A review on graphene nanoribbons for advanced biomedical applications

Shende Pravin,Augustine Steffi,Prabhakar Bala 한국탄소학회 2020 Carbon Letters Vol.30 No.5

Graphene nanoribbons materialize as a next-generation carrier for development of nanodimensional diagnostic devices and drug delivery systems due to the unique and cutting-edge electronic, thermal, mechanical and optical properties associated with graphene. This review article focuses on the important applications of GNRs in the feld of biomedicine and biosensing. Graphene nanoribbons are highly developed form of graphene with a wide importance due to their distinctive properties such as large surface area, enhanced mechanical strength and improved electro-conductivity. GNRs are efective substitutes for conventional silicon-based transistors used in biochemical reactions and exploited in the felds of biomedicine and diagnos�tics due to their efective uptake by mammalian cells. The cellular interactions of GNRs consist of highly specifc receptor�mediated transport, phagocytosis and non-specifc transport systems involving copious forces of adhesion. The presence of quantum chains in GNRs increases their potential for fabrication of technically challenging sensing devices in the future.

Least absolute deviation estimator based consistent model selection in regression

Shende, K.S.,Kashid, D.N. The Korean Statistical Society 2019 Communications for statistical applications and me Vol.26 No.3

We consider the problem of model selection in multiple linear regression with outliers and non-normal error distributions. In this article, the robust model selection criterion is proposed based on the robust estimation method with the least absolute deviation (LAD). The proposed criterion is shown to be consistent. We suggest proposed criterion based algorithms that are suitable for a large number of predictors in the model. These algorithms select only relevant predictor variables with probability one for large sample sizes. An exhaustive simulation study shows that the criterion performs well. However, the proposed criterion is applied to a real data set to examine its applicability. The simulation results show the proficiency of algorithms in the presence of outliers, non-normal distribution, and multicollinearity.

Solid State Synthesis Processing and Electrical Properties of Sr(TixZr1-x)O3 (0=x=1) Ceramics for high Voltage Applications

RajeshV.Shende,DanielS.Krueger,StephenJ.Lombardo 한양대학교 세라믹연구소 2003 Journal of Ceramic Processing Research Vol.4 No.4

Burden of diseases in fifty-three urban agglomerations of India due to particulate matter (PM<SUB>2.5</SUB>) exposure

Pritanjali Shende,Asif Qureshi 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.3

A nested 3d-chemical transport model, GEOS-Chem, was used to estimate the burden of disease (BoD) from PM2.5 exposure in fifty-three urban agglomerations (UAs) in India with population of 1 million or more, and the contribution of different chemical components to the PM2.5 burden in these locations. Premature mortality due to four diseases (ischemic heart disease, IHD, chronic obstructive pulmonary disease, COPD, stroke and lung cancer) caused by exposure to PM2.5 was estimated using an integrated exposure response function. The studied 53 UAs accounted for approximately 20% of the total premature mortality of 0.54 (0.45–0.63) million in India. Delhi had the maximum premature mortality (11945) followed by Kolkata (9204), Mumbai (8817), Bangalore (4528) Hyderabad (4157) and Chennai (3818). Premature mortality was 2% to 59% higher than the country average in model regions containing UAs. Contribution from different chemical components was in the order: organic carbon (18–30%) > NO₃<SUP>-</SUP> (8–21%) > SO₄<SUP>2-</SUP> (5–16%) > NH₄<SUP>+</SUP> (6–9%) > black carbon (2.5–4%). Our estimates suggest policies targeting multiple compounds are required to achieve large reductions in PM2.5 pollution in urban regions.

Real time simulation of groundwater quality index using adaptive neuro-fuzzy inference

Ashay Devidas Shende,Mrunmayee Manjari Sahoo 대한공간정보학회 2024 Spatial Information Research Vol.32 No.1

o ensure sufcient quality and quantity of water for drinking, it is imperative to determine the contamination and quantifcation of potential damage of existing groundwater resources. The indexing of various water quality parameters and prediction of groundwater quality provide extensive technical assistance for the strategic management of groundwater resource. In this study, simulation of the groundwater quality index is carried out using adaptive neuro fuzzy inference system (ANFIS). The diferent combinations of input parameters are selected to develop the optimal model using grid partitioning and subtractive clustering FIS type. The architecture of ANFIS model is designed using Gaussian type membership function optimized through hybrid of back propagation and least square method. A total of 893 groundwater samples from 68 locations used for model development. The performance of models is weighed using correlation coefcient (R) and root mean square error. The Model 4 consisting physio0chemical and anions produces R as 0.921 and 0.837 for training and testing. The results suggested that ANFIS is a robust model that could be used with high accuracy for the prediction of groundwater quality index. Selection of adequate input parameter and ANFIS structure is a right approach for the prediction of groundwater quality and useful for decision makers for allocating water resources.

Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway

김완식,김채하,이정민,전정호,강범구,Madhuri Shende Warkad,괴즈데 인치,서홍원,임순성,김성찬,김재봉,이재용 한국통합생물학회 2021 Animal cells and systems Vol.25 No.1

Purple corn extract (PCE) is a nutraceutical, an activator of AMPK, and it has antioxidants and anticancer properties. Therefore, PCE could be a candidate for alleviating cigarette smoke (CS)- induced oxidative DNA damage. This study examined whether PCE can have a protective effect on blood cells in an animal model of cigarette smoke (CS)-induced DNA damage. PCE was orally administered to CS-inhaled Spraque-Dawley (SD) rats, followed by the target cells being examined for markers of DNA damage. The study also sought to elucidate the mechanism of PCE action in the PCE treated animals. SD rat inhalation of CS was for once a day for 30 min, repeated for 7 days. PCE was administered orally before CS inhalation. Pretreatment of the animals with oral PCE kept the numbers of white blood cells (WBC) as well as neutrophils (NE), lymphocytes (LY), monocytes (Mo), eosinophils (EO), abd jasophils (BA) from increasing as those were increased in the CS-inhaling SD rats. The amount of phosphorylated γ-H2AX, a DNA damage marker, was assayed in the circulating blood cells collected from the animals and western blot analysis with anti-Foxo3a, p-Foxo3a, p-AMPK, MnSOD antibodies were performed on those cells. PCE protected the circulating blood cells from CS inhalation-induced DNA damage by 44% as assayed by increases in γ-H2AX. PCE also increased the nuclear localization of Foxo3a by 52% over control cells. Mechanistically, PCE appears to efficiently protect various blood cell types from CS-induced DNA damage through removal of ROS via activation of the AMPK/Foxo3a/MnSOD pathway.

Phosphonium based ionic liquids: Potential green solvents for separation of butanol from aqueous media

Kalyani Ashok Motghare,Diwakar Zaparu Shende,Kailas Lachchhuram Wasewar 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.10

Depleting conventional resources leads to the development of alternate energy sources as a result of rising energy demand. As a result of its high energy content, bio-butanol is an appealing fuel. Yet, a fermentation method of butanol generation by acetone*butanol*ethanol using solventogenic Clostridium has significant limitations. In addition to repressing microbial movement (normally greater than 10 g/L), it also affects their production. In order to separate butanol from aging broth, various separation techniques can be used. As an alternative to traditional solvents, ionic liquids can be used as novel extractants to counter these problems. In the present paper, separation of butanol (simulated) from aqueous media utilizing typical hydrophobic ionic liquids was studied at 298±1 K. Various parameters, such as distribution coefficent (Kd), extraction efficiency (%), diffusion coefficient, solvent-to-feed ratio diffusion coefficient, and number of stages necessary for butanol separation, have been studied. Separation of butanol from aqueous solutions (0.25-2.5 wt%)Trihexyltetradecylphosphonium bis(trifluoromethylsulfonyl) amide-CYPHOS IL 109 THTDP [NTF2] ionic liquid, (purity 95.0%), Trihexyltetradecylphosphonium chloride-CYPHOS IL 101 THTDP[Cl] (purity 95.0%), at ambient conditions (298.15±1 K) was carried out. The average separation efficiency of butanol was observed highest (%E 80.43) with hydrophobic THTDP [NTF2] ionic liquid. The maximum average distribution coefficient (Kd) 11.055 was found for RTIL ionic liquid THTDP [NTF2] compared to THTDP [Cl] ionic liquid. Minimum solvent-tofeed ratio was observed for ionic liquid, THTDP [NTF2], (S/Fmin, 0.3829) and for THTDP [Cl], (S/Fmin, 0.201). Due to excellent/better mixing blending properties with gasoline and diesel fuels, recovery of this prospective butanol by ionic liquid could be utilized in gasoline-driven combustion systems. It would be a more promising alternative to ethanol and gasoline for large-scale applications. Thus, after evaluating the above parameters, it has been determined that butanol would be the most effective renewable biofuel for commercialization using ionic liquids as an extractant.

