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Sergey Nikolaevich Novikov(Sergey Nikolaevich Novikov ),Irina Aleksandrovna Baldueva(Irina Aleksandrovna Baldueva ),Anton Yurievich Zozulya(Anton Yurievich Zozulya ),Natalya Viktorovna Emelyanova(Nata 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.1
Purpose: To perform the analysis of the peripheral blood lymphocyte changes after stereotactic ablative radiotherapy (SABR) in patients with oligometastatic cancers. Materials and Methods: The dynamics of the immune status in peripheral blood was prospectively evaluated in 46 patients with lung (17 cases) or liver (29 cases) metastases treated by SABR. Flow cytometry of peripheral blood lymphocyte subpopulations was performed before SABR, 3–4 weeks and 6–8 weeks after the end of SABR: 3 fractions of 15–20 Gy or 4 fractions of 13.5 Gy. The number of treated lesions varied from 1 (32 patients) to 2–3 (14 patients). Results: SABR induced a significant increase of T-lymphocytes (CD3+CD19–) (p = 0.001), T-helper (CD3+CD4+) (p = 0.004), activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+) (p = 0.001), activated T-helpers (CD3+CD4+HLA-DR+) (p < 0.001). A significant decrease of T-regulated immune suppressive lymphocytes (CD4+CD25brightCD127low) (p = 0.002) and NKT-cells (CD3+CD16+CD56+) (p = 0.007) was recorded after the SABR. The comparative analysis demonstrated that lower doses of SABR (EQD2Gy(α/β=10) = 93.7–105.7 Gy) induced significant increase of T-lymphocytes, activated cytotoxic T-lymphocytes, and activated CD4+CD25+ T-helpers, while SABR with higher doses (EQD2Gy(α/β=10) = 150 Gy) was not associated with these effects. A more efficient activations of T-lymphocytes (p = 0.010), activated T-helpers (p < 0.001), and cytotoxic T-lymphocytes (p = 0.003) were associated with SABR to a single lesion. A significant increase of T-lymphocytes (p = 0.002), T-helpers (p = 0.003), and activated cytotoxic T-lymphocytes (p = 0.001) was observed after SABR for hepatic metastases in contrast to SABR for lung lesions. Conclusion: Changes in peripheral blood lymphocytes after SABR could be influenced by the location or the number of irradiated metastasis, and the dose of SABR.
Axisymmetric bending of a circular plate with stiff edge on a soft FGM layer
Sergey S. Volkov,Alexander N. Litvinenko,Sergey M. Aizikovich,Yun-Che Wang,Andrey S. Vasiliev 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.59 No.2
A circular plate with constant thickness, finite radius and stiff edge lying on an elastic halfspace is considered. The half-space consists of a soft functionally graded (FGM) layer with arbitrary varying elastic properties and a homogeneous elastic substrate. The plate bends under the action of arbitrary axisymmetric distributed load and response from the elastic half-space. A semi-analytical solution for the problem effective in whole range of geometric (relative layer thickness) and mechanical (elastic properties of coating and substrate, stiffness of the plate) properties is constructed using the bilateral asymptotic method (Aizikovich et al. 2009). Approximated analytical expressions for the contact stresses and deflections of the plate are provided. Numerical results showing the qualitative dependence of the solution from the initial parameters of the problem are obtained with high precision.
Influence of a soft FGM interlayer on contact stresses under a beam on an elastic foundation
Sergey M. Aizikovich,Boris I. Mitrin,Nikolai M. Seleznev,Yun-Che Wang,Sergey S. Volkov 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.58 No.4
Contact interaction of a beam (flexible element) with an elastic half-plane is considered, when a soft inhomogeneous (functionally graded) interlayer is present between them. The beam is bent under the action of a distributed load applied to the surface and a reaction of the elastic interlayer and the half-space. Solution of the contact problem is obtained for different values of thickness and parameters of inhomogeneity of the layer. The interlayer is assumed to be significantly softer than the underlying halfplane; case of 100 times difference in Young’s moduli is considered as an example. The influence of the interlayer thickness and gradient of elastic properties on the distribution of the contact stresses under the beam is studied.
Sergey Nikolaevich Novikov,Pavel Ivanovich Krzhivitskii,Zamira Achmedovna Radgabova,Maxim Andreevitch Kotov,Mikhail Markovich Girshovich,Anna Sergeevna Artemyeva,Yulia Sergeevna Melnik,Sergey Vasilevi 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.3
Purpose: To evaluate correlation of single photon emission computed tomography-computed tomography (SPECT-CT) data on lymph flow (LF) from oral tongue cancer (OC) and the topography of lymph nodes (LN) metastases; to determine the clinical value of lymph flow guided radiotherapy (LFGRT). Materials and Methods: SPECT-CT visualization of LF from the OC lesions was performed after peritumoral injection of 99mTc-phytate in 26 primary patients with clinical stage cT1-2N0M0 disease. We determined the individual drainage (unilateral/bilateral) from the tumor, and localization of sentinel LNs according to the neck levels. Metastases in LNs were verified with histology and a 2-year follow-up. Results: SPECT-CT detected bilateral LF in 10 (38.5%) of 26 patients; in 16 (61.5%) cases the drainage was unilateral. Histology revealed LNs metastases in three cases; regional recurrences were diagnosed in other four patients. In all seven observations metastases were located at the same site and level as the sentinel LNs. In eight (30.8%) of 26 patients sentinel LNs were visualized unilaterally at levels Ib-IIa; in five cases, unilaterally at levels I-IIa-III. In these patients, LFGRT demonstrated 59%-70% reduction of irradiated volume, and 26%-42% and 51%-70% decrease of the mean dose to the spinal cord and the contralateral parotid gland. In patients with a bilateral drainage the reduction of doses absorbed by the spinal cord and contralateral parotid gland was 19% and 6%, respectively. Conclusion: Localization of sentinel LNs determined by SPECT-CT corresponds to the localization of metastatic LNs in terms of side and levels.
Neutronic and thermohydraulic blanket analysis for hybrid fusion-fission reactor during operation
Sergey V. Bedenko,Igor O. Lutsik,Vadim V. Prikhodko,Anton A. Matyushin,Sergey D. Polozkov,Vladimir M. Shmakov,Dmitry G. Modestov,Hector Rene Vega-Carrillo Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7
This work demonstrates the results of full-scale numerical experiments of a hybrid thorium-containing fuel plant operating in a state close to critical due to a controlled source of D-T neutrons. The proposed facility represented a level of generated power (~10-100 MW<sub>t</sub>) in a small pilot. In this work, the simulation of the D-T neutron plasma source operation in conjunction with the facility blanket was performed. The fission of fuel nuclei and the formation of spatial-energy release were studied in this simulation, in pulsed and stationary modes of the facility operation. The optimization results of neutronic and fluid dynamics studies to level the emerging offsets of the radial energy formed in the volume of the facility multiplying part due to the pulsed operation of the D-T neutron plasma source were presented. The results will be useful in improving the power control-based subcriticality monitoring method in coupled systems of the "pulsed neutron source-subcritical fuel assembly" type.
Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma
Sergey A. Staroverov,Vladimir A. Sidorkin,Sergey Yu. Shchyogolev,Lev A. Dykman,Alexander S. Fomin 대한수의학회 2011 Journal of Veterinary Science Vol.12 No.4
In this work, we used a preparation of diminazene, which belongs to the group of aromatic diamidines. This compound acts on the causative agents of blood protozoan diseases produced by both flagellated protozoa (Trypanosoma) and members of the class Piroplasmida (Babesia, Theileria, and Cytauxzoon) in various domestic and wild animals, and it is widely used in veterinary medicine. We examined the behavior of water-disperse diminazene (immobilized in Tween 80 micelles) at the cellular and organismal levels. We assessed the interaction of an aqueous and a water-disperse preparation with cells of the reticuloendothelial system. We compared the kinetic parameters of aqueous and water-disperse diminazene in sheep erythrocytes and plasma. The therapeutic properties of these two preparations were also compared. We found that the surface-active substances improved intracellular penetration of the active substance through interaction with the cell membrane. In sheep blood erythrocytes, micellar diminazene accumulated more than its aqueous analog. This form was also more effective therapeutically than the aqueous analog. Our findings demonstrate that use of micellar diminazene allows the injection dose to be reduced by 30%.
Sergey V. Gnedenkov,Denis P. Opra,Sergey L. Sinebryukhov,Alexander K. Tsvetnikov,Alexander Y. Ustinov,Valentin I. Sergienko 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.3
Electrochemical energy production has been extensively used in large scale applications. At present,organic compounds are considered as efficient and environmentally friendly electrode materials. Thepaper describes the study of the possibility of using hydrolysis lignin as the lithium battery cathodematerial. Hydrolysis lignin features have been investigated by the impedance spectroscopy, scanningelectron microscopy, and energy-dispersive X-ray spectroscopy. The discharge performance ofhydrolysis lignin-based lithium battery was investigated at room temperature using 1 M LiBF4 in gbutyrolactonelectrolyte system. It was found that the specific capacity of hydrolysis lignin was equal to450 mAh g1 at a discharge current density of 25 mA/cm2. Two main voltage plateaus located at ~1.8 and~1.1 V were observed. The chemical composition of cathode materials upon battery discharge down to0.9 V was studied by the X-ray photoelectron spectroscopy and infrared spectroscopy. The suggestionson possible electrochemical reactions occurring in the lithium/hydrolysis lignin system were made onthe basis of the products composition analysis. The results demonstrate the potential of hydrolysis ligninbased batteries to be used as low-rate power sources.
Sergey Nikolaevich Novikov,Petr Krivorotko,Zhanna Bryantseva,Irina Akulova,Alexander Emelyanov,Viktoria Mortada,Olga Ponomareva,Pavel Krzhivitskiy,Sergey Kanaev 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.4
Purpose: We evaluate various approaches to target volume definition and boost delivery in patients with complete response to neoadjuvant systemic therapy (NST) who were treated by radiotherapy without a surgery. Materials and Methods: A pathological complete response (pCR) was diagnosed in 21 of 27 patients included in “surgery de-escalation” prospective observation study. Clips were placed in the primary tumor volume (PrTV) before NST and during the vacuum aspiration biopsy. Twenty patients with pCR underwent the whole breast irradiation and a boost to the PrTV. High-dose rate brachytherapy (HDRB) was the basic technique for boost delivery. Finally, we identified the value of fused images (computed tomography [CT] before NST with simulation CT), clips and their combination for an accurate boost delivery. Results: A complete overlap between PrTV on pre-treatment CT with the localization of the clips on simulation CT was mentioned in 10, partial mismatch in three patients. In 12 of these 13 women, HDRB was successfully used for the boost delivery. In five cases we mentioned a marked discrepancy between the PrTV on fused images and the topography of the clips. In other two women we did not find clips on simulation CT. The fused images in five of these seven patients showed anatomical landmarks (scar, fibrosis) used for identification of the gross tumor volume. In all 20 women with pCR (average follow-up of 16.6 months), there were no locoregional recurrences. Conclusion: Combination of the clips with fusion of pre-NST and simulation CTs is important for an accurate boost delivery.