폐경기 여성에서 호르몬 대치 요법시 병행 투여된 프로제스토젠 투여 방법에 따른 골대사의 생화학적 지표에 미치는 영향

이권해,강선영,임경빈,이해혁,구도형,이석민 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Purpose : To evaluate the impact of added progestogen on biochemical markers of the bone turnover undergoing hormone replacement therapy in the postmenopausal women. Materials and Methods : There are 71 postmentopausal women who are divided into three groups (Group I, Group II, Group III). Group I(continuous combined)is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group II(unopposed estrogen) is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12). And there were measured serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion before starting hormone replacement therapy and 12 months later. Results : The serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion significantly decreased after hormone replacement therapy (Group, I, II, III). And there was no significance in decreases in biochemical markers of the bone turnover among three groups. Conclusions : It was concluded that the impact of added progestogen on the biochemical markers of the bone turnover undergoing hormone replaced therapy in postmenopausal women was not significant than nothing added group. Thus we concluded that progestogen was not impact on decreasing on the biochemical markers of the bone turnover in postmenopausal women undergoing hormone replacement therapy.

3D 광학 스캐너를 이용한 인체모형 팬텀 표면 데이터 획득 및 X-ray 에너지의 몬테카를로 시뮬레이션(MCs)을 이용한 팬텀 선량 평가와 영상구현

신준봉(Jun-Bong Shin),이도희(Do-Heui Lee),윤경준(Kyoung-Jun Yoon),박민재(Min-Jae Park),고영문(Young-Moon Go),김성우(Sung-Woo Kim),홍승모(Seung-Mo Hong),이현철(Hyun-Cheol Lee),이의섭(Ui-Seob Lee),노선영(Seon-Yeong No),강석윤(Seok-Yoon 대한영상의학기술학회 2021 대한영상의학기술학회 논문지 Vol.2021 No.-