Histomorphometric demonstration of the effect of chronic use of nonsteroidal anti-inflammatory drugs–ibuprofen on mucosa of small intestine

Yuganti Prabhakar Vaidya,Aditya M. Tarnekar,Moreshwar R. Shende 대한해부학회 2018 Anatomy & Cell Biology Vol.51 No.2

The purpose of this study was to ascertain change in structure of mucosa of small intestine, if any, in small intestine of Swiss albino mice as an effect of chronic use of nonsteroidal anti-inflammatory drugs‒Ibuprofen. Longitudinal study conducted on 46 adult Swiss albino mice, 23 as experimental and 23 as control. Ibuprofen was given at a dose of 40 g/g body weight per day for 6 weeks by intragastric route in experimental group of mice while control group of mice received same volume of distilled water. Mice of both the groups were sacrificed and desired segments of small intestines were dissected out and tissues were subjected to histological processing. Histomorphometry was performed and relevant photomicrographs were obtained. Student’s unpaired t test by GraphPad Prism 6 software. Height of villi was not significantly altered but there was significant reduction of the number of goblet and non-goblet cells (enterocytes and other columnar cells) in mucosal lining of the small intestine of experimental group of mice. Percent distribution of the goblet and non-goblet cells was not altered in villi of two groups. Chronic exposure of Ibuprofen in therapeutic dosage caused reduction of the functional cell mass in lining epithelium of villi of middle segment of small intestine. However, there was no evidence of ulcerative or hemorrhagic lesion.

Synthesis, characterization and application of 1-butyl-3-methylimidazolium tetrafluoroborate for extractive desulfurization of liquid fuel

Dharaskar, S.A.,Wasewar, K.L.,Varma, M.N.,Shende, D.Z.,Yoo, C. Elsevier ; King Saud University 2016 Arabian journal of chemistry Vol.9 No.4

<P>In the present paper the experimental data of extractive desulfurization of liquid fuel using 1-butyl-3-methylimidazolium tetrafluoroborate [BMIM]BF4 have been presented. The data of FTIR, 1 H NMR and C-13 NMR have been discussed for the molecular confirmation of synthesized [BMIM]BF4. Further, the thermal properties, conductivity, solubility, and viscosity analysis of the [BMIM]BF4 were carried out. The effects of reaction time, reaction temperature, sulfur compounds, and recycling of ionic liquid without regeneration on dibenzothiophene removal of liquid fuel were presented. In extractive desulfurization process, the removal of dibenzothiophene in n-dodecane was 73.02% for mass ratio of 1: 1 in 30 min at 30 degrees C under the mild reaction conditions. The ionic liquids could be reused four times without a significant decrease in activity. Also, the desulfurizations of real fuels, multistage extraction were presented. The data and results provided in the present paper explore the significant insights of imidazoled ILs for extractive desulfurization of liquid fuels. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.</P>

Extractive Desulfurization of Liquid Fuels by Energy Efficient Green Thiazolium based Ionic Liquids

Dharaskar, Swapnil A.,Wasewar, Kailas L.,Varma, Mahesh N.,Shende, Diwakar Z.,Yoo, Chang Kyoo American Chemical Society 2014 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.53 No.51

<P>In the present paper, experimental data on extractive desulfurization of liquid fuel using 3-butyl-4-methylthiazolium thiocyanate [BMTH]SCN is presented. The Fourier transform infrared (FTIR), <SUP>1</SUP>H NMR, and <SUP>13</SUP>C NMR analyses have been discussed for the molecular confirmation of synthesized [BMTH]SCN. Further, conductivity, solubility, and viscosity analyses of [BMTH]SCN were performed. The effects of reaction time, reaction temperature, sulfur compounds, ultrasonication, and recycling of [BMTH]SCN without regeneration on removal of dibenzothiophene from liquid fuel were also investigated. In the extractive desulfurization process, the removal of dibenzothiophene in octane was 81.2% for mass ratio of 1:1 in 30 min at 30 °C under the mild reaction conditions. Thiazolium ionic liquids could be reused five times without a significant decrease in activity. Also, the desulfurization of real fuels, multistage extraction was examined. The data and results provided in present paper explore the significant insights of thiazolium based ionic liquids as novel extractant for extractive desulfurization of liquid fuels.</P>