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RISS 인기검색어
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- 저자 : Seojin Lee (검색결과 89 건)
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Lee, JooBuom,Lee, Kyungsun,Choe, Keunbum,Jung, Hyunseob,Cho, Hyunseok,Choi, Kiseok,Kim, Taegon,Kim, Seojin,Lee, Hyeong-Seok,Cha, Mi-Jin,Song, Si-Whan,Lee, Chul Kyu,Chun, Gie-Taek Korean Society of ToxicologyKorea Environmental Mu 2015 Toxicological Research Vol.31 No.4
TS-DP2 is a recombinant human granulocyte colony stimulating factor (rhG-CSF) manufactured by TS Corporation. We conducted a four-week study of TS-DP2 (test article) in repeated intravenous doses in male and female Sprague-Dawley (SD) rats. Lenograstim was used as a reference article and was administered intravenously at a dose of $1000{\mu}g/kg/day$. Rats received TS-DP2 intravenously at doses of 250, 500, and $1000{\mu}g/kg/day$ once daily for 4 weeks, and evaluated following a 2-week recovery period. Edema in the hind limbs and loss of mean body weight and body weight gain were observed in both the highest dose group of TS-DP2 and the lenograstim group in male rats. Fibro-osseous lesions were observed in the lenograstim group in both sexes, and at all groups of TS-DP2 in males, and at doses of TS-DP2 $500{\mu}g/kg/day$ and higher in females. The lesion was considered a toxicological change. Therefore, bone is the primary toxicological target of TS-DP2. The lowest observed adverse effect level (LOAEL) in males was $250{\mu}g/kg/day$, and no observed adverse effect level (NOAEL) in females was $250{\mu}g/kg/day$ in this study. In the toxicokinetic study, the serum concentrations of G-CSF were maintained until 8 hr after administration. The systemic exposures ($AUC_{0-24h}$ and $C_0$) were not markedly different between male and female rats, between the administration periods, or between TS-DP2 and lenograstim. In conclusion, TS-DP2 shows toxicological similarity to lenograstim over 4-weeks of repeated doses in rats.
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JooBuom Lee,Kyungsun Lee,Keunbum Choe,Hyunseob Jung,Hyunseok Cho,Kiseok Choi,Taegon Kim,Seojin Kim,Hyeong-Seok Lee,Mi-Jin Cha,Si-Whan Song,Chul Kyu Lee,Gie-Taek Chun 한국독성학회 2015 Toxicological Research Vol.31 No.4
TS-DP2 is a recombinant human granulocyte colony stimulating factor (rhG-CSF) manufactured by TS Corporation. We conducted a four-week study of TS-DP2 (test article) in repeated intravenous doses in male and female Sprague-Dawley (SD) rats. Lenograstim was used as a reference article and was administered intravenously at a dose of 1000 μg/kg/day. Rats received TS-DP2 intravenously at doses of 250, 500, and 1000 μg/kg/day once daily for 4 weeks, and evaluated following a 2-week recovery period. Edema in the hind limbs and loss of mean body weight and body weight gain were observed in both the highest dose group of TS-DP2 and the lenograstim group in male rats. Fibro-osseous lesions were observed in the lenograstim group in both sexes, and at all groups of TS-DP2 in males, and at doses of TS-DP2 500 μg/kg/day and higher in females. The lesion was considered a toxicological change. Therefore, bone is the primary toxicological target of TS-DP2. The lowest observed adverse effect level (LOAEL) in males was 250 μg/kg/day, and no observed adverse effect level (NOAEL) in females was 250 μg/kg/day in this study. In the toxicokinetic study, the serum concentrations of G-CSF were maintained until 8 hr after administration. The systemic exposures (AUC0-24h and C0) were not markedly different between male and female rats, between the administration periods, or between TS-DP2 and lenograstim. In conclusion, TS-DP2 shows toxicological similarity to lenograstim over 4-weeks of repeated doses in rats.
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Seojin Stacey Lee,Joonkyung Kim,Yaeri Kim,Kiwan Park 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
The spread of COVID-19 changes consumer preferences and behaviors greatly across the world. Extant literature has demonstrated that when there is a threat to disease, people stay away from those who do not seem healthy as they can be potentially infectious. Based on the previous literature, this research shows that individuals exposed to disease threat avoid products of which designs are high in visual complexity. When disease threat was present, individuals had lower purchase intention for products with complex designs. The perceived uncleanliness mediated the effect of visual complexity and disease threat on purchase intention. The findings provide a novel insight into the effect of disease salience on consumer perception of product design.
