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      • KCI등재

        Study on the engineering and electricity properties of cement mortar added with waste LCD glass and piezoelectric powders

        Shu-Chuan Chang,Chien-Chih Wang,Her-Yung Wang 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.3

        This study used a volumetric method for design. The control group used waste Liquid Crystal Displayplay (LCD) glass powder to replace cement (0%, 10%, 20%, 30%), and the PZT group used Pd-Zr-Ti piezoelectric (PZT) powder to replace 5% of the fine aggregate to make cement mortar. The engineering and the mechanical and electricity properties were tested; flow, compressive strength, ultrasonic pulse velocity (UPV), water absorption and resistivity (SSD and OD electricity at 50 V and 100 V) were determined; and the correlations were determined by linear regression. The compressive strength of the control group (29.5-31.8 MPa) was higher than that of the PZT group (25.1-29 MPa) by 2.8-4.4 MPa at the curing age of 28 days. A 20% waste LCD glass powder replacement (31.8 MPa) can fill up finer pores and accelerate hydration. The control group had a higher 50 V-SSD resistivity (1870-3244 Ω.cm), and the PZT group had a lower resistivity (1419-3013 Ω.cm), meaning that the resistivity increases with the replacement of waste LCD glass powder. This is because the waste LCD glass powder contains 62% SiO2, which is a low dielectric material that is an insulator. Therefore, the resistivity increases with the SiO2 content.

      • KCI등재

        Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts

        Chuan-Te Tsai,Yung-Ming Chang,Shu-Luan Lin,Yueh-Sheng Chen,Yu-Lan Yeh,Viswanadha Vijaya Padma,Chin-Chuan Tsai,Ray-Jade Chen,Tsung-Jung Ho,Chih-Yang Huang 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.3

        Angiotensin II (Ang II) is a very important cardiovascular disease inducer and may cause cardiac pathological hypertrophy and remodeling. We evaluated a Chinese traditional medicine, alpinate oxyphyllae fructus (AOF), for therapeutic efficacy for treating Ang II-induced cardiac hypertrophy. AOF has been used to treat patients with various symptoms accompanying hypertension and cerebrovascular disorders in Korea. We investigated its protective effect against Ang II-induced cytoskeletal change and hypertrophy in H9c2 cells. The results showed that treating cells with Ang II resulted in pathological hypertrophy, such as increased expression of transcription factors NFAT-3/p-NFAT-3, hypertrophic response genes (atrial natriuretic peptide [ANP] and b-type natriuretic peptide [BNP]), and Gαq down-stream effectors (PLCβ3 and calcineurin). Pretreatment with AOF (60–100 μg/mL) led to significantly reduced hypertrophy. We also found that AOF pretreatment significantly suppressed the cardiac remodeling proteins, metalloproteinase (MMP9 and MMP2), and plasminogen activator, induced by Ang II challenge. In conclusion, we provide evidence that AOF protects against Ang II-induced pathological hypertrophy by specifically inhibiting the insulin-like growth factor (IGF) II/IIR-related signaling pathway in H9c2 cells. AOF might be a candidate for cardiac hypertrophy and ventricular remodeling prevention in chronic cardiovascular diseases.

      • SSCISCIESCOPUSKCI등재
      • Equivocal Association of RAD51 Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population

        Zhang, Shu-Xiang,Yang, Shan,Xu, Chang-Qing,Hou, Rui-Ping,Zhang, Chuan-Zhen,Xu, Cui-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Aim: To study the contribution of genetic variation in RAD51 to risk of esophageal squamous cell carcinoma (ESCC). Methods: Three single nucleotide polymorphisms (SNPs) in RAD51 (rs1801320, rs4144242 and rs4417527) were genotyped in 316 ESCC patients and 316 healthy controls in Anyang area of China using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Demographic variables between cases and controls were statistically compared by T test and Chi-square test. Hardy-Weinberg equilibrium was evaluated by the Chi-square test. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure any association with ESCC. Haplotype frequencies were estimated by Phase 2.1. Result: The genotype frequencies of rs1801320, rs4144242 and rs4417527 in patients with ESCC demonstrated no significant differences from those in control group (P>0.05). When the haplotypes of these three SNPs were constructed and their relationships with ESCC risk investigated, however, CGG was observed to increase the risk (P=0.020, OR=2.289). Conclusions: There was no association between the three SNPs of RAD51 and ESCC susceptibility in our Chinese population. However, the CGG haplotype might be a risk factor.