목 적:본 연구의 목적은 기존 컴퓨터단층촬영(Computed tomography, 이하 CT) 스캔 방법 대신 3D 광학 스캐너 (3D optical scanner)를 이용하여 인체모형 팬텀의 표면 데이터를 획득하고 기존 CT 스캔 표면 데이터와 3D 광학 스캔 표면 데이터 차이를 비교 분석하는 것이며, 3D 광학 스캔 표면 데이터를 몬테카를로 시뮬레이션(Monte Carlo Simulation, MCs)에 적용하여 일반 촬영 에너지조건으로 팬텀 선량 평가와 영상 구현을 연구하는 것입니다. 연구방법: 일반촬영의 선량 평가를 위해 환자 표면 데이터를 얻을 때 3D 광학 스캐너를 활용할 것을 제안합니다. 우리는 3D 광학 스캐너(Go!SCAN SPARKTM, CREAFORM) 사용하여 기존 CT 스캔 방법을 대신해 인체모형 팬텀의 표면 데이터를 얻었습니다. 3D 스캔 표면 데이터를 정렬하고 편집하기 위해 Meshlab 프로그램을 이용하였으며, 3D slicer 프로그램을 이용하여 CT 스캔 표면 데이터와 3D 스캔 표면 데이터 차이를 정량적으로 비교분석 하였습니다. 또한 3D 스캔 표면 데이터 분석 프로그램(VXelements, CREAFORM)을 사용하여 인체 모형 팬텀의 재현성을 평가 하였습니다. SpekCalc 프로그램을 이용하여 X-ray beam 에너지 스펙트럼을 계산하고 Geant4 기반의 MCs인 TOPAS를 이용하여 X-ray Beam을 모델링 하였습니다. 인체모형 팬텀을 MCs에 적용 하여 일반촬영 에너지 조건으로 팬텀 선량을 평가하고 Phase space data 통해 영상을 구현을 연구 하였습니다. 결 과:3D slicer를 이용한 CT 스캔 표면 데이터와 3D 광학 스캔 표면 데이터의 정량적 비교 분석에서 Hounsdroff distance는 Average 2.45 mm, Dice coefficient는 0.97로 나타나 CT 스캔 표면 데이터와 3D 스캔 표면 데이터가 거의 일치하는 것을 확인할 수 있었습니다. 또한 인체모형 팬텀 재현성 평가에서 인체모형 팬텀의 AP position, RAO position, LAO position 기준으로 팔이 있는 팬텀의 error distribution은 2 mm 오차 범위에서 평균 89.78%가, 4 mm 오차 범위에서 96.05%가 일치하는 것으로 나타났으며, 팔을 제외한 경우 error distribution은 2 mm 오차 범위에서 평균 96.48%가, 4 mm 오차 범위에서 99.45%가 일치하는 것으로 나타나 3D 광학 스캐너의 표면 데이터 재현성이 우수한 것으로 나타났습니다. 인체모형 팬텀을 이용한 3D 스캔 표면 데이터를 MCs에 적용하여 전신일반촬영 에너지 조건으로 팬텀선량 평가가 가능하며, Phase space data 통해 영상을 구현할 수 있다는 것을 확인 하였습니다. 결 론:본 연구에서 3D 광학 스캐너를 사용한 인체모형 팬텀 데이터 획득은 기존 CT scan 방식보다 간편하고 방사선 노출 없이 다양한 위치와 균일한 표면 구조의 정보를 정밀하게 얻을 수 있으며 MCs을 이용한 선량계산이 가능하며, Phase space data 통해 영상을 구현이 가능함에 따라 앞으로 일반촬영 분야의 활용과 선량평가에 매우 유용할 것으로 생각 됩니다. Purpose:The purpose of this work is to acquire surface data of anthropromophic phantom using 3D optical scanner instead of conventional computed tomography (CT) scanning methods and to compare the differences between existing CT scan surface data and 3D optical scan surface data. also it is to apply 3D optical scan surface data to Monte Carlo simulations (MCs) to study whether phantom dose evaluation and image implementation are possible under general shooting energy conditions. Targets and Methods:We suggest utilizing a 3D optical scanner when obtaining patient surface data for dose evaluation of normal photography. We obtained surface data of anthropromophic phantom instead of conventional CT scanning methods using 3D optical scanners (Go!SCAN SPARKTM, CREAFORM). The Meshlab program was used to sort and edit 3D scan surface data, and the CT scan surface data and 3D scan surface data differences were quantitatively compared using the 3D slicer program. The reproducibility of the dummy phantom was also evaluated using the 3D Scan Surface Data Analysis Program (VXelements, CREAFORM). Using the SpekCalc program, the X-ray beam energy spectrum was calculated and the X-ray beam was modeled using TOPAS, a Geant4-based MCs. We applied the anthropromophic phantom to MCs evaluate the phantom dose in X-ray energy conditions and study whether the image can be implemented through phase space data. Result:Quantitative comparative analysis of CT scan surface data and 3D optical scan surface data using 3D slicer showed that Hounsdroff distance was Average 2.45 mm and Dice coefficient was 0.97, indicating a close match between CT scan surface data and 3D scan surface data. In addition, the anthropromophic phantom reproducibility assessment shows that the error distribution of the phantom with arms by AP position, RAO position, and LAO position of the anthropromophic phantom averaged 89.78% in the 2 mm error range and 96.05% in the 4 mm error range. MCs using anthropromophic phantom confirmed that 3D scan surface data can be applied to Monte Carlo simulation to evaluate phantom dose under X-ray energy conditions through phase space data. Conclusion:In this study, anthropromophic phan tom data acquisition using 3D optical scanners is simpler than conventional CT scan methods, provides precise information of various locations and uniform surface structures without radiation exposure, enables dosing using MCs, and enables image implementation through phase space data.