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Lee, SeoJin,Panthi, Sandesh,Jo, Hyun Woo,Cho, Jaeyoung,Kim, Min-Sik,Jeong, Na Young,Song, In Ok,Jung, Junyang,Huh, Youngbuhm Medknow PublicationsMedia Pvt Ltd 2017 Neural regeneration research Vol.12 No.3
<P>Dominant intermediate Charcot-Marie-Tooth disease type C (DI-CMTC) is a dominantly inherited neuropathy that has been classified primarily based on motor conduction velocity tests but is now known to involve axonal and demyelination features. DI-CMTC is linked to tyrosyl-tRNA synthetase (YARS)-associated neuropathies, which are caused by E196K and G41R missense mutations and a single <I>de novo</I> deletion (153-156delVKQV). It is well-established that these YARS mutations induce neuronal dysfunction, morphological symptoms involving axonal degeneration, and impaired motor performance. The present study is the first to describe a novel mouse model of YARS-mutation-induced neuropathy involving a neuron-specific promoter with a deleted mitochondrial targeting sequence that inhibits the expression of YARS protein in the mitochondria. An adenovirus vector system and <I>in vivo</I> techniques were utilized to express YARS fusion proteins with a Flag-tag in the spinal cord, peripheral axons, and dorsal root ganglia. Following transfection of YARS-expressing viruses, the distributions of wild-type (WT) YARS and E196K mutant proteins were compared in all expressed regions; G41R was not expressed. The proportion of Flag/green fluorescent protein (GFP) double-positive signaling in the E196K mutant-type mice did not significantly differ from that of WT mice in dorsal root ganglion neurons. All adenovirus genes, and even the empty vector without the YARS gene, exhibited GFP-positive signaling in the ventral horn of the spinal cord because GFP in an adenovirus vector is driven by a cytomegalovirus promoter. The present study demonstrated that anatomical differences in tissue can lead to dissimilar expressions of YARS genes. Thus, use of this novel animal model will provide data regarding distributional defects between mutant and WT genes in neurons, the DI-CMTC phenotype, and potential treatment approaches for this disease.</P>
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기업과 소비자의 사회적 책임이 지속가능소비생활 실천과 소비생활만족에 미치는 영향
이민환(Lee, Min-HWan),이서진(Lee, Seojin Stacey) 한국상품학회 2021 商品學硏究 Vol.39 No.5
본 연구의 목적은 기업의 사회적 책임과 소비자의 사회적 책임이 소비생활만족에 미치는 영향을 파악하는 것이며, 구체적으로 기업의 사회적 책임과 소비자의 사회적 책임이 지속가능소비생활 실천을 통하여 소비생활만족에 미치는 영향을 살펴보고자 하였다. 이를 위하여 한국소비자원에서 2년 주기로 조사·발표되고 있는 「2019 한국의 소비생활지표」통계 데이터를 활용하여 실증분석을 수행하였다. 분석결과 기업의 사회적 책임과 소비자의 사회적 책임은 지속가능소비생활 실천과 소비생활만족에 긍정적인 영향을 미치는 것으로 나타났다. 또한, 기업의 사회적 책임과 소비자의 사회적 책임은 지속가능한 소비생활실천을 통하여 소비생활만족에 긍정적인 영향을 미치는 것으로 나타나 매개효과가 검증되었다. 이러한 연구변수 간의 관계에 대한 영향력의 유무와 크기는 나이, 성별, 소비자교육 및 소비자참여활동 참여의사와 같은 개인적 특성에 따라 차이를 보여 조절효과가 있는 것으로 나타났다. 특히, 소비자교육 및 소비자참여활동 참여의사의 정도에 따라 지속가능한 소비생활 실천의 매개효과의 유무와 영향력의 방향성이 상반되는 결과를 보이며 주도적이고 적극적인 소비자의 역할에 따른 유의미한 차이를 나타냈다. 이러한 결과를 통해 기업의 사회적 책임과 소비자의 사회적 책임을 강화하고 이를 지속가능소비와 연결시키고자하는 학문적 및 정책적 기여에 대하여 논의하였고, 본 연구의 한계점과 향후 연구방향을 제시하였다. This research aims to investigate the effects of corporate social responsibility, consumer social responsibility, and sustainable consumption practice on consumer life satisfaction. We hypothesize that both corporate social responsibility and consumer social responsibility positively influence consumer life satisfaction via sustainable consumption practice. The structural equation modeling (SEM) is used to analyze the data from 「2019 Korea Consumer Life Index」, which is investigated and published every two years by the Korea Consumer Agency. The findings suggest that corporate social responsibility and consumer social responsibility have positive effects on sustainable consumption practice and consumer life satisfaction. Especially, sustainable consumption practices mediate the effects of corporate social responsibility as well as consumer social responsibility on consumer life satisfaction. Furthermore, it is confirmed that individual differences including age, gender, participation intention of consumer education, and participation intention of consumer participation activities moderates the observed effects. In particular, the presence and the direction of sustainable consumption practice showed a meaningful difference in the leading and active consumers. Theoretical and practical implications of the present studyare discussed, and limitations and future research directions are suggested.
