Time-related Mapping of Quantitative Trait Loci Controlling Dry Matter Accumulation and Partitioning in Rice

Shao Bo Li,Zhi Hong Zhang,Shao Qing Li,Yang Sheng Li,You Lin Zhu,Ying Guo Zhu 한국유전학회 2008 Genes & Genomics Vol.30 No.4

Grain yield is a result of dry matter accumulation and partitioning in rice (Oryza sativa L.). To characterize the genetic basis of dynamics of traits representing dry matter accumulation and partitioning as well as their relationships with each other, composite interval mapping of quantitative trait loci (QTL) was conducted based on time-related phenotypic data obtained from a population of 258 recombinant inbred lines (F12), which was derived from a cross between Lemont (japonica var.) and Teqing (indica var.). A total of twenty-three QTL were identified for leaf weight, stem weight and panicle weight at four measuring stages after heading. However, these three dynamic traits were observed to be controlled by different QTL (genes) at different growth stages. An extreme example was that at least three types of QTL (genes) might be involved in the development of panicle weight. Growth duration, which is closely related to dry matter accumulation and partitioning, was also identified to be significantly affected by four QTL. The close correlations among the studied four traits were explained to some extent by six co-located QTL. Nevertheless, it would be of great importance to distinguish the pleiotropic or linked effects of the co-located QTL. In addition, the chromosome regions or QTL identified in this study were compared with those previously reported for the same or related traits with the same RIL population.

Trajectory Tracking Control of Nonholonomic Wheeled Mobile Robots Using Model Predictive Control Subjected to Lyapunov-based Input Constraints

Jing-Jun Zhang,Rui-Zhen Gao,Zhi-Li Fang,Zhong-Qi Zhang,Shao-Bo Zhang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.5

This paper studies the trajectory tracking control for the nonholonomic wheeled mobile robot (WMR) based on model predictive control (MPC). Concerning overcome stable problem occurred from optimization control of MPC, we develop an MPC controller subjected to Lyapunov-based input constraints (LMPC) to solve the trajectory tracking problem for the nonholonomic WMR. The Lyapunov stable characteristic of the feedback linearization (FL) is utilized to ensure the stability of the control system. The recursive feasibility of input and stability of the control system based on LMPC is analyzed by the contraction constraint of FL. Besides, the paper also demonstrates the stability of the trajectory tracking control by the receding horizon optimized control solution embedded in LMPC. The simulation experiment results significantly verify the validity of the proposed LMPC approach in trajectory tracking.

Downregulated MicroRNA-133a in Gastric Juice as a Clinicopathological Biomarker for Gastric Cancer Screening

Shao, Juan,Fang, Peng-Hua,He, Biao,Guo, Li-Li,Shi, Ming-Yi,Zhu, Yan,Bo, Ping,Zhang, Zhen-Wen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5

Circulatory miR-133a is a marker shared by several types of cancer. In this study we evaluated the feasibility of using miR-133a levels in gastric juice to screen for gastric cancer. A total of 204 samples of gastric juice and mucosa from gastric cancer, atrophic gastritis, gastric ulcer, superficial gastritis and healthy cases were collected by gastroscopy. The results showed that miR-133a levels in gastric juice and carcinoma tissues of patients with gastric cancer were significantly downregulated and positively correlated. Moreover, miR-133a in gastric juice has high operability, high reliability, high sensitivity, high specificity and relative stability, fit for clinical diagnosis of gastric cancer.

Intranasal Oxytocin Increases Perceptual Salience of Faces in the Absence of Awareness

Shao-Wei Xue,Hua-Bo Wu,Lanhua Zhang,De-Xuan Zhang 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.4

Objective The neuropeptide oxytocin has been found to improve human social cognition and promote prosocial behavior. However, it is still unclear about the mechanisms underlying these effects of oxytocin on neural processes, such as visual perception and awareness. Especially, it is still unclear whether oxytocin influences perceptual salience of social stimuli in the absence of awareness. Methods In a randomized double-blind, placebo-controlled trial we applied an interocular suppression paradigm and eye tracking methods to investigate the influence of intranasally administered oxytocin on perceptual salience of social stimuli. Suppression times and pupillometric data were measured during subjects being presented with gradually introduced pictures of social stimuli (neutral expression faces) or nonsocial stimuli (grayscale watch pictures) that were suppressed and invisible in 10 men who were administered 24 IU oxytocin and 10 men who were administered a placebo. Results The results demonstrated that the oxytocin group perceived social stimuli more quickly accompanied by subsequent larger increasing pupil diameter than nonsocial stimuli, indicating an increased unconscious salience of social stimuli. Conclusion These findings provided new insights into oxytocin’s modulatory role to social information processing, suggesting that oxytocin might enhance attentional bias to social stimuli even after removal of awareness.