      • KCI등재

        Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility

        Wei-Yi Lei,Shu-Wei Liang,Taher Omari,Wei-Chuan Chang,Ming-Wun Wong,Jui-Sheng Hung,Chih-Hsun Yi,Tso-Tsai Liu,Lin Lin,C Prakash Gyawali,Chien-Lin Chen 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.4

        Background/Aims Straight leg raise (SLR) can be utilized to evaluate the integrity of the esophagogastric junction during high-resolution manometry (HRM). We aim to assess the value of transient hiatal separation during SLR in symptomatic reflux patients. Methods Consecutive reflux patients undergoing esophageal HRM and pH monitoring were included. Transient hiatal separation was defined by a ≥ 1 cm separation between the lower esophageal sphincter and crural diaphragm during SLR. We compared esophageal motor patterns and reflux monitoring parameters between patients with normal, transiently abnormal and consistently abnormal esophagogastric junction morphology during SLR. Results Of 85 (56.3% female, mean age: 46.7 ± 12.3 years) completed SLR, esophagogastric junction morphology was normal in 31 (36.5%), transient hiatal separation in 19 (22.3%), and consistently hiatal hernia in 35 (41.2%). The values of total acid exposure time (P = 0.016), longest acid reflux episodes (P = 0.024), and DeMeester scores (P = 0.016) were higher in hiatal hernia compared to patients with non-transient hiatal separation, but there were no differences between those with and without transient hiatal separation. Within ineffective esophageal motility, the presence of transient hiatal separation during SLR significantly associated with a higher total acid exposure time (P = 0.014), higher DeMeester scores (P = 0.019), higher total acid reflux events (P = 0.037), and higher longest acid reflux episodes (P = 0.006). Conclusion Our work suggests that SLR may have value as a provocative test during HRM, and future outcome studies are warranted to elucidate the clinical relevance of motor abnormalities depicted from SLR.

      • The Structure of Polysemy: A study of multi-sense words based on WordNet

        ( Jen Yi Lin ),( Chang Hua Yang ),( Shu Chuan Tseng ),( Chu Ren Huang ) 한국언어정보학회 2002 국제 워크샵 Vol.2002 No.-

        The issues in polysemy with respect to the verbs in WordNet will be discussed in this paper. The hypernymy/hyponymy structure of the multiple senses is observed when we try to build a bilingual network for Chinese and English. There are several types of polysemic patterns and a co-hypernym may have the same word form as its subordinates. Fellbaum (2000) dubbed autotroponymy that the verbs linked by manner relation share the same verb form. However, her syntactic criteria seem not compatible to the hierarchies in WN. Either the criteria or the network should be reconducted. For most verbs in WN 1.7, polysemous relations are unlikely to extend over 3 levels of IS-A relation. Highly polysemous verbs are more complicated and may be involved in certain semantic structures. Semi-automatic sense grouping may be helpful for multimlinguital information retrieveal.

      • A Pediatric Oncology Diverse Learning Course on Caring for nursing students’ reflection

        Miao Hsing Chen,Shu-Chuan Chang,Yu-Ping Huang,Yueh Chih Chen 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

        Aim(s): This study aimed to determine if a pediatric oncology diverse learning course could enhance nursing students’ theoretical knowledge and understanding of clinical care for children with leukemia and their families. Method(s): This was a qualitative retrospective study. Data were collected in July 2016. Participants were college nursing students (N = 33) enrolled in a diverse learning course in pediatric oncology, which was taught between November 2014 and January 2015 at a science and technology university in Taiwan. The three-part course included reading picture books, participating in role-playing, and watching a cancer-related family movie. Focus group discussions occurred during each part. Students maintained written reflections during the course, which were submitted to an e-learning website. Reflections were analyzed using content analysis. Result(s): Students’ reflections resulted in five main themes: (1) Pediatric oncology nursing knowledge and skills learned; (2) Understanding children with leukemia and their families suffering; (3) Empathy parents’ and children’s reactions to the effects of leukemia; (4) Nursing skills necessary for caring for children with leukemia; and (5) Expect future role as a pediatric oncology nurse. Conclusion(s): The pediatric oncology simulation course employed multiple teaching strategies. The improvements in student cognition, empathy, and understanding of care requirements of children with leukemia and emotional needs of families as pediatric oncology nurses suggest the teaching objectives of enhancing student learning were achieved. The knowledge and skills acquired could assist students in developing professional competencies and values in nursing.