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라이프스타일 변화에 따른 PB 밀키트 상품 트렌드 연구 - 이마트 피코크 상품을 중심으로 -
이서진 ( Seojin Lee ) 한국디자인트렌드학회 2021 한국디자인포럼 Vol.26 No.1
연구배경 코로나바이러스감염증-19의 확산은 우리의 일상생활에서 많은 것들을 바꾸어 놓았다. 사회적 거리 두기가 강화됨에 따라 재택 생활이 장기화하고 있으며 이로 인해 살림을 담당하는 가족 구성원의 가사 노동량은 급격히 증가하였다. 반복되는 식사 준비의 수고를 덜고자 음식 배달서비스와 가정간편식 HMR(Home Meal Replacement) 시장이 가파르게 성장하였다. 가정간편식 중에서도 외식의 내식화를 이끈 밀키트 시장은 괄목할 만한 성장을 이어가고 있다. 본 연구는 라이프스타일 변화에 따라 확대되고 있는 PB(Private Brand)상품 중에서 식생활 문화의 변화를 가져온 밀키트 상품의 현황을 살펴보고 그 트렌드와 디자인의 방향성을 연구하고자 하였다. 연구방법 본 연구에서는 2장에서 이론적 고찰로 PB상품의 의미, 가정간편식의 역사와 동향 그리고 가정간편식 중 최근 주목받고 있는 밀키트에 대해 살펴보았다. 3장에서는 우리나라 대표적 유통 3사의 PB 밀키트 브랜드 사례를 살펴보고 업계 선두인 이마트 PB 피코크 사례를 중심으로 조사하여 밀키트 상품의 트렌드와 디자인 특성을 조사·분석하였다. 연구결과 시장이 확대되고 경쟁이 치열해짐에 따라 PB밀키트 상품은 다양화와 고급화가 추진되고 있었다. 이마트 PB 피코크는 기존 PB 식품브랜드들을 통합하고 다양한 맛집과의 컬래버레이션 제품 출시, 개념 소비 진작을 통해 프리미엄 전략을 진행하고 있었다. 결론 밀키트 디자인은 식재료의 신선도에 대한 신뢰성을 소구하고 요리를 쉽게 할 수 있도록 돕는 정보전달의 결합이 중요한 요소임을 알 수 있었다. 편리미엄 추구와 개념 소비가 트렌드로 떠오르면서 PB상품의 프리미엄 전략이 진행되고 있었으며 이용의 편리성을 높이고 환경친화적인 포장재를 사용한 밀키트 디자인이 추세임을 알 수 있었다. Background The COVID-19 pandemic has changed many things in our daily lives. Due to the reinforcement of social distancing and prolonged home life, the amount of housework for family members in charge of housekeeping increased sharply, and the food delivery service and HMR(Home Meal Replacement) market grew steeply in order to reduce the trouble of preparing meals. Among the HMR, the Meal Kit market, which led to the internalization of eating out, is drawing attention. This study attempted to examine the status of Meal Kit among PB(Private Brand) products that are expanding according to lifestyle changes, and to study the Meal Kit trend and the design direction in line with changes in dietary culture. Methods In this study, in Chapter 2, the meaning of PB products, the history and trends of HMR, and Meal Kit, which has recently attracted attention among HMR, were examined as theoretical considerations in Chapter 2. In Chapter 3, I examined the cases of PB Meal Kit products of three leading Korean distributors, and focused on the case of E-Mart Peacock brand to investigate and analyze the trends and package design characteristics of Meal Kit products. Result As the market expanded and competition intensified, the PB Meal Kit products were diversified and advanced. E-Mart PB Peacock was implementing a premium strategy by integrating existing brands, collaborating with various restaurants, and promoting concept consumption. Conclusion The combination of the reliability of the freshness of food ingredients and the power to communicate information that makes cooking easier has become an important factor for customers who want rational consumption. As the pursuit of convenience and concept consumption emerged as a trend, the premium strategy of PB products was in progress, and it could be seen that the trend is the Meal Kit design that uses eco-friendly packaging materials and enhances the convenience of use.
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