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      • KCI우수등재
      • KCI등재

        Effects of diesel exhaust particles and urban particles on brain endothelial cells

        Kim Ji Young,Hong Seonmi,Bolormaa Ochirpurev,Seo Je Hoon,Eom Sang-Yong,Kim Yong-Dae,Kim Heon 한국독성학회 2022 Toxicological Research Vol.38 No.1

        Exposure to diesel exhaust particles (DEPs) and urban particles (UPs) increases the incidence of degenerative brain diseases as well as respiratory diseases. However, there is limited evidence on the mechanism of neurotoxicity on exposure to these particles. In the present study, the damage to blood–brain barrier (BBB) function by DEP or UP exposure was evaluated in bEnd.3 cells, which are derived from the brain tissue of Balb/c mice. It was demonstrated that DEP and UP exposure may induce oxidative stress via increasing reactive oxygen species (ROS) and decreasing total antioxidant capacity (TAC) level in bEnd.3 cells. In addition, cells exposed to DEP and UP demonstrated a resistance value of about 50% each compared to the value noted prior to exposure; additionally, Claudin-5 and ZO-1 expression levels were significantly decreased compared to the corresponding levels in the control. It was inferred that DEP or UP exposure diminishes the expression of tight junction proteins in endothelial cells through ROS generation, thereby enhancing endothelial membrane permeability. This study showed that DEPs or UPs induced cell permeability and oxidative stress by increasing ROS generation in bEnd.3 cells. This suggests the possibility that exposure to DEPs or UPs may compromise the integrity of the BBB and induce adverse effects in the CNS.

      • 모체태아의학

        김혜인 ( Hye In Kim ),( Seonmi Nam ),( Yejin Park ),( Yun Ji Jung ),( Ha Yan Kim ),( Kyung Won Kim ),( Myung Hyun Sohn ),( Young-han Kim ),( Joon-ho Lee ),( Soo Jong Hong ),( Ja-young Kwon ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

        Objective: In this study, we evaluated the prevalence of allergic disease in offsprings delivered via the delivery modes of vaginal delivery vs. planned Cesarean section vs. Cesarean section with labor. Methods: This study included 175 mother-neonate pairs from Severance Hospital who were enrolled in the Cohort for Childhood Origin of Asthma and allergic diseases study. Information regarding prenatal environmental factors, delivery, and diagnosis of allergic diseases was obtained from a questionnaire and medical record review. Patients with at least 3 years of follow-up data were included in this study. Results were adjusted for sex, birthweight, gestational age at birth, season of birth, neonatal intensive care unit admission, parity, breastfeeding, and maternal factors. Results: A total of 175 offsprings were eligible for analysis. Among the subjects, 52.0% were delivered by vaginal delivery, 34.3% by planned Cesarean section, and 16.6% by Cesarean section with labor. Fifty-nine offsprings (33.7%) were diagnosed with allergic disease at a median age of 1 year (range 0.5-3 years). The prevalence of allergic disease was not associated with delivery mode after adjusting for confounding variables. Time period from membrane rupture to delivery, duration of the active phase, and the beginning of the pelvic division prior to Cesarean section were not associated with allergic disease development in offsprings. Conclusion: Cesarean section, irrespective of the occurrence of labor before surgery, did not increase the prevalence of allergic disease in infants up to 3 years of age.

      • KCI등재

        엔트로피 가중치를 활용한 지역별 홍수취약도 기반의 서울지역 강우기준 산정기법

        이선미,최영제,이은경,지정원,이재응,Lee, Seonmi,Choi, Youngje,Lee, Eunkyung,Ji, Jungwon,Yi, Jaeeung 한국수자원학회 2022 한국수자원학회논문집 Vol.55 No.4

        Recently Flood damage volume has increased as heavy rain has frequently occurred. Especially urban areas are a vulnerability to flooding damage because of densely concentrated population and property. A local government is preparing to mitigate flood damage through the heavy rain warning issued by Korea Meteorological Administration. This warning classification is identical for a national scale. However, Seoul has 25 administrative districts with different regional characteristics such as climate, topography, disaster prevention state, and flood damage severity. This study considered the regional characteristics of 25 administrative districts to analyze the flood vulnerability using entropy weight and Euclidean distance. The rainfall classification was derived based on probability rainfall and flood damage rainfall that occurred in the past. The result shows the step 2 and step 4 of rainfall classification was not significantly different from the heavy rain classification of the Korea Meteorological Administration. The flood vulnerability is high with high climate exposure and low adaptability to climate change, and the rainfall classification is low in the northern region of Seoul. It is possible to preemptively respond to floods in the northern region of Seoul based on relatively low rainfall classification. In the future, we plan to review the applicability of rainfall forecast data using the rainfall classification of results from this study. These results will contribute to research for preemptive flood response measures.