First report of tobacco mosaic virus infecting Vitis coignetiae in Korea

Seon-Min Go,Hyo-Jeong Lee,Nam-Yeon Kim,Hwi-Won Jeong,Rae-Dong Jeong 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10

Antimicrobial effect of non-thermal atmospheric plasma and its application for control of postharvest pathogenic decay of paprika

Seon-Min Go,Hyun-Seung Kim,Mi-Ri Park,Rae-Dong Jeong 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10

Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation

Go Min Ji,Kim Jong Min,Kang Jin Yong,Park Seon Kyeong,Lee Chang Jun,Kim Min Ji,Lee Hyo Rim,Kim Tae Yoon,Joo Seung Gyum,김대옥,허호진 한국미생물·생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.9

In this study, we investigated the anti-amnesic effect of Korean red pine (Pinus densiflora) bark extract (KRPBE) against amyloid beta1-42 (Aβ1-42)-induced neurotoxicity. We found that treatment with KRPBE improved the behavioral function in Aβ-induced mice, and also boosted the antioxidant system in mice by decreasing malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activities, and reducing glutathione (GSH) levels. In addition, KRPBE improved the cholinergic system by suppressing reduced acetylcholine (ACh) content while also activating acetylcholinesterase (AChE), regulating the expression of choline acetyltransferase (ChAT), postsynaptic density protein-95 (PSD-95), and synaptophysin. KRPBE also showed an ameliorating effect on cerebral mitochondrial deficit by regulating reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP levels. Moreover, KRPBE modulated the expression levels of neurotoxicity indicators Aβ and phosphorylated tau (p-tau) and inflammatory cytokines TNF-α, p- IκB-α, and IL-1β. Furthermore, we found that KRPBE improved the expression levels of neuronal apoptosis-related markers BAX and BCl-2 and increased the expression levels of BDNF and p-CREB. Therefore, this study suggests that KRPBE treatment has an anti-amnestic effect by modulating cholinergic system dysfunction and neuroinflammation in Aβ1-42-induced cognitive impairment in mice.

Thermal Control for Formation of 2-Tetradecylcyclobutanone in Irradiated Ground Pork

Seon-Min Go,Beom-Seok Song,Jae-Kyung Kim,Jong-Heum Park,Ha-Young Park,Jong-Bang Eun,Dong-Ho Kim 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

First report of tobacco mosaic virus infecting Dahlia pinnata in Korea

Seon-Min Go,Hyo-Jeong Lee,Nam-Yeon Kim,Hwi-Won Jeong,Rae-Dong Jeong 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10

수상태양광 발전시설 현황 및 주요 환경 쟁점 고찰

안채민(Chae Min Ahn),주진철(Jin Chul Joo),김진호(Jin Ho Kim),최선화(Sun Hwa Choi),장진선(Jin Seon Jang),고현우(Hyeon Woo Go) 대한환경공학회 2021 대한환경공학회지 Vol.43 No.4

