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우황청심원(牛黃淸心元)이 저산소증 유발 배양신경세포에 미치는 영향
조규선,신길조,문일수,이원철,정승현,Cho, Gyu-Seon,Shin, Gil-Cho,Moon, Il-Soo,Lee, Won-Chul,Chung, Sung-Hyun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.2
Objectives : The purpose of this investigation is to evaluate the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast. Methods : To evaluate the effect of Woohwangcheongsim-won on neuronal death caused by hypoxia, the survival rate of E18 cortical neuroblast was measured with MTT assay and the changes of several synaptic proteins and enzymes were investigated with the immunoblot assays. Results : The E18 cortical neuroblasts were added 50, 100, 500, 1,000, and $5,000{\mu}g/ml$ Woohwangcheongsim-won. They showed neurotoxicity, when the concentration of Woohwangcheongsim-won was above $1,000{\mu}g/ml$. The E18 cortical neuroblasts, which were added 50, 100, and $500{\mu}g/ml$ Woohwangcheongsim-won, were exposed 98% $N_2/5%\;CO_2$ for 3 hours to induce hypoxia, 3 days later, the survival rate of $50{\mu}g/ml$ Woohwangcheongsim-won was 141.5% when compared to the control group. On the immuneblot assays, the expressions of ${\alpha}$CaMKII, NR2A, NR28, PDE2, PSD-95, and eEF-$1{\alpha}$ were increased in normoxia, but those of NR2A, NR2B were decreased in hypoxia when compared to the control group. Conclusions : The data shows that the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast is a significant result.
( Shin Hwang Sang ),( Hyun Kang Young ),( Joo Lee Ki ),( Hun Kim Chul ),( Soo Ahn Deok ),( Bog Moon Tae ),( Yong Ha Gi ),( Won Song Dong ),( Hwan Jung Sung ),( Gyu Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Several important changes were made to the 8th edition of American Joint Commission on Cancer (AJCC) tumor staging system for intrahepatic cholangiocarcinoma (ICC). We assessed the prognostic impact of this new tumor staging system compared to the 7th edition. Methods: A retrospective single-institution study was performed with 626 patients who underwent R0 resection for ICC over 20-year period. Results: Anatomical resection and concurrent bile duct resection were performed in 571 (91.2%) and 62 (9.9%) patients, respectively. Cumulative tumor recurrence and patient survival rates were 40.6% and 73.3% at 1 year; 66.7% and 43.8% at 3 years; 73.6% and 30.4% at 5 years; and 74.4% and 20.3% at 10 years, respectively. Independent prognostic factors for tumor recurrence and patient survival were multiple tumors, CA 19-9 >200 U/mL, tumor size >5 cm, direct invasion to extrahepatic structure, and lymph node metastasis. For TNM stages in the 7th versus the 8th editions, C-index was 0.615 and 0.625 for tumor recurrence and 0.626 and 0.628 for patient survival, respectively. Conclusions: The 8th edition AJCC appears to provide high prognostic contrast for T stage categories, except for T3. However, overall prognostic performance of the 8th edition was not markedly improved over the 7th edition.
Resection of Pulmonary Metastases from Hepatocellular Carcinoma following Liver Transplantation
Shin Hwang,Yong-Hee Kim,Dong Kwan Kim,Chul-Soo Ahn,Deog-Bok Moon,Ki-Hun Kim,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Hyeong Ryul Kim,Gil-Chun Park,Yong-dong Yu,Sung-Gyu Lee 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.4
( Shin Hwang ),( Young-joo Lee ),( Ki-hun Kim ),( Chul-soo Ahn ),( Deok-bog Moon ),( Tae-yong Ha ),( Gi-won Song ),( Sung-gyu Lee ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Purpose: We hypothesized that microvascular invasion (MVI) and the post-resection prognosis in patients with solitary hepatocellular carcinoma (HCC) could be predicted using blood tumor markers and tumor burden. Thus, we intended to identify a simple surrogate marker via a combination of clinical variables. Methods: This retrospective study used a narrowly selected development cohort (n=1,176) and a validation cohort (n=551) containing patients who underwent curative resection of solitary HCC. Results: In the development cohort, the median values were 13.7 mL for tumor volume (TV), 24.2 ng/mL for a-fetoprotein (AFP), and 75 mAU/mL for des-γ-carboxy prothrombin (DCP); there was no correlation among these three factors (r2≤0.237, p=0.000). The 1-, 2-, 3-, and 5-year rates were 22.4%, 34.4%, 41.7%, and 46.8% for tumor recurrence and 93.6%, 88.2%, 84.0%, and 78.2% for patient survival, respectively (Fig. 1). Independent risk factors for both tumor recurrence and patient survival were tumor diameter>5cm or TV>50 mL, MVI, satellite nodules, and high DCP. Multiplication of AFP, DCP, and TV (the ADV score) resulted in an MVI cutoff of 5log with a sensitivity of 73.9% and specificity of 66.7%. Patient stratification according to an ADV score with cutoffs of 5log alone or 6log/9log and combination with MVI showed significant prognostic differences (all p<0.000). This prognostic significance was reliably reproduced in the validation cohort (all p<0.000). Conclusion: The ADV score is an integrated surrogate marker of HCC prognosis. We believe that it can be used to predict MVI and the post-resection prognosis before and after surgery.