      • KCI등재

        Prediction models of compressive strength and UPV of recycled material cement mortar

        Chien-Chih Wang,Her-Yung Wang,Shu-Chuan Chang 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.4

        With the rising global environmental awareness on energy saving and carbon reduction, as well as the environmental transition and natural disasters resulted from the greenhouse effect, waste resources should be efficiently used to save environmental space and achieve environmental protection principle of “sustainable development and recycling”. This study used recycled cement mortar and adopted the volumetric method for experimental design, which replaced cement (0%, 10%, 20%, 30%) with recycled materials (fly ash, slag, glass powder) to test compressive strength and ultrasonic pulse velocity (UPV). The hyperbolic function for nonlinear multivariate regression analysis was used to build prediction models, in order to study the effect of different recycled material addition levels (the function of Rm(F, S, G) was used and be a representative of the content of recycled materials, such as fly ash, slag and glass) on the compressive strength and UPV of cement mortar. The calculated results are in accordance with laboratory-measured data, which are the mortar compressive strength and UPV of various mix proportions. From the comparison between the prediction analysis values and test results, the coefficient of determination R2 and MAPE (mean absolute percentage error) value of compressive strength are 0.970-0.988 and 5.57-8.84%, respectively. Furthermore, the R2 and MAPE values for UPV are 0.960-0.987 and 1.52-1.74%, respectively. All of the R2 and MAPE values are closely to 1.0 and less than 10%, respectively. Thus, the prediction models established in this study have excellent predictive ability of compressive strength and UPV for recycled materials applied in cement mortar.

      • KCI등재

        Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry

        Wei-Yi Lei,Tso-Tsai Liu,Wei-Chuan Chang,Chih-Hsun Yi,Jui-Sheng Hung,Ming-Wun Wong,Shu-Wei Liang,Lin Lin,Chien-Lin Chen 대한소화기 기능성질환∙운동학회 2024 Journal of Neurogastroenterology and Motility (JNM Vol.30 No.1

        Background/AimsThis study aims to evaluate the effects of acute codeine administration on primary and secondary esophageal peristalsis in patients with ineffective esophageal motility (IEM). MethodsEighteen IEM patients (8 women; mean age 37.8 years, range 23-64 years) were enrolled in the study. The patients underwent high-resolution manometry exams, consisting of 10 single wet swallows, multiple rapid swallows, and ten 20 mL rapid air injections to trigger secondary peristalsis. All participants completed 2 separate sessions, including acute administration of codeine (60 mg) and placebo, in a randomized order. ResultsCodeine significantly increased the distal contractile integral (566 ± 81 mmHg∙s∙cm vs 247 ± 36 mmHg∙s∙cm, P = 0.001) and shortened distal latency (5.7 ± 0.2 seconds vs 6.5 ± 0.1 seconds, P < 0.001) for primary peristalsis compared with these parameters after placebo treatment. The mean total break length decreased significantly after codeine treatment compared with the length after placebo (P = 0.003). Codeine significantly increased esophagogastric junction-contractile integral (P = 0.028) but did not change the 4-second integrated relaxation pressure (P = 0.794). Codeine significantly decreased the frequency of weak (P = 0.039) and failed contractions (P = 0.009), resulting in increased frequency of normal primary peristalsis (P < 0.136). No significant differences in the ratio of impaired multiple rapid swallows inhibition and parameters of secondary peristalsis were detected. ConclusionsIn IEM patients, acute administration of codeine increases contraction vigor and reduces distal latency of primary esophageal peristalsis, but has no effect on secondary peristalsis. Future studies are required to further elucidate clinical relevance of these findings, especially in the setting of gastroesophageal reflux disease with IEM.

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