목적 : 수상태양광 발전시설의 유형과 특징, 국내외 설치사례를 조사・분석하여, 수상태양광 발전시설의 발전용량과 수면 점유율을 비교하고, 수질 및 수생태계에 미치는 영향에 관련된 주요 환경 쟁점에 대해 고찰하였다. 방법 : 국내외 수상태양광 발전시설에 대한 기존 문헌 및 수상태양광 설치 회사에서 제공하는 정보와 데이터를 추출하여 통계적으로 분석하였다. 결과 및 토의 : 수상태양광 발전시설은 일반적으로 폰튠형, 프레임형, 태양 추적형의 3가지 유형으로 구분되어 국가별・지역별로 다양하게 설치되고 있다. 2018년 하반기 기준 전 세계적으로 수상태양광 발전용량은 1.3 GWp로 중국, 일본, 한국, 대만, 영국 순서로 수상태양광 발전시설이 많이 설치되고 있으며, 한국을 제외한 다른 국가들에서는 폰튠형이 한국의 경우 프레임형이 주로 설치되었다. 수원의 활용구분에 따라 식수용 수자원은 낮은 발전용량과 수면점유율로 설치된 반면, 농업용 수자원은 다양한 발전용량과 수면 점유율로 설치되었다. 이외에도 산업용, 빗물저장, 기타 수자원에는 비교적 높은 발전용량과 수면 점유율로 설치되어 있음을 확인하였다. 수상태양광 발전시설설치에 따른 주요 환경 쟁점인 기자재 유해물질 용출, 정체구역 발생에 따른 수질변화, 수면 점유율에 따른 수질변화 및 수생생물 군집변화, 수온・조도 변화, 전자파로 인한 수생태계 교란 가능성에 관련된 기존 문헌 고찰결과, 수상태양광 발전시설이 미치는 영향은 미미하며, 녹조저감과 수생태계 복원의 긍정적인 효과를 확인할 수 있었다. 결론 : 수상태양광 발전시설의 설치가 수환경(수질・수생태계)에 미치는 영향은 미미한 것으로 확인되었으나, 극한 조건을 반영한 추가 실험, 수상태양광 수면 점유율, 배열 및 유형별 장기간 지속적인 수질・수생태계 모니터링이 필요한 것으로 판단된다. Objectives : After investigation of types, characteristics, and domestic and overseas installation cases of floating photovoltaic power plants (FPVs), both power generation capacity and coverage ratio of the FPVs were analyzed, and the major environmental issues impacting on water quality and aquatic ecosystem were reviewed. Methods : Both information and data of the FPVs extracted from existing literature and provided by the FPVs installation companies were statistically analyzed. Results and Discussion : FPVs divided into three types such as pontoon type, frame type, and solar tracking type are installed in various ways by country and region. As of the second half of 2018, the global power generation capacity of FPVs is 1.3 GWp, and FPVs have been intensively installed in China, Japan, Korea, Taiwan, and UK. While the pontoon type has been mainly installed in other countries except Korea, the frame type was mainly installed in Korea. Among various water resources, FPVs installed in agricultural water resources have various power generation capacity and coverage ratio whereas FPVs installed in industrial, rainwater storage, and other water resources have relatively high power generation capacity and coverage ratio. Compared to FPVs installed in other water resources, FPVs installed in drinking water resources have relatively low power generation capacity and coverage ratio. After reviewing the major environmental issues related to FPVs (i.e., leaching of hazardous substances, deterioration of water quality and aquatic ecosystem, changes in water temperature and illumination, and disturbance of aquatic ecosystem), the impacts of the FPVs on water environment are found to be insignificant, and the positive effects (i.e., mitigation of green tide and restoration of the aquatic ecosystem) are confirmed. Conclusions : Although the impacts of the FPVs on water environment (water quality and aquatic ecosystem) are found to be insignificant, additional experiments reflecting extreme conditions and long-term continuous monitoring of water quality and aquatic ecosystem in terms of coverage ratio, array and type of FPVs are required.

LUnar Space Environment Monitor (LUSEM), the first achievement in Korea for the CLPS Project

Go Woon Na,Jongho Seon,Kyu-Sung Chae,Woo-Hyeong Seol,Chan-Haeng Lee,Young-Jun Choi,Dukhang Lee,Chae Kyung Sim,Seul-Min Baek,Jehyuck Shin,Jun Yong Park,Young Jin Jun 한국천문학회 2023 天文學會報 Vol.48 No.2

Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism

Seon-A Yoon,Young-Min Ham,Sang-Chul Han,Ho Bong Hyun,Boram Go,Yong-Hwan Jung,Eun-Sook Yoo,Weon-Jong Yoon 한국식품영양과학회 2023 Preventive Nutrition and Food Science Vol.28 No.3

In this study, immature persimmon (Diospyros kaki Thunb.) ethanol extract was administered to an obese animal model fed a high-fat diet to measure weight change, adipose tissue weight, serum lipid level, and expression level of adipose-related genes to evaluate its efficacy. Administration of D. kaki ethanol extract (DKE) (100 and 500 mg/kg/d) decreased the body weight gain, adipose tissue weight, and serum triglyceride levels in mice fed a high-fat diet. Furthermore, it improved the leptin and adiponectin levels in the blood as well as gene expression in the liver. It also inhibited the expression of sterol regulatory element-binding protein-1c, inhibiting the production of triglyceride biosynthetic enzyme fatty acid synthesis and acetyl-CoA carboxylase, and decreased the expressions of peroxisome proliferator-activated receptor  and CCAAT/enhancer-binding proteins that induce adipocyte differentiation. Therefore, these data suggest that DKE exerts beneficial effects on high-fat diet-induced obesity by modulating lipid metabolism in mice fed a high-fat diet.