the skin of the rex rabbits with different coat colors was found to be regular, and the expression level was found to be the highest in the skin of the black rex rabbits (P < 0.05). The overexpression/knockdown of CDK1 was found to significantly increase/decrease the melanin content in the melanocytes (P < 0.01). Besides, CDK1 was found to significantly promote the proliferation of the melanocyte and inhibit apoptosis (P < 0.01). Furthermore, the overexpression of CDK1 was found to significantly affect the expression of the other melanin-related genes like TYR, PMEL, DCT, as well as the mRNA expression of the cyclin-dependent kinases CDK4, CDK6, CDK8, CCNB1. Conclusions: The results indicated that CDK1 can serve as a key gene regulating melanogenesis, melanocyte proliferation, and apoptosis, providing a new theoretical basis for studying the mechanism by which the different colors of the fur evolve in mammals.
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Shulin Cai,Shuaishuai Hu,Jianming Wu,An Huang,Lihong Geng,Xiangfang Peng 한국섬유공학회 2022 Fibers and polymers Vol.23 No.5
Cellulose-based fluorescent fibers were successfully fabricated by interfacial polyelectrolyte complexation (IPC)spinning, in which thioglycolic acid-modified CdTe quantum dots (QDs) were incorporated. The fibers exhibited differentfluorescent colors depending on different sizes of CdTe QDs. The IPC spinning process based on the progressive selfassemblyof negatively charged cellulose nanofibers (CNFs) and positively charged chitosan endowed the fibers highorientation degree. Together with the superior mechanical property of CNFs and the strong interfacial ionic bond andhydrogen bond interaction between CNFs and chitosan, the fluorescent fibers showed a high tensile strength above 689 MPaand toughness above 25 MJ/m3, which provided a guarantee for weaving the fluorescent fibers into textiles. With excellentoptical and mechanical performance, the resulting fluorescent fibers showed a promising potential as flexible wearable anticounterfeitingdevices, which the hard-to-see tag woven using the fluorescent fibers appeared clearly under 365 nmultraviolet light illumination. This paper would provide a new avenue for the preparation of high-performance environmentfriendlyfluorescent anti-counterfeiting textiles.
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Facile Synthesis of CdTe Nanorods from the Growth of Te Nanorods
Xu, Weiwei,Niu, Jinzhong,Zheng, Shuang,Tian, Guimin,Wu, Xinghui,Cheng, Yongguang,Hu, Xiaoyang,Liu, Shuaishuai,Hao, Haoshan Korean Chemical Society 2017 대한화학회지 Vol.61 No.4
One-dimensional CdTe nanorods (NRs) are obtained by the reaction of various Cd precursors with single crystalline Te nanorod templates, which are pre-synthesized from Te precursors by a simple and reproducible solvothermal method. Throughout the process, the diffraction intensity of different crystal facets of single crystalline Te NRs varied with reaction times. Finally, by alloying Cd ions along the axial direction of Te NRs, polycrystalline cubic phase CdTe NRs with diameters of 80-150 nm and length up to $1.2-2.4{\mu}m$ are obtained. The nucleation and growth processes of Te and CdTe NRs are discussed in details, and their properties are characterized by XRD, SEM, TEM, Raman scattering, and UV-vis absorption spectra. It was found that the key elements of synthesizing CdTe NRs such as reaction temperatures and Cd sources will strongly influence the final shape of CdTe NRs.
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Shuang Liang,Zhiyuan Bao,Bohao Zhao,Tong Zhou,Jiali Li,Ming Liu,Shuaishuai Hu,Naisu Yang,Yang Chen,Xinsheng Wu 한국유전학회 2020 Genes & Genomics Vol.42 No.11
Background Keratin-associated protein (KAP), the structural protein molecule of hair fibers, plays a key role in determiningthe physical properties of hair. Studies of Krtap11-1 have focused only on its localization. Functional studies of Krtap11-1in hair follicle development have so far not been reported. Objective This study aimed to provide evidence for the role of Krtap11-1 in skin and hair development. Methods Full-length cloning and analysis of Krtap11-1 were conducted to ascertain its function. Overexpression vectors andinterference sequences were constructed and transfected into RAB-9 cells. Quantitative real-time polymerase chain reaction(qRT-PCR) was used to investigate the hair follicle developmental stage of Krtap11-1, the expression of different tissues,and the effects on other hair follicle development-related genes. Results The full length of cloned Krtap11-1 was 947 bp. Krtap11-1 was confirmed to be a hydrophilic protein localizedmostly in mitochondria. The greatest mRNA expression was observed in skin. Using a follicle synchronization model, itwas found that Krtap11-1 mRNA expression levels first increased then decreased over the passage of time, principally duringhair follicle catagen and telogen. Following the overexpression of Krtap11-1, mRNA expression levels of the WNT-2,KRT17, BMP-2, and TGF-β-1 genes increased, and LEF-1 decreased (P < 0.05), the converse after the corresponding useof si-RNA interference. Conclusions Krtap11-1 exerts a promoting effect. The results provide novel insight into the relationship between hair follicledevelopment and Krtap11-1 gene expression.
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