The small GTPase CDC42 regulates actin dynamics during porcine oocyte maturation

ZHANG, Yu,WANG, Qiao-Chu,LIU, Jun,XIONG, Bo,CUI, Xiang-Shun,KIM, Nam-Hyung,SUN, Shao-Chen 家畜繁殖硏究所 2017 Journal of Reproduction and Development Vol. No.

<P> The mammalian oocyte undergoes an asymmetric division during meiotic maturation, producing a small polar body and a haploid gamete. This process involves the dynamics of actin filaments, and the guanosine triphosphatase (GTPase) protein superfamily is a major regulator of actin assembly. In the present study, the small GTPase CDC42 was shown to participate in the meiotic maturation of porcine oocytes. Immunofluorescent staining showed that CDC42 was mainly localized at the periphery of the oocytes, and accumulated with microtubules. Deactivation of CDC42 protein activity with the effective inhibitor ML141 caused a decrease in actin distribution in the cortex, which resulted in a failure of polar body extrusion. Moreover, western blot analysis revealed that besides the Cdc42-N-WASP pathway previously reported in mouse oocytes, the expression of ROCK and p-cofilin, two molecules involved in actin dynamics, was also decreased after CDC42 inhibition during porcine oocyte maturation. Thus, our study demonstrates that CDC42 is an indispensable protein during porcine oocyte meiosis, and CDC42 may interact with N-WASP, ROCK, and cofilin in the assembly of actin filaments during porcine oocyte maturation.</P>

Terahertz Spectral Characteristics of Electrolyte Solutions under Different Magnetic Fields

Siyu Shao,Haiyun Huang,Bo Peng,Guoyang Wang,Ping Ye,Jiahui Wang,Bo Su,Hailin Cui,Cunlin Zhang 한국광학회 2022 Current Optics and Photonics Vol.6 No.3

Microfluidic chips are new devices that can manipulate liquids at the micrometer level, and terahertz (THz) time-domain spectroscopy has good applicability in biochemical detection. The combination of these two technologies can shorten the distance between sample and THz wave, reduce THz wave absorption by water, and more effectively analyze the kinetics of biochemical reactions in aqueous solutions. This study investigates the effects of different external magnetic field intensities on the THz transmission characteristics of deionized water, CuSO 4 , CuCl 2 , (CH 3 COO) 2 Cu, Na 2 SO 4 , NaCl, and CH 3 COONa; the THz spectral intensity of the sample solutions decrease with increasing intensity of the applied magnetic field. Analysis shows that the magnetic field leads to a change in the dipole moment of water molecules in water and electrolyte solutions, which enhances not only the hydrogen-bond networking ability of water but also the hydration around ions in electrolyte solutions, increasing the number of hydrogen bonds. Increasing the intensity of this magnetic field further promotes the hydrogen-bond association between water molecules, weakening the THz transmission intensity of the solution.

Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis

Juan Zhang,Dong-Ling Xu,Xiao-Bo Liu,Shao-jie Bi,Tong Zhao,Shu-Jian Sui,Xiao-Ping Ji,Qing-Hua Lu 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.2

Purpose: Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and Rho kinase activity may be associated with atherosclerosis. The principal aim of this study was to examine whether darapladib (a selective Lp-PLA2 inhibitor) could reduce the elevated Lp-PLA2 and Rho kinase activity in atherosclerosis. Materials and Methods: Studies were performed in male Sprague-Dawley rats. The atherosclerosis rats were prepared by feeding them with a high-cholesterol diet for 10 weeks. Low-dose darapladib (25 mg·kg-1·d-1) and high-dose darapladib (50 mg·kg-1·d-1) interventions were then administered over the course of 2 weeks. Results: The serum levels of triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoproteincholesterol (HDL-C), high-sensitivity C-reactive protein (hs-CRP), and Lp-PLA2, significantly increased in atherosclerosis model groups, as did Rho kinase activity and cardiomyocyte apoptosis (p<0.05 vs. sham group), whereas nitric oxide (NO) productionwas reduced. Levels of TC, LDL-C, CRP, Lp-PLA2, and Rho kinase activity were respectively reduced in darapladib groups, whereas NO production was enhanced. When compared to the low-dose darapladib group, the reduction of the levels of TC, LDL-C, CRP, and Lp-PLA2 was more prominent in the high-dose darapladib group (p<0.05), and the increase of NO productionwas more prominent (p<0.05). Cardiomyocyte apoptosis of the high-dose darapladib group was also significantly reduced compared to the low-dose darapladib group (p<0.05). However, there was no significant difference in Rho kinase activity between the low-dose darapladib group and the high-dose darapladib group (p>0.05). Conclusion: Darapladib, a Lp-PLA2 inhibitor, leads to cardiovascular protection that might be mediated by its inhibition of both Rho kinase and Lp-PLA2 in atherosclerosis.

An association study between IL1RAPL2 gene and non-specific mental retardation in Chinese children

Ke-Jin Zhang,Bo He,Ping-Yuan Gong,Xiao-Cai Gao,Zi-Jian Zheng,Shao-Ping Huang,Fu-Chang Zhang 한국유전학회 2010 Genes & Genomics Vol.32 No.2

Non-specific mental retardation (NSMR) is one of common children psychiatric diseases with a high prevalence (1−3%). Here we investigated the association between the genetic variants of IL1RAPL2 gene and NSMR in the children of QinBa region of China. We chose five common SNPs of IL1RAPL2,examined their individual genotype frequencies using the conventional polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method, and evaluated the association between these genetic polymorphisms and NSMR with the suitable biostatistic software. The allele and genotype distributions of two SNPs (rs5962298 and rs9887672) showed significant differences between the control and NSMR groups (allele: p = 0.020 and 0.017; genotype: p =0.025 for rs9887672 respectively). The distribution differences became more significant in girls, but disappeared in boys, suggesting a gender effect. Taken together, we provide substantial evidence that IL1RAPL2 conferred a NSMR susceptibility to children of Qinba region in China. In future, further work should be carried out to scan mutations and to investigate the specific-gender effect in this gene.

Scandium-doped barium ceria ferrites-based composite mixed conducting hollow fiber membranes for H2 and O2 permeation

Jian Song,Claudia Li,Shao Zhang,Kai Wang,Bo Meng,Xiaoyao Tan,Jaka Sunarso,Shaomin Liu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-

BaCeO3-based ceramics are a unique class of perovskites that exhibit protonic and oxygen ionic conduction,which are ideal for high temperature hydrogen separation applications. This work features Sc-dopedBCFe composites with nominal composition of BaCe0.70Fe0.30-xScxO3d (BCFSc) (x = 0, 0.05, 0.1, 0.15, and0.2) that exhibit enhanced thermal, chemical, and mechanical stability. The BCFSc20 (x = 0.20) hollowfiber membranes demonstrated the highest hydrogen and oxygen fluxes among the Sc-doped compositesof up to 0.32 and 0.20 mL min1 cm2, respectively, at 1000 C. The BCFSc20 hollow fibers also displayedexcellent stability under the hydrogen and oxygen permeation environments, while the permeation performanceof the other BCFSc samples with low Sc content gradually deteriorated over the 120-h stabilitytest.

Two Luminescent Cd(II) Coordination Polymers: Enhancement Activity on Pancreatic Cancer Combined with Biliary Stent Placement and 125I Particles

Jie-Peng Jia,Quan Shao,Ying-Kai Wang,Bo Qian,Wen Zhang,Tao Hu,Ji-Jun Zhang 한국고분자학회 2021 Macromolecular Research Vol.29 No.11

With the reaction between bib ligands, 5-substituted isophthalic acid and Cd(II) ions, we produced two coordination polymers in success, that is, [Cd(5-meo-ip) (bib)0.5]n (2) and [Cd(5-me-ip)(bib)(H2O)]n·n(H2O) (1) (bib is 1,4-bis(imidazoly)butane, 5-meo-H2ip is 5-methoxyisophthalic acid, and 5-me-H2ip is 5-methylisophthalic acid). The luminescent performances and thermal stability of the two compounds were also explored. Their anti-pancreatic cancer activity combined with biliary stent placement and 125I particles was evaluated and the specific mechanism was explored as well. Firstly, after the model construction and compound treatment, the weight and volume of the tumor tissue was measured. Next, the apoptosis level of the cancer cells were evaluated with Annexin V-FITC/PI apoptosis assay.