( Won Tae Kim ),( Kang Moon Seo ),( Yeo Sung Yoon ),( Jae Hoon Kim ),( Jung Hee Yoon ),( Man Bok Jeong ),( Sun Shin Yi ),( Shin Ae Park ),( Hyung Gun Kim ),( Jeong Taek Ahn ),( Chull Gyu Park ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.4
The objective of the present study was to evaluate the effect of a mixed extract of three herbs, Panax Notoginseng, Rehmanniae Radix and Acanthopanacis cortex (AIF), for the treatment of horses with experimentally induced osteoarthritis. Twelve healthy male horses were included in this study. Horses were assigned to one of two groups: the AIF group (n=6) or the control group (n=6). Osteoarthritis was induced in all horses by intraarticular injection of sodium monoiodoacetate (0.12 mg/kg). Horses in the AIF group received 3 g of AIF with food daily, and those in the control group received food only. Treatment began on the day of intraarticular injection. Clinical and radiographic evaluations were performed every 2 weeks. At week 12, horses were euthanatized, and postmortem gross pathologic and histologic examinations of the middle carpal joint were performed. There were no significant differences in clinical values between the two groups. Radiographic evaluation revealed that the percentages of narrowness of joint space width in the control group were significantly higher than those in the AIF group (p<0.02). On gross pathologic examination, the mean total dimensions of articular cartilage erosions and fibrillations in the control group (101.5±41.5 mm²) were significantly wider than those in the AIF group (29.3±39.7 mm²; p<0.01). On histopathologic evaluation, significantly higher grades of staining intensity and lower empty lacunae (EL) ratios were found in the AIF group (p<0.03). The present study revealed that AIF had significant disease modifying effects in horses with experimentally induced osteoarthritis.
( Shin Hwang ),( Woo-hyoung Kang ),( Eunyoung Tak ),( Gi-won Song ),( Ki-hun Kim ),( Chul-soo Ahn ),( Deok-bog Moon ),( Tae-yong Ha ),( Dong-hwan Jung ),( Gil-chun Park ),( Sung-gyu Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: We investigated metformin-induced cytotoxic effects in vitro and assessed the chemopreventive effects of metformin in patients undergoing hepatic resection (HR) for hepatocellular carcinoma (HCC). Methods: This study consisted of two independent parts: a laboratory research and a clinical study to assess the antitumor effects of metformin. The laboratory research assessed whether exposure to metformin has any cytotoxic effect on liver tumor cell lines. In the clinical study, the rate of tumor recurrence and overall patient survival after HR of HCC were investigated to assess whether long-term exposure to metformin has any chemopreventive effects. Results: In vitro study using HCC cell lines revealed noticeable cytotoxic effects of metformin, which were largely weaker than those of sorafenib. In the clinical study, no statistical differences were found in tumor recurrence or overall survival between metformin and control groups. In contrast, there was a non-significant difference in tumor recurrence between metformin and propensity score-matched control groups, but there was significant difference in overall patient survival. Metformin administration was an independent risk factor for patient survival. Conclusions: In conclusion, our in vitro laboratory study demonstrated presence of cytotoxic effects of metformin. Metformin administration was associated with reduced tumor recurrence and helped induce significant improvements in overall patient survival in patients who underwent HR for HCC.
Shin Hwang,Kyung Jin Lee,Deok-Bog Moon,Gi-Won Song,Dong-Hwan Jung,Yun Kyu Kim,Hunji Yang,Da Eun An,Sion Lee,Sung-Gyu Lee 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.1
Purpose: The programmed death protein 1 (PD-1) pathway is the critical mechanism in development of hepatocellular carcinoma (HCC). The present study analyzed the prognostic impact of pretransplant serum soluble PD-1 (sPD-1) concentration and α-FP–des-γ-carboxyprothrombin–tumor volume (ADV) score in patients with previously untreated HCC undergone liver transplantation (LT). Methods: This retrospective single-center study enrolled 100 patients with HCC who underwent living donor LT from 2010 to 2016. Concentrations of sPD-1 were measured in stored serum samples. Results: Receiver operating characteristic curve analysis of 2-year tumor recurrence resulted in an sPD-1 cutoff of 177.1 μg/mL, which was associated with higher rates of tumor recurrence (P = 0.022), but not with overall patient survival (P = 0.460). The derived cutoff for pretransplant ADV score was 5.4log, which was associated with higher tumor recurrence rate (P < 0.001) and lower overall patient survival rate (P < 0.001). Both sPD-1 of >177.1 μg/mL (hazard ratio [HR], 2.26; P = 0.020) and pretransplant ADV score of >5.4log (HR, 3.56; P < 0.001) were independent risk factors for posttransplant HCC recurrence. The combination of these 2 factors enabled the stratification of patients into 3 groups, with groups having 0, 1, and 2 risk factors differing significantly in the prognosis of tumor recurrence (P < 0.001) and overall patient survival (P = 0.006). Conclusion: Both sPD-1 concentration and ADV score have prognostic impacts in patients who underwent LT for untreated HCCs. These factors, both individually and combined, can help in predicting posttransplant prognosis.
Liver retransplantation for adult recipients
Shin Hwang,Chul-Soo Ahn,Ki-Hun Kim,Deok-Bog Moon,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Gil-Chun Park,Sung-Gyu Lee 한국간담췌외과학회 2013 한국간담췌외과학회지 Vol.17 No.1
Living donor liver graft can be used for the first or second liver transplantation. The timing of retransplantation also should be stratified as 2 types according to the reoperation timing. Combination of these two classifications results in 6 types of living donor liver transplantation (LDLT)-associated retransplantation. However, late retransplantation to LDLT might have not been performed in most LDLT programs, thus other 4 types of LDLT-associated retransplantation can be taken into account. The most typical type of LDLT-associated retransplantation might be early living donor-to-deceased donor retransplantation. For early living donor-to-living donor retransplantation, its eligibility criteria might be similar to those of early living donor-to-deceased donor retransplantation. For early deceased donor-to-living donor retransplantation, its indications are exactly the same to those for aforementioned living donor-to-living donor retransplantation. Late deceased donor retransplantation after initial LDLT has the same indication for ordinary late deceased donor retransplantation.