      • SCOPUSKCI등재

        우리나라 자살률의 추세변동에 관한 연구

        박종순(Jongsoon Park),김순덕(Soonduck Kim),지선미(Seonmi Ji),이제숙(Jesuk Lee) 한국역학회 2003 Epidemiology and Health Vol.25 No.2

        Purpose :This study was conducted to analysis the trends and states of suicide mortality in Korea from 1983 to 2001. Methods: This study was based on data published in 1983-2001 from the annual report of the cause of death statistics of National Statistical Office. Results: First, both of annual suicide rate and adjusted suicide rate rapidly went up in 1996 and hit the highest in 1998. Second, since 1983 only when the suicide rate was the highest in the ages 20-24 rather than other age groups, the suicides have been continuously shown to be the highest in the old age group. Third, the seasonal percentages of suicides were generally high in spring and summer, the seasons when the percentage of sunshine is relatively high, in both results for men and women. Fourth, men have most frequently committed suicide through hanging while their suicide through falling from a high site have least frequently occurred but currently tends to gradually increase. Meanwhile, women have most frequently done suicide generally by using insecticide. Conclusion: In Korea, the suicide rate and suicide percentage of the old people have been yearly increasing, and their suicide rate is also shown to the highest rather than those of other age groups. Therefore, it is necessary to prevent the suicide of the old people through a systematic analysis. Moreover, it is necessary to verify the risk factors and defensive factors for the suicide impulse and suicide attempt. On the basis of this, the construction of a nationwide social safety network for the national mental health is very important to find and treat the problems of the mental health to lead the people to suicide.

      • SCOPUSKCI등재

        서울시 일부 보건소에 등록된 폐결핵 재발 환자의 특성에 관한 연구

        한송이(Songyi Han),김순덕(Soonduck Kim),박종순(Jongsoon Park),지선미(Seonmi Ji),이제숙(Jesuk Lee) 한국역학회 2003 Epidemiology and Health Vol.25 No.2

        Purpose: The purpose of this study is to survey general and clinical characteristics of a group of relapsed patients with pulmonary tuberculosis, who are registered at a public health center in order to provide basic data for treatment of a patient s relapse, follow-up examination after the flrst treatment and health education. Subject: Among 68 relapsed patients with pulmonary tuberculosis registered at two public health centers in Seoul from Jan, I, 2002 to Dec. 31, 2002, 50 patients were selected as research subjects because they were contactable by telephone and they agreed to be a research subject. Method: The research carried out the structured questionnaire survey by telephone and surveyed research subjects' general and clinical characteristics, diseases except tuberculosis, drinking and smoking habit and knowledge about pulmonary tuberculosis treatment. Furthermore, the results of x-ray, whether a cavity existed or not, bacteriologic test, culture examination and drug resistance examination were examined and interval to relapse and history of dose attitude were surveyed. Results: Among relapsed tuberculosis patients, male patients were 60% and they were more than women(40%). Patients over 60 were 42% most. ]n their occupation, 30% of them were unemployed and 50% of patients surveyed had monthly income below one million won. According to the findings in radiographic extent, most 50% of them were minimal, 44% were moderately advanced and 2% were far advanced. Patients who had cavity were 30%. According to the result in bacteriologic test, 54% showed positive smear pulmonary tuberculosis and 50.0% positive culture. According to the result in drug resistance, 24% showed drug resistance against one drug and 76% showed sensitive response. 46% had experienced medication side effects. According to interval to a relapse, 32% were relapsed less than 2 years, 14% less than 3-5 years and 54% more than 5 years. Average interval before a relapse were 11.6 years(11.6±11.15). There was a difference between their past regimen and their present regimen(P=0.001). The attitude towards taking a medication was assessed and they showed higher compliance with medication at present than in the past(P=0.001). In a case of smoking rate during treatment, the rate of non-smokers, who had been smokers, were higher(P=0.047). Conclusion: As a result, in order to prevent the disease from being relapsed and to increase the rate of treatment effectiveness, we need to make patients recognize the importance of regular follow-up examination and we should control thoroughly the patients. Furthermore, we need to provide them with more health education not to stop taking a medication earlier.

