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First Finding of a Bivalve-Inhabiting Hydrozoan (Cnidaria, Hydrozoa) from Korea
Shin Kubota,이지민,장천영 한국동물분류학회 2019 Animal Systematics, Evolution and Diversity Vol.35 No.2
Eutima japonica Uchida, 1925, a bivalve-inhabiting hydrozoan was collected for the first time in Korea, associating with Mytilus galloprovincialis. The morphology of male medusae of this hydrozoan is clarified by culture and described as well as other developmental stages. As the present material from Korea is in good accord with that of the northern Japanese form of E. japonica, so the geographical distribution of the northern form of this species is widened, Japan, China and Korea. Green fluorescent protein distribution pattern of this medusa is also described and compared with that of the most related species Eutima sapinhoa Narchi and Hebling, 1975.
First Finding of a Bivalve-Inhabiting Hydrozoan (Cnidaria, Hydrozoa) from Korea
Kubota, Shin,Lee, Jimin,Chang, Cheon Young The Korean Society of Systematic Zoology 2019 Animal Systematics, Evolution and Diversity Vol.35 No.2
Eutima japonica Uchida, 1925, a bivalve-inhabiting hydrozoan was collected for the first time in Korea, associating with Mytilus galloprovincialis. The morphology of male medusae of this hydrozoan is clarified by culture and described as well as other developmental stages. As the present material from Korea is in good accord with that of the northern Japanese form of E. japonica, so the geographical distribution of the northern form of this species is widened, Japan, China and Korea. Green fluorescent protein distribution pattern of this medusa is also described and compared with that of the most related species Eutima sapinhoa Narchi and Hebling, 1975.
Evaluating the activity of N-89 as an oral antimalarial drug
Nagwa S. M. Aly,Hiroaki Matsumori,Thi Quyen Dinh,Akira Sato,Shin-Ichi Miyoshi,장경수,유학선,Takaaki Kubota,Yuji Kurosaki,Duc Tuan Cao,Gehan A. Rashed,김혜숙 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.3
Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t1/2 was 0.97 h, Tmax was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED50) and ED90 values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89- treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic char-acteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.