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Sewoong Lee,Junho Lee,Sayeon Cho 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.9
Triple-negative breast cancer (TNBC) is one of the most difficult cancer types totreat. Because three key receptors are absent in these cancer cells, the cellsbypass the human immune system and chemotherapy does not work well. AristolactamI (AL-I) is a natural compound in the plant genus Aristolochia. Previousstudies have shown that aristolactam variants exhibit an inhibitory effect on severalbioactive cancer developments. However, the regulatory mechanism andbiological activity of AL-I in TNBC cell lines have not been identified. In this study,AL-I affected an increase in E-cadherin expression in MDA-MB-231 cancer cells. AL-I increased E-cadherin mRNA expression by down-regulating Twist1 proteinexpression. The novel anticancer effect of AL-I was confirmed to be inhibition ofthe development of breast cancer cells through reduced cell mobility.
Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research
Sewoong Kim,MinKyoung Kim,Daeyoung Oh,SangHyuk Lee,Borah Kim 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and glial cells. The present review focuses on the recent advancements in modeling psychiatric disorders such as Phelan-McDermid syndrome, Timothy syndrome, Rett syndrome, schizophrenia, bipolar disorder, and dementia. The treatment effects identified in studies on iPSCs using known therapeutic compounds are also summarized in this review. Here we discuss validation of cellular models and explore iPSCs as a novel drug screening tool. Although there are several limitations associated with the current methods used to study mental disorders, using iPSCs as a model system provides the advantage of rewinding and reviewing the development and degeneration of human neural cells.
Sewoong An,Jong Hyang Bae,Ho Cheol Kim,Yurina Kwack 한국원예학회 2021 원예과학기술지 Vol.39 No.5
Since the first commercial vegetable seedling production business was established in the Republic of Korea in 1992, technologies for the production of vegetable grafted seedlings have been developed. Commercial grafting nurseries have promoted the efficiency of grafted seedling production by the selection and concentration strategy. At present, most scions and rootstocks are concentrated on one or two cultivars and all grafted seedlings are made by the splice grafting method. To overcome the disadvantages of the splice grafting method, such as delayed formation of the grafted union and delayed rooting, light-emitting diode (LED) healing chambers (LHCs) have been developed for enhancing grafted union formation, and are currently used in 20% of commercial grafting nurseries. The commercial grafting nurseries in Korea have been facing highly difficult situations because of climate change, increased seedling production cost and labor shortage. To confront this challengeable circumstance, it is essential to optimize grafted seedling production practices to produce high-quality seedlings at lower cost and low impact on the environment, and to ensure a consistent supply to vegetable growers year round. Here, we explored several practices to improve productivity and reduce the environmental impact of grafted seedling production, including the development of disease resistant or abiotic stress tolerant rootstock cultivars, the development of more precise and efficient facilities and cultivation systems such as a grafting robot, the application of a plant factory with artificial lighting, the improvement of light condition in LHCs, and wastewater reuse.