      • KCI등재

        자료 발생 기법을 활용한 저수지 최소유입량 예측 기법 개발 : 섬진강댐을 대상으로

        이철희,이선미,이은경,지정원,윤정인,이재응,Lee, Chulhee,Lee, Seonmi,Lee, Eunkyung,Ji, Jungwon,Yoon, Jeongin,Yi, Jaeeung 한국수자원학회 2024 한국수자원학회논문집 Vol.57 No.5

        Climate change has been intensifying drought frequency and severity. Such prolonged droughts reduce reservoir levels, thereby exacerbating drought impacts. While previous studies have focused on optimizing reservoir operations using historical data to mitigate these impacts, their scope is limited to analyzing past events, highlighting the need for predictive methods for future droughts. This research introduces a novel approach for predicting minimum inflow at the Seomjingang dam which has experienced significant droughts. This study utilized the Stochastic Analysis Modeling and Simulation (SAMS) 2007 to generate inflow sequences for the same period of observed inflow. Then we simulate reservoir operations to assess firm yield and predict minimum inflow through synthetic inflow analysis. Minimum inflow is defined as the inflow where firm yield is less than 95% of the synthetic inflow in many sequences during periods matching observed inflow. The results for each case indicated the firm yield for the minimum inflow is on average 9.44 m<sup>3</sup>/s, approximately 1.07 m<sup>3</sup>/s lower than the observed inflow's firm yield of 10.51 m<sup>3</sup>/s. The minimum inflow estimation can inform reservoir operation standards, facilitate multi-reservoir system reviews, and assess supplementary capabilities. Estimating minimum inflow emerges as an effective strategy for enhancing water supply reliability and mitigating shortages. 최근 국내에서는 이상기후로 인해 가뭄의 빈도 및 심도가 증가하고 있으며 장기간의 가뭄으로 인한 저수지의 저수량 감소로 전국적인 가뭄 피해가 발생하였다. 가뭄 기간 동안의 피해를 최소화하기 위해 관측자료를 이용한 최적의 저수지 운영 방법을 제안하는 다양한 연구가 수행되었지만, 실측 자료만을 활용할 경우 과거 가뭄 사상에 대해서만 분석이 가능하기 때문에 미래에 발생할 수 있는 극심한 가뭄을 예측하고 분석하기 위한 기술이 필요한 실정이다. 본 연구에서는 최근 가뭄피해가 발생한 섬진강 유역에 위치한 섬진강댐을 대상으로 최소유입량 예측 기법을 제시하였다. 수문 분석 모형인 Stochastic Analysis Modeling and Simulation (SAMS) 2007을 이용하여 섬진강댐의 관측자료와 통계적 특성이 유사한 동일한 길이의 유입량을 다수 발생시키고, 저수지 모의운영에 따른 보장공급량 산정 결과를 활용하여 최소유입량을 예측하였다. 본 연구에서는 최소유입량을 대상 저수지의 관측자료와 동일한 기간을 갖는 다수의 발생유입량 중 보장공급량을 기준으로 95%는 이보다 작지 않은 값을 갖는 유입량으로 정의하였다. Case별 저수지 모의운영 분석 결과 섬진강댐 최소유입량의 보장공급량은 관측자료의 보장공급량인 10.51 m<sup>3</sup>/s 대비 평균 1.07 m<sup>3</sup>/s 낮게 분석되었다. 본 연구에서 산정한 최소유입량은 가뭄 시 저수지 운영 기준을 마련하는데 활용할 수 있을 것으로 판단되며 최소유입량을 활용하여 댐 연계운영, 추가 확보 가능한 용수공급량 등을 검토할 수 있다. 이는 가뭄 시 용수공급 안정성 확보 및 하류 물부족 문제 해소 등을 위한 대안 마련 시 활용될 수 있을 것으로 기대